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81. 发明专利

AU2016201819B2 Biodegradable drug delivery composition 未知
公开(公告)号：AU2016201819B2
公开(公告)日：2017-12-14
申请号：AU2016201819
申请日：2016-03-23
申请人： DURECT CORP
发明人： VAN OSDOL WILLIAM W , YUM SU IL , THEEUWES FELIX , SEKAR MICHAEL , GIBSON JOHN , BRANHAM KEITH , SU HUEY-CHING
IPC分类号： A61K38/08
摘要： The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.

82. 发明专利

EA026964B1 БИОРАЗЛАГАЕМАЯ КОМПОЗИЦИЯ ДЛЯ ДОСТАВКИ ЛЕКАРСТВЕННОГО СРЕДСТВА (ВАРИАНТЫ) 未知
公开(公告)号：EA026964B1
公开(公告)日：2017-06-30
申请号：EA201390612
申请日：2011-11-23
申请人： DURECT CORP
发明人： VAN OSDOL WILLIAM W , YUM SU IL , THEEUWES FELIX , SEKAR MICHAEL , GIBSON JOHN , BRANHAM KEITH , SU HUEY-CHING
IPC分类号： A61K38/08
摘要： Предлагаетсянеявляющаясяэмульсиейкомпозициядлядоставкилекарственногосредствас вязкостьюпринулевомсдвигеменеечем 1,2 Па∙с (1200 сантипуаз) при 25°С. Композициясодержитноситель, включающийбиоразлагаемыйполимерв количествеот 5 до 25% отмассыносителя, представляющийсобойпоменьшеймереодинполимер, выбранныйизполилактидов, полигликолидов, поликапролактонови ихсополимерови терполимеров. Такженосительвключаетгидрофобныйрастворительв количествеот 95 до 75% отмассыносителя, содержащийпоменьшеймереодинрастворитель, выбранныйизбензиловогоспирта, метилбензоата, этилбензоата, н-пропилбензоата, изопропилбензоата, бутилбензоата, изобутилбензоата, втор-бутилбензоата, трет-бутилбензоата, изоамилбензоатаилибензилбензоата. Композициятакжесодержиткомплекс, диспергированныйв носителе, срастворимостьюв носителеменеечем 1 мг/млпри 25°С, содержащийактивныйагент, представляющийбелок, пептид, нуклеиновуюкислотуилинизкомолекулярноесоединениес молекулярноймассойнижеилиравной 800 Да, ипротивоионбелка, пептида, нуклеиновойкислотыилинизкомолекулярногосоединения. Помимоэтогопредлагаетсяспособвведениятакогоактивногоагента.

83. 发明专利

AU2012321101A1 Radiation-sterilized biodegradable drug delivery compositions 未知
公开(公告)号：AU2012321101A1
公开(公告)日：2013-06-06
申请号：AU2012321101
申请日：2012-11-21
申请人： DURECT CORP
发明人： SEKAR MICHAEL , YUM SU IL , THEEUWES FELIX , VAN OSDOL WILLIAM W
IPC分类号： A61K38/00
摘要： Atty. Dkt: DURE-079WO RADIATION-STERILIZED BIODEGRADABLE DRUG DELIVERY COMPOSITIONS [00178] The present disclosure is directed to a method of making a composition by combining a vehicle, e.g., a single phase vehicle, and an insoluble component comprising a beneficial agent, and sterilizing the composition using ionizing radiation prior to use, wherein the beneficial agent is stable following exposure to a sterilizing dose of ionizing radiation. Related compositions and methods are provided. r4o

84. 发明专利

AU2011336896A1 Biodegradable drug delivery composition 未知
公开(公告)号：AU2011336896A1
公开(公告)日：2013-04-11
申请号：AU2011336896
申请日：2011-11-23
申请人： DURECT CORP
发明人： VAN OSDOL WILLIAM W , YUM SU IL , THEEUWES FELIX , SEKAR MICHAEL , GIBSON JOHN , BRANHAM KEITH , SU HUEY-CHING
IPC分类号： A61K38/08
摘要： The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.

85. 发明专利

CA2457097C IMPLANTABLE DEVICES AND METHODS FOR TREATMENT OF PAIN BY DELIVERY OF FENTANYL AND FENTANYL CONGENERS 未知
公开(公告)号：CA2457097C
公开(公告)日：2010-11-02
申请号：CA2457097
申请日：2002-08-29
申请人： DURECT CORP
发明人： JOHNSON RANDOLPH MELLUS , THEEUWES FELIX , BROWN JAMES E , CULWELL JOHN , FILICE JAMES A , GILLIS EDWARD M , WICKMAN PETER , YUM SU IL , POUTIATINE ANDREW , DINKA JOHN
IPC分类号： A61J1/10 , A61K31/4468 , A61F2/00 , A61F2/02 , A61K9/00 , A61K9/22 , A61K31/4535 , A61K47/10 , A61K47/14 , A61K47/26 , A61L27/00 , A61L27/54 , A61M5/14 , A61M5/142 , A61M5/145 , A61M5/148 , A61M5/168 , A61M31/00 , A61M37/00 , A61P25/04
摘要： The invention features devices and methods for treatment of pain. The drug delivery device is a drug delivery system adapted for whole implantation in a subject and to provide pain relief by delivery of fentanyl or a fentanyl congener (e.g., sufentanil) over a protracted period of time (e.g., at least 3 days or more than 3 days). The device comprises a housing defining a reservoir that contains a drug formulation, a pump operatively connected to the housing so as to facilitate movement of drug out of the reservoir and out of the device, and a thermal expansion element that defines a flow pathway comprising a thermal expansion channel to accommodate thermal expansion of formulation in the reservoir. The device can further comprise a valve positioned within the flow pathway so as to prevent movement of drug out of the reservoir prior to use.

86. 发明专利

DK1814531T3 Transdermale leveringssystemer 未知
公开(公告)号：DK1814531T3
公开(公告)日：2010-10-11
申请号：DK05815696
申请日：2005-10-21
申请人： DURECT CORP
发明人： YUM SU II , THEEUWES FELIX
IPC分类号： A61K31/445 , A61K9/70

87. 发明专利

DE602005021909D1 TRANSDERMALE VERABREICHUNGSSYSTEME 未知
公开(公告)号：DE602005021909D1
公开(公告)日：2010-07-29
申请号：DE602005021909
申请日：2005-10-21
申请人： DURECT CORP
发明人： YUM SU II , THEEUWES FELIX
IPC分类号： A61K9/70 , A61K31/445

88. 发明专利

DE60234702D1 未知
公开(公告)号：DE60234702D1
公开(公告)日：2010-01-21
申请号：DE60234702
申请日：2002-08-30
申请人： DURECT CORP
发明人： THEEUWES FELIX
IPC分类号： A61K9/22 , A61M5/142 , A61M5/168 , A61M31/00 , F16K99/00
摘要： Flow regulators for implantable drug delivery devices (100) and drug delivery devices produced therewith. Implantable drug delivery devices (100) employing diffusion, osmosis, electrodiffusion, electroosmosis, or a combination of one or more of these for driving one or more drugs therefrom are provided with cover members (126, 128) for varying at least one of an effective cross-sectional area and transport characteristics through which fluids diffuse or osmose. The cover members may be remotely actuated from a location outside of an implantation site after implantation of a device.

89. 发明专利

AT451098T 未知
公开(公告)号：AT451098T
公开(公告)日：2009-12-15
申请号：AT02802414
申请日：2002-08-30
申请人： DURECT CORP
发明人： THEEUWES FELIX
IPC分类号： A61K9/22 , A61M5/142 , A61M5/168 , A61M31/00 , F16K99/00
摘要： Flow regulators for implantable drug delivery devices (100) and drug delivery devices produced therewith. Implantable drug delivery devices (100) employing diffusion, osmosis, electrodiffusion, electroosmosis, or a combination of one or more of these for driving one or more drugs therefrom are provided with cover members (126, 128) for varying at least one of an effective cross-sectional area and transport characteristics through which fluids diffuse or osmose. The cover members may be remotely actuated from a location outside of an implantation site after implantation of a device.

90. 发明专利

AT431130T 未知
公开(公告)号：AT431130T
公开(公告)日：2009-05-15
申请号：AT01973234
申请日：2001-09-19
申请人： DURECT CORP
发明人： THEEUWES FELIX , NELSON TIMOTHY
IPC分类号： A61K9/00 , A61F13/02 , A61K9/70
摘要： The present invention features devices and methods for delivery of drug to an internal organ surface by delivery of drug directly to the surface of the organ such that the drug traverses the organ surface and enters the organ tissue. The device is in the form of an implantable drug delivery patch comprising a first layer, which is generally substantially drug-impermeable. When the first layer is placed on an outer surface of an organ, a drug reservoir is defined by the first layer and the organ surface.

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