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1. 发明专利

CZ1248U1 Means to detach tick from skin 未知
公开(公告)号：CZ1248U1
公开(公告)日：1994-03-16
申请号：CZ152093
申请日：1993-11-05
申请人： VIMR STANISLAV ING
发明人： VIMR STANISLAV ING
IPC分类号： A61K31/045 , A61K33/18 , A61K031/045 , A61K033/18

2. 发明专利

AU2001258061B2 Novel antibiotic compounds 未知
公开(公告)号：AU2001258061B2
公开(公告)日：2005-09-29
申请号：AU2001258061
申请日：2001-05-22
申请人： COMMW SCIENT IND RES ORG
发明人： TROWELL STEPHEN CHARLES , RICKARDS RODNEY WARREN , ZHAO CHUNJIU
IPC分类号： A61K31/015 , A61K31/045 , A61K31/047 , A61K31/185 , A61L2/18 , A61P31/04 , A61P31/06 , A61P31/08 , C07C13/573 , C07C013/573 , A61K031/015 , A61K031/045 , A61K031/047 , A61K031/185 , A61L002/18 , A61P031/04 , A61P031/06 , A61P031/08

3. 发明申请

WO2003049774A1 TRANSDERMAL TRANSPORT OF COMPOUNDS 审中-公开
标题翻译：化合物的转运
公开(公告)号：WO2003049774A1
公开(公告)日：2003-06-19
申请号：PCT/AU2002/001686
申请日：2002-12-13
申请人： VITAL HEALTH SCIENCES PTY LTD , WEST, Simon, Michael , KANNAR, David
发明人： WEST, Simon, Michael , KANNAR, David
IPC分类号： A61K031/045
CPC分类号： A61K9/0014 , A61K31/045 , A61K31/66 , A61K47/18
摘要： There is provided a topical formulation comprising an effective skin-penetrating amount of one or more phosphate derivatives of one or more pharmaceutical hydroxy compounds and an acceptable carrier.
摘要翻译：提供了包含有效皮肤穿透量的一种或多种药物羟基化合物和可接受载体的一种或多种磷酸酯衍生物的局部制剂。

4. 发明申请

US20040266887A1 Inhibition of exoprotein production using aromatic compositions in non-absorbent articles 审中-公开
标题翻译：在非吸收性物品中抑制使用芳香族组合物产生的外来蛋白
公开(公告)号：US20040266887A1
公开(公告)日：2004-12-30
申请号：US10803819
申请日：2004-03-18
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Rae Ellen Syverson , Richard A. Proctor
IPC分类号： A61K031/045
CPC分类号： A61K31/165 , A61K31/325 , A61L15/46 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/45 , A61L2300/802
摘要： Non-absorbent articles are disclosed. The non-absorbent articles include an effective amount of an aromatic inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria. The aromatic inhibitory compounds of the present invention have the general formula: 1 wherein R1 is nullOR6OH; R6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; R2, R3, and R4 are independently selected from the group consisting of H, OH, COOH, and nullC(O)R9; R9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety.

5. 发明申请

US20040127556A1 Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis 有权
标题翻译：用于治疗皱纹，细纹和多汗症的组合物和递送方法
公开(公告)号：US20040127556A1
公开(公告)日：2004-07-01
申请号：US10334887
申请日：2002-12-31
发明人： Michelle Zheng Lu , Robert E. Kalafsky , Michele C. Duggan
IPC分类号： A61K031/365 , A61K031/045 , A61K031/01
CPC分类号： A61Q19/08 , A61K8/046 , A61K8/14 , A61K8/97 , A61K31/00 , A61K31/01 , A61K31/045 , A61K31/365 , A61K45/06 , A61K2800/70 , A61K2300/00
摘要： The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, wherein the compositions include limonoid constituents which inhibit acetylcholine release at neuromuscular junctions of skeletal muscle so as to relax the muscles involved with wrinkling, folding and creasing of skin, e.g., facial movement and expression. The limonoids preferably include the plant alkaloids toosendanin and azadirachtin. The compositions, which also are used to treat hyperhidrosis, are preferably applied to the skin, or are delivered by directed means to a site in need thereof.
摘要翻译：本发明描述了用于治疗，预防和改善皮肤外观，特别是治疗，预防，改善，减少和/或消除皮肤细纹和/或皱纹的组合物和方法，其中组合物包括抑制乙酰胆碱释放的柠檬醛成分在骨骼肌的神经肌肉接头处，以便放松与皮肤起皱，折叠和皱纹相关的肌肉，例如面部运动和表达。柠檬醛优选包括植物生物碱toosendanin和印苦楝子素。也用于治疗多汗症的组合物优选施用于皮肤，或通过定向方式递送至有需要的部位。

6. 发明申请

US20040116482A1 Potassium channel opener 失效
标题翻译：钾通道开启剂
公开(公告)号：US20040116482A1
公开(公告)日：2004-06-17
申请号：US10664165
申请日：2003-09-17
发明人： Yuji Imaizumi , Tomohiko Ohwada
IPC分类号： A61K031/44 , A61K031/40 , A61K031/275 , A61K031/19 , A61K031/045 , A61K031/12
CPC分类号： A61K31/19
摘要： A potassium channel opener comprising a compound (e.g., pimaric acid) represented by the formula nullInull: 1 wherein R1, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, alkyl, alkenyl, halogen, hydroxy, halogenated alkyl, hydroxyalkyl, aminoalkyl, alkoxy, aryl, heteroaryl, acyl, carboxyl, alkoxycarbonyl, hydroxamate, sulfo, carbamoyl, sulfonamide, aldehyde, or nitrile; or R4 and R5 may be bonded to each other to form a ring; or R6 and R7 may be bonded to each other to form a ring; and all of three bonds represented by are single bonds, or one of the three bonds is double bond and the other bonds are single bonds, or a physiologically acceptable salt thereof as an effective ingredient.
摘要翻译：钾通道开放剂，其包含由式[I]表示的化合物（例如，海松酸）：其中R 1，R 2，R 3，R 4，R 5，R 6 和R 7各自独立地为氢，烷基，烯基，卤素，羟基，卤代烷基，羟基烷基，氨基烷基，烷氧基，芳基，杂芳基，酰基，羧基，烷氧基羰基，异羟肟酸酯，磺基，氨基甲酰基，磺酰胺，醛或腈 ; 或R 4和R 5可以彼此键合形成环; 或R 6和R 7可以彼此键合形成环; 并且由表示的所有三个键都是单键，或者是三键为双键，其他键为单键，或其生理学上可接受的盐作为有效成分。

7. 发明申请

US20040092588A1 Antiseptic for wounds and mucous membranes 审中-公开
标题翻译：伤口和粘膜的防腐剂
公开(公告)号：US20040092588A1
公开(公告)日：2004-05-13
申请号：US10469431
申请日：2003-08-28
发明人： Axel Kramer , Frank-Albert Pitten
IPC分类号： A61K031/205 , A61K031/045
CPC分类号： A61Q17/005 , A01N43/40 , A61K8/365 , A61K8/4926 , A61Q19/00 , A01N37/36 , A01N37/04 , A01N37/02 , A01N31/02 , A01N2300/00
摘要： The invention relates to an octenidine antiseptic for wounds and mucous membranes that is characterized by a content in ethanol and a physiologically acceptable organic acid.
摘要翻译：本发明涉及用乙醇和生理上可接受的有机酸含量表征的伤口和粘膜的辛烯尼酸消毒剂。

8. 发明申请

US20040023889A1 Alpha lipoic acid based food supplement for increasing lean muscle mass and strength 审中-公开
标题翻译：用于增加瘦肌肉质量和强度的基于硫辛酸的食物补充剂
公开(公告)号：US20040023889A1
公开(公告)日：2004-02-05
申请号：US10414359
申请日：2003-04-15
发明人： Paul Gardiner , Derek Woodgate
IPC分类号： A61K038/05 , A61K038/04 , A61K031/70 , A61K031/385 , A61K031/198 , A61K031/045 , A61K035/78
CPC分类号： A23L33/19 , A23L33/175 , A23L33/40 , A23V2002/00 , A23V2200/316 , A23V2250/026 , A23V2250/062 , A23V2250/61 , A23V2250/54252 , A23V2250/0606 , A23V2250/0628 , A23V2250/0638 , A23V2250/0632 , A23V2250/70 , A23V2250/156
摘要： Food supplement compositions and their methods of use in increasing lean mass and/or muscle size and/or strength in individuals, particularly, athletes is described. The food supplements described comprise null lipoic acid or a derivative thereof, and an amino acid. Other food supplements described comprise a substance which can enhance and/or mimic activity of null lipoic acid, and a source of amino acid. The food supplement compositions described are suitable for supplementing the diet of an athlete and particularly for enhancing an athlete's muscle size and/or strength.
摘要翻译：描述了食物补充剂组合物及其用于增加个体，特别是运动员的瘦体重和/或肌肉尺寸和/或强度的方法。所述的食品添加剂包括α-硫辛酸或其衍生物和氨基酸。所描述的其它食品添加剂包括可以增强和/或模拟α-硫辛酸的活性的物质和氨基酸的来源。所描述的食物补充剂组合物适于补充运动员的饮食，特别是用于增强运动员的肌肉尺寸和/或强度。

9. 发明申请

US20030207851A1 Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith 失效
标题翻译：治疗性1,2,3,6-四氢嘧啶-2-酮组合物及其方法
公开(公告)号：US20030207851A1
公开(公告)日：2003-11-06
申请号：US10139193
申请日：2002-05-02
发明人： Edward T. Wei
IPC分类号： A61K031/573 , A61K031/513 , A61K031/137 , A61K031/045
CPC分类号： A61K9/0075 , A61K9/0043 , A61K31/00 , A61K31/513 , A61K31/56 , A61K31/573 , A61K45/06 , A61M15/08 , A61M2202/064 , A61K2300/00
摘要： A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one cold receptor agonist in a therapeutically effective amount and preferably further comprises one or more pharmaceutically active drugs such as an anti-inflammatory glucocorticosteroid, a sympathomimetic amine decongestant, an anti-histamine, a local anesthetic, menthol or a menthol analog, and mixtures thereof. The cold receptor agonist may be represented by the general formula 1-null1R-phenylnull-4-nullR2-phenylnull-1,2,3,6-tetrahydropyrimidine-2-one wherein: R1 is -hydroxy, -chloro, -fluoro, -alkyl, -acetoxy, -trifluoromethyl; and R2 is -nitro, -chloro, -fluoro, -alkyl, -trifluoromethyl. Therapeutic compositions of the invention elicit long-lasting cooling or soothing, particularly when formulated for delivery to suppress the sensations of itch and pain, such as for delivery to inflamed skin, to the mucous membranes of the anogenital areas, and to the enteric mucosa.
摘要翻译：提供了治疗组合物，其包含治疗有效量的1-R 1 - 苯基，4-R 2 - 苯基取代的1,2,3,6-四氢嘧啶-2-酮冷受体激动剂，优选还包含一种或多种药学活性药物如抗炎糖皮质激素，拟交感胺减充血剂，抗组胺，局部麻醉剂，薄荷醇或薄荷醇类似物及其混合物。冷受体激动剂可以由通式1- [1R-苯基] -4- [R2-苯基] -1,2,3,6-四氢嘧啶-2-酮表示，其中：R1是 - 羟基， - 氯， - 氟， - 烷基， - 乙酰氧基， - 三氟甲基; 并且R 2是 - 硝基， - 氯， - 氟， - 烷基， - 三氟甲基。本发明的治疗组合物引起持久的冷却或舒缓，特别是当配制用于输送以抑制瘙痒和疼痛的感觉，例如用于递送至发炎的皮肤，向肛门生殖区域的粘膜和肠粘膜时。

10. 发明申请

US20030139469A1 Use of inhibitors of soluble epoxide hydrolase to inhibit vascular smooth muscle cell proliferation 审中-公开
标题翻译：使用可溶性环氧化物水解酶抑制剂抑制血管平滑肌细胞增殖
公开(公告)号：US20030139469A1
公开(公告)日：2003-07-24
申请号：US10056284
申请日：2002-01-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Robert H. Weiss , Bruce D. Hammock
IPC分类号： A61K031/335 , A61K031/17 , A61K031/13 , A61K031/045
CPC分类号： A61K31/335 , A61K31/00 , A61K31/045 , A61K31/13 , A61K31/17
摘要： The present invention provides methods of slowing or inhibiting vascular smooth muscle (VSM) cell proliferation to slow the development or recurrence of atherosclerosis by contacting VSM cells with soluble epoxide hydrolase (sEH) inhibitors. Further, the methods of the invention can be used to slow or to inhibit vascular restenosis after angioplasty and the stenosis of vascular stents. Further, the methods of the invention can be used to slow or to inhibit the stenosis of hemodialysis grafts and other natural and synthetic vascular grafts.
摘要翻译：本发明提供了通过使VSM细胞与可溶性环氧化物水解酶（sEH）抑制剂接触来减缓或抑制血管平滑肌（VSM）细胞增殖以减缓动脉粥样硬化的发展或复发的方法。此外，本发明的方法可用于减缓或抑制血管成形术和血管支架狭窄后的血管再狭窄。此外，本发明的方法可用于减缓或抑制血液透析移植物和其它天然和合成血管移植物的狭窄。

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