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1. 发明授权

US07553448B2 Electrochemiluminescence flow cell and flow cell components 失效
标题翻译：电化学发光流通池和流通池组件
公开(公告)号：US07553448B2
公开(公告)日：2009-06-30
申请号：US10600164
申请日：2003-06-19
申请人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
发明人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
IPC分类号： G01N21/76 , C12M3/00 , G01N21/64 , G01N33/00
CPC分类号： G01N33/5438 , G01N21/69 , G01N21/76 , G01N33/582 , G01N2021/0389
摘要： An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
摘要翻译：一种电化学发光电池，其包括能够将电化学发光活性物质引入电化学发光的电极。电极优选由铑，铱或与包含过渡元素的合金材料合金化的铂，铑或铱的合金制成。电极可以用作电化学发光单元中的对电极和/或作为工作电极。电池优选包括反电极和附接到对电极的支撑体。支撑件包括与工作电极对准的透明部分。对电极可以包括插入在透明部分和工作电极之间的一个或多个场延伸元件。场延伸元件优选地是梯子或栅格。

2. 发明申请

US20090246076A1 ELECTROCHEMILUMINESCENCE FLOW CELL AND FLOW CELL COMPONENTS 审中-公开
标题翻译：电致发光细胞和流动细胞组分
公开(公告)号：US20090246076A1
公开(公告)日：2009-10-01
申请号：US12477063
申请日：2009-06-02
申请人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
发明人： Sudeep M. Kumar , Josephus Marinus Otten , Charles Quentin Davis , Hans Biebuyck
IPC分类号： G01N21/76
CPC分类号： G01N33/5438 , G01N21/69 , G01N21/76 , G01N33/582 , G01N2021/0389
摘要： An electrochemiluminescence cell comprising an electrode capable of inducing an electrochemiluminescence-active species to electrochemiluminesce. The electrode is preferably made of rhodium, iridium or an alloy of platinum, rhodium or iridium alloyed with an alloy material comprising a transition element. The electrode may be used as counter electrode and/or as a working electrode in the electrochemiluminescence cell. The cell preferably includes a counter electrode and a support attached to the counter electrode. The support comprises a transparent portion in optical registration with the working electrode. The counter electrode may include one or more field extending elements interposed between the transparent portion and the working electrode. The field extending element is preferably a ladder or a grid.
摘要翻译：一种电化学发光电池，其包括能够将电化学发光活性物质引入电化学发光的电极。电极优选由铑，铱或与包含过渡元素的合金材料合金化的铂，铑或铱的合金制成。电极可以用作电化学发光单元中的对电极和/或作为工作电极。电池优选包括反电极和附接到对电极的支撑体。支撑件包括与工作电极对准的透明部分。对电极可以包括插入在透明部分和工作电极之间的一个或多个场延伸元件。场延伸元件优选地是梯子或栅格。

3. 外观设计

USD499035S1 Detection apparatus 失效
标题翻译：检测装置
公开(公告)号：USD499035S1
公开(公告)日：2004-11-30
申请号：US29180894
申请日：2003-05-01
申请人： Richard Cook , Charles Quentin Davis , David Robert DeLalio , Pankaj Oberoi , Hans Biebuyck , Rober Krikor Matikyan , Neil S. Rothman , Christopher W. Glupker , Lance Hussey , Ravi K. Sawhney
设计人： Richard Cook , Charles Quentin Davis , David Robert DeLalio , Pankaj Oberoi , Hans Biebuyck , Rober Krikor Matikyan , Neil S. Rothman , Christopher W. Glupker , Lance Hussey , Ravi K. Sawhney

4. 外观设计

USD697226S1 Sample cassette for a diagnostic instrument 有权
公开(公告)号：USD697226S1
公开(公告)日：2014-01-07
申请号：US29420961
申请日：2012-05-15
申请人： Charles Quentin Davis , Michael D. Nelson , Joseph N. K. Ullman , Nadine Wohlstadter , Richard Cook
设计人： Charles Quentin Davis , Michael D. Nelson , Joseph N. K. Ullman , Nadine Wohlstadter , Richard Cook

5. 外观设计

USD700355S1 Sample cassette for a diagnostic instrument 有权
标题翻译：用于诊断仪器的样品盒
公开(公告)号：USD700355S1
公开(公告)日：2014-02-25
申请号：US29420967
申请日：2012-05-15
申请人： Charles Quentin Davis , Michael D. Nelson , Joseph N. K. Ullman , Nadine Wohlstadter , Richard Cook
设计人： Charles Quentin Davis , Michael D. Nelson , Joseph N. K. Ullman , Nadine Wohlstadter , Richard Cook

6. 发明申请

US20090299767A1 Automated systems and methods for obtaining, storing, processing and utilizing immunologic information of individuals and populations for various uses 有权
标题翻译：用于获取，存储，处理和利用个人和群体免疫学信息的各种用途的自动化系统和方法
公开(公告)号：US20090299767A1
公开(公告)日：2009-12-03
申请号：US12291529
申请日：2008-11-10
申请人： Francis Michon , Samuel L. Moore , Samuel J. Wohlstadter , Charles Quentin Davis , Glen Otero , Aaron Haleva
发明人： Francis Michon , Samuel L. Moore , Samuel J. Wohlstadter , Charles Quentin Davis , Glen Otero , Aaron Haleva
IPC分类号： G06Q50/00 , G06F17/30 , G06F17/40
CPC分类号： G16H10/60 , G06F19/00 , G06Q50/22 , G06Q50/24 , G16H50/30 , G16H50/70 , G16H50/80 , Y02A90/22 , Y02A90/24 , Y02A90/26
摘要： A system and method for assessing the immunological status of one or more individuals in a patient population is presented. The method includes establishing a database comprising a plurality of records of information each representative of the immune status of an individual in the population, each of said records including (1) current information from one or more assays for the presence of a biochemical, and (2) individual specific information comprising one or more of said individual's medical history, said individual's doctors' observations and historical, demographic, lifestyle, and familial information relating to said individual. The method further includes processing the information in said database to find trends or patterns relating to the immune status of individuals in said patient population; and using the said trends or patterns as part of a health care related decision making process. In exemplary embodiments of the present invention, processing the information in the database includes generating a list of correlations between variables or fields in the database. The correlations in the list can be further refined automatically, and a set of hypotheses or literature citations can be linked to the final correlations. The correlations, the processing, their associated hypotheses can then be reported to a user or automatically fed into another system component to generate a medical or health related decision. In exemplary embodiments of the present invention, a first assay panel containing a plurality of cytokine assays can be administered and the results processed. Based on automatic analyses of the cytokine data, a second tier or set of assays can be run on the same individual. The cytokine assay results being used to inform the contents of a second assay panel.
摘要翻译：提出了一种用于评估患者群体中一个或多个个体的免疫状态的系统和方法。该方法包括建立数据库，该数据库包括多个代表个体在个体中的免疫状态的信息记录，每个所述记录包括（1）来自一个或多个生物化学物质存在的测定的当前信息，和 2）个体特定信息，其包括所述个人的病史，所述个人的医生观察以及与所述个人有关的历史，人口，生活方式和家庭信息中的一个或多个。所述方法还包括处理所述数据库中的信息以发现与所述患者人群中个体的免疫状态有关的趋势或模式; 并将所述趋势或模式用作与保健相关的决策过程的一部分。在本发明的示例性实施例中，处理数据库中的信息包括生成数据库中的变量或字段之间的相关性的列表。列表中的相关性可以自动进一步改进，一组假设或文献引用可以与最终相关性相关联。然后可以将相关性，处理及其相关假设报告给用户或自动进入另一系统组件以产生医疗或健康相关决定。在本发明的示例性实施方案中，可以施用含有多种细胞因子测定的第一测定组，并且处理结果。基于细胞因子数据的自动分析，第二层或一组测定可以在相同的个体上运行。细胞因子测定结果用于通知第二测定面板的内容物。

7. 外观设计

USD694422S1 Diagnostic instrument and sample cassette combination 有权
标题翻译：诊断仪器和样品盒组合
公开(公告)号：USD694422S1
公开(公告)日：2013-11-26
申请号：US29420965
申请日：2012-05-15
申请人： Richard Cook , Charles Quentin Davis , Michael D. Nelson , Joseph N. K. Ullman , Nadine Wohlstadter
设计人： Richard Cook , Charles Quentin Davis , Michael D. Nelson , Joseph N. K. Ullman , Nadine Wohlstadter

8. 发明授权

US08498879B2 Automated systems and methods for obtaining, storing, processing and utilizing immunologic information of individuals and populations for various uses 有权
标题翻译：用于获取，存储，处理和利用个人和群体免疫学信息的各种用途的自动化系统和方法
公开(公告)号：US08498879B2
公开(公告)日：2013-07-30
申请号：US12291529
申请日：2008-11-10
申请人： Francis Michon , Samuel L. Moore , Samuel J. Wohlstadter , Charles Quentin Davis , Glen Otero , Aaron Haleva
发明人： Francis Michon , Samuel L. Moore , Samuel J. Wohlstadter , Charles Quentin Davis , Glen Otero , Aaron Haleva
IPC分类号： G06Q10/00
CPC分类号： G16H10/60 , G06F19/00 , G06Q50/22 , G06Q50/24 , G16H50/30 , G16H50/70 , G16H50/80 , Y02A90/22 , Y02A90/24 , Y02A90/26
摘要： A system and method for assessing the immunological status of one or more individuals in a patient population is presented. The method includes establishing a database comprising a plurality of records of information each representative of the immune status of an individual in the population, each of said records including (1) current information from one or more assays for the presence of a biochemical, and (2) individual specific information comprising one or more of said individual's medical history, said individual's doctors' observations and historical, demographic, lifestyle, and familial information relating to said individual. The method further includes processing the information in said database to find trends or patterns relating to the immune status of individuals in said patient population; and using the said trends or patterns as part of a health care related decision making process.
摘要翻译：提出了一种用于评估患者群体中一个或多个个体的免疫状态的系统和方法。该方法包括建立数据库，该数据库包括多个代表个体在个体中的免疫状态的信息记录，每个所述记录包括（1）来自一个或多个生物化学物质存在的测定的当前信息，和 2）个体特定信息，其包括所述个人的病史，所述个人的医生观察以及与所述个人有关的历史，人口，生活方式和家庭信息中的一个或多个。所述方法还包括处理所述数据库中的信息以发现与所述患者人群中个体的免疫状态有关的趋势或模式; 并将所述趋势或模式用作与保健相关的决策过程的一部分。

9. 发明授权

US08234129B2 Systems and methods for obtaining, storing, processing and utilizing immunologic and other information of individuals and populations 有权
标题翻译：用于获取，存储，处理和利用个人和人群的免疫学和其他信息的系统和方法
公开(公告)号：US08234129B2
公开(公告)日：2012-07-31
申请号：US11796727
申请日：2007-04-27
申请人： Francis Michon , Samuel L. Moore , Peter C. Fusco , Samuel J. Wohlstadter , Charles Quentin Davis , Aaron Haleva
发明人： Francis Michon , Samuel L. Moore , Peter C. Fusco , Samuel J. Wohlstadter , Charles Quentin Davis , Aaron Haleva
IPC分类号： A61B5/00
CPC分类号： G06Q50/24 , G06F19/00 , G06F19/18 , G06F19/24 , G06Q40/08 , G06Q50/22 , G16H50/70 , G16H50/80 , Y02A90/22 , Y02A90/24 , Y02A90/26
摘要： A system and method for assessing immunological status of individuals and populations is presented. The method includes establishing a database containing a plurality of records, each record containing information representative of the immune status of an individual, including (1) bioassay results, and (2) individual specific information such as, medical history, clinical observations and historical, demographic, lifestyle, and familial/genetic information. By processing the information trends and/or patterns are obtained correlating various variables in the records across an individual, population or sub-population. The identified trends and/or patterns can, for example, be used in health care related decision making. In exemplary embodiments such processing can include generating a set of correlations and for each correlation generating a set of explanatory or relevant hypotheses. Then, for example, each hypothesis can be automatically refuted or supported, to the extent possible. The identified correlations, their associated hypotheses and the results of such automated vetting can then be reported to a user.
摘要翻译：提出了一种评估个体和群体免疫状况的系统和方法。该方法包括建立包含多个记录的数据库，每个记录包含代表个体免疫状态的信息，包括（1）生物测定结果，和（2）个体特定信息，例如病史，临床观察和历史记录，人口，生活方式和家庭/遗传信息。通过处理获得的信息趋势和/或模式是通过个体，群体或子群体的记录中的各种变量相关联的。所确定的趋势和/或模式可以例如用于与保健相关的决策。在示例性实施例中，这种处理可以包括生成一组相关性，并且对于每个相关性产生一组解释性或相关假说。然后，例如，可以在可能的范围内自动驳斥或支持每个假设。所识别的相关性，其相关假设和这种自动审查的结果然后可以被报告给用户。

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