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81. 发明申请

US20090246076A1 ELECTROCHEMILUMINESCENCE FLOW CELL AND FLOW CELL COMPONENTS 审中-公开
标题翻译：电致发光细胞和流动细胞组分
公开(公告)号：US20090246076A1
公开(公告)日：2009-10-01
申请号：US12477063
申请日：2009-06-02
申请人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
发明人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
IPC分类号： G01N21/76
CPC分类号： G01N33/5438 , G01N21/69 , G01N21/76 , G01N33/582 , G01N2021/0389
摘要： An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
摘要翻译：一种电化学发光电池，其包括能够将电化学发光活性物质引入电化学发光的电极。电极优选由铑，铱或与包含过渡元素的合金材料合金化的铂，铑或铱的合金制成。电极可以用作电化学发光单元中的对电极和/或作为工作电极。电池优选包括反电极和附接到对电极的支撑体。支撑件包括与工作电极对准的透明部分。对电极可以包括插入在透明部分和工作电极之间的一个或多个场延伸元件。场延伸元件优选地是梯子或栅格。

82. 发明申请

US20080101986A1 Analytical test strip with electroluminescent module 审中-公开
标题翻译：带电致发光模块的分析测试条
公开(公告)号：US20080101986A1
公开(公告)日：2008-05-01
申请号：US11591313
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/00
CPC分类号： G01N21/76 , G01N21/69 , G01N2021/6439
摘要： An analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a substrate layer, an electroluminescent module disposed on the substrate layer, a sample chamber configured for receiving the bodily fluid sample disposed above the substrate layer; and a fluorophore-containing photometric enzymatic reagent disposed within the sample chamber. Moreover, the electroluminescent module is in optical communication with the sample chamber and is configured to emit light that facilitates a fluorescent chemical reaction sequence involving the fluorophore-containing photometric enzymatic reagent and the analyte.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的分析测试条包括基底层，设置在基底层上的电致发光模块，被配置为接收设置在基底层上方的体液样品; 和设置在样品室内的含荧光团的光度测定酶试剂。此外，电致发光模块与样品室光学连通，并且被配置为发射促进涉及含荧光团的光度测定酶试剂和分析物的荧光化学反应序列的光。

83. 发明申请

US20080101984A1 Method for determining an analyte in a bodily fluid sample 审中-公开
标题翻译：用于测定体液样品中分析物的方法
公开(公告)号：US20080101984A1
公开(公告)日：2008-05-01
申请号：US11591316
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/76
CPC分类号： G01N21/69 , G01N21/76 , G01N2021/6439
摘要： A method for the determination of an analyte in a bodily fluid sample includes transferring a bodily fluid sample (such as a whole blood sample) to a sample chamber of an analytical test strip. The analytical test strip to which the bodily fluid sample is transferred has a substrate layer, an electroluminescent module disposed on the substrate layer and in optical communication with the sample chamber, and a fluorophore-containing photometric enzymatic reagent disposed within the sample chamber. In addition, the electroluminescent module is configured to emit light that facilitates a fluorescent chemical reaction sequence involving the fluorophore-containing photometric enzymatic reagent and the analyte. The method also includes exposing the fluorophore-containing photometric enzymatic reagent to the bodily fluid sample and to light emitted from the electroluminescent module such that photons are emitted from the fluorophore-containing photometric enzymatic reagent via a fluorescent chemical reaction sequence. Moreover, the method includes detecting the photons with a photodetector.
摘要翻译：用于测定体液样品中的分析物的方法包括将体液样品（例如全血样品）转移到分析测试条的样品室。体液样本被转移到的分析测试条具有衬底层，设置在衬底层上并与样品室光学连通的电致发光模块，以及置于样品室内的含荧光团的光度测定试剂。此外，电致发光模块被配置为发射促进包含含荧光团的光度测定酶试剂和分析物的荧光化学反应序列的光。该方法还包括将含荧光团的光度测试酶试剂暴露于体液样品和从电致发光模块发射的光，使得通过荧光化学反应顺序从含荧光团的光度测定酶试剂发射光子。此外，该方法包括用光电检测器检测光子。

84. 发明授权

US06995091B2 Process for chemically mechanically polishing wafers 失效
公开(公告)号：US06995091B2
公开(公告)日：2006-02-07
申请号：US10304131
申请日：2002-11-25
申请人： Germar Schneider
发明人： Germar Schneider
IPC分类号： H01L21/302
CPC分类号： B24B37/005 , B24B49/12 , G01N1/2035 , G01N21/3103 , G01N21/69
摘要： The invention relates to a process for chemically mechanically polishing and grinding wafers. The CMP slurry that is used for grinding is analyzed using slurry atomic absorption spectroscopy. This allows rapid and sensitive analysis of the slurry constituents, in particular of interfering ions. The process can be automated and makes it possible to process wafers with a constant quality. Furthermore, rapid fault analysis or optimization of the process parameters used during the grinding is possible.

85. 发明申请

US20050012038A1 ATMOSPHERIC PRESSURE, GLOW DISCHARGE, OPTICAL EMISSION SOURCE FOR THE DIRECT SAMPLING OF LIQUID MEDIA 审中-公开
标题翻译：大气压力，玻璃放电，液体介质的直接采样光源排放源
公开(公告)号：US20050012038A1
公开(公告)日：2005-01-20
申请号：US10622187
申请日：2003-07-17
申请人： R. Marcus , W. Davis
发明人： R. Marcus , W. Davis
IPC分类号： G01J3/10 , G01N21/67 , G01N21/69 , H01J49/12 , G01J3/30
CPC分类号： G01N21/67 , G01J3/10 , G01N21/69 , H01J49/00
摘要： A glow discharge optical emission spectroscopy (GD-OES) source operates at atmospheric pressure. One of the discharge electrodes of the device is formed by an electrolytic solution 27 containing the analyte specimen. The passage of electrical current (either electrons or positive ions) across the solution/gas phase interface causes local heating and the volatilization of the analyte species. Collisions in the discharge region immediately above the surface of the solution results in optical emission that is characteristic of the analyte elements. The device uses the analyte solution as either the cathode or anode. Operating parameters depend on the electrolyte concentration (i.e. solution conductivity) and the gap 35 between the solution surface and the counter electrode. Typical conditions include discharge currents of about 30 to about 60 mA and potentials of about 200 to about 1000 volts. Electrolyte solutions of pH, pNa or pLi values of about 0.5 to about 2 and interelectrode gaps of about 0.5 to about 3 mm produce stable plasmas where the analyte solutions are totally consumed at flow rates of up to about 2.0 mL/min.
摘要翻译：辉光放电光发射光谱（GD-OES）源在大气压下工作。器件的放电电极之一由含有分析物样品的电解液27形成。通过溶液/气相界面的电流（电子或正离子）通过导致局部加热和分析物种的挥发。在溶液表面正上方的放电区域中的碰撞导致分析物质特征的光发射。该设备使用分析物溶液作为阴极或阳极。操作参数取决于电解质浓度（即溶液电导率）和溶液表面和对电极之间的间隙35。典型的条件包括约30至约60mA的放电电流和约200至约1000伏特的电位。约0.5至约2的pH值，pNa值或pLi值的电解质溶液约为0.5至约3毫米的电极间隙产生稳定的等离子体，其中分析物溶液以高达约2.0毫升/分钟的流速完全消耗。

86. 发明申请

US20040090168A1 Electrochemiluminescence flow cell and flow cell components 失效
标题翻译：电化学发光流通池和流通池组件
公开(公告)号：US20040090168A1
公开(公告)日：2004-05-13
申请号：US10600164
申请日：2003-06-19
发明人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
IPC分类号： H01J063/04
CPC分类号： G01N33/5438 , G01N21/69 , G01N21/76 , G01N33/582 , G01N2021/0389
摘要： An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
摘要翻译：一种电化学发光电池，其包括能够将电化学发光活性物质引入电化学发光的电极。电极优选由铑，铱或与包含过渡元素的合金材料合金化的铂，铑或铱的合金制成。电极可以用作电化学发光单元中的对电极和/或作为工作电极。电池优选包括反电极和附接到对电极的支撑体。支撑件包括与工作电极对准的透明部分。对电极可以包括插入在透明部分和工作电极之间的一个或多个场延伸元件。场延伸元件优选地是梯子或栅格。

87. 发明授权

US06707043B2 On-site analyzer 失效
标题翻译：现场分析仪
公开(公告)号：US06707043B2
公开(公告)日：2004-03-16
申请号：US10201184
申请日：2002-07-22
申请人： John Coates , Neil Rosenbaum , Yosef Abuneaj
发明人： John Coates , Neil Rosenbaum , Yosef Abuneaj
IPC分类号： G01J330
CPC分类号： G01N33/30 , G01J3/28 , G01J3/443 , G01N21/274 , G01N21/3577 , G01N21/67 , G01N21/69 , G01N33/2847 , G01N33/2858 , G01N33/2888
摘要： An apparatus (10) for analyzing lubricant oils and functional fluids includes an optical emission spectrometer (OES) (26) having a substantially continuously valued wavelength versus intensity output (140). The OES (26) analyzes light captured from a spark emission stand (58) through which the fluid sample is flowed. An expert system (160-172) operates according to a set of Rules, and generates diagnostic text (174) for an operator based on the information about the fluid sample provided by the OES (26) and other measurement devices. The apparatus (10) is reduce in size, weight and cost.
摘要翻译：用于分析润滑油和功能流体的装置（10）包括具有基本上连续值的波长对强度输出（140）的光发射光谱仪（OES）（26）。 OES（26）分析从流体样品流过的火花发射台（58）捕获的光。专家系统（160-172）根据一组规则操作，并且基于由OES（26）和其他测量装置提供的关于流体样本的信息，为操作者生成诊断文本（174）。装置（10）的尺寸，重量和成本都降低。

88. 发明申请

US20040026616A1 Atmospheric pressure, glow discharge, optical emission source for the direct sampling of liquid media 失效
标题翻译：大气压力，辉光放电，用于液体介质直接取样的光发射源
公开(公告)号：US20040026616A1
公开(公告)日：2004-02-12
申请号：US10636177
申请日：2003-08-07
发明人： R. Kenneth Marcus , W. Clay Davis
IPC分类号： H01J049/10 , G01N021/68
CPC分类号： G01N21/67 , G01N21/69
摘要： A glow discharge spectroscopy (GDS) source operates at atmospheric pressure. One of the discharge electrodes of the device is formed by an electrolytic solution 27 containing the analyte specimen. The passage of electrical current (either electrons or positive ions) across the solution/gas phase interface causes local heating and the volatilization of the analyte species. Collisions in the discharge region immediately above the surface of the solution results in optical emission and ionization that are characteristic of the analyte elements. As such, these analyte elements can be identified and quantified by optical emission spectroscopy (OES) or mass spectrometry (MS). The device uses the analyte solution as either the cathode or anode. Operating parameters depend on the electrolyte concentration (i.e. solution conductivity) and the gap 35 between the solution surface and the counter electrode. Typical conditions include discharge currents of about 10 to about 60 mA and potentials of about 200 to about 1000 volts. Electrolyte solutions of pH, pNa or pLi values of about 0.5 to about 2 and interelectrode gaps of about 0.5 to about 3 mm produce stable plasmas where the analyte solutions are totally consumed at flow rates of up to about 2.0 mL/min.
摘要翻译：辉光放电光谱（GDS）源在大气压下工作。器件的放电电极之一由含有分析物样品的电解液27形成。通过溶液/气相界面的电流（电子或正离子）通过导致局部加热和分析物种的挥发。在溶液表面正上方的放电区域中的碰撞导致作为分析物元件特征的光发射和电离。因此，可以通过光发射光谱（OES）或质谱（MS）鉴定和量化这些分析物质。该设备使用分析物溶液作为阴极或阳极。操作参数取决于电解质浓度（即溶液电导率）和溶液表面和对电极之间的间隙35。典型的条件包括约10至约60mA的放电电流和约200至约1000伏特的电位。约0.5至约2的pH值，pNa值或pLi值的电解质溶液约为0.5至约3毫米的电极间隙产生稳定的等离子体，其中分析物溶液以高达约2.0毫升/分钟的流速完全消耗。

89. 发明申请

US20030118477A1 Apparatus and methods for carrying out electrochemiluminescence test measurements 审中-公开
标题翻译：用于进行电化学发光测试测量的装置和方法
公开(公告)号：US20030118477A1
公开(公告)日：2003-06-26
申请号：US10313411
申请日：2002-12-06
申请人： IGEN International, Inc.
发明人： John Liljestrand , Jue Zhang , David R. Gambrel , Sergey Ivanov , Jacob N. Wohlstadter
IPC分类号： G01N021/76
CPC分类号： G01N21/69 , G01N21/76
摘要： Apparatus for the conduct of electrochemiluminescence measurements includes an ECL chamber having a transparent window defining one wall of the chamber and a photodetector mounted closely adjacent thereto. An assay fluid is subject to a magnetic field and is electrically energized. Electrochemiluminescence induced in the fluid is measured by the photodetector.
摘要翻译：用于进行电化学发光测量的装置包括ECL室，其具有限定室的一个壁的透明窗口和与其紧邻地安装的光电检测器。测定流体经受磁场并且被电通电。通过光电检测器测量在流体中诱导的电化学发光。

90. 发明授权

US06509195B1 Electrochemoluminescent detector 失效
标题翻译：电化学发光检测器
公开(公告)号：US06509195B1
公开(公告)日：2003-01-21
申请号：US09445663
申请日：2000-03-02
申请人： Nico De Rooij , Giovanni C. Fiaccabrino , Milena Koudelka-Hep
发明人： Nico De Rooij , Giovanni C. Fiaccabrino , Milena Koudelka-Hep
IPC分类号： G01N2176
CPC分类号： G01N21/69 , G01N21/76
摘要： Electrochemoluminescent detector for analyzing a biochemical or biological substance, comprising at least a cell (11, 12) generating and detecting the electrogenerated chemoluminescence, which includes: at least a working electrode (16, 17) produced on a substrate (20); electric power supply (13) connected to the electrode; a photodiode (14) detecting the light generated by electrochemoluminescence; and a device for measuring the signal delivered by the photodiode. The photodiode (14) is produced by being integrated in the substrate (20). The cell comprises two interdigital working electrodes protected by a passivation layer (18) leaving part of their top surface in contact with outside. An intermediate layer (19) of dielectric material is inserted between the electrodes and the substrate (20).
摘要翻译：用于分析生物化学或生物物质的电化学发光检测器，至少包括产生和检测电生化发光的细胞（11,12），其包括：至少在衬底（20）上产生的工作电极（16,17）; 电源（13）连接到电极; 检测由电化学发光产生的光的光电二极管（14）; 以及用于测量由光电二极管传递的信号的装置。光电二极管（14）通过集成在基板（20）中来制造。电池包括由钝化层（18）保护的两个叉指工作电极，使其顶表面的一部分与外部接触。介电材料的中间层（19）插入在电极和基板（20）之间。

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