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71. 发明申请

US20110278464A1 RADIATION DETECTOR AND FABRICATION PROCESS 有权
标题翻译：辐射探测器和制造工艺
公开(公告)号：US20110278464A1
公开(公告)日：2011-11-17
申请号：US12779355
申请日：2010-05-13
申请人： Andrew Clark , David L. Williams
发明人： Andrew Clark , David L. Williams
IPC分类号： G01T1/20 , H01L21/30 , G01T1/208
CPC分类号： G01T1/202 , G01T1/2018
摘要： A monolithic integrated radiation detector includes a photodetector and a scintillator deposited directly on the photodetector. Preferably the photodetector is silicon and the scintillator is a rare earth phosphor. The rare earth phosphor is crystal lattice matched to the silicon by a transitional layer epitaxially grown therebetween.
摘要翻译：单片集成放射线检测器包括直接沉积在光电检测器上的光电检测器和闪烁体。优选地，光电检测器是硅，闪烁体是稀土荧光体。稀土荧光体通过其间外延生长的过渡层与硅晶格匹配。

72. 发明申请

US20060159625A1 Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use 有权
公开(公告)号：US20060159625A1
公开(公告)日：2006-07-20
申请号：US11187757
申请日：2005-07-22
申请人： Thomas Tarara , Jeffry Weers , Michael Eldon , Rangachari Narashimhan , Andrew Clark
发明人： Thomas Tarara , Jeffry Weers , Michael Eldon , Rangachari Narashimhan , Andrew Clark
IPC分类号： A61L9/04
CPC分类号： A61K31/7048 , A61K9/0075 , A61K9/1617
摘要： Formulations are provided for pulmonary administration of an antifungal agent to a patient. Methods of using the formulations in the treatment of antifungal infections are also provided, including treatment of pulmonary aspergillosis with amphotericin B-containing formulations. Methods of manufacturing the formulations to achieve optimum properties are provided as well.

73. 发明申请

US20050127577A1 Injection molded article having integral thermoplastic skin and method for making same 审中-公开
标题翻译：具有整体热塑性皮肤的注塑制品及其制造方法
公开(公告)号：US20050127577A1
公开(公告)日：2005-06-16
申请号：US10888035
申请日：2004-07-09
申请人： Andrew Clark , Kevin Bull , John Misner
发明人： Andrew Clark , Kevin Bull , John Misner
IPC分类号： B29C45/14 , B29C45/17
CPC分类号： B29C45/14778 , B29C45/1418 , B29C45/14836 , B29C45/1703 , B29C2045/14213 , B29K2027/06 , B29L2031/771
摘要： An injection molded article having an integral thermoplastic skin, and a method for making such an article. The article includes an injection molded substrate and a thermoplastic skin integrally bonded to the substrate during the injection molding process. The process includes the steps of opening the mold; placing the thermoplastic skin in the mold: closing the mold; injection molding the plastic substrate at a temperature, pressure, and fill rate that avoids thermal or mechanical damage to the skin; opening the mold; and removing the article from the mold. In a first refinement, the mold is pressurized prior to injection molding to force the skin into conformance with the mold. In a second refinement, the marginal edge of the skin is sandwiched between the mold halves so that the marginal edge remains free of the plastic substrate.
摘要翻译：具有整体热塑性皮肤的注塑制品和制造这种制品的方法。该制品包括在注射成型过程中注射成型基材和与基材整体结合的热塑性表皮。该方法包括打开模具的步骤; 将热塑性皮肤放置在模具中：关闭模具; 以避免对皮肤的热或机械损伤的温度，压力和填充率注塑塑料基材; 打开模具; 并将物品从模具中取出。在第一细化中，在注塑之前模具被加压以迫使皮肤与模具一致。在第二个细化中，皮肤的边缘被夹在半模之间，使得边缘保持没有塑料基底。

74. 发明申请

US20050016533A1 Systems and methods for aerosolizing pharmaceutical formulations 审中-公开
标题翻译：雾化药物制剂的系统和方法
公开(公告)号：US20050016533A1
公开(公告)日：2005-01-27
申请号：US10601127
申请日：2003-06-19
申请人： Carlos Schuler , Steve Paboojian , Derrick Tuttle , Adrian Smith , Dennis Rasmussen , Aneesh Bakshi , Andrew Clark , Brian Ward , William Alston , Kevin Nason
发明人： Carlos Schuler , Steve Paboojian , Derrick Tuttle , Adrian Smith , Dennis Rasmussen , Aneesh Bakshi , Andrew Clark , Brian Ward , William Alston , Kevin Nason
IPC分类号： A61M15/00 , A61M16/20 , A61M16/00
CPC分类号： A61M15/0028 , A61M15/002 , A61M15/0036 , A61M15/0051 , A61M15/0068 , A61M15/0083 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M16/0493 , A61M16/0495 , A61M16/0866 , A61M16/206 , A61M16/208 , A61M2202/064
摘要： Systems and methods are provided for aerosolizing a pharmaceutical formulation. According to one method, respiratory gases are prevented from flowing to the lungs when attempting to inhale. Then, respiratory gases are abruptly permitted to flow to the lungs. The flow of respiratory gases may then be used to extract a pharmaceutical formulation from a receptacle and to place the pharmaceutical formulation within the flow of respiratory gases to form an aerosol.
摘要翻译：提供了用于雾化药物制剂的系统和方法。根据一种方法，当试图吸气时，防止呼吸气体流向肺部。然后，呼吸道气体突然被允许流向肺部。呼吸气体的流动然后可用于从容器中提取药物制剂并将药物制剂置于呼吸气体流中以形成气溶胶。

75. 发明授权

US06666312B2 Modulatable power transmission clutch and a marine transmission 有权
标题翻译：可调式动力传动离合器和海上变速箱
公开(公告)号：US06666312B2
公开(公告)日：2003-12-23
申请号：US10128755
申请日：2002-04-24
申请人： Gerald Matranga , Andrew Clark
发明人： Gerald Matranga , Andrew Clark
IPC分类号： F16D2510
CPC分类号： B63H23/30 , F16D25/0638 , F16D25/14 , F16D48/02 , F16D48/0206 , F16D2048/0209 , F16D2048/0221 , F16D2048/0266 , F16D2500/1045 , F16D2500/1105 , F16D2500/3146 , F16D2500/7041
摘要： A transmission housing having a modulatable power transmission therein which includes a clutch having interleaved clutch plates and having a central power transmitting shaft extending axially through the clutch. The clutch includes a fluid operated movable piston for effecting clutch operation by compression of the plates. The piston has a smaller piston area and a larger piston area, the smaller piston area has fluid flow directed to it at a variable fluid pressure whereby the clutch is modulatable. The larger piston area is adapted to have fluid flow directed thereto to effect maximum and unmodulatable engagement of the clutch. A spring loaded normally closed trigger valve controls fluid flow to the larger piston area in response to fluid pressure above a predetermined amount at the smaller piston area. The trigger valve is mounted on the outside of the transmission housing and is readily accessible for adjustment, for example. The trigger valve is normally closed so that pressure fluid is directed to the smaller piston area at a variable fluid pressure whereby the clutch is modulatable. When the valve is open by fluid pressure over a predetermined amount, the valve permits fluid flow to the larger piston area to effect maximum and unmodulatable engagement of the clutch for full clutch capacity.
摘要翻译：一种其中具有可调节动力传递的变速器壳体，其包括具有交错离合器片的离合器，并具有轴向延伸穿过离合器的中心动力传递轴。离合器包括流体操作的可移动活塞，用于通过压板来实现离合器操作。活塞具有较小的活塞面积和较大的活塞面积，较小的活塞面积以可变流体压力流向其中，从而离合器是可调节的。较大的活塞面积适于使流体流动引导到其上以实现离合器的最大和不可调制的接合。弹簧加载的常闭触发阀响应于较小活塞区域处的预定量的流体压力控制流入较大活塞面积的流体。触发阀安装在变速器壳体的外侧，并且例如易于调节。触发阀常闭，使得压力流体以可变的流体压力被引导到较小的活塞区域，由此离合器是可调节的。当阀门通过流体压力超过预定量打开时，阀门允许流体流向较大的活塞区域，以实现离合器的最大和不可调制的接合以实现完全离合器的容量。

76. 发明授权

US06655379B2 Aerosolized active agent delivery 有权
标题翻译：气雾剂活性剂输送
公开(公告)号：US06655379B2
公开(公告)日：2003-12-02
申请号：US09266720
申请日：1999-03-11
申请人： Andrew Clark , George H. Foulds
发明人： Andrew Clark , George H. Foulds
IPC分类号： A61M1600
CPC分类号： A61M15/00 , A61K9/0073 , A61M15/002
摘要： The present invention is directed to methods and devices for delivering an active agent formulation to the lung of a human patient. The active agent formulation may be in dry powder form, it may be nebulized, or it may be in admixture with a propellant. The active agent formulation is delivered to a patient at an inspiratory flow rate of less than 17 liters per minute. The bioavailability of the active agent was found to increase at these flow rates when compared to inspiratory flow rates of 17 liters per minute or more.
摘要翻译：本发明涉及用于将活性剂制剂递送到人类患者的肺的方法和装置。活性剂制剂可以是干粉形式，它可以是雾化的，或者它可以与推进剂混合。活性剂制剂以小于17升/分钟的吸气流速输送给患者。当与每分钟17升/分钟的吸气流速相比时，发现活性剂的生物利用度在这些流速下增加。

77. 发明授权

US6077543A Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients 失效
公开(公告)号：US6077543A
公开(公告)日：2000-06-20
申请号：US999097
申请日：1997-12-29
申请人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
发明人： Marc S. Gordon , Andrew Clark , Thomas K. Brewer
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K31/07 , A61K31/12 , A61K31/122 , A61K31/353 , A61K31/355 , A61K31/557 , A61K31/56 , A61K31/573 , A61K31/58 , A61K31/59 , A61K31/7012 , A61K31/715 , A61K38/00 , A61K45/00 , A61K47/00 , B01D1/18 , B01J2/04 , A61K9/72
CPC分类号： A61K9/0075 , A61K31/353 , A61K31/355 , A61K31/557 , A61K31/56 , A61K31/573 , A61K31/59 , A61K31/7012 , A61K31/715 , A61K9/1611 , A61K9/1623 , A61K9/1694 , B01D1/18 , B01J2/04 , Y10S514/938 , Y10S514/951 , Y10S514/958 , Y10S977/775 , Y10S977/783 , Y10S977/829 , Y10S977/884 , Y10S977/89 , Y10S977/906 , Y10S977/915 , Y10S977/926
摘要： Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.

78. 发明授权

US09710857B2 Detecting anomalous user activity 有权
公开(公告)号：US09710857B2
公开(公告)日：2017-07-18
申请号：US12950884
申请日：2010-11-19
申请人： Ulrich Flegel , Shane Bracher , Pascal Hochwarth , Hermann Resch , Paola Sala , Stephan Wollny , Hua Wang , Andrew Clark , George Mohay , Roheena Khan , Malcolm Corney
发明人： Ulrich Flegel , Shane Bracher , Pascal Hochwarth , Hermann Resch , Paola Sala , Stephan Wollny , Hua Wang , Andrew Clark , George Mohay , Roheena Khan , Malcolm Corney
IPC分类号： G06Q10/00 , G06Q99/00 , G06F11/00 , G06Q40/06
CPC分类号： G06Q40/06
摘要： Systems, methods and articles for determining anomalous user activity are disclosed. Data representing a transaction activity corresponding to a plurality of user transactions can be received and user transactions can be grouped according to types of user transactions. The transaction activity can be determined to be anomalous in relation to the grouped user transactions based on a predetermined parameter.

79. 发明授权

US08845568B2 Distractor straps for use with distractor apparatuses 有权
标题翻译：牵引器带用于牵引器装置
公开(公告)号：US08845568B2
公开(公告)日：2014-09-30
申请号：US13435040
申请日：2012-03-30
申请人： Andrew Clark , David Chella , Jesse Drake
发明人： Andrew Clark , David Chella , Jesse Drake
IPC分类号： A61F5/04 , A61F5/37
CPC分类号： A61F5/3776 , A61F5/04
摘要： Distractor straps for use with distractor apparatuses are disclosed. In one embodiment, a distractor strap includes a cinch strap having a free end and a second end. The second end of the cinch strap includes an adjustment mechanism receiving the free end of the cinch strap such that the cinch strap forms a closed loop. A diameter of the closed loop is adjustable with the adjustment mechanism. The distractor strap further includes a cross strap comprising a first loop, a second loop, and strapping connecting the first loop and the second loop. The cinch strap is positioned in the first loop and the second loop such that the cross strap extends across the diameter of the closed loop formed by the cinch strap and the cross strap and the cinch strap are slidable with respect to one another.
摘要翻译：公开了用于牵引器装置的牵引带。在一个实施例中，牵引带包括具有自由端和第二端的束带。束带的第二端包括接收束带的自由端的调节机构，使得束带形成闭环。闭环的直径可用调节机构调节。牵引带还包括交叉带，其包括第一回路，第二回路和连接第一回路和第二回路的捆扎带。系带位于第一环和第二环中，使得交叉带横跨由带束带形成的闭环的直径延伸，并且交叉带和带束带可相对于彼此滑动。

80. 发明授权

US08777011B2 Capsule package with moisture barrier 有权
标题翻译：胶囊包装防潮
公开(公告)号：US08777011B2
公开(公告)日：2014-07-15
申请号：US10313419
申请日：2002-12-06
申请人： Scot Cheu , William Leung , Mei-Chang Kuo , Andrew Clark
发明人： Scot Cheu , William Leung , Mei-Chang Kuo , Andrew Clark
IPC分类号： B65D83/04
CPC分类号： B65D81/24 , B65D81/2015 , B65D81/2038
摘要： A package for storing an aerosolizable pharmaceutical formulation comprises a capsule adapted to contain the aerosolizable pharmaceutical formulation, and a moisture barrier around the capsule. The moisture barrier comprises a material that is resistant to moisture passage, whereby the moisture barrier reduces the amount of moisture in contact with the aerosolizable pharmaceutical formulation so that the aerosolizable pharmaceutical formulation may be aerosolized when the capsule is opened. In one version, the moisture barrier comprises a metal.
摘要翻译：用于储存可雾化药物制剂的包装包括适于容纳可雾化药物制剂的胶囊和胶囊周围的防潮屏障。防潮层包括耐潮湿通道的材料，由此防潮剂减少与可雾化药物制剂接触的水分量，使得当胶囊打开时可雾化的药物制剂可以雾化。在一个版本中，防潮层包括金属。

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