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71. 发明授权

US06389478B1 Efficient non-contiguous I/O vector and strided data transfer in one sided communication on multiprocessor computers 失效
标题翻译：在多处理器计算机上的单面通信中有效的非连续I / O向量和跨数据传输
公开(公告)号：US06389478B1
公开(公告)日：2002-05-14
申请号：US09365696
申请日：1999-08-02
申请人： Robert Sidney Blackmore , Xin Chen , Rama Krishna Govindaraju , Anan Vishwanath Hudli
发明人： Robert Sidney Blackmore , Xin Chen , Rama Krishna Govindaraju , Anan Vishwanath Hudli
IPC分类号： G06F1500
CPC分类号： H04L29/06 , H04L67/10 , H04L69/22 , H04L69/329
摘要： A method for grouping I/O vectors to be transferred across a distributed computing environment comprising a plurality of processing nodes coupled together over a network. The method reduces the number of packets transmitted over a network between two or more nodes. The method includes the grouping of two or more I/O vectors into a single message, consisting of one packet with a predetermined maximum size, provided the sizes of the vectors are small enough to be placed into a single packet. The grouping method finds an efficient collection of vectors to form groups that fit inside a single packet. If two or more of the vectors can be combined so that the resulting single packet size does not exceed the predetermined maximum size, the vectors are grouped accordingly. Vectors whose size approach the predetermined maximum packet size are sent as a separate message.
摘要翻译：一种用于分组要在分布式计算环境中传送的I / O向量的方法，包括通过网络耦合在一起的多个处理节点。该方法减少了两个或多个节点之间通过网络传输的数据包数量。该方法包括将两个或更多个I / O向量分组为单个消息，由具有预定最大大小的一个分组组成，只要向量的大小足够小以便放置在单个分组中。分组方法找到有效的向量集合以形成适合单个数据包内的组。如果可以组合两个或更多个向量，使得所得到的单个分组大小不超过预定的最大大小，则矢量被相应地分组。大小接近预定最大数据包大小的向量作为单独消息发送。

72. 发明授权

US06365711B1 Methods and reagents for modulating TGF-&bgr; superfamily signalling 失效
标题翻译：用于调节TGF-β超家族信号传导的方法和试剂
公开(公告)号：US06365711B1
公开(公告)日：2002-04-02
申请号：US09087134
申请日：1998-05-28
申请人： Malcolm Whitman , Xin Chen
发明人： Malcolm Whitman , Xin Chen
IPC分类号： C07K1447
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/463 , C07K2319/00 , C12Q1/6897 , G01N2333/495
摘要： FAST-1 and Smad2 or Smad3 form a complex that is specifically induced by signals generated by a TGF-&bgr; superfamily member. We have shown that a domain of FAST-1 directly interacts with Smad2 or Smad3, and that this interaction is mediated by specific domains of the two interacting molecules, namely, the MH2 domain of Smad2 or Smad3 and the Smad Interaction Domain (SID) of FAST-1. This result allows the development of methods and reagents for the isolation of compounds that are involved in, and/or modulate, TGF-&bgr; superfamily signalling.
摘要翻译： FAST-1和Smad2或Smad3形成由TGF-β超家族成员产生的信号特异性诱导的复合物。我们已经表明，FAST-1的结构域与Smad2或Smad3直接相互作用，并且这种相互作用由两个相互作用的分子的特定结构域介导，即Smad2或Smad3的MH2结构域和Smad2的Smad相互作用域（SID） FAST-1。该结果允许开发用于分离参与和/或调节TGF-β超家族信号传导的化合物的方法和试剂。

73. 发明授权

US12018325B2 3′-O-modified nucleotide analogues with different cleavable linkers for attaching fluorescent labels to the base for DNA sequencing by synthesis 有权
公开(公告)号：US12018325B2
公开(公告)日：2024-06-25
申请号：US16498132
申请日：2018-03-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Shiv Kumar , James Russo , Minchen Chien
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Shiv Kumar , James Russo , Minchen Chien
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/20 , C12Q1/6869
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20
摘要： Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.

74. 发明授权

US11856246B2 CDN optimization platform 有权
公开(公告)号：US11856246B2
公开(公告)日：2023-12-26
申请号：US17774447
申请日：2019-11-04
申请人： MICROSOFT TECHNOLOGY LICENSING, LLC , Gang Xue , Xin Chen , Frederick C. Chong , Huaiye Zhang , Bin Zhou
发明人： Frederick C. Chong , Huaiye Zhang , Bin Zhou , Gang Xue , Xin Chen
IPC分类号： H04N21/24 , G06N7/01 , H04N21/2543
CPC分类号： H04N21/2402 , G06N7/01 , H04N21/2543
摘要： Techniques are disclosed for distributing data in a content delivery network configured to provide edge services using a plurality of service providers. Data indicative of data usage and cost data for the plurality of service providers is accessed. Based on the accessed data, an effective unit cost, multiplex efficiency, and channel utilization are determined for a selected user. A Bayesian optimization algorithm is applied to at least a portion of the accessed data. The content delivery network is configured to redistribute data traffic for the selected user based on a result of the applied Bayesian optimization algorithm.

75. 外观设计

USD997268S1 Plank abdominal wheel 有权
公开(公告)号：USD997268S1
公开(公告)日：2023-08-29
申请号：US29886911
申请日：2023-03-15
申请人： Xin Chen
设计人： Xin Chen
摘要： FIG. 1 is a front, right and top perspective view of an plank abdominal wheel, showing my design.
FIG. 2 is a rear, left and bottom perspective view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a left side elevation view thereof.
FIG. 6 is a right side elevation view thereof.
FIG. 7 is a top plan view thereof.
FIG. 8 is a bottom plan view thereof.
FIG. 9 is an enlarged view of detail 9 in FIG. 1.
FIG. 10 is an enlarged view of detail 10 in FIG. 2; and,
FIG. 11 is another front, right and top perspective view of the plank abdominal wheel, wherein the two parts of the plank abdominal wheel are separated from each other.
The dash-dash lines depict portions of the plank abdominal wheel that form no part of the claimed design. The dot-dash broken lines in FIGS. 1, 2, 9, and 10 depict the boundaries of the enlargements and form no part of the claimed design.

76. 外观设计

USD993668S1 Cervical pillow 有权
公开(公告)号：USD993668S1
公开(公告)日：2023-08-01
申请号：US29820588
申请日：2021-12-22
申请人： Xin Chen
设计人： Xin Chen
摘要： FIG. 1 is a front, right side, top perspective view of a cervical pillow showing my new design;
FIG. 2 is a front elevational view thereof;
FIG. 3 is a rear elevational view thereof;
FIG. 4 is a left side elevational view thereof;
FIG. 5 is a right side elevational view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.

77. 发明申请

US20220411860A1 DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 有权
公开(公告)号：US20220411860A1
公开(公告)日：2022-12-29
申请号：US17373295
申请日：2021-07-12
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20
摘要： Disclosed herein, inter alfa, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

78. 外观设计

USD970925S1 Cervical pillow 有权
公开(公告)号：USD970925S1
公开(公告)日：2022-11-29
申请号：US29843075
申请日：2022-06-17
申请人： Xin Chen
设计人： Xin Chen

79. 发明申请

US20170367683A1 Measuring Tissue Shear Wave Properties using One Excitation Pulse and Excitation Pulses having Different Widths and Shapes 审中-公开
公开(公告)号：US20170367683A1
公开(公告)日：2017-12-28
申请号：US15090357
申请日：2016-04-04
申请人： Yi Zheng , Siping Chen , Tianfu Wang , Xin Chen , Haoming Lin
发明人： Yi Zheng , Siping Chen , Tianfu Wang , Xin Chen , Haoming Lin
IPC分类号： A61B8/08 , G01S7/52 , G01S7/62
CPC分类号： A61B8/485 , A61B8/5223 , G01S7/52022 , G01S7/52038 , G01S7/52042 , G01S7/52071 , G01S7/6263
摘要： Methods and apparatus measuring tissue nonlinear shear wave property are disclosed. When tissue shear responses are different to ultrasound radiation forces generated by pulses having different shapes, its nonlinear effect can be used to estimate tissue property at single location without measurements of group velocities or phase velocities. Ultrasound radiation force using a single tone burst pulse is applied to a selected location in a tissue region. The induced shear wave is detected in the region and its spectral distribution is calculated and analyzed. This detection may be repeated with other excitation pulses having different widths or different shapes at the same location. The spectral analysis of the detected shear wave is performed according to a nonlinear shear model for solving nonlinearity and viscoelasticity of the tissue at a single location in a tissue region. The detection location can be at one point at a time for imaging two-dimensional or three-dimensional tissue nonlinearities and shear wave properties. The property includes nonlinear magnitude variations, nonlinear phase variations, nonlinear coefficients, and viscoelasticity. The induced shear wave are detected at multiple locations along the shear propagation directions in the tissue region for calculating different shear group velocities and different shear phase velocities using different excitation pulses, and calculating nonlinearity and viscoelasticity. A difference between certain aspects of this disclosure and the prior art of ultrasound elastography is the utilization of nonlinear responses of the tissue shear property.

80. 发明授权

US09660831B2 Method of packaging and displaying an E-mail 有权
公开(公告)号：US09660831B2
公开(公告)日：2017-05-23
申请号：US12991160
申请日：2009-05-04
申请人： Xin Chen , Wan Kei Ricky Ha
发明人： Xin Chen , Wan Kei Ricky Ha
IPC分类号： G06F15/16 , H04L12/58 , G06Q10/10
CPC分类号： H04L51/22 , G06Q10/107 , H04L51/08 , H04L51/10
摘要： A method of packaging and displaying an email, comprising the steps of creating an email having at least a first independent digital object and a corresponding first tag, and at least a first dependent digital object associated with the first independent digital object through said first tag; processing the email for extraction of said first dependent digital object for matching with the associated first independent digital object, thereby forming a first processed content; and displaying the email such that the first independent digital object and the first dependent digital object of the first processed content are presented simultaneously. According to the present invention both the sender composing the message, having at least an independent digital object and at least an associated dependent object, and the recipient to whom the message is presented, are faced with a user-friendly interface.

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