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    • 83. 发明授权
    • Fluorescent particles comprising nanoscale ZnO layer and exhibiting cell-specific toxicity
    • 荧光颗粒包含纳米尺度的ZnO层并显示细胞特异性毒性
    • US07939560B2
    • 2011-05-10
    • US12235575
    • 2008-09-22
    • Hua WangDenise WingettKevin FerisMadhusudan R KongaraAlex Punnoose
    • Hua WangDenise WingettKevin FerisMadhusudan R KongaraAlex Punnoose
    • A61K31/315A61K9/28
    • A61K49/0043A61K31/315A61K49/0093B82Y5/00B82Y20/00B82Y30/00Y02A50/473Y10S977/701Y10S977/712Y10S977/715
    • Multifunctional “smart” nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO2 core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO2-FITC core. These ˜200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations ≧250-500 μg/mL (for Staphylococcus aureus and Escherichia coli, respectively). These results indicate that the FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.
    • 公开了多功能“智能”纳米结构,其包括具有纳米尺度ZnO整理层的异氰酸荧光素(FITC) - 包封的SiO2核 - 壳颗粒,其中在SiO 2 -FFTC芯上形成外部ZnO层。 这些〜200nm大小的颗粒分别显示出使用细菌大肠杆菌和Jurkat癌细胞的细胞成像和细胞摄取研究的希望。 FITC封装的ZnO颗粒在优先杀死Jurkat癌细胞中具有优异的选择性,对正常的初级免疫细胞具有最小的毒性(暴露于60μg/ mL后分别为18%和75%的活力),并抑制革兰氏阳性 和浓度为250-500μg/ mL的革兰氏阴性细菌(分别用于金黄色葡萄球菌和大肠杆菌)。 这些结果表明,具有纳米尺度ZnO表面层的FITC封装的多功能颗粒可用作微粒跟踪,细胞成像,抗菌治疗和癌症治疗的智能纳米结构。
    • 85. 发明申请
    • NOISE SUPPRESSION TECHNIQUES IN HIGH PRECISION LONG-TERM FREQUENCY/TIMING MEASUREMENTS
    • 噪声抑制技术在高精度长期频率/时序测量
    • US20100245100A1
    • 2010-09-30
    • US12710334
    • 2010-02-22
    • Hua WangSeyed Ali HajimiriShouhei Kousai
    • Hua WangSeyed Ali HajimiriShouhei Kousai
    • G08B21/00G01R13/34
    • G01R29/26G01R31/31709
    • A frequency/timing measurement apparatus includes a reference source having a reference source output terminal. At least one target source has a target source output terminal. The at least one target source is communicatively coupled to the reference source. A frequency timing measurement block has a first input terminal electrically coupled to the reference source output terminal. A second input terminal is electrically coupled to the target source output terminal and at least one output terminal. The frequency timing measurement block is configured to perform a noise shaping technique to reduce measurement error attributable to a phase noise that is correlated between the reference source and the target source, and to provide a reduced correlated noise measurement at the at least one output terminal. A method to reduce correlated noise is also described.
    • 频率/定时测量装置包括具有参考源输出端的参考源。 至少一个目标源具有目标源输出端。 至少一个目标源通信地耦合到参考源。 频率定时测量块具有电耦合到参考源输出端的第一输入端。 第二输入端子电耦合到目标源输出端子和至少一个输出端子。 频率定时测量块被配置为执行噪声整形技术以减少归因于在参考源和目标源之间相关的相位噪声的测量误差,并且在至少一个输出端子处提供减小的相关噪声测量。 还描述了一种降低相关噪声的方法。
    • 90. 发明授权
    • Process for the recovery of alkoxysilanes obtained from the direct reaction of silicon with alkanols
    • 由硅与烷醇的直接反应获得的烷氧基硅烷的回收方法
    • US07365220B2
    • 2008-04-29
    • US11238199
    • 2005-09-29
    • Kenrick Martin LewisHua Wang
    • Kenrick Martin LewisHua Wang
    • C07F7/04
    • C07F7/025
    • A process is provided for separating a mixture of alkoxysilanes and alkanol, e.g., the crude product effluent of the Direct Reaction of silicon metal with alkanol, which comprises: a) introducing a mixture of alkoxysilane(s) and alkanol to a separation unit possessing a separation membrane having a first surface and an opposing second surface; b) contacting the mixture of alkoxysilane(s) and alkanol with the first surface of the separation membrane whereby one or more components of the mixture selectively absorb into the first surface and permeate therethrough to the second surface under the influence of a concentration gradient across the membrane thereby separating the mixture into an alkanol-enriched permeate fraction and an alkanol-deficient retentate fraction or an alkoxysilane-enriched permeate fraction and an alkoxysilane-deficient retentate fraction; and, c) recovering the permeate fraction.
    • 提供了一种用于分离烷氧基硅烷和链烷醇的混合物的方法,例如硅金属与烷醇的直接反应的粗产物流出物,其包括:a)将烷氧基硅烷和烷醇的混合物引入到具有 分离膜具有第一表面和相对的第二表面; b)使烷氧基硅烷和链烷醇的混合物与分离膜的第一表面接触,由此混合物中的一种或多种组分选择性地吸收到第一表面中并在跨越第一表面的浓度梯度的影响下渗透到第二表面 从而将混合物分离成富含链烷醇的渗透物馏分和链烷醇缺乏的滞留物部分或富含烷氧基硅烷的渗透物部分和烷氧基硅烷缺乏的滞留物部分; 和c)回收渗透部分。