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71. 发明授权

US08835841B2 Mass spectrometer and mass spectrometry 有权
标题翻译：质谱仪和质谱仪
公开(公告)号：US08835841B2
公开(公告)日：2014-09-16
申请号：US13519587
申请日：2010-12-22
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Hiroyuki Satake
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Hiroyuki Satake
IPC分类号： H01J49/42
CPC分类号： H01J49/423
摘要： A mass spectrometer possessing both high resolution and durability in a simple, compact structure compared to mass spectrometers of the related art, and characterized in possessing a linear ion trap unit containing a multipolar rod electrode including rod electrodes having fine orifices to allow passage of electrons or ions; a mechanism to move the ions inside the linear ion trap unit along the axis of the multipolar rod electrode; and a detector to selectively detect by mass, ions ejected from the linear ion trap unit.
摘要翻译：质谱仪与现有技术的质谱仪相比在简单，紧凑的结构中具有高分辨率和耐久性，并且其特征在于具有线性离子阱单元，其包含多极杆电极，其包括具有细孔以允许电子通过的棒状电极或离子沿着多极棒电极的轴线移动线性离子阱单元内的离子的机构; 以及用于选择性地检测从线性离子阱单元喷出的离子的检测器。

72. 发明申请

US20120082697A1 METHOD FOR PROPHYLAXIS OF INFLUENZA USING VACCINE FOR INTRANASAL ADMINISTRATION 有权
标题翻译：使用疫苗预防流感病毒进行肠内营养的方法
公开(公告)号：US20120082697A1
公开(公告)日：2012-04-05
申请号：US13262515
申请日：2010-03-31
申请人： Hideki Hasegawa , Sadao Manabe , Takeshi Tanimoto , Takashi Miyazaki , Taizou Kamishita
发明人： Hideki Hasegawa , Sadao Manabe , Takeshi Tanimoto , Takashi Miyazaki , Taizou Kamishita
IPC分类号： A61K39/145 , A61P31/16 , A61P37/04
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/525 , A61K2039/5254 , A61K2039/543 , A61K2039/55555 , A61K2039/55561 , A61K2039/58 , A61K2039/6093 , C12N2760/16134
摘要： The present invention provides a vaccine composition for transnasal mucous membrane administration, which contains an influenza virus antigen, polyriboinosinic polyribocytidylic acid (poly (I:C)) or a derivative thereof and a carboxyvinyl polymer. The present invention also provides a prophylactic method of influenza, including a step of administering the vaccine composition at least once to the nasal mucosa of a subject in need thereof.
摘要翻译：本发明提供一种用于经鼻粘膜给药的疫苗组合物，其包含流感病毒抗原，多核糖肌苷酸多核糖胞苷酸（聚（I：C））或其衍生物和羧乙烯基聚合物。本发明还提供了一种流感的预防方法，包括将疫苗组合物至少一次施用于有需要的受试者的鼻粘膜的步骤。

73. 发明申请

US20120000284A1 HUMIDITY SENSOR PACKAGE AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：湿度传感器封装及其制造方法
公开(公告)号：US20120000284A1
公开(公告)日：2012-01-05
申请号：US13169918
申请日：2011-06-27
申请人： Shinya Yokoyama , Satoshi Waga , Atsushi Tondokoro , Tadashi Sakashita , Hideki Hasegawa , Sumihito Morita , Hideki Kamimura , Masaya Yamatani
发明人： Shinya Yokoyama , Satoshi Waga , Atsushi Tondokoro , Tadashi Sakashita , Hideki Hasegawa , Sumihito Morita , Hideki Kamimura , Masaya Yamatani
IPC分类号： G01N27/22 , B23P25/00
CPC分类号： G01D11/245 , G01N33/0014 , Y10T29/4998
摘要： A humidity sensor package includes: a humidity sensor that is mounted on a main surface of a package substrate and that have a humidity-sensing area; a control IC that is mounted on the main surface of the package substrate; a sealing resin that seals at least an external connection portion of the humidity sensor; and a partition member that partitions a sealing area of the sealing resin and the humidity-sensing area from each other so as to expose the humidity-sensing area to an external environment. Here, a first distance in the thickness direction from the package substrate to the top surface of the partition member is smaller than a second distance in the thickness direction from the package substrate to the top surface of the sealing resin.
摘要翻译：一种湿度传感器包括：湿度传感器，其安装在封装基板的主表面上并具有湿度感测区域; 控制IC，其安装在所述封装基板的主表面上; 至少密封湿度传感器的外部连接部分的密封树脂; 以及分隔构件，其将密封树脂的密封区域和湿度感测区域彼此分隔开，以将湿度感测区域暴露于外部环境。这里，从封装基板到分隔部件的顶面的厚度方向的第一距离小于从封装基板到密封树脂的顶面的厚度方向的第二距离。

74. 发明申请

US20110248157A1 MASS SPECTROMETER AND MASS SPECTROMETRY METHOD 审中-公开
标题翻译：质谱仪和质谱方法
公开(公告)号：US20110248157A1
公开(公告)日：2011-10-13
申请号：US13123901
申请日：2009-10-13
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hiroyuki Yasuda , Shinji Nagai , Shintaro Kubo , Takefumi Yokokura
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hiroyuki Yasuda , Shinji Nagai , Shintaro Kubo , Takefumi Yokokura
IPC分类号： H01J49/42
CPC分类号： H01J49/063 , H01J49/4215
摘要： Objects of the present invention is to provide a quadrupole mass filter that can be fabricated at low cost and has a high transmission efficiency even under a high pressure (0.5 mTorr or more), and to provide a mass spectrometer or mass spectrometry method that reduces crosstalk in a wide mass range. Now, in a mass spectrometer, an ion separating unit is configured to include quadrupole rod electrodes that form a quadrupole radio-frequency electric field, electrodes that form a quadrupole electrostatic field, and a power supply that allows the voltage of the electrodes to form a quadrupole electrostatic field to change. In a collision cell configured to perform collision induced dissociation, harmonic potentials in a plurality of stages are produced to resonance excite ions in the axial direction, so that the ions obtain kinetic energy to move in the direction of the detector. This energy allows a time period to shorten for which ions stay in the collision cell.
摘要翻译：本发明的目的是提供一种即使在高压（0.5mTorr以上）下也能低成本制造且具有高透射率的四极质量过滤器，并提供降低串扰的质谱仪或质谱法在广泛的质量范围。现在，在质谱仪中，离子分离单元被构造为包括形成四极射频电场的四极杆电极，形成四极静电场的电极和允许电极的电压形成的电源四极静电场改变。在被配置为执行碰撞诱导解离的碰撞单元中，产生多个级中的谐波电位以使轴向上的激发离子共振，使得离子获得沿检测器的方向移动的动能。该能量允许缩短时间段，离子停留在碰撞池中。

75. 发明申请

US20110133075A1 MASS SPECTROMETER 有权
标题翻译：质谱仪
公开(公告)号：US20110133075A1
公开(公告)日：2011-06-09
申请号：US13058054
申请日：2009-08-25
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama
IPC分类号： H01J49/26 , H01J49/34 , H01J49/28 , H01J49/10 , B01D59/46
CPC分类号： H01J49/4225
摘要： The mass spectrometer is characterized in that a linear ion trap, that consists of electrodes for mass-selective discharge, is provided with a mechanism that excites ions in a first direction that is perpendicular to the rod axes and a mechanism that simultaneously generates an electric field on the axes in a second direction that is perpendicular to the axial direction and the first direction in order to generate an electric field on the central axis. Highly efficient, high-speed scanning can be achieved using this configuration.
摘要翻译：质谱仪的特征在于，由用于质量选择性放电的电极组成的线性离子阱设置有在垂直于杆轴的第一方向上激发离子的机构和同时产生电场的机构在垂直于轴向方向和第一方向的第二方向上的轴上，以便在中心轴线上产生电场。使用此配置可以实现高效，高速扫描。

76. 发明授权

US07956322B2 Mass spectrometer and mass spectrometric analysis method 有权
标题翻译：质谱仪和质谱分析方法
公开(公告)号：US07956322B2
公开(公告)日：2011-06-07
申请号：US12354245
申请日：2009-01-15
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0045
摘要： An MS/MS spectrometric analysis method obtains throughput and mass resolving power of precursor ions. In a mass spectrometer, ions, which are introduced and accumulated in an ion trap unit, are resonance-extracted mass-selectively. A profile of precursor ions at the m/z axis of the ion trap and a profile at the mass analyzer portion, which performs mass analysis of the ions extracted from a collision induced dissociation portion, is obtained by performing a measurement when the injection energy to the collision induced dissociation portion is low, and when the injection energy to the collision induced dissociation portion is high. The profile at the m/z axis of the ion trap of the obtained two-dimensional spectrum is substituted with the profile at the m/z axis of the mass analyzer portion. In this way, the m/z of both the precursor ions and the fragment ions can be determined with high mass resolving power.
摘要翻译： MS / MS光谱分析方法获得前体离子的通量和质量分辨能力。在质谱仪中，离子阱单元中引入和积聚的离子是质量选择性共振提取的。在离子阱的m / z轴处的前体离子的轮廓和质量分析器部分的轮廓，其进行从碰撞诱导的解离部分提取的离子的质量分析，通过在将注入能量碰撞诱导的解离部分低，并且当碰撞诱导解离部分的注入能量高时。所获得的二维光谱的离子阱的m / z轴的轮廓被质量分析器部的m / z轴的轮廓所取代。以这种方式，可以以高质量分辨能力确定前体离子和碎片离子两者的m / z。

77. 发明授权

US07829846B2 Analytical system and method utilizing the dependence of signal intensity on matrix component concentration 有权
标题翻译：利用信号强度对基质成分浓度的依赖性的分析系统和方法
公开(公告)号：US07829846B2
公开(公告)日：2010-11-09
申请号：US12037148
申请日：2008-02-26
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
IPC分类号： H01J49/40 , G06F19/00 , G01N31/00
CPC分类号： H01J49/0036
摘要： The present invention achieves accurate quantitative determination without reducing measurement throughput and also without having to add a multi-component reference standard. An analytical instrument of the present invention for determining the concentration of a target compound contained in a target sample includes: a means for ionizing a mixture having a specific compound added to the target sample; a means for performing mass analysis on resulting ions; and a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, wherein the database is used to calibrate the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means. The present invention achieves a multi-component analyzer using low-cost, high-throughput mass analysis, as compared to conventional technique.
摘要翻译：本发明可以在不降低测量吞吐量的情况下实现准确的定量测定，而且不必添加多组分参考标准。本发明的用于测定目标样品中包含的目标化合物的浓度的分析仪包括：将具有特定化合物的混合物电离于目标样品的装置; 对所得离子进行质量分析的手段; 以及数据库，其存储信号强度对于每种目标化合物和加成化合物的特定基质成分的浓度的依赖性，其中所述数据库用于从源自目标化合物的信号校准目标化合物的浓度，以及来自加成化合物的信号，通过质量分析装置得到的各信号。与现有技术相比，本发明实现了使用低成本，高吞吐量质量分析的多分量分析仪。

78. 发明授权

US07589321B2 Reaction cell and mass spectrometer 有权
标题翻译：反应池和质谱仪
公开(公告)号：US07589321B2
公开(公告)日：2009-09-15
申请号：US11671562
申请日：2007-02-06
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： H01J49/42
CPC分类号： H01J49/4295 , H01J49/005 , H01J49/0054
摘要： An ion trap in which highly accurate isolation, ECD, and CID can be efficiently performed. A reaction cell and a mass spectrometer of the present invention include an ion-trap which has a plurality of rod electrodes and creates a multipole field, a means for generating a magnetic field in the axial direction of the ion-trap, a means for creating a DC harmonic potential in the axial direction of the ion-trap, and an electron source for introducing electrons into the central axis of the ion-trap. The identification ability is greatly improved compared with the prior art.
摘要翻译：可以有效地执行高精度隔离，ECD和CID的离子阱。本发明的反应池和质谱仪包括具有多个棒电极并产生多极场的离子阱，用于在离子阱的轴向产生磁场的装置，用于产生在离子阱的轴向上的DC谐波电位和用于将电子引入离子阱的中心轴的电子源。与现有技术相比，识别能力大大提高。

79. 发明授权

US07569814B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07569814B2
公开(公告)日：2009-08-04
申请号：US12010977
申请日：2008-01-31
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Hiroyuki Satake , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Hiroyuki Satake , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/4265
摘要： A mass spectrometer includes: an ion source for ionizing a specimen to generate ions, an ion transport portion for transporting the ions, a linear ion trap portion for accumulating the transported ions by a potential formed axially, and a control portion of ejecting the ions within a second m/z range different from a first m/z range, from the linear ion trap portion, and substantially at the same timing as the timing of accumulating the ions within the first m/z range from the transport portion into the linear ion trap portion. The ion transportation portion having a mass selection means for selecting the ions in the first m/z range.
摘要翻译：质谱仪包括：离子源，用于离子化样品以产生离子;离子传输部分，用于输送离子;线性离子捕获部分，用于通过轴向形成的电位积聚所运送的离子;以及控制部分，与线性离子阱部分不同于第一m / z范围的第二m / z范围，并且基本上与从运输部分到线性离子的离子在第一m / z范围内的积累时间基本相同的时刻陷阱部分。该离子传送部分具有用于选择第一m / z范围内的离子的质量选择装置。

80. 发明授权

US07378650B2 Ion-mobility spectrometer and ion-mobility analysis method 有权
标题翻译：离子迁移谱仪和离子迁移率分析方法
公开(公告)号：US07378650B2
公开(公告)日：2008-05-27
申请号：US11882419
申请日：2007-08-01
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/40 , B01D59/44
CPC分类号： G01N27/622
摘要： There is provided an ion-mobility spectrometer. This apparatus includes the following configuration components: An ion source for generating first ions, a first drift unit for separating the first ions by flight drift times, an ion dissociation unit for generating second ions by dissociating the first ions separated, and a second drift unit for separating the second ions by flight drift times. Moreover, the first drift unit, the ion dissociation unit, and the second drift unit are located inside a chamber whose pressure is set at 10 mTorr or higher. This apparatus allows execution of low-cost and high-resolving-power ion separation and detection.
摘要翻译：提供了离子迁移谱仪。该装置包括以下配置组件：用于产生第一离子的离子源，用于通过飞行漂移时间分离第一离子的第一漂移单元，用于通过解离分离的第一离子产生第二离子的离子解离单元和第二漂移单元用于通过飞行漂移时间分离第二离子。此外，第一漂移单元，离子解离单元和第二漂移单元位于压力设定在10mTorr以上的室内。该装置允许执行低成本和高分辨率的离子分离和检测。

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