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1. 发明申请

WO2010084173A1 STABLE GROWTH HORMONE COMPOUNDS 审中-公开
标题翻译：稳定的生长激素化合物
公开(公告)号：WO2010084173A1
公开(公告)日：2010-07-29
申请号：PCT/EP2010/050725
申请日：2010-01-22
申请人： NOVO NORDISK HEALTH CARE AG , OLSEN, Ole Hvilsted , BREINHOLT, Jens , SCHIØDT, Christine Bruun , DEMUTH, Helle , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter
发明人： OLSEN, Ole Hvilsted , BREINHOLT, Jens , SCHIØDT, Christine Bruun , DEMUTH, Helle , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter
IPC分类号： C07K14/61 , A61K38/27
CPC分类号： C07K14/61 , A61K38/00
摘要： The present invention relates to stable growth hormone (GH) compounds, which through the introduction of cysteine residues have disulphide bridges, which make the compounds resistant to proteolytic degradation.
摘要翻译：本发明涉及通过引入半胱氨酸残基具有二硫键的稳定生长激素（GH）化合物，其使得化合物对蛋白水解降解具有抗性。

2. 发明申请

WO2011089250A2 STABLE GROWTH HORMONE COMPOUNDS 审中-公开
标题翻译：稳定的生长激素化合物
公开(公告)号：WO2011089250A2
公开(公告)日：2011-07-28
申请号：PCT/EP2011050909
申请日：2011-01-24
申请人： NOVO NORDISK HEALTHCARE AG , DEMUTH HELLE , SCHIOEDT CHRISTINE BRUUN SCHIOEDT , NOERSKOV-LAURITSEN LEIF , CHEN JIANHE , THYGESEN PETER
发明人： DEMUTH HELLE , SCHIOEDT CHRISTINE BRUUN SCHIOEDT , NOERSKOV-LAURITSEN LEIF , CHEN JIANHE , THYGESEN PETER
IPC分类号： A61K47/48 , A61P5/00
CPC分类号： A61K47/48215 , A61K38/00 , A61K47/60 , C07K14/61
摘要： The present invention relates to growth hormone (GH) compounds having additional disulphide bridges and at least one additional single point mutation making the compounds resistant to proteolytic degradation.
摘要翻译：本发明涉及具有另外的二硫桥键和至少一个额外的单点突变的生长激素（GH）化合物，使得该化合物抵抗蛋白水解降解。

3. 发明申请

WO1997023486A1 ACTIVE BIO-COMPOUNDS 审中-公开
标题翻译：活性生物化合物
公开(公告)号：WO1997023486A1
公开(公告)日：1997-07-03
申请号：PCT/DK1996000543
申请日：1996-12-18
申请人： NOVO NORDISK A/S , DEMUTH, Helle , BREINHOLT, Jens , NIELSEN, Salka, E. , GÜRTLER, Hanne
发明人： NOVO NORDISK A/S
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , A01N43/90 , A23L3/3544 , A23L3/3571 , C09D5/14 , C12P17/188
摘要： The invention relates to biologically active novel compounds having general formula (I), wherein R , R , R , and R independently are hydrogen, straight or branched chain alkyl with 1-6 carbon atoms, straight or branched chain alkenyl with 2-6 carbon atoms, straight or branched chain alkynyl with 2-6 carbon atoms, or R and R independently are acyl (-COR), where R is defined as R to R above, and R and R are as above, X is halogen, preferably Cl or Br, especially Cl, mono- or plurisubstituted in the ring. Also disclosed are methods of preparing said compounds, fungicidal compositions comprising, as an active ingredient, these compounds, use of the compounds, and methods of controlling fungi at loci infested or liable to be infested therewith.
摘要翻译：本发明涉及具有通式（I）的生物活性新型化合物，其中R 1，R 2，R 3和R 4独立地是氢，具有1-6个碳原子的直链或支链烷基原子，具有2-6个碳原子的直链或支链烯基，具有2-6个碳原子的直链或支链炔基，或者R 1和R 3独立地是酰基（-COR），其中R定义为R R 4和R 4如上所述，X是卤素，优选Cl或Br，特别是C1，在环中被单取代或多取代。还公开了制备所述化合物的方法，所述杀真菌组合物包含作为活性成分的这些化合物，所述化合物的用途，以及在侵染或易于侵染的基因座中控制真菌的方法。

4. 发明申请

WO2011089250A3 STABLE GROWTH HORMONE COMPOUNDS 审中-公开
公开(公告)号：WO2011089250A3
公开(公告)日：2011-07-28
申请号：PCT/EP2011/050909
申请日：2011-01-24
申请人： NOVO NORDISK HEALTH CARE AG , DEMUTH, Helle , SCHIØDT, Christine, Bruun, Schiødt , NØRSKOV-LAURITSEN, Leif , CHEN, Jianhe , THYGESEN, Peter
发明人： DEMUTH, Helle , SCHIØDT, Christine, Bruun, Schiødt , NØRSKOV-LAURITSEN, Leif , CHEN, Jianhe , THYGESEN, Peter
IPC分类号： A61K38/27 , C07K14/61 , A61K47/48 , A61P5/00
摘要： The present invention relates to growth hormone (GH) compounds having additional disulphide bridges and at least one additional single point mutation making the compounds resistant to proteolytic degradation.

5. 发明申请

WO1997011076A1 NEW FURYL-PYRIDONE COMPOUNDS, USEFUL AS FUNGICIDES AND OBTAINED FROM THE FUNGUS CLADOBOTRYUM 审中-公开
标题翻译：新型富马酸化合物，有害的作为杀真菌剂，并从真菌中获得
公开(公告)号：WO1997011076A1
公开(公告)日：1997-03-27
申请号：PCT/DK1996000398
申请日：1996-09-19
申请人： NOVO NORDISK A/S , DEMUTH, Helle , BREINHOLT, Jens , RASSING, Birgitte, Romer
发明人： NOVO NORDISK A/S
IPC分类号： C07D491/048
CPC分类号： C07D491/04 , A01N43/90 , A01N63/04 , C12P17/18 , C12R1/645 , Y10S435/911
摘要： The invention relates to biologically active novel compounds having general formula (I), wherein R1 is aryl, optionally mono- or plurisubstituted with alkyl with 1-6 carbon atoms, hydroxy, alkoxy, halogen, amino or a nitro group, R2 is hydrogen, straight or branched chain alkyl with 1-6 carbon atoms, straight or branched chain alkenyl with 2-6 carbon atoms, straight or branched chain alkynyl with 2-6 carbon atoms, R3 is hydrogen, straight or branched chain alkyl with 1-10 carbon atoms, straight or branched chain alkenyl with 2-10 carbon atoms, straight or branched chain alkynyl with 2-10 carbon atoms, R4 is hydrogen, straight or branched chain alkyl with 1-6 carbon atoms, straight or branched chain alkenyl with 2-6 carbon atoms, straight or branched chain alkynyl with 2-6 carbon atoms, and R5 is hydroxymethyl, formyl, carboxyl, or carboxyl ester with 1-6 carbon atoms. Also disclosed are methods of preparing said compounds, fungicidal compositions comprising, as an active ingredient, these compounds, use of the compounds, and methods of controlling fungi at loci infested or liable to be infested therewith. Finally an isolated pure culture of the microorganism NN006437 (CBS 331.95) or a mutant thereof capable of producing said compounds.
摘要翻译：本发明涉及具有通式（I）的生物活性的新型化合物，其中R 1为任选被1-6个碳原子的烷基，羟基，烷氧基，卤素，氨基或硝基单取代或多取代的芳基，R 2为氢，具有1-6个碳原子的直链或支链烷基，具有2-6个碳原子的直链或支链烯基，具有2-6个碳原子的直链或支链炔基，R3是氢，具有1-10个碳原子的直链或支链烷基原子，具有2-10个碳原子的直链或支链烯基，具有2-10个碳原子的直链或支链炔基，R4是氢，具有1-6个碳原子的直链或支链烷基，具有2- 6个碳原子，具有2-6个碳原子的直链或支链炔基，R5是具有1-6个碳原子的羟甲基，甲酰基，羧基或羧基酯。还公开了制备所述化合物的方法，所述杀真菌组合物包含作为活性成分的这些化合物，所述化合物的用途，以及在侵染或易于侵染的基因座中控制真菌的方法。最后是分离的纯培养物NN006437（CBS 331.95）或其能够产生所述化合物的突变体。

6. 发明申请

WO1993022444A1 FUNGICIDALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：杀真菌活性化合物
公开(公告)号：WO1993022444A1
公开(公告)日：1993-11-11
申请号：PCT/DK1993000145
申请日：1993-04-30
申请人： NOVO NORDISK A/S , BREINHOLT, Jens , ROSENDAHL, Connie, Ninna , DEMUTH, Helle
发明人： NOVO NORDISK A/S
IPC分类号： C12P17/02
CPC分类号： C12R1/645 , A01N49/00 , A01N63/04 , C07D309/38 , C12P17/162
摘要： Compounds of formula (I), wherein R is hydrogen, straight or branched alkyl with 1 to 6 carbon atoms, such as methyl, straight or branched hydroxyalkyl with 1 to 6 carbon atoms, such as CH2OH, straight or branched alkylethers with 1 to 6 carbon atoms or optionally substituted aromatic ethers; each R independently are hydrogen, straight or branched alkyl with 1 to 6 carbon atoms, such as methyl, straight or branched hydroxyalkyl with 1 to 6 carbon atoms, such as CH2OH, straight or branched alkylethers with 1 to 6 carbon atoms, or optionally substituted aromatic ethers; and each R independently are hydrogen, hydroxy, methoxy, acetoxy, straight or branched alkylethers with 1 to 6 carbon atoms, or optionally substituted aromatic ethers; and wherein the chiral centres a, b, c, d, e, f, and g each independently may have the R or S configuration; except for the compound, wherein R is -CH2-OH, all of R are -CH3, and all of R are -OH (formula Ib); or agronomically acceptable salts or esters thereof have been found to have fungicidal activity. Furthermore processes for producing such compounds by cultivation of a species belonging to the genus Fusarium on suitable nutrient media are given. The invention also relates to fungicidal compositions comprising these compounds, either alone or in combination with known biocides or growth regulators, and the use of the compounds or compositions of the invention for controlling fungi.
摘要翻译：式（I）的化合物，其中R 1是氢，具有1至6个碳原子的直链或支链烷基，例如具有1至6个碳原子的甲基，直链或支链羟烷基，例如CH 2 OH，直链或支链烷基醚， 1至6个碳原子或任选取代的芳族醚; 每个R 2独立地是氢，具有1至6个碳原子的直链或支链烷基，例如甲基，具有1至6个碳原子的直链或支链羟烷基，例如CH 2 OH，具有1至6个碳原子的直链或支链烷基醚，或任选取代的芳族醚; 并且每个R 3独立地是氢，羟基，甲氧基，乙酰氧基，具有1至6个碳原子的直链或支链烷基醚或任选取代的芳族醚; 并且其中手性中心a，b，c，d，e，f和g各自独立地可以具有R或S构型; 除了其中R 1是-CH 2 -OH的化合物外，所有R 2都是-CH 3，并且所有的R 3都是-OH（式Ib）; 或其农艺学上可接受的盐或酯已被发现具有杀真菌活性。此外，给出了通过在合适的营养培养基上种植属于镰刀菌属的物种来生产这种化合物的方法。本发明还涉及包含这些化合物的杀真菌组合物，其单独或与已知的杀生物剂或生长调节剂组合，以及本发明化合物或组合物用于防治真菌的用途。

7. 发明申请

WO2012010516A1 GROWTH HORMONE CONJUGATES 审中-公开
标题翻译：生长激素
公开(公告)号：WO2012010516A1
公开(公告)日：2012-01-26
申请号：PCT/EP2011/062152
申请日：2011-07-15
申请人： NOVO NORDISK HEALTH CARE AG , ANDERSEN, Henrik Sune , MADSEN, Kjeld , DEMUTH, Helle , SCHIØDT, Christine Bruun , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter , BEHRENS, Carsten , GULDBRANDT, Mette
发明人： ANDERSEN, Henrik Sune , MADSEN, Kjeld , DEMUTH, Helle , SCHIØDT, Christine Bruun , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter , BEHRENS, Carsten , GULDBRANDT, Mette
IPC分类号： A61K47/48 , A61P5/06
CPC分类号： C07K14/61 , A61K47/554
摘要： The present invention relates to growth hormone conjugates comprising a bile acid residue, said conjugation may occur through wt or mutant amino acid residues. The growth hormone polypeptide may be wt human growth hormone or a growth hormone variant.
摘要翻译：本发明涉及包含胆汁酸残基的生长激素缀合物，所述缀合可以通过wt或突变体氨基酸残基进行。生长激素多肽可以是人生长激素或生长激素变体。

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