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71. 发明申请

WO1997011076A1 NEW FURYL-PYRIDONE COMPOUNDS, USEFUL AS FUNGICIDES AND OBTAINED FROM THE FUNGUS CLADOBOTRYUM 审中-公开
标题翻译：新型富马酸化合物，有害的作为杀真菌剂，并从真菌中获得
公开(公告)号：WO1997011076A1
公开(公告)日：1997-03-27
申请号：PCT/DK1996000398
申请日：1996-09-19
申请人： NOVO NORDISK A/S , DEMUTH, Helle , BREINHOLT, Jens , RASSING, Birgitte, Romer
发明人： NOVO NORDISK A/S
IPC分类号： C07D491/048
CPC分类号： C07D491/04 , A01N43/90 , A01N63/04 , C12P17/18 , C12R1/645 , Y10S435/911
摘要： The invention relates to biologically active novel compounds having general formula (I), wherein R1 is aryl, optionally mono- or plurisubstituted with alkyl with 1-6 carbon atoms, hydroxy, alkoxy, halogen, amino or a nitro group, R2 is hydrogen, straight or branched chain alkyl with 1-6 carbon atoms, straight or branched chain alkenyl with 2-6 carbon atoms, straight or branched chain alkynyl with 2-6 carbon atoms, R3 is hydrogen, straight or branched chain alkyl with 1-10 carbon atoms, straight or branched chain alkenyl with 2-10 carbon atoms, straight or branched chain alkynyl with 2-10 carbon atoms, R4 is hydrogen, straight or branched chain alkyl with 1-6 carbon atoms, straight or branched chain alkenyl with 2-6 carbon atoms, straight or branched chain alkynyl with 2-6 carbon atoms, and R5 is hydroxymethyl, formyl, carboxyl, or carboxyl ester with 1-6 carbon atoms. Also disclosed are methods of preparing said compounds, fungicidal compositions comprising, as an active ingredient, these compounds, use of the compounds, and methods of controlling fungi at loci infested or liable to be infested therewith. Finally an isolated pure culture of the microorganism NN006437 (CBS 331.95) or a mutant thereof capable of producing said compounds.
摘要翻译：本发明涉及具有通式（I）的生物活性的新型化合物，其中R 1为任选被1-6个碳原子的烷基，羟基，烷氧基，卤素，氨基或硝基单取代或多取代的芳基，R 2为氢，具有1-6个碳原子的直链或支链烷基，具有2-6个碳原子的直链或支链烯基，具有2-6个碳原子的直链或支链炔基，R3是氢，具有1-10个碳原子的直链或支链烷基原子，具有2-10个碳原子的直链或支链烯基，具有2-10个碳原子的直链或支链炔基，R4是氢，具有1-6个碳原子的直链或支链烷基，具有2- 6个碳原子，具有2-6个碳原子的直链或支链炔基，R5是具有1-6个碳原子的羟甲基，甲酰基，羧基或羧基酯。还公开了制备所述化合物的方法，所述杀真菌组合物包含作为活性成分的这些化合物，所述化合物的用途，以及在侵染或易于侵染的基因座中控制真菌的方法。最后是分离的纯培养物NN006437（CBS 331.95）或其能够产生所述化合物的突变体。

72. 发明申请

WO1997010726A1 A PROCESS FOR THE IMPROVEMENT OF GEL FORMATION OR VISCOSITY INCREASE 审中-公开
标题翻译：改善凝胶形成或粘度增加的方法
公开(公告)号：WO1997010726A1
公开(公告)日：1997-03-27
申请号：PCT/DK1996000391
申请日：1996-09-17
申请人： NOVO NORDISK A/S , BUDOLFSEN, Gitte , HELDT-HANSEN, Hans, Peter
发明人： NOVO NORDISK A/S
IPC分类号： A23L01/0522
CPC分类号： C12Y301/01011 , A23L2/84 , A23L19/09 , A23L21/11 , A23L23/00 , A23L27/60 , A23L27/63 , C12Y302/01025 , C12Y302/01032 , C12Y302/01055
摘要： A process for increasing the viscosity or gel strength of certain food products is disclosed. By the process a pectinaceous homogenate or slurry is subjected to: a) a treatment with a mixture of enzymes, comprising one or more among galactanases, arabinanases, alpha -arabinofuranosidases, rhamnogalacturonan acetyl esterases (RGAE), endoglucanases, mannanases, xylanases, and proteolytic enzymes; b) a treatment with a pectinesterase (PE), which PE is essentially free from pectic depolymerizing enzymes; followed by c) an enzyme inactivating treatment; said process being performed in the presence of divalent metal ions, especially Ca , said ions being inherently present in said homogenate or slurry, or said ions being added at any time prior to, during or after the process steps (a) to (c). The final product may be a jam, marmalade, jelly, juice, paste, soup, dressing, sauce, condiment, ketchup, salsa, chutney, pudding, mousse, or other dessert.
摘要翻译：公开了提高某些食品的粘度或凝胶强度的方法。通过该方法，将果胶匀浆或浆液进行：a）用半乳聚糖酶，阿拉伯聚糖酶，α-阿拉伯呋喃糖苷酶，鼠李糖半乳聚糖乙酰酯酶（RGAE），内切葡聚糖酶，甘露聚糖酶，木聚糖酶和蛋白水解酶中的一种或多种酶的混合物的处理酶; b）用果胶灭菌酶（PE）处理，其中PE基本上不含果胶解聚酶; 其次是c）酶灭活处理; 所述方法是在二价金属离子（特别是Ca 2+）的存在下进行的，所述离子固有地存在于所述匀浆或浆液中，或所述离子在工艺步骤（a）之前，期间或之后的任何时间加入，至（c）。最终产品可能是果酱，果酱，果冻，果汁，酱料，汤，酱料，调味品，番茄酱，莎莎，酸辣酱，布丁，摩丝或其他甜点。

73. 发明申请

WO1997010239A1 ACID ADDITION SALTS OF 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE COMPOUNDS 审中-公开
标题翻译： 2,3,4,5-四氢-1H-苯并噻吩化合物的添加量
公开(公告)号：WO1997010239A1
公开(公告)日：1997-03-20
申请号：PCT/DK1996000383
申请日：1996-09-12
申请人： NOVO NORDISK A/S , HANSEN, Louis, Brammer , AMSLER, Rolf, Emil , MCGRAW, Scott, Eugene
发明人： NOVO NORDISK A/S
IPC分类号： C07D405/04
CPC分类号： C07D405/04
摘要： The invention provides a series of crystalline salts of (S) (+)-8-chloro-5-(5,6-dichloro-2,3-dihydrobenzofuran-7-yl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-ol, their preparation and use as therapeutic agents.
摘要翻译：本发明提供一系列（S）（+） - 8-氯-5-（5,6-二氯-2,3-二氢苯并呋喃-7-基）-3-甲基-2,3,4， 5-四氢-1H-3-苯并氮杂-7-醇，它们的制备和用作治疗剂。

74. 发明申请

WO1997008325A2 PURIFIED COPRINUS LACCASES AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：纯化的番茄红素和核酸编码它们
公开(公告)号：WO1997008325A2
公开(公告)日：1997-03-06
申请号：PCT/US1996013728
申请日：1996-08-20
申请人： NOVO NORDISK BIOTECH, INC. , NOVO NORDISK A/S
发明人： NOVO NORDISK BIOTECH, INC. , NOVO NORDISK A/S , YAVER, Debbie, Sue , BROWN, Kimberly, M. , KAUPPINEN, Sakari , HALKIER, Torben
IPC分类号： C12N15/53
CPC分类号： C12N9/0061 , C07K14/37
摘要： The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides.
摘要翻译：本发明涉及具有漆酶活性的多肽和分离的编码多肽的核酸序列。本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及产生多肽的方法。

75. 发明申请

WO1997007202A1 NOVEL LIPOLYTIC ENZYMES 审中-公开
标题翻译：新型脂肪酶
公开(公告)号：WO1997007202A1
公开(公告)日：1997-02-27
申请号：PCT/DK1996000341
申请日：1996-08-12
申请人： NOVO NORDISK A/S , OKKELS, Jens, Sigurd , SVENDSEN, Allan , BORCH, Kim , THELLERSEN, Marianne , PATKAR, Shamkant, Anant , PETERSEN, Dorte, Aaby , ROYER, John, C. , KRETZSCHMAR, Titus
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/20
CPC分类号： C11D3/38627 , C12N9/20
摘要： Novel lipolytic enzymes are disclosed which are capable of removing substantial amounts of lard from a lard stained swatch in a one cycle wash. Preferred lipolytic enzymes are variants of the Humicola lanuginosa lipase which may be prepared by recombinant DNA techniques. The enzymes are advantageously used in detergent compositions.
摘要翻译：公开了新的脂肪分解酶，其能够在一次循环洗涤中从猪油染色的样本中除去大量的猪油。优选的脂肪分解酶是可通过重组DNA技术制备的Humicola lanuginosa脂肪酶的变体。酶有利地用于洗涤剂组合物中。

76. 发明申请

WO1997004078A1 A MODIFIED ENZYME WITH LIPOLYTIC ACTIVITY 审中-公开
标题翻译：具有脂质活性的改良酶
公开(公告)号：WO1997004078A1
公开(公告)日：1997-02-06
申请号：PCT/DK1996000321
申请日：1996-07-12
申请人： NOVO NORDISK A/S , FUGLSANG, Claus, Crone , OKKELS, Jens, Sigurd , PERTERSEN, Dorte, Aaby , PATKAR, Shamkant, Anant , THELLERSEN, Marianne , VIND, Jesper , HALKIER, Torben , JORGENSEN, Steen, Troels
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/20
CPC分类号： C12N9/20 , C11D3/38627
摘要： The invention relates to a modified enzyme with lipolytic activity recovered from a filamentous fungi or a bacteria having one or more peptide additions at the N-terminal and/or the C-terminal ends in comparison to the parent enzyme. Further, the invention relates to a DNA sequence encoding said modified enzyme, a vector comprising said DNA sequence, a host cell harbouring said DNA sequence or said vector, and a process for producing said modified enzyme with lipolytic activity.
摘要翻译：本发明涉及从丝状真菌中回收的具有脂肪分解活性的修饰酶，或者与母体酶相比，在N末端和/或C末端具有一个或多个肽添加的细菌。此外，本发明涉及编码所述修饰酶的DNA序列，包含所述DNA序列的载体，携带所述DNA序列或所述载体的宿主细胞，以及产生具有脂肪分解活性的所述修饰酶的方法。

77. 发明申请

WO1997002753A1 CLEANING-IN-PLACE WITH A SOLUTION CONTAINING A PROTEASE AND A LIPASE 审中-公开
标题翻译：用含有蛋白酶和脂肪的溶液清洁
公开(公告)号：WO1997002753A1
公开(公告)日：1997-01-30
申请号：PCT/DK1996000301
申请日：1996-07-03
申请人： NOVO NORDISK A/S , OLSEN, Hans, Sejr
发明人： NOVO NORDISK A/S
IPC分类号： A23C07/02
CPC分类号： B08B9/032 , A23C7/02 , B01D65/02 , B01D2321/166 , B08B9/0323 , B08B9/08 , C11D3/38627 , C11D11/0041 , C12Y301/01003 , C12Y301/01004 , C12Y302/01001 , C12Y302/01004 , C12Y304/21004 , C12Y304/21014
摘要： A method of cleaning-in-place soiled process equipment comprising circulating a solution comprising a protease and a lipase for a sufficient period of time to permit action of the enzymes.
摘要翻译：一种现场清洁污染的工艺设备的方法，包括使包含蛋白酶和脂肪酶的溶液循环足够的时间以允许酶的作用。

78. 发明申请

WO1997002043A1 PREVENTION OF A DISEASE HAVING THE CHARACTERISTICS OF DIABETES 审中-公开
标题翻译：防止患有糖尿病特征的疾病
公开(公告)号：WO1997002043A1
公开(公告)日：1997-01-23
申请号：PCT/DK1996000297
申请日：1996-07-01
申请人： NOVO NORDISK A/S , DYRBERG, Thomas , WORSAAE, Anne
发明人： NOVO NORDISK A/S
IPC分类号： A61K38/28
CPC分类号： A61K38/28
摘要： Insulins and insulin analogues which are substantially devoid of hypoglycaemic effect can be used for preventing or delaying the onset of type 1 diabetes or for amelioration of an early stage thereof in a mammal at risk of developing said disease.
摘要翻译：基本上没有低血糖作用的胰岛素和胰岛素类似物可用于预防或延缓发生所述疾病风险的哺乳动物中1型糖尿病的发病或改善其早期阶段。

79. 发明申请

WO1997000871A1 TETRAHYDRO-BETACARBOLINE DERIVATIVES AND THEIR PREPARATION AND USE 审中-公开
标题翻译：四氢吡喃衍生物及其制备和使用
公开(公告)号：WO1997000871A1
公开(公告)日：1997-01-09
申请号：PCT/DK1996000258
申请日：1996-06-14
申请人： NOVO NORDISK A/S , HANSEN, John, Bondo
发明人： NOVO NORDISK A/S
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Tetrahydro-betacarboline derivatives of formula (I), wherein R and R independently are hydrogen, alkyl, cycloalkyl, alkoxy, aralkyl, halogen, halogenalkyl, nitro, alkylthio; R , R and R independently are hydrogen, alkyl, alkenyl, or cycloalkyl; and R is (a), wherein A-B-C together with the benzene ring forms a five-membered heterocyclic ring comprising one or more N-, O- or S- atoms, and optionally substituted; and R and R independently are hydrogen, halogen, alkyl, alkenyl, nitro, CN, halogenalkyl or cycloalkyl, are useful in the treatment of disorders influenced by dysfunctions of the 5-HT2C receptors.
摘要翻译：式（I）的四氢 - betacarolineoline衍生物，其中R 1和R 2独立地是氢，烷基，环烷基，烷氧基，芳烷基，卤素，卤代烷基，硝基，烷硫基; R 3，R 5和R 6独立地是氢，烷基，链烯基或环烷基; 和R 4为（a），其中A-B-C与苯环一起形成包含一个或多个N，O-或S-原子并任选取代的五元杂环; R 7和R 8独立地为氢，卤素，烷基，烯基，硝基，CN，卤代烷基或环烷基，可用于治疗受5-HT 2C受体功能障碍影响的疾病。

80. 发明申请

WO1997000020A1 ENZYME-CONTAINING ORAL COMPOSITION FOR ANIMALS AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：用于动物的含酶的口服组合物及其生产方法
公开(公告)号：WO1997000020A1
公开(公告)日：1997-01-03
申请号：PCT/JP1996001579
申请日：1996-06-11
申请人： NOVO NORDISK A/S , ITO, Shinobu , KAMACHI, Motoaki , SATO, Hajime
发明人： NOVO NORDISK A/S
IPC分类号： A23K01/165
CPC分类号： A23K20/189
摘要： An oral composition for animals which contains thermostable enzymes having a residual activity of 60 % or above after being heated at 80 DEG C for 20 seconds. It is useful as feed, food or drug that can be taken through the mouths of animals including humans, fish and birds and that are improved in functionality, nutritive value, storability, and in vivo digestibility.
摘要翻译：一种用于动物的口腔用组合物，其含有在80℃下加热20秒后具有60％或更高残留活性的热稳定酶。作为饲料，食品或药物，可以通过包括人类，鱼类和鸟类在内的动物的嘴巴进行，并且功能性，营养价值，保存性和体内消化率得到改善是有用的。

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