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    • 84. 发明申请
    • USE OF VISTA AGONISTS AND ANTAGONISTS TO SUPPRESS OR ENHANCE HUMORAL IMMUNITY
    • 使用VISTA激动剂和拮抗剂来抑制或增强人体免疫力
    • WO2015191881A2
    • 2015-12-17
    • PCT/US2015/035371
    • 2015-06-11
    • GREEN, Kathy A.WANG, LiNOELLE, Randolph J.GREEN, William R.
    • GREEN, Kathy A.WANG, LiNOELLE, Randolph J.GREEN, William R.
    • A61K39/395A61K31/198
    • A61K39/3955A61K31/198A61K39/39541A61K45/06C07K16/2827C07K2317/76A61K2300/00
    • The present invention is directed to the use of VISTA agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an iNOS/NO promoter or nitric oxide or a PD-1 or PD-L1 agonist or a CD40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. The present invention is further directed to the use of VISTA antagonists alone or in association with other immune agonists, preferably another enhancer of humoral immunity such as iNOS/NO inhibitor or a PD-1 or PD-L1 antagonist or anti-CTLA-4 antibody or a CD40 agonist for the treatment or prevention of conditions wherein the enhancement of humoral immunity is therapeutically beneficial. Also, the invention relates to the use of VISTA antagonists alone or in association with another immune agonist, e.g., an iNOS/NO inhibitor or a CD40 agonist to promote the efficacy of therapeutic and prophylactic vaccines, e.g., antitumor, and antiviral vaccines.
    • 本发明涉及单独或与其它免疫抑制剂,优选另一种体液免疫抑制剂如iNOS / NO启动子或一氧化氮或PD-1或PD-L1激动剂或CD40拮抗剂相结合的VISTA激动剂的用途 用于治疗或预防其中抑制体液免疫是治疗有益的条件。 本发明还涉及单独使用或与其它免疫激动剂,优选体液免疫的另一增强剂如iNOS / NO抑制剂或PD-1或PD-L1拮抗剂或抗CTLA-4抗体联合使用的VISTA拮抗剂 或用于治疗或预防其中增强体液免疫是治疗有益的条件的CD40激动剂。 此外,本发明涉及单独或与另一种免疫激动剂例如iNOS / NO抑制剂或CD40激动剂联合以增强治疗性和预防性疫苗(例如抗肿瘤剂和抗病毒疫苗)的功效的用途。
    • 85. 发明申请
    • POLARIZER AND A METHOD FOR FORMING THE SAME
    • 偏振器及其形成方法
    • WO2015056191A1
    • 2015-04-23
    • PCT/IB2014/065338
    • 2014-10-15
    • EULITHA A.G.SOLAK, HarunWANG, Li
    • SOLAK, HarunWANG, Li
    • G02B5/18G02B5/30
    • G02B5/3058G02B5/1809
    • A method for manufacturing a bi-layer wire-grid polarizer, which method includes forming a periodic pattern of alternating and parallel pre-formed lines and grooves on a surface of a substrate, depositing polarizing material onto the pattern to form a top wire of polarizing material having a first width on the top of each pre-formed line and a bottom wire of polarizing material having a second width on the bottom of each groove, each top wire and each of its neighbouring bottom wires having a lateral separation between them, and enlarging the lateral separation between each top wire and each of its neighbouring bottom wires by at least one of increasing the period of the periodic pattern and reducing the first and second widths of the respective top and bottom wires, whereby certain desired transmission and/or polarization properties of the bi-layer wire-grid polarizer are obtained.
    • 一种用于制造双层线栅偏振器的方法,该方法包括在衬底的表面上形成交替和平行的预制线和凹槽的周期性图案,将偏振材料沉积到图案上以形成极化的顶部线 在每个预成形线的顶部具有第一宽度的材料和在每个凹槽的底部上具有第二宽度的偏振材料的底部线,每个顶部线及其每个相邻的底部线在它们之间具有横向间隔;以及 通过增加周期性图案的周期并减小相应的顶部和底部线的第一和第二宽度中的至少一个来扩大每个顶部线及其每个相邻底部线之间的横向间隔,由此某些期望的透射和/或极化 获得双层线栅偏振器的特性。
    • 86. 发明申请
    • CABLE MANAGEMENT SYSTEM FOR MEDICAL TREATMENT DEVICE
    • 医疗处理设备电缆管理系统
    • WO2015042905A1
    • 2015-04-02
    • PCT/CN2013/084576
    • 2013-09-29
    • COVIDIEN LPWANG, Li
    • WANG, LiZHANG, QuanHONG, Chunlang
    • H02G11/02H01R13/72
    • A61B19/0256A61B18/1206A61B18/18A61B50/20A61B2018/00178A61B2050/21B65H75/28B65H75/40B65H75/4473B65H2701/34
    • -24- IEM130028PCT ABSTRACT OF THE DISCLOSURE An enclosure of a power source for medical treatment devices includes a handle portion extending from a first surface of the enclosure. The handle portion includes a standoff extending away from the first surface, and a flange extending transversely from the standoff and defining a plane that is generally parallel to the first surface. Together, the first surface, the standoff, and the flange define an open annular space. A power cable may be wound about the standoff to at least partially occupy the open annular space. One or more notches in the flange are configured to seat the power cable to secure its loose end(s). In this manner, the power cable can be safely stored to reduce the risks that the power cable may become damaged, may interfere with other devices in the treatment area, or may be misplaced.
    • 本发明摘要用于医疗处理装置的电源的外壳包括从外壳的第一表面延伸的手柄部分。 手柄部分包括远离第一表面延伸的支座,以及从支座横向延伸并限定大致平行于第一表面的平面的凸缘。 一起,第一表面,隔离物和凸缘限定开放的环形空间。 电力电缆可以围绕支架缠绕以至少部分地占据开放的环形空间。 法兰中的一个或多个凹口被配置为安置电源电缆以固定其松动的端部。 以这种方式,可以安全地存储电力电缆,以减少电力电缆可能被损坏的风险,可能干扰处理区域中的其他设备,或者可能放错位置。
    • 90. 发明申请
    • PROCESS FOR PREPARING ALLOY COMPOSITE NEGATIVE ELECTRODE MATERIAL FOR LITHIUM ION BATTERIES
    • 锂离子电池合金复合电极材料的制备工艺
    • WO2010099864A1
    • 2010-09-10
    • PCT/EP2010/000927
    • 2010-02-16
    • UMICORETSINGHUA UNIVERSITYREN, JianguoHE, XiangmingWANG, LiYAN, RunbaoPU, WeihuaLl, JianjunGAO, Jian
    • REN, JianguoHE, XiangmingWANG, LiYAN, RunbaoPU, WeihuaLl, JianjunGAO, Jian
    • H01M4/04H01M4/133H01M4/1393
    • H01M4/38H01M4/42H01M4/46H01M4/583H01M4/587H01M4/625H01M2004/027
    • The present invention relates to a process for preparing an alloy composite negative electrode material having a spherical carbon matrix structure for lithium ion batteries by spray-drying carbothermal reduction. The invention covers a process for preparing a negative electrode material for a lithium ion battery with a general formula A-M/Carbon, wherein A is a metal selected from the group consisting of Si, Sn, Sb, Ge and Al; and wherein M is different from A and is at least one element selected from the group consisting of B, Cr, Nb, Cu, Zr, Ag, Ni, Zn, Fe, Co, Mn, Sb, Zn, Ca, Mg, V, Ti, In, Al, Ge; and comprising the steps of: - providing a solution comprising an organic polymer and either chemically reducible nanometric A- and M-precursor compounds, or nanometric Si and a chemically reducible M-precursor compound, when said metal A is Si; - spray-drying said solution whereby a A- and M-precursor bearing polymer powder is obtained, and - calcining said powder in a neutral atmosphere at a temperature between 500 and 1000° C for 3 to 10 hours whereby, in this carbothermal reduction, a carbon matrix is obtained bearing homogeneously distributed A-M alloy particles.
    • 本发明涉及通过喷雾干燥碳热还原制备具有锂离子电池的球形碳基质结构的合金复合负极材料的方法。 本发明涉及一种制备具有通式A-M /碳的锂离子电池用负极材料的方法,其中A为选自Si,Sn,Sb,Ge和Al的金属; 其中M与A不同,为选自B,Cr,Nb,Cu,Zr,Ag,Ni,Zn,Fe,Co,Mn,Sb,Zn,Ca,Mg,V中的至少一种元素 ,Ti,In,Al,Ge; 并且包括以下步骤:当所述金属A为Si时,提供包含有机聚合物和化学还原性纳米A和M前体化合物或纳米Si和化学还原性M前体化合物的溶液; - 喷雾干燥所述溶液,由此获得具有A和M前体的聚合物粉末,并且在中性气氛中在500-1000℃的温度下煅烧所述粉末3至10小时,由此在该碳热还原中, 得到带有均匀分布的AM合金颗粒的碳基体。