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1. 发明授权

US11999999B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 有权
公开(公告)号：US11999999B2
公开(公告)日：2024-06-04
申请号：US17373295
申请日：2021-07-12
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869 , C12Q2525/117 , C12Q2563/107
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

2. 发明申请

US20190390271A1 DNA SEQUENCING WITH NON-FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS AND CLEAVABLE LABEL MODIFIED NUCLEOTIDE TERMINATORS 审中-公开
公开(公告)号：US20190390271A1
公开(公告)日：2019-12-26
申请号：US16384461
申请日：2019-04-15
申请人： Jingyue Ju , Dae Hyun Kim , Jia Guo , Qinglin Meng , Zengmin Li , Huanyan Cao
发明人： Jingyue Ju , Dae Hyun Kim , Jia Guo , Qinglin Meng , Zengmin Li , Huanyan Cao
IPC分类号： C12Q1/6874 , C07H19/04 , C12Q1/6869 , C12Q1/6876
摘要： This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached thereto.

3. 发明申请

US20190085388A1 DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开
公开(公告)号：US20190085388A1
公开(公告)日：2019-03-21
申请号：US16208379
申请日：2018-12-03
申请人： Jingyue Ju , Huanyan Cao , Zengmin Li , Qinglin Meng , Jia Guo , Shenglong Zhang , Lin Yu
发明人： Jingyue Ju , Huanyan Cao , Zengmin Li , Qinglin Meng , Jia Guo , Shenglong Zhang , Lin Yu
IPC分类号： C12Q1/6869 , C07H19/20 , C07H19/10 , C07H19/14 , C07H19/06 , C07H19/16
摘要： This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

4. 发明申请

US20180327828A1 ION SENSOR DNA AND RNA SEQUENCING BY SYNTHESIS USING NUCLEOTIDE REVERSIBLE TERMINATORS 审中-公开
公开(公告)号：US20180327828A1
公开(公告)日：2018-11-15
申请号：US15777416
申请日：2016-11-18
申请人： Jingyue Ju , Xiaoxu Li , Zengmin Li , Shiv Kumar , Xin Chen , Cheng Guo , Shundi Shi , Jianyi Ren , Chuanjuan Tao , Minchen Chien , James J. Russo , Lin Yu
发明人： Jingyue Ju , Xiaoxu Li , Zengmin Li , Shiv Kumar , Xin Chen , Cheng Guo , Shundi Shi , Jianyi Ren , Chuanjuan Tao , Minchen Chien , James J. Russo , Lin Yu
IPC分类号： C12Q1/6869
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20 , C12Q2525/101 , C12Q2527/119 , C12Q2565/607
摘要： This disclosure is related to a method for determining the identity of a nucleotide residue of a single-stranded DNA or RNA, or sequencing DNA or RNA, in a solution using an ion-sensing field effect transistor and reversible nucleotide terminators.

5. 发明申请

US20140093869A1 DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 有权
标题翻译：可溶性荧光核素的设计和合成作为合成DNA序列的可逆终止子
公开(公告)号：US20140093869A1
公开(公告)日：2014-04-03
申请号：US13951269
申请日：2013-07-25
申请人： Jingyue Ju , Huanyan Cao , Zengmin Li , Qinglin Meng , Jia Guo , Shenglong Zhang
发明人： Jingyue Ju , Huanyan Cao , Zengmin Li , Qinglin Meng , Jia Guo , Shenglong Zhang
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/20
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C12Q2525/301 , C12Q2537/157
摘要： This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.
摘要翻译：本发明提供了具有附着于其上的可检测标记的脱氧核苷酸类似物的新型叠氮基连接体。

6. 发明授权

US6147244A Preparations of thiophosphites and thiophosphonates 失效
标题翻译：硫代亚磷酸酯和硫代磷酸酯的制备
公开(公告)号：US6147244A
公开(公告)日：2000-11-14
申请号：US304252
申请日：1999-05-03
申请人： Charles E. McKenna , Zengmin Li
发明人： Charles E. McKenna , Zengmin Li
IPC分类号： C07F9/201 , C07F9/40 , C07F9/06
CPC分类号： C07F9/4065 , C07F9/201
摘要： Improved methods for converting phosphite or phosphonate esters into corresponding thiophosphites or thiophosphonates and for synthesizing specific thiophosphite and thiophosphonate compounds so produced are disclosed and claimed. The methods start from phosphite diesters using P.sub.4 S.sub.10 as the thionation reagent. The reaction mixture is refluxed until the reaction is complete and may be followed by separation and chloroformate ester phosphonation steps to produce pure thiophosphonocarboxylate triesters. Alternatively, these esters may be prepared directly by action of P.sub.4 S.sub.10 on the corresponding phosphonocarboxylate esters. The former method was used to prepare dimethyl thiophosphite and thence trimethyl thiophosphonoformate, a key intermediate in synthesis of salts of thiophosphonoformic acid, which have anti-viral properties.
摘要翻译：公开和要求保护的方法将亚磷酸酯或膦酸酯转化成相应的硫代亚磷酸酯或硫代膦酸酯并合成特定的硫代亚磷酸酯和硫代膦酸酯化合物。该方法从使用P4S10作为硫化试剂的亚磷酸二酯开始。将反应混合物回流直到反应完成，然后分离和氯甲酸酯膦酸化步骤以产生纯的硫代膦酰基羧酸酯三酯。或者，这些酯可以通过P4S10在相应的膦酰基羧酸酯上的作用直接制备。使用前一种方法制备二硫代亚磷酸二甲酯，然后制备硫代膦酰甲酸三甲酯，这是合成硫代膦酰甲酸盐的关键中间体，具有抗病毒性质。

7. 发明申请

US20180274024A1 DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开
公开(公告)号：US20180274024A1
公开(公告)日：2018-09-27
申请号：US15763364
申请日：2016-09-28
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/6869 , C07H19/20 , C07H19/10 , C07H19/14
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q2525/117 , C12Q2563/107
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

8. 发明申请

US20180135121A1 PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：US20180135121A1
公开(公告)日：2018-05-17
申请号：US15868593
申请日：2018-01-11
申请人： Jingyue Ju , Zengmin Li , Sergey Kalachikov , Carl Fuller
发明人： Jingyue Ju , Zengmin Li , Sergey Kalachikov , Carl Fuller
IPC分类号： C12Q1/6874 , C12N9/96 , C12N9/12 , C07K14/31
CPC分类号： C12Q1/6874 , A61K47/545 , A61K47/62 , A61K47/6889 , A61K47/69 , C07K14/31 , C07K19/00 , C12N9/1252 , C12N9/96 , C12Y207/07007
摘要： The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming conjugates in nanopore devices and methods.

9. 发明申请

US20170321267A1 DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开
公开(公告)号：US20170321267A1
公开(公告)日：2017-11-09
申请号：US15596379
申请日：2017-05-16
申请人： Jingyue Ju , Huanyan Cao , Zengmin Li , Qinglin Meng , Jia Guo , Shenglong Zhang , Lin Yu
发明人： Jingyue Ju , Huanyan Cao , Zengmin Li , Qinglin Meng , Jia Guo , Shenglong Zhang , Lin Yu
IPC分类号： C12Q1/68 , C07H19/14 , C07H19/06 , C07H19/10 , C07H19/20 , C07H19/16
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C12Q2525/301 , C12Q2537/157
摘要： This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.

10. 发明授权

US09624539B2 DNA sequencing by synthesis using Raman and infrared spectroscopy detection 有权
公开(公告)号：US09624539B2
公开(公告)日：2017-04-18
申请号：US14119846
申请日：2012-05-23
申请人： Jingyue Ju , Jian Wu , Zengmin Li
发明人： Jingyue Ju , Jian Wu , Zengmin Li
IPC分类号： C12Q1/68 , C07H19/06 , C07H19/16 , C07H21/00
CPC分类号： C07H19/06 , C07H19/16 , C07H21/00 , C12Q1/6827 , C12Q1/6869 , C12Q1/6874 , C12Q2525/101 , C12Q2533/101 , C12Q2565/632
摘要： This invention provides nucleoside triphosphate analogs having the structure: wherein B is a base and is adenine, guanine, cytosine, uracil or thymine, wherein R″ is an OH or an H, and wherein R′ is azidomethyl, a hydrocarbyl, or a substituted hydrocarbyl, and which has a Raman spectroscopy peak with wavenumber from 2000 cm−1 to 2300 cm−1 or a Fourier transform-infrared spectroscopy spectroscopy peak with wavenumber from 2000 cm−1 to 2300 cm−1, and also to methods of DNA sequencing and SNP detection.

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