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1. 发明公开

EP3154585A4 USE OF VISTA AGONISTS AND ANTAGONISTS TO SUPPRESS OR ENHANCE HUMORAL IMMUNITY 有权转让
公开(公告)号：EP3154585A4
公开(公告)日：2017-12-06
申请号：EP15806089
申请日：2015-06-11
申请人： GREEN KATHY A , WANG LI , NOELLE RANDOLPH J , GREEN WILLIAM R
发明人： GREEN KATHY A , WANG LI , NOELLE RANDOLPH J , GREEN WILLIAM R
IPC分类号： A61K31/198 , A61K39/395 , A61K45/06 , A61P35/00 , A61P37/04 , A61P37/06 , C07K16/18
CPC分类号： A61K39/3955 , A61K31/198 , A61K39/39541 , A61K45/06 , C07K16/2827 , C07K2317/76 , A61K2300/00
摘要： The present invention is directed to the use of VISTA agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an iNOS/NO promoter or nitric oxide or a PD-1 or PD-L1 agonist or a CD40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. The present invention is further directed to the use of VISTA antagonists alone or in association with other immune agonists, preferably another enhancer of humoral immunity such as iNOS/NO inhibitor or a PD-1 or PD-L1 antagonist or anti-CTLA-4 antibody or a CD40 agonist for the treatment or prevention of conditions wherein the enhancement of humoral immunity is therapeutically beneficial. Also, the invention relates to the use of VISTA antagonists alone or in association with another immune agonist, e.g., an iNOS/NO inhibitor or a CD40 agonist to promote the efficacy of therapeutic and prophylactic vaccines, e.g., antitumor, and antiviral vaccines.

2. 发明公开

EP3154585A2 USE OF VISTA AGONISTS AND ANTAGONISTS TO SUPPRESS OR ENHANCE HUMORAL IMMUNITY 有权转让
标题翻译： VISTA激动剂和拮抗剂减少或改善体液免疫USE
公开(公告)号：EP3154585A2
公开(公告)日：2017-04-19
申请号：EP15806089.7
申请日：2015-06-11
申请人： Green, Kathy A. , Wang, Li , Noelle, Randolph, J. , Green, William R.
发明人： Green, Kathy A. , Wang, Li , Noelle, Randolph, J. , Green, William R.
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： A61K39/3955 , A61K31/198 , A61K39/39541 , A61K45/06 , C07K16/2827 , C07K2317/76 , A61K2300/00
摘要： The present invention is directed to the use of VISTA agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an iNOS/NO promoter or nitric oxide or a PD-1 or PD-L1 agonist or a CD40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. The present invention is further directed to the use of VISTA antagonists alone or in association with other immune agonists, preferably another enhancer of humoral immunity such as iNOS/NO inhibitor or a PD-1 or PD-L1 antagonist or anti-CTLA-4 antibody or a CD40 agonist for the treatment or prevention of conditions wherein the enhancement of humoral immunity is therapeutically beneficial. Also, the invention relates to the use of VISTA antagonists alone or in association with another immune agonist, e.g., an iNOS/NO inhibitor or a CD40 agonist to promote the efficacy of therapeutic and prophylactic vaccines, e.g., antitumor, and antiviral vaccines.
摘要翻译：本发明涉及单独使用或与其他免疫抑制剂，体液免疫的优选另一抑制剂关联VISTA激动剂：如对iNOS / NO启动子或一氧化氮或PD-1或PD-L1激动剂或CD40拮抗用于治疗或预防的条件worin体液免疫的抑制是治疗上有益的。本发明还涉及使用单独或者与其他免疫激动剂，体液免疫的优选另一增强剂关联VISTA拮抗剂：如iNOS的/ NO抑制剂或PD-1或PD-L1拮抗剂或抗CTLA-4抗体或用于治疗或预防的状况的CD40激动剂worin体液免疫的增强是治疗上有益的。所以，本发明涉及单独使用或与另一种免疫激动剂，E. G.，iNOS的/无抑制剂或CD40激动剂的关联，以促进治疗性和预防性疫苗，E. G.，抗肿瘤和抗病毒疫苗的效力VISTA拮抗剂。

3. 发明申请

WO2015191881A9 USE OF VISTA AGONISTS AND ANTAGONISTS TO SUPPRESS OR ENHANCE HUMORAL IMMUNITY 审中-公开
公开(公告)号：WO2015191881A9
公开(公告)日：2015-12-17
申请号：PCT/US2015/035371
申请日：2015-06-11
申请人： GREEN, Kathy A. , WANG, Li , NOELLE, Randolph J. , GREEN, William R.
发明人： GREEN, Kathy A. , WANG, Li , NOELLE, Randolph J. , GREEN, William R.
IPC分类号： A61K39/395 , C07K16/18
摘要： The present invention is directed to the use of VISTA agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an iNOS/NO promoter or nitric oxide or a PD-1 or PD-L1 agonist or a CD40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. The present invention is further directed to the use of VISTA antagonists alone or in association with other immune agonists, preferably another enhancer of humoral immunity such as iNOS/NO inhibitor or a PD-1 or PD-L1 antagonist or anti-CTLA-4 antibody or a CD40 agonist for the treatment or prevention of conditions wherein the enhancement of humoral immunity is therapeutically beneficial. Also, the invention relates to the use of VISTA antagonists alone or in association with another immune agonist, e.g., an iNOS/NO inhibitor or a CD40 agonist to promote the efficacy of therapeutic and prophylactic vaccines, e.g., antitumor, and antiviral vaccines.

4. 发明申请

WO2015191881A3 USE OF VISTA AGONISTS AND ANTAGONISTS TO SUPPRESS OR ENHANCE HUMORAL IMMUNITY 审中-公开
公开(公告)号：WO2015191881A3
公开(公告)日：2015-12-17
申请号：PCT/US2015/035371
申请日：2015-06-11
申请人： GREEN, Kathy A. , WANG, Li , NOELLE, Randolph J. , GREEN, William R.
发明人： GREEN, Kathy A. , WANG, Li , NOELLE, Randolph J. , GREEN, William R.
IPC分类号： A61K39/395 , C07K16/18
摘要： The present invention is directed to the use of VISTA agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an iNOS/NO promoter or nitric oxide or a PD-1 or PD-L1 agonist or a CD40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. The present invention is further directed to the use of VISTA antagonists alone or in association with other immune agonists, preferably another enhancer of humoral immunity such as iNOS/NO inhibitor or a PD-1 or PD-L1 antagonist or anti-CTLA-4 antibody or a CD40 agonist for the treatment or prevention of conditions wherein the enhancement of humoral immunity is therapeutically beneficial. Also, the invention relates to the use of VISTA antagonists alone or in association with another immune agonist, e.g., an iNOS/NO inhibitor or a CD40 agonist to promote the efficacy of therapeutic and prophylactic vaccines, e.g., antitumor, and antiviral vaccines.

5. 发明申请

WO2015191881A2 USE OF VISTA AGONISTS AND ANTAGONISTS TO SUPPRESS OR ENHANCE HUMORAL IMMUNITY 审中-公开
标题翻译：使用VISTA激动剂和拮抗剂来抑制或增强人体免疫力
公开(公告)号：WO2015191881A2
公开(公告)日：2015-12-17
申请号：PCT/US2015/035371
申请日：2015-06-11
申请人： GREEN, Kathy A. , WANG, Li , NOELLE, Randolph J. , GREEN, William R.
发明人： GREEN, Kathy A. , WANG, Li , NOELLE, Randolph J. , GREEN, William R.
IPC分类号： A61K39/395 , A61K31/198
CPC分类号： A61K39/3955 , A61K31/198 , A61K39/39541 , A61K45/06 , C07K16/2827 , C07K2317/76 , A61K2300/00
摘要： The present invention is directed to the use of VISTA agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an iNOS/NO promoter or nitric oxide or a PD-1 or PD-L1 agonist or a CD40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. The present invention is further directed to the use of VISTA antagonists alone or in association with other immune agonists, preferably another enhancer of humoral immunity such as iNOS/NO inhibitor or a PD-1 or PD-L1 antagonist or anti-CTLA-4 antibody or a CD40 agonist for the treatment or prevention of conditions wherein the enhancement of humoral immunity is therapeutically beneficial. Also, the invention relates to the use of VISTA antagonists alone or in association with another immune agonist, e.g., an iNOS/NO inhibitor or a CD40 agonist to promote the efficacy of therapeutic and prophylactic vaccines, e.g., antitumor, and antiviral vaccines.
摘要翻译：本发明涉及单独或与其它免疫抑制剂，优选另一种体液免疫抑制剂如iNOS / NO启动子或一氧化氮或PD-1或PD-L1激动剂或CD40拮抗剂相结合的VISTA激动剂的用途用于治疗或预防其中抑制体液免疫是治疗有益的条件。本发明还涉及单独使用或与其它免疫激动剂，优选体液免疫的另一增强剂如iNOS / NO抑制剂或PD-1或PD-L1拮抗剂或抗CTLA-4抗体联合使用的VISTA拮抗剂或用于治疗或预防其中增强体液免疫是治疗有益的条件的CD40激动剂。此外，本发明涉及单独或与另一种免疫激动剂例如iNOS / NO抑制剂或CD40激动剂联合以增强治疗性和预防性疫苗（例如抗肿瘤剂和抗病毒疫苗）的功效的用途。

6. 发明专利

AU2015274504B2 Use of VISTA agonists and antagonists to suppress or enhance humoral immunity 未知
公开(公告)号：AU2015274504B2
公开(公告)日：2021-02-04
申请号：AU2015274504
申请日：2015-06-11
申请人： GREEN KATHY A , GREEN WILLIAM R , NOELLE RANDOLPH J , WANG LI
发明人： GREEN KATHY A , WANG LI , NOELLE RANDOLPH J , GREEN WILLIAM R
IPC分类号： C07K16/18 , A61K39/395
摘要： The present invention is directed to the use of VISTA agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an iNOS/NO promoter or nitric oxide or a PD-1 or PD-L1 agonist or a CD40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. The present invention is further directed to the use of VISTA antagonists alone or in association with other immune agonists, preferably another enhancer of humoral immunity such as iNOS/NO inhibitor or a PD-1 or PD-L1 antagonist or anti-CTLA-4 antibody or a CD40 agonist for the treatment or prevention of conditions wherein the enhancement of humoral immunity is therapeutically beneficial. Also, the invention relates to the use of VISTA antagonists alone or in association with another immune agonist, e.g., an iNOS/NO inhibitor or a CD40 agonist to promote the efficacy of therapeutic and prophylactic vaccines, e.g., antitumor, and antiviral vaccines.

7. 发明专利

CA2951885A1 USE OF VISTA AGONISTS AND ANTAGONISTS TO SUPPRESS OR ENHANCE HUMORAL IMMUNITY 未知
公开(公告)号：CA2951885A1
公开(公告)日：2015-12-17
申请号：CA2951885
申请日：2015-06-11
申请人： GREEN KATHY A , WANG LI , NOELLE RANDOLPH J , GREEN WILLIAM R
发明人： GREEN KATHY A , WANG LI , NOELLE RANDOLPH J , GREEN WILLIAM R
IPC分类号： A61K39/395 , A61K31/198 , C07K16/18
摘要： The present invention is directed to the use of VISTA agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an iNOS/NO promoter or nitric oxide or a PD-1 or PD-L1 agonist or a CD40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. The present invention is further directed to the use of VISTA antagonists alone or in association with other immune agonists, preferably another enhancer of humoral immunity such as iNOS/NO inhibitor or a PD-1 or PD-L1 antagonist or anti-CTLA-4 antibody or a CD40 agonist for the treatment or prevention of conditions wherein the enhancement of humoral immunity is therapeutically beneficial. Also, the invention relates to the use of VISTA antagonists alone or in association with another immune agonist, e.g., an iNOS/NO inhibitor or a CD40 agonist to promote the efficacy of therapeutic and prophylactic vaccines, e.g., antitumor, and antiviral vaccines.

8. 发明专利

AU2015274504A1 Use of VISTA agonists and antagonists to suppress or enhance humoral immunity 未知
公开(公告)号：AU2015274504A1
公开(公告)日：2017-01-12
申请号：AU2015274504
申请日：2015-06-11
申请人： GREEN KATHY A , GREEN WILLIAM R , NOELLE RANDOLPH J , WANG LI
发明人： GREEN KATHY A , WANG LI , NOELLE RANDOLPH J , GREEN WILLIAM R
IPC分类号： C07K16/18 , A61K39/395
摘要： The present invention is directed to the use of VISTA agonists alone or in association with other immune inhibitors, preferably another inhibitor of humoral immunity such as an iNOS/NO promoter or nitric oxide or a PD-1 or PD-L1 agonist or a CD40 antagonist for the treatment or prevention of conditions wherein the suppression of humoral immunity is therapeutically beneficial. The present invention is further directed to the use of VISTA antagonists alone or in association with other immune agonists, preferably another enhancer of humoral immunity such as iNOS/NO inhibitor or a PD-1 or PD-L1 antagonist or anti-CTLA-4 antibody or a CD40 agonist for the treatment or prevention of conditions wherein the enhancement of humoral immunity is therapeutically beneficial. Also, the invention relates to the use of VISTA antagonists alone or in association with another immune agonist, e.g., an iNOS/NO inhibitor or a CD40 agonist to promote the efficacy of therapeutic and prophylactic vaccines, e.g., antitumor, and antiviral vaccines.

9. 发明专利

CA2673153A1 A MULTI-PURPOSE UTILITY TOOL FOR HOCKEY EQUIPMENT 未知
公开(公告)号：CA2673153A1
公开(公告)日：2011-01-20
申请号：CA2673153
申请日：2009-07-20
申请人： GREEN WILLIAM R , STRONG SCOTT R , KLINCK MICHAEL D
发明人： GREEN WILLIAM R , STRONG SCOTT R , KLINCK MICHAEL D
IPC分类号： B25F1/04 , B26B11/00
摘要： A multi-purpose utility tool for hockey equipment includes a handle and a plurality of devices pivotally attached to the tool by a plurality of pivot pins. Each device has a storage position within the handle. The tool comprises the following devices: a combination flat screw driving blade and bottle opener; a lace pulling tool; a lanyard mount; a scissor; a pliers; a screwing tool; a pick; and, tweezers.

10. 发明专利

CA119085A TRAP 未知
公开(公告)号：CA119085A
公开(公告)日：1909-06-22
申请号：CA119085D
申请日：1909-03-26
申请人： GREEN WILLIAM R
发明人： GREEN WILLIAM R

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