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1. 发明申请

US20110094882A1 TEST METER FOR USE WITH A DUAL CHAMBER, MULTI-ANALYTE TEST STRIP WITH OPPOSING ELECTRODES 有权
标题翻译：用于双室的测试仪，带有电极的多分析测试条
公开(公告)号：US20110094882A1
公开(公告)日：2011-04-28
申请号：US12606496
申请日：2009-10-27
申请人： Gavin MACFIE , Graeme WEBSTER , Marco F. CARDOSI , Christopher Philip LEACH , Steven SETFORD , Selwayan SAINI
发明人： Gavin MACFIE , Graeme WEBSTER , Marco F. CARDOSI , Christopher Philip LEACH , Steven SETFORD , Selwayan SAINI
IPC分类号： G01N33/50
CPC分类号： G01N27/3272 , G01N2035/00118
摘要： A test meter for use with a dual-chamber, multi-analyte test strip includes a test strip receiving module and a signal processing module. The test strip receiving module has a first electrical connector configured for contacting a first analyte contact pad of a first working electrode of the test strip; a second electrical connector configured for contacting a second analyte contact pad of a second working electrode of the test strip, a third electrical connector configured for contacting a first counter/reference contact pad of a first counter/reference electrode layer of the test strip, and a fourth electrical connector configured for contacting a second counter/reference contact pad of a second counter/reference electrode layer of the test strip. The signal processing module is configured to receive a first signal via the first electrical connector and the third electrical connector and employ the first signal for the determination of a first analyte (such as glucose) in a bodily fluid sample (for example, whole blood sample) applied to the dual-chamber, multi-analyte test strip. Moreover, the signal processing module is also configured to receive a second signal via the second electrical connector and fourth electrical connector and employ the second signal for the determination of a second analyte (e.g., a ketone analyte) in the bodily fluid sample applied to the dual-chamber, multi-analyte test strip. Furthermore, the third and fourth electrical contacts provide contact in an opposing manner.
摘要翻译：用于双腔多分析物测试条的测试仪包括测试条接收模块和信号处理模块。测试条接收模块具有第一电连接器，其被配置用于接触测试条的第一工作电极的第一分析物接触焊盘; 第二电连接器，其被配置用于接触测试条的第二工作电极的第二分析物接触焊盘;第三电连接器，其被配置用于接触测试条的第一计数器/参考电极层的第一计数器/参考接触焊盘，以及第四电连接器，其被配置为接触测试条的第二计数器/参考电极层的第二计数器/参考接触焊盘。信号处理模块被配置为经由第一电连接器和第三电连接器接收第一信号，并且采用第一信号来确定体液样品中的第一分析物（例如葡萄糖）（例如，全血样品）应用于双室多分析物测试条。此外，信号处理模块还被配置为经由第二电连接器和第四电连接器接收第二信号，并且使用第二信号来确定施加到所述第二电连接器和第四电连接器的体液样品中的第二分析物（例如，酮分析物）双室多分析物测试条。此外，第三和第四电触点以相反的方式提供接触。

2. 发明申请

US20050082175A1 Diagnosis by sensing volatile components 审中-公开
标题翻译：通过感测挥发性成分进行诊断
公开(公告)号：US20050082175A1
公开(公告)日：2005-04-21
申请号：US10475310
申请日：2002-04-19
申请人： Selwayan Saini , Conrad Bessant , Christian Liedtke , Jan Leiferkus
发明人： Selwayan Saini , Conrad Bessant , Christian Liedtke , Jan Leiferkus
IPC分类号： G01N33/497 , A61B1/00 , A61B5/08 , A61B5/20 , C12Q1/04 , G01N5/02 , G01N27/12 , G01N33/84 , G06F19/00 , C12Q1/00 , G01F1/64 , G01N31/00
CPC分类号： C12Q1/04 , G01N33/84 , G01N2333/24 , G01N2333/245
摘要： A state, particularly a disease state, associated with the production of volatiles is detected by passing a sample containing the volatiles to a single sensor. This may be a semiconductor gas sensor element or a surface acoustic wave device. This provides an output signal, e.g. in the form of a tailing peak. A plurality of characteristics of the signal (e.g. peak height and maximum positive gradient) are measured to characterise the sample and hence the underlying state. For example we can discriminate between urine samples which are (a) infected with proteus, (b) infected with E. coli or (c) uninfected.
摘要翻译：通过将含有挥发物的样品通过单个传感器检测与挥发物的产生有关的状态，特别是疾病状态。这可以是半导体气体传感器元件或声表面波器件。这提供输出信号，例如。以尾峰的形式。测量信号的多个特征（例如峰高和最大正梯度）以表征样本并因此表征基础状态。例如，我们可以区分（a）感染了proteus的尿样本，（b）感染大肠杆菌或（c）未感染的尿液样本。

3. 发明授权

US08632664B2 Test meter for use with a dual chamber, multi-analyte test strip with opposing electrodes 有权
标题翻译：用于具有相对电极的双室多分析物测试条的测试仪
公开(公告)号：US08632664B2
公开(公告)日：2014-01-21
申请号：US12606496
申请日：2009-10-27
申请人： Gavin Macfie , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
发明人： Gavin Macfie , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , G01N2035/00118
摘要： A test meter for use with a dual-chamber, multi-analyte test strip includes a test strip receiving module and a signal processing module. The test strip receiving module has a first electrical connector configured for contacting a first analyte contact pad of a first working electrode of the test strip; a second electrical connector configured for contacting a second analyte contact pad of a second working electrode of the test strip, a third electrical connector configured for contacting a first counter/reference contact pad of a first counter/reference electrode layer of the test strip, and a fourth electrical connector configured for contacting a second counter/reference contact pad of a second counter/reference electrode layer of the test strip. The signal processing module is configured to receive a first signal via the first electrical connector and the third electrical connector and employ the first signal for the determination of a first analyte (such as glucose) in a bodily fluid sample (for example, whole blood sample) applied to the dual-chamber, multi-analyte test strip. Moreover, the signal processing module is also configured to receive a second signal via the second electrical connector and fourth electrical connector and employ the second signal for the determination of a second analyte (e.g., a ketone analyte) in the bodily fluid sample applied to the dual-chamber, multi-analyte test strip. Furthermore, the third and fourth electrical contacts provide contact in an opposing manner.
摘要翻译：用于双腔多分析物测试条的测试仪包括测试条接收模块和信号处理模块。测试条接收模块具有第一电连接器，其被配置用于接触测试条的第一工作电极的第一分析物接触焊盘; 第二电连接器，其被配置用于接触测试条的第二工作电极的第二分析物接触焊盘;第三电连接器，其被配置用于接触测试条的第一计数器/参考电极层的第一计数器/参考接触焊盘，以及第四电连接器，其被配置为接触测试条的第二计数器/参考电极层的第二计数器/参考接触焊盘。信号处理模块被配置为经由第一电连接器和第三电连接器接收第一信号，并且采用第一信号来确定体液样品中的第一分析物（例如葡萄糖）（例如，全血样品）应用于双室多分析物测试条。此外，信号处理模块还被配置为经由第二电连接器和第四电连接器接收第二信号，并且使用第二信号来确定施加到所述第二电连接器和第四电连接器的体液样品中的第二分析物（例如，酮分析物）双室多分析物测试条。此外，第三和第四电触点以相反的方式提供接触。

4. 发明申请

US20080101985A1 System for determination of an analyte in a bodily fluid sample that includes an electroluminescent component 有权
标题翻译：用于测定包含电致发光组分的体液样品中的分析物的系统
公开(公告)号：US20080101985A1
公开(公告)日：2008-05-01
申请号：US11591138
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/00
CPC分类号： G01N21/69 , G01N21/76 , G01N2021/6439
摘要： A system for the determination of an analyte in a bodily fluid sample includes an analytical test strip and an analytical meter. The analytical test strip has a substrate layer, an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) disposed on the substrate layer, and a sample chamber configured for receiving a bodily fluid sample disposed above the substrate layer. Moreover, the analytical meter is configured for insertion of the analytical test strip therein and subsequent determination of the analyte.
摘要翻译：用于测定体液样品中的分析物的系统包括分析测试条和分析计。分析测试条具有设置在基底层上的基底层，电致发光元件（电致发光模块和/或电致发光灯），以及被配置为接收设置在基底层上方的体液样品的样本室。此外，分析仪被配置用于在其中插入分析测试条并随后确定分析物。

5. 发明授权

US06717658B1 Detection of liquids 失效
标题翻译：检测液体
公开(公告)号：US06717658B1
公开(公告)日：2004-04-06
申请号：US09926220
申请日：2001-10-17
申请人： Selwayan Saini , Lawrence Ritchie , Clive Patrick Ferguson
发明人： Selwayan Saini , Lawrence Ritchie , Clive Patrick Ferguson
IPC分类号： G01N3328
CPC分类号： G01N21/55
摘要： Liquid, particularly leaked oil or other hydrophobic liquid, is detected by a sensor. This preferably has a hydrophobic membrane (G) that takes up the oil selectively, a radiation source (A) that beams radiation at an interface between the membrane (G) and a window (F), and a radiation detector (H) that receives radiation resulting from interaction (such as reflection, scattering or fluorescence) of the input radiation with the liquid-containing membrane (G). The detector may employ a spectrofluorimeter (H) whose output can be used to characterise the liquid.
摘要翻译：液体，特别是泄漏的油或其它疏水性液体，由传感器检测。这优选具有选择性吸收油的疏水膜（G），在膜（G）和窗口（F）之间的界面处射出辐射的辐射源（A）和接收由含有液体膜（G）的输入辐射的相互作用（例如反射，散射或荧光）引起的辐射。检测器可以使用其输出可用于表征液体的分光荧光计（H）。

6. 发明授权

US08323467B2 Dual chamber, multi-analyte test strip with opposing electrodes 有权
标题翻译：具有相对电极的双室多分析物测试条
公开(公告)号：US08323467B2
公开(公告)日：2012-12-04
申请号：US12606467
申请日：2009-10-27
申请人： Gavin MacFie , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
发明人： Gavin MacFie , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , G01N2035/00118
摘要： A dual chamber, multi-analyte test strip has a first insulating layer, a first electrically conductive layer, with a first working electrode, disposed on the first insulating layer and a first patterned spacer layer positioned above the first electrically conductive layer. The first patterned spacer layer has a first sample-receiving chamber, with first and second end openings, defined therein that overlies the first working electrode. The test strip also includes a first counter/reference electrode layer that is exposed to the first sample receiving chamber and is in an opposing relationship to the first working electrode. The test strip further includes a counter/reference insulating layer disposed over the first counter/reference electrode layer and a second counter/reference electrode layer disposed on the counter/reference substrate. Also included in the test strip is a second patterned spacer layer that is positioned above the second counter/reference electrode layer. The second patterned spacer layer has a second sample-receiving chamber, with first and second end openings, defined therein. The test strip additionally has a second electrically conductive layer, with a second working electrode, disposed above the second patterned spacer layer, a second insulating layer disposed above the second electrically conductive layer, a first analyte reagent layer disposed on the first working electrode within the first sample-receiving chamber; and a second analyte reagent layer disposed on the second working electrode within the second sample-receiving chamber. The second counter/reference electrode layer is exposed to the second sample receiving chamber and is in an opposing relationship to the second working electrode.
摘要翻译：双室多分析物测试条具有设置在第一绝缘层上的第一绝缘层，第一导电层和第一工作电极，以及位于第一导电层上方的第一图案化间隔层。第一图案化间隔层具有第一样品接收室，其中限定在其中的第一和第二端部开口覆盖在第一工作电极上。测试条还包括暴露于第一样品接收室并与第一工作电极相对关系的第一计数器/参考电极层。测试条还包括设置在第一计数器/参考电极层上的计数器/参考绝缘层和设置在反向/参考基板上的第二计数器/参考电极层。还包括在测试条中的是位于第二计数器/参考电极层上方的第二图案化间隔层。第二图案化间隔层具有第二样品接收室，其中限定有第一和第二端部开口。测试条另外具有第二导电层，第二工作电极设置在第二图案化间隔层上方，设置在第二导电层上方的第二绝缘层，设置在第二工作电极内的第一分析物试剂层，第一采样室; 以及设置在第二样品接收室内的第二工作电极上的第二分析物试剂层。第二计数器/参考电极层暴露于第二样品接收室，并且与第二工作电极相对。

7. 发明申请

US20080101986A1 Analytical test strip with electroluminescent module 审中-公开
标题翻译：带电致发光模块的分析测试条
公开(公告)号：US20080101986A1
公开(公告)日：2008-05-01
申请号：US11591313
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/00
CPC分类号： G01N21/76 , G01N21/69 , G01N2021/6439
摘要： An analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a substrate layer, an electroluminescent module disposed on the substrate layer, a sample chamber configured for receiving the bodily fluid sample disposed above the substrate layer; and a fluorophore-containing photometric enzymatic reagent disposed within the sample chamber. Moreover, the electroluminescent module is in optical communication with the sample chamber and is configured to emit light that facilitates a fluorescent chemical reaction sequence involving the fluorophore-containing photometric enzymatic reagent and the analyte.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的分析测试条包括基底层，设置在基底层上的电致发光模块，被配置为接收设置在基底层上方的体液样品; 和设置在样品室内的含荧光团的光度测定酶试剂。此外，电致发光模块与样品室光学连通，并且被配置为发射促进涉及含荧光团的光度测定酶试剂和分析物的荧光化学反应序列的光。

8. 发明申请

US20080101984A1 Method for determining an analyte in a bodily fluid sample 审中-公开
标题翻译：用于测定体液样品中分析物的方法
公开(公告)号：US20080101984A1
公开(公告)日：2008-05-01
申请号：US11591316
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/76
CPC分类号： G01N21/69 , G01N21/76 , G01N2021/6439
摘要： A method for the determination of an analyte in a bodily fluid sample includes transferring a bodily fluid sample (such as a whole blood sample) to a sample chamber of an analytical test strip. The analytical test strip to which the bodily fluid sample is transferred has a substrate layer, an electroluminescent module disposed on the substrate layer and in optical communication with the sample chamber, and a fluorophore-containing photometric enzymatic reagent disposed within the sample chamber. In addition, the electroluminescent module is configured to emit light that facilitates a fluorescent chemical reaction sequence involving the fluorophore-containing photometric enzymatic reagent and the analyte. The method also includes exposing the fluorophore-containing photometric enzymatic reagent to the bodily fluid sample and to light emitted from the electroluminescent module such that photons are emitted from the fluorophore-containing photometric enzymatic reagent via a fluorescent chemical reaction sequence. Moreover, the method includes detecting the photons with a photodetector.
摘要翻译：用于测定体液样品中的分析物的方法包括将体液样品（例如全血样品）转移到分析测试条的样品室。体液样本被转移到的分析测试条具有衬底层，设置在衬底层上并与样品室光学连通的电致发光模块，以及置于样品室内的含荧光团的光度测定试剂。此外，电致发光模块被配置为发射促进包含含荧光团的光度测定酶试剂和分析物的荧光化学反应序列的光。该方法还包括将含荧光团的光度测试酶试剂暴露于体液样品和从电致发光模块发射的光，使得通过荧光化学反应顺序从含荧光团的光度测定酶试剂发射光子。此外，该方法包括用光电检测器检测光子。

9. 发明申请

US20070105232A1 Voltammetric detection of metabolites in physiological fluids 审中-公开
标题翻译：生理液中代谢物的伏安检测
公开(公告)号：US20070105232A1
公开(公告)日：2007-05-10
申请号：US10562229
申请日：2004-06-28
申请人： Selwayan Saini , Conrad Bessant , Jon Lee-Davey , Michael Malecha
发明人： Selwayan Saini , Conrad Bessant , Jon Lee-Davey , Michael Malecha
IPC分类号： G01N33/00
CPC分类号： G01N27/3273 , Y10T436/144444
摘要： For the determination of analytes in body fluids, voltammetry using a simple, non-selective, electrode sensor system has been found to work. The signal is desirably processed by a technique such as neural network analysis, which can permit plural analytes to be determined simultaneously.
摘要翻译：为了测定体液中的分析物，已经发现使用简单的非选择性电极传感器系统进行伏安法工作。该信号期望通过诸如神经网络分析的技术来处理，这可以允许同时确定多个分析物。

10. 发明申请

US20110094896A1 DUAL CHAMBER, MULTI-ANALYTE TEST STRIP WITH OPPOSING ELECTRODES 有权
标题翻译：双室，多分析测试带与电极
公开(公告)号：US20110094896A1
公开(公告)日：2011-04-28
申请号：US12606467
申请日：2009-10-27
申请人： Gavin MACFIE , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
发明人： Gavin MACFIE , Graeme Webster , Marco F. Cardosi , Christopher Philip Leach , Steven Setford , Selwayan Saini
IPC分类号： G01N27/26
CPC分类号： G01N27/3272 , G01N2035/00118
摘要： A dual chamber, multi-analyte test strip has a first insulating layer, a first electrically conductive layer, with a first working electrode, disposed on the first insulating layer and a first patterned spacer layer positioned above the first electrically conductive layer. The first patterned spacer layer has a first sample-receiving chamber, with first and second end openings, defined therein that overlies the first working electrode. The test strip also includes a first counter/reference electrode layer that is exposed to the first sample receiving chamber and is in an opposing relationship to the first working electrode. The test strip further includes a counter/reference insulating layer disposed over the first counter/reference electrode layer and a second counter/reference electrode layer disposed on the counter/reference substrate. Also included in the test strip is a second patterned spacer layer that is positioned above the second counter/reference electrode layer. The second patterned spacer layer has a second sample-receiving chamber, with first and second end openings, defined therein. The test strip additionally has a second electrically conductive layer, with a second working electrode, disposed above the second patterned spacer layer, a second insulating layer disposed above the second electrically conductive layer, a first analyte reagent layer disposed on the first working electrode within the first sample-receiving chamber; and a second analyte reagent layer disposed on the second working electrode within the second sample-receiving chamber. The second counter/reference electrode layer is exposed to the second sample receiving chamber and is in an opposing relationship to the second working electrode.
摘要翻译：双室多分析物测试条具有设置在第一绝缘层上的第一绝缘层，第一导电层和第一工作电极，以及位于第一导电层上方的第一图案化间隔层。第一图案化间隔层具有第一样品接收室，其中限定在其中的第一和第二端部开口覆盖在第一工作电极上。测试条还包括暴露于第一样品接收室并与第一工作电极相对关系的第一计数器/参考电极层。测试条还包括设置在第一计数器/参考电极层上的计数器/参考绝缘层和设置在反向/参考基板上的第二计数器/参考电极层。还包括在测试条中的是位于第二计数器/参考电极层上方的第二图案化间隔层。第二图案化间隔层具有第二样品接收室，其中限定有第一和第二端部开口。测试条另外具有第二导电层，第二工作电极设置在第二图案化间隔层上方，设置在第二导电层上方的第二绝缘层，设置在第二工作电极内的第一分析物试剂层，第一采样室; 以及设置在第二样品接收室内的第二工作电极上的第二分析物试剂层。第二计数器/参考电极层暴露于第二样品接收室，并且与第二工作电极相对。

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