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1. 发明申请

WO1994027998A1 PSORALEN* DERIVATIVES, THEIR PREPARATION AND USE 审中-公开
标题翻译： PSORALEN3 *衍生物，其制备和使用
公开(公告)号：WO1994027998A1
公开(公告)日：1994-12-08
申请号：PCT/DK1994000200
申请日：1994-05-25
申请人： NOVO NORDISK A/S , HANSEN, John, Bondo , GRONVALD, Frederik, Christian
发明人： NOVO NORDISK A/S
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： A compound of general formula (I) wherein A is hydrocarbon containing 2-6 C-atoms; R is (a) wherein R , R , R , R and R are H, halogen, alkyl, cycloalkyl, cyano, nitro or perhalomethyl; or R is (b) wherein R , R , R and R are H, halogen, alkyl, cycloalkyl, cyano, nitro or perhalomethyl; or R represents phenyl optionally substituted, or R is naphtyl, azanaphtyl or diazanaphthyl either of which may be substituted; B is O, S or NH; W is N or CH; X is CH or N; R is a sporalen3* or pharmaceutically acceptable salts thereof are useful in the treatment of indications related to the CNS-system, cardiovascular system or gastrointestinal disorders.
摘要翻译：通式（I）的化合物，其中A是含有2-6个C原子的烃; R 1是（a）其中R 3，R 4，R 5，R 6和R 7是H，卤素，烷基，环烷基，氰基，硝基或全卤代甲基; 或R 1为（b）其中R 8，R 9，R 10和R 11为H，卤素，烷基，环烷基，氰基，硝基或全卤代甲基; 或R 1表示任选取代的苯基，或R 1是可被取代的萘基，氮杂萘基或二氮萘基; B是O，S或NH; W是N或CH; X是CH或N; R 2是sporalen3 *或其药学上可接受的盐可用于治疗与CNS系统，心血管系统或胃肠道疾病有关的适应症。

2. 发明申请

WO1997000871A1 TETRAHYDRO-BETACARBOLINE DERIVATIVES AND THEIR PREPARATION AND USE 审中-公开
标题翻译：四氢吡喃衍生物及其制备和使用
公开(公告)号：WO1997000871A1
公开(公告)日：1997-01-09
申请号：PCT/DK1996000258
申请日：1996-06-14
申请人： NOVO NORDISK A/S , HANSEN, John, Bondo
发明人： NOVO NORDISK A/S
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Tetrahydro-betacarboline derivatives of formula (I), wherein R and R independently are hydrogen, alkyl, cycloalkyl, alkoxy, aralkyl, halogen, halogenalkyl, nitro, alkylthio; R , R and R independently are hydrogen, alkyl, alkenyl, or cycloalkyl; and R is (a), wherein A-B-C together with the benzene ring forms a five-membered heterocyclic ring comprising one or more N-, O- or S- atoms, and optionally substituted; and R and R independently are hydrogen, halogen, alkyl, alkenyl, nitro, CN, halogenalkyl or cycloalkyl, are useful in the treatment of disorders influenced by dysfunctions of the 5-HT2C receptors.
摘要翻译：式（I）的四氢 - betacarolineoline衍生物，其中R 1和R 2独立地是氢，烷基，环烷基，烷氧基，芳烷基，卤素，卤代烷基，硝基，烷硫基; R 3，R 5和R 6独立地是氢，烷基，链烯基或环烷基; 和R 4为（a），其中A-B-C与苯环一起形成包含一个或多个N，O-或S-原子并任选取代的五元杂环; R 7和R 8独立地为氢，卤素，烷基，烯基，硝基，CN，卤代烷基或环烷基，可用于治疗受5-HT 2C受体功能障碍影响的疾病。

3. 发明申请

WO1994027992A1 PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE 审中-公开
标题翻译：哌啶衍生物，其制备和使用
公开(公告)号：WO1994027992A1
公开(公告)日：1994-12-08
申请号：PCT/DK1994000199
申请日：1994-05-25
申请人： NOVO NORDISK A/S , HANSEN, John, Bondo , GRONVALD, Frederik, Christian , MOGENSEN, John, Patrick
发明人： NOVO NORDISK A/S
IPC分类号： C07D405/14
CPC分类号： C07D405/14 , C07D413/12 , C07D413/14
摘要： Piperidine derivatives of formula (I) wherein n and m independently are 0, 1, 2, or 3; A is cycloalkylene or cycloalkylidenes; X is O or NH; Y is O, S, NH, NCN, or N-lower alkyl; R is 1,2-benzisoxazol-3-yl, 1H-indazol-3-yl, or 1-methyl-1H-indazol-3-yl, all of which may be substituted; R is H or alkyl; and R is phenyl optionally substituted, or R is (a) wherein Z together with the double bond in the phenyl ring represents a 5- or 6-membered heterocyclic ring; or R and R together with the nitrogen atom form a fused heterocyclic ring system; or pharmaceutically acceptable salts thereof are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders.
摘要翻译：其中n和m独立地是0,1,2或3的式（I）的哌啶衍生物; A是亚环烷基或环亚烷基; X是O或NH; Y是O，S，NH，NCN或N-低级烷基; R 1是1,2-苯并异恶唑-3-基，1H-吲唑-3-基或1-甲基-1H-吲唑-3-基，它们都可以被取代; R 2是H或烷基; R 3是任选取代的苯基，或R 3是（a）其中Z与苯环中的双键一起代表5-或6-元杂环; 或R 2和R 3与氮原子一起形成稠合杂环体系; 或其药学上可接受的盐可用于治疗与CNS系统，心血管系统或胃肠道疾病有关的适应症。

4. 发明申请

WO1997011072A1 NOVEL SUBSTITUTED AZACYCLIC OR AZABICYCLIC COMPOUNDS 审中-公开
标题翻译：新的取代的季铵化合物或偶氮化合物
公开(公告)号：WO1997011072A1
公开(公告)日：1997-03-27
申请号：PCT/DK1996000401
申请日：1996-09-20
申请人： NOVO NORDISK A/S , OLESEN, Preben, Houlberg , HANSEN, John, Bondo , HANSEN, Holger, C.
发明人： NOVO NORDISK A/S
IPC分类号： C07D453/02
CPC分类号： C07D401/06 , C07D453/02 , C07D487/08
摘要： The present invention relates to therapeutically active heterocyclic compounds, to methods for their preparation and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system related to malfunctioning of the nicotinic cholinergic system.
摘要翻译：本发明涉及治疗活性杂环化合物，其制备方法和包含该化合物的药物组合物。该新化合物可用于治疗与烟碱性胆碱能系统功能异常有关的中枢神经系统疾病。

5. 发明申请

WO1997001558A1 NOVEL SUBSTITUTED AZABICYCLIC COMPOUNDS 审中-公开
标题翻译：新型替代化合物
公开(公告)号：WO1997001558A1
公开(公告)日：1997-01-16
申请号：PCT/DK1996000294
申请日：1996-06-28
申请人： NOVO NORDISK A/S , OLESEN, Preben, H. , HANSEN, John, Bondo
发明人： NOVO NORDISK A/S
IPC分类号： C07D453/02
CPC分类号： C07D487/08 , C07D453/02
摘要： A compound of formula (I), wherein p is 1 and m is 0 and n is 1 or 2, or p is 1 and m is 1 and n is 1, or p is 2 and m is 0 and n is 1; and wherein Y is formula (a). The present invention relates to therapeutically active heterocyclic compounds (I), to methods for their preparation and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system related to malfunctioning of the nicotinic cholinergic system.
摘要翻译：式（I）化合物，其中p为1且m为0，n为1或2，或p为1，m为1，n为1，p为2，m为0，n为1; 并且其中Y为式（a）。本发明涉及治疗活性杂环化合物（I），其制备方法和包含该化合物的药物组合物。该新化合物可用于治疗与烟碱性胆碱能系统功能异常有关的中枢神经系统疾病。

6. 发明申请

WO1996036636A1 PROCESS FOR PREPARING 4-ARYL-PIPERIDINE DERIVATIVES 审中-公开
标题翻译：制备4-芳基哌啶衍生物的方法
公开(公告)号：WO1996036636A1
公开(公告)日：1996-11-21
申请号：PCT/DK1996000185
申请日：1996-04-25
申请人： NOVO NORDISK A/S , HANSEN, John, Bondo , TREPPENDAHL, Svend , ENGELSTOFT, Mogens , BENTZEN, Bjorn , LEHMANN, Soren
发明人： NOVO NORDISK A/S
IPC分类号： C07D405/12
CPC分类号： C07D405/12
摘要： A process for the preparation of a compound of formula (VIII), wherein R is C2-5-alkyl, phenyl-C1-5-alkyl, or substituted phenyl-C1-5-alkyl.
摘要翻译：制备式（VIII）化合物的方法，其中R 1是C 2-5 - 烷基，苯基-C1-5-烷基或取代的苯基-C1-5-烷基。

7. 发明申请

WO1994027996A1 1,2,5-THIADIAZOLE DERIVATIVES, THEIR PREPARATION AND USE 审中-公开
标题翻译： 1,2,5-噻二唑衍生物，其制备和用途
公开(公告)号：WO1994027996A1
公开(公告)日：1994-12-08
申请号：PCT/DK1994000198
申请日：1994-05-25
申请人： NOVO NORDISK A/S , HANSEN, John, Bondo , GRONVALD, Frederik, Christian
发明人： NOVO NORDISK A/S
IPC分类号： C07D417/14
CPC分类号： C07D417/12 , C07D417/14
摘要： 1,2,5-thiadiazole derivatives of formula (I) wherein A is a straight or branched, saturated acyclic hydrocarbon of 2-6 carbon atoms; Y is CH or N; X is O, S, NH, NCH3, or CH2; R is 1,2-benzisothiazol-3-yl, 1,2-benzisoxazol-3-yl, 1H-indazol-3-yl, or 1-methyl-1H-indazol-3-yl, all of which may be substituted; or R is 4-fluorobenzoyl or phenyl optionally substituted; R is optionally substituted aryl or heteroaryl; and pharmaceutically acceptable salts thereof are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders.
摘要翻译：式（I）的1,2,5-噻二唑衍生物，其中A是2-6个碳原子的直链或支链饱和无环烃; Y是CH或N; X是O，S，NH，NCH 3或CH 2; R 1是1,2-苯并异噻唑-3-基，1,2-苯并异恶唑-3-基，1H-吲唑-3-基或1-甲基-1H-吲唑-3-基，所有这些可以被替代或R 1为4-氟苯甲酰基或任选取代的苯基; R 2是任选取代的芳基或杂芳基; 和其药学上可接受的盐可用于治疗与CNS系统，心血管系统或胃肠道疾病有关的适应症。

8. 发明授权

EP0687319B1 A PROCESS FOR PROVIDING LOCALIZED VARIATION IN THE COLOUR DENSITY OF FABRICS 失效
标题翻译：方法用于织物色彩饱和度提供本地变异
公开(公告)号：EP0687319B1
公开(公告)日：1998-06-10
申请号：EP94908295.2
申请日：1994-02-25
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S
IPC分类号： D06P5/00 , C12N9/42
CPC分类号： D06P1/5257 , D06P1/525 , D06P1/647 , D06P5/158
摘要： Process for providing improved localised variation in the colour density of the surface of dyed fabrics, the process comprising treating a dyed fabric with a cellulytic enzyme in an aqueous liquor comprising a di- or trivalent cation and a chelating agent in a molar ratio of 1:0.1-50.

9. 发明公开

EP0687319A1 A PROCESS FOR PROVIDING LOCALIZED VARIATION IN THE COLOUR DENSITY OF FABRICS 失效
标题翻译：方法用于织物色彩饱和度提供本地变异
公开(公告)号：EP0687319A1
公开(公告)日：1995-12-20
申请号：EP94908295.0
申请日：1994-02-25
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S
IPC分类号： C12N9 , D06M16 , D06P1 , D06P5 , C12R1
CPC分类号： D06P1/5257 , D06P1/525 , D06P1/647 , D06P5/158
摘要： Process for providing improved localised variation in the colour density of the surface of dyed fabrics, the process comprising treating a dyed fabric with a cellulytic enzyme in an aqueous liquor comprising a di- or trivalent cation and a chelating agent in a molar ratio of 1:0.1-50.

10. 发明申请

WO1998028409A1 PHYTASE POLYPEPTIDES 审中-公开
公开(公告)号：WO1998028409A1
公开(公告)日：1998-07-02
申请号：PCT/DK1997000568
申请日：1997-12-15
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , LASSEN, Soren, Flensted , BECH, Lisbeth , OHMANN, Anders , BREINHOLT, Jens , FUGLSANG, Claus, Crone
IPC分类号： C12N09/16
CPC分类号： C12Y301/03026 , A23K20/189 , A23L5/25 , A23L29/06 , C12N9/16
摘要： The present invention relates to isolated polypeptides having phytase activity, the corresponding cloned DNA sequences, a process for preparing such polypeptides, and the use thereof for a number of industrial applications. In particular, the invention relates to phytases derived from the phyllum Basidiomycota, phytases of certain consensus sequences and fungal 6-phytases.
摘要翻译：本发明涉及具有植酸酶活性的分离的多肽，相应的克隆的DNA序列，制备该多肽的方法及其在许多工业应用中的应用。特别地，本发明涉及源自担子菌的植酸酶，某些共有序列的植酸酶和真菌6-肌醇六磷酸酶。

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