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81. 发明申请

US20030176364A1 Antimicrobial therapeutic compositions and methods of use 失效
标题翻译：抗微生物治疗组合物和使用方法
公开(公告)号：US20030176364A1
公开(公告)日：2003-09-18
申请号：US10370411
申请日：2003-02-18
发明人： Dusan Ninkov
IPC分类号： A61K031/7024 , A61K031/24 , A61K031/05
CPC分类号： A61K31/05 , A61K31/16 , A61K45/06 , A61K2300/00
摘要： The invention provides therapeutic antimicrobial compositions and methods for their use based on natural organic phenolic compounds combined with pharmacological agents. The antimicrobial activities of each carvacrol and thymol are believed to be enhanced, while the pharmacological properties of procaine and related compounds are added to provide their unique properties to facilitate usefulness and effectiveness in humans. The therapeutic compositions are active against bacterial, fungal, and protozoan infections. The forms of the invention are intended to treat various internal infections through parenteral, subcutaneous, intradermal, intravenous, and intramuscular injections. They are also intended as useful agents to treat microbial infections that have become resistant to conventional anitibiotics as well as secondary opportunistic infections.
摘要翻译：本发明提供治疗性抗微生物组合物及其基于天然有机酚类化合物与药物代谢物组合使用的方法。据信，每种香芹酚和百里酚的抗微生物活性得到增强，而普鲁卡因和相关化合物的药理学性质被加入以提供其独特的性质来促进人类的有用性和有效性。治疗组合物对细菌，真菌和原生动物感染具有活性。本发明的形式旨在通过肠胃外，皮下，皮内，静脉内和肌内注射治疗各种内部感染。它们也被用作治疗已经变得对常规的抗生素以及次级机会性感染具有抗性的微生物感染的有用试剂。

82. 发明申请

US20030171429A1 Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxyltilbenes and novel stilbene derivatives and analogues 审中-公开
标题翻译：抗炎和牛皮癣治疗和蛋白激酶抑制由羟基芘和新颖的二苯乙烯衍生物和类似物
公开(公告)号：US20030171429A1
公开(公告)日：2003-09-11
申请号：US10148863
申请日：2002-10-28
发明人： Genhui Chen , John M. Webster , Jianxiong Li , Kaiji Hu , Jiang Zhu
IPC分类号： A61K031/335 , A61K031/05 , C07C33/14 , C07D303/34
CPC分类号： C07D303/22 , A61K9/0014 , A61K31/05 , A61K31/336 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , C07D303/14 , C07D303/16 , C07D405/04 , Y02A50/406
摘要： Disclosed herein are compositions containing hydroxylstilbenes or their derivatives or analogues. The compositions are useful to inhibit protein kinease, and for the treatment of inflammatory diseases, including psoriasis, multiple sclerosis, rhumatoid arthritis, restinosis, inflammatory bowel disease, and inflammatory lung disease. They are also useful to treat surgical adhesions and graft rejection. Novel derivatives and analogues are also disclosed.
摘要翻译：本文公开了含有羟基茋或其衍生物或类似物的组合物。该组合物可用于抑制蛋白激酶和用于治疗炎性疾病，包括牛皮癣，多发性硬化症，类风湿性关节炎，再狭窄，炎性肠病和炎性肺部疾病。它们也可用于治疗手术粘连和移植排斥。还公开了新的衍生物和类似物。

83. 发明申请

US20030133992A1 Method and composition for preventing or reducing the symptoms of insulin resistance syndrome 有权
标题翻译：用于预防或减少胰岛素抵抗综合征症状的方法和组合物
公开(公告)号：US20030133992A1
公开(公告)日：2003-07-17
申请号：US10265093
申请日：2002-10-04
发明人： Debasis Bagchi , Harry G. Preuss , Shil C. Kothari
IPC分类号： A61K033/32 , A61K033/04 , A61K031/7048 , A61K031/704 , A61K031/095 , A61K031/05 , A61K031/19
CPC分类号： A61K31/185 , A61K31/05 , A61K31/095 , A61K31/19 , A61K31/194 , A61K31/28 , A61K31/44 , A61K31/455 , A61K31/704 , A61K31/7048 , A61K33/04 , A61K33/24 , A61K33/30 , A61K45/06 , Y10S514/824 , Y10S514/866 , Y10S514/909 , A61K2300/00
摘要： A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bound chromium that prevents or reduces the symptoms. Compositions incorporating niacin-bound chromium and additional compounds also are disclosed that are particularly effective in synergistically preventing or reducing these symptoms.
摘要翻译：预防和/或减少胰岛素抵抗症状和相关综合征的方法包括鉴定患有或有风险患有这些症状的个体，并向其施用有效量的包含烟酸结合的铬的组合物，其防止或减少症状还公开了包含烟酸结合的铬和其它化合物的组合物，其在协同地预防或减少这些症状方面特别有效。

84. 发明申请

US20030118617A1 Resveratrol analogues 审中-公开
标题翻译：白藜芦醇类似物
公开(公告)号：US20030118617A1
公开(公告)日：2003-06-26
申请号：US10032151
申请日：2001-12-21
申请人： AVON PRODUCTS, INC.
发明人： Lynn Soby , Eugenia H. Theophilus , Dmitri Ptchelintsev , Paul S. Attar
IPC分类号： A61K031/70 , A61K007/00 , A61K031/277 , A61K031/198 , A61K031/05 , A61K031/075
CPC分类号： A61Q19/007 , A61K8/33 , A61K8/34 , A61K8/345 , A61K8/347 , A61K8/35 , A61K8/36 , A61K8/42 , A61K31/05 , A61K31/075 , A61K31/198 , A61K31/277 , A61K31/70 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： A method for treating the skin of a human is disclosed. Also disclosed is a composition for carrying out such method, in which the composition has at least one resveratrol analogue represented by the formula 1 wherein each X1 and X2 are not both hydrogen but each X1 and X2 are otherwise independently selected from the group consisting of hydrogen, hydroxy, alkoxy, acyl and carboxyl; wherein each X3 is selected from the group consisting of hydrogen, hydroxy, alkoxy and acyl; wherein each Y1 is selected from the group consisting of carbohydrate, hydrogen and hydroxyl; wherein R1 and R2 are double-bonded in cis or trans configuration and each R1 and R2 are independently selected from the group consisting of hydrogen, alkoxy, carboxyl, methoxy, nitryl, isonitryl and cyano.
摘要翻译：公开了一种治疗人的皮肤的方法。还公开了用于进行这种方法的组合物，其中组合物具有由下式表示的至少一种白藜芦醇类似物，其中每个X 1和X 2不是氢，而是X 1和X 2各自独立地选自氢，羟基，烷氧基，酰基和羧基; 其中每个X3选自氢，羟基，烷氧基和酰基; 其中每个Y1选自碳水化合物，氢和羟基; 其中R1和R2以顺式或反式构型双键键合，并且每个R 1和R 2独立地选自氢，烷氧基，羧基，甲氧基，硝基，异壬基和氰基。

85. 发明申请

US20030069317A1 High efficacy antibacterial compositions having enhanced esthetic and skin care properties 有权
标题翻译：具有增强的美学和护肤性能的高效抗菌组合物
公开(公告)号：US20030069317A1
公开(公告)日：2003-04-10
申请号：US10103246
申请日：2002-03-21
发明人： Earl P. Seitz JR. , Gregory A. Konishi , Andrea Lynn Waggoner , Timothy J. Taylor , Janice Lynn Fuls , Sydney Lindsay Schilcher , DeAnn Marie Popisil Davis
IPC分类号： A61K031/05
CPC分类号： A01N31/08 , A01N31/16 , A01N25/30 , A01N25/16 , A01N25/02 , A01N2300/00
摘要： Antibacterial compositions having high antibacterial effectiveness and excellent esthetic properties are disclosed. The compositions also impart skin conditioning properties and improved feel to cleansed skin. The antibacterial compositions contain a phenolic antibacterial agent, a surfactant, esthetic enhancers, skin care ingredients, and water, wherein a percent saturation of the antibacterial agent in the aqueous phase of the composition is at least 25%.
摘要翻译：公开了具有高抗菌效果和优异的美学特性的抗菌组合物。组合物还赋予皮肤调理性能并改善对清洁皮肤的感觉。抗菌组合物含有酚类抗菌剂，表面活性剂，美容增效剂，护肤成分和水，其中组合物水相中抗菌剂的饱和百分比至少为25％。

86. 发明申请

US20030027870A1 Fullerene derivatives that modulate nitric oxide synthase and clamodulin activity 审中-公开
标题翻译：富勒烯衍生物调节一氧化氮合酶和cl调素活性
公开(公告)号：US20030027870A1
公开(公告)日：2003-02-06
申请号：US10147453
申请日：2002-05-15
发明人： Stephen R. Wilson , Donald J. Wolff , David I. Schuster , Christine F. Richardson , Alexandru Dragos Petru Papoiu , John Michael Alford
IPC分类号： A61K031/135 , A61K031/05
CPC分类号： A61K31/05 , A61K31/135
摘要： This invention provides novel fullerene derivatives, particularly fullerene derivatives that are water-soluble, that modulate the activity of nitric oxide synthase (NOS) and/or calmodulin. The invention provides methods for modulating NOS activity and particularly provides methods for inhibiting NOS activity, by contacting one or more fullerene derivatives of this invention with cells or tissue that exhibit NOS activity. In a specific embodiment, the invention provides water-soluble fullerene derivatives that are selective inhibitors of neuronal NOS or iNOS. Preferred water soluble fullerenes have substituents that contain one or more amine groups, amine cationic groups. More generally, water-soluble fullerenes of this invention contain one or more polar, one or more charged or more zwitterionic groups
摘要翻译：本发明提供新型富勒烯衍生物，特别是水溶性的富勒烯衍生物，其调节一氧化氮合酶（NOS）和/或钙调蛋白的活性。本发明提供调节NOS活性的方法，特别是通过使本发明的一种或多种富勒烯衍生物与表现出NOS活性的细胞或组织接触来提供抑制NOS活性的方法。在具体实施方案中，本发明提供作为神经元NOS或iNOS的选择性抑制剂的水溶性富勒烯衍生物。优选的水溶性富勒烯具有含有一个或多个胺基，胺阳离子基团的取代基。更一般地，本发明的水溶性富勒烯含有一个或多个极性，一个或多个带电荷或更多的两性离子基团

87. 发明申请

US20020173547A1 Pharmaceuticals compositions 审中-公开
标题翻译：药物组合物
公开(公告)号：US20020173547A1
公开(公告)日：2002-11-21
申请号：US09984020
申请日：2001-10-26
发明人： Christopher Buchan Jones , John Henry Platt
IPC分类号： A61K031/195 , A61K031/05
CPC分类号： A61K31/05 , A61K9/0019 , A61K9/1075 , A61K47/183 , Y02A50/473
摘要： Pharmaceutical compositions containing 2,6-diisopropylphenol (propofol) are described for use as anesthetics. A method for their preparation is described, as their use in producing anesthesia including induction and maintenance of general anesthesia and sedation.
摘要翻译：描述了含有2,6-二异丙基苯酚（丙泊酚）的药物组合物用作麻醉剂。描述了其制备方法，作为它们在产生麻醉中的用途，包括诱导和维持全身麻醉和镇静。

88. 发明申请

US20020168397A1 Antiallergic agents 失效
标题翻译：抗过敏剂
公开(公告)号：US20020168397A1
公开(公告)日：2002-11-14
申请号：US09778820
申请日：2001-02-08
发明人： Kenkou Tsuji , Mari Yamamoto , Keiko Kawamoto , Hirofumi Tachibana
IPC分类号： A61K007/00 , A61K047/00 , A61K031/05
CPC分类号： A61K31/05 , A61K8/60 , A61K8/97 , A61K9/0056 , A61Q19/10 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/847 , Y10S514/848
摘要： This invention is to provide an agent for therapy and prevention of allergic diseases which has no adverse action, shows a high safety even by administration for a long period and is able to be utilized to food and/or beverage, cosmetics, etc. which are used daily. To be specific, it provides antiallergic agent and anti-inflammatory agent characterized in containing at least one polyphenol selected from strictinin and methylated derivatives thereof as an effective ingredient; a method for the addition of an antiallergic agent for oral administration or an anti-inflammatory agent for oral administration which is characterized in containing at least one polyphenol selected from strictinin and methylated derivatives thereof as an effective ingredient to food and/or beverage for prevention, suppression and mitigation of allergic symptoms or inflammatory symptoms.
摘要翻译：本发明提供一种治疗和预防过敏性疾病的药剂，其不会产生不良反应，即使长时间施用也能显示高安全性，并且能够用于食品和/或饮料，化妆品等每天使用具体而言，提供抗变应性剂和抗炎剂，其特征在于含有至少一种选自严格菌素及其甲基化衍生物的多酚作为有效成分; 用于口服给药的抗过敏剂或口服抗炎剂的添加方法，其特征在于，含有至少一种选自其严格抑制素和甲基化衍生物的多酚作为有效成分用于预防食品和/或饮料，抑制和缓解过敏症状或炎症症状。

89. 发明申请

US20020165146A1 FSH article of manufacture 审中-公开
标题翻译： FSH制品
公开(公告)号：US20020165146A1
公开(公告)日：2002-11-07
申请号：US09973918
申请日：2001-10-10
发明人： James Arthur Hoffman , Jirong Lu
IPC分类号： A61K038/28 , A61K031/05 , A61K031/14
CPC分类号： C07K14/59 , A61K9/0019 , A61K38/24 , A61K47/10 , A61K47/186
摘要： This invention relates to FSH or a FSH variant containing an alpha and beta subunit contained in formulations, and articles of manufacture. The invention provides advantageous new proteins and nucleic acids, multi-use pharmaceutical solutions, formulations and products of said proteins and nucleic acids where none approved for commercial use had previously existed having such extended use indications. These products are particularly useful in therapeutic regimens for increasing serum levels of FSH or a FSH variant over a period of treatment. Thus, inter alia, the invention fills the need for convenient products of FSH or from a FSH variant.
摘要翻译：本发明涉及含有制剂中所含的α和β亚基的FSH或FSH变体和制品。本发明提供了有利的新蛋白质和核酸，多用途药物溶液，所述蛋白质和核酸的制剂和产品，其中没有经过商业用途的批准用于具有这种延长使用适应症。这些产品在治疗期间特别可用于在治疗期间提高FSH或FSH变体的血清水平。因此，除其他外，本发明填补了对FSH或FSH变体的便利产品的需要。

90. 发明申请

US20020151600A1 Autonomic nerve regulating agent 有权
标题翻译：自主神经调节剂
公开(公告)号：US20020151600A1
公开(公告)日：2002-10-17
申请号：US09972887
申请日：2001-10-10
申请人： Kao Corporation
发明人： Yoshinao Nagashima , Keiichi Sugata , Yukihiro Yada , Kazuyuki Fukuda
IPC分类号： A61K009/00 , A61K031/05 , A61K031/045
CPC分类号： A61K31/045 , A61K9/007
摘要： The autonomic nerve regulating agent of the present invention, which, has sedative action, sleep inducing action, and stress mitigating action in individuals, regardless of individual variation in sensitivity to or preference for fragrance, contains as an active ingredient a sesquiterpene alcohol with a boiling point of 250null C. or higher, particularly cedrol.
摘要翻译：本发明的具有镇静作用，睡眠诱导作用和对个体的压力减轻作用的本发明的自主神经调节剂，无论对于香味的敏感性或偏爱性的个体变化如何，均含有沸腾的倍半萜醇作为活性成分点在250℃以上，特别是雪佛龙。

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