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1. 发明授权

US07939560B2 Fluorescent particles comprising nanoscale ZnO layer and exhibiting cell-specific toxicity 失效
标题翻译：荧光颗粒包含纳米尺度的ZnO层并显示细胞特异性毒性
公开(公告)号：US07939560B2
公开(公告)日：2011-05-10
申请号：US12235575
申请日：2008-09-22
申请人： Hua Wang , Denise Wingett , Kevin Feris , Madhusudan R Kongara , Alex Punnoose
发明人： Hua Wang , Denise Wingett , Kevin Feris , Madhusudan R Kongara , Alex Punnoose
IPC分类号： A61K31/315 , A61K9/28
CPC分类号： A61K49/0043 , A61K31/315 , A61K49/0093 , B82Y5/00 , B82Y20/00 , B82Y30/00 , Y02A50/473 , Y10S977/701 , Y10S977/712 , Y10S977/715
摘要： Multifunctional “smart” nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO2 core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO2-FITC core. These ˜200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations ≧250-500 μg/mL (for Staphylococcus aureus and Escherichia coli, respectively). These results indicate that the FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.
摘要翻译：公开了多功能“智能”纳米结构，其包括具有纳米尺度ZnO整理层的异氰酸荧光素（FITC） - 包封的SiO2核 - 壳颗粒，其中在SiO 2 -FFTC芯上形成外部ZnO层。这些〜200nm大小的颗粒分别显示出使用细菌大肠杆菌和Jurkat癌细胞的细胞成像和细胞摄取研究的希望。 FITC封装的ZnO颗粒在优先杀死Jurkat癌细胞中具有优异的选择性，对正常的初级免疫细胞具有最小的毒性（暴露于60μg/ mL后分别为18％和75％的活力），并抑制革兰氏阳性和浓度为250-500μg/ mL的革兰氏阴性细菌（分别用于金黄色葡萄球菌和大肠杆菌）。这些结果表明，具有纳米尺度ZnO表面层的FITC封装的多功能颗粒可用作微粒跟踪，细胞成像，抗菌治疗和癌症治疗的智能纳米结构。

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