专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08164053B2 Mass analyzer and mass analyzing method 有权
标题翻译：质量分析仪和质量分析方法
公开(公告)号：US08164053B2
公开(公告)日：2012-04-24
申请号：US12039306
申请日：2008-02-28
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
IPC分类号： B01D59/44
CPC分类号： H01J49/0045
摘要： There has been a problem that both detection sensitivity and throughput cannot be improved simultaneously by a conventional MS/MS analysis method.A mass analyzer having an ion trap for ejecting ions in a specific mass range, a collisional dissociation part for causing ions ejected from the ion trap to be dissociated, a mass analyzing part for performing a mass analysis of ions ejected from the collisional dissociation part, and a control part including a list in which measurement conditions for each ion are stored selectively resonance-ejects ions introduced into and accumulated in the ion trap based on masses. A scanning operation is a repetition of an operation of ejecting specific precursor ions in a direction of the collisional dissociation part and an operation of ejecting nothing, and each ion can be measured under optimal measurement conditions by controlling an output voltage of each part with reference to list information, realizing a mass analyzer that can perform an MS/MS measurement with high throughput and high sensitivity.
摘要翻译：存在通过常规MS / MS分析方法不能同时改善检测灵敏度和通过量的问题。 1.一种质量分析装置，具有用于将特定质量范围的离子排出的离子阱，用于使从离子阱排出的离子离解的碰撞解离部，用于进行从碰撞解离部喷出的离子的质量分析的质量分析部，以及包括其中存储每个离子的测量条件的列表的控制部分选择性地基于质量共振 - 喷射引入和积聚在离子阱中的离子。扫描操作是重复在碰撞解离部分的方向上排出特定的前体离子的操作和不喷射的操作，并且可以在最佳测量条件下测量每个离子，通过参考每个部分的输出电压列表信息，实现能够以高吞吐量和高灵敏度执行MS / MS测量的质量分析器。

2. 发明授权

US07718960B2 Ion mobility spectrometer and ion-mobility-spectrometry/mass-spectrometry hybrid spectrometer 有权
标题翻译：离子迁移光谱仪和离子迁移光谱/质谱混合光谱仪
公开(公告)号：US07718960B2
公开(公告)日：2010-05-18
申请号：US12149737
申请日：2008-05-07
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
IPC分类号： H01J49/10 , H01J49/40
CPC分类号： G01N27/622
摘要： A low-cost and high-ion-transmission-ratio ion-mobility spectrometry filter, including an ion source, a first drift region in which a gas flow direction and a DC electric-field direction are opposite to each other, a second drift region in which a gas flow direction is provided, the gas flow direction being different from the gas flow direction in the first drift region, and being opposite to a DC electric-field application direction in the second drift region, an intermediate region having an electric field for causing ions to travel between the first drift region and the second drift region, and a detector for detecting ions which have passed through the first drift region and the second drift region.
摘要翻译：一种低成本和高离子透射率的离子迁移谱分析滤光器，包括离子源，气流方向和DC电场方向彼此相反的第一漂移区，第二漂移区其中设置有气体流动方向，气体流动方向与第一漂移区域中的气体流动方向不同，并且与第二漂移区域中的直流电场施加方向相反，具有电场的中间区域用于使离子在第一漂移区域和第二漂移区域之间行进;以及检测器，用于检测已经通过第一漂移区域和第二漂移区域的离子。

3. 发明申请

US20090065688A1 ANALYTICAL INSTRUMENT 有权
标题翻译：分析仪器
公开(公告)号：US20090065688A1
公开(公告)日：2009-03-12
申请号：US12037148
申请日：2008-02-26
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
IPC分类号： B01D59/44
CPC分类号： H01J49/0036
摘要： The present invention achieves accurate quantitative determination without reducing measurement throughput and also without having to add a multi-component reference standard. An analytical instrument of the present invention for determining the concentration of a target compound contained in a target sample includes: a means for ionizing a mixture having a specific compound added to the target sample; a means for performing mass analysis on resulting ions; and a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, wherein the database is used to calibrate the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means. The present invention achieves a multi-component analyzer using low-cost, high-throughput mass analysis, as compared to conventional technique.
摘要翻译：本发明可以在不降低测量吞吐量的情况下实现准确的定量测定，而且不必添加多组分参考标准。本发明的用于测定目标样品中包含的目标化合物浓度的分析仪包括：将具有特定化合物的混合物电离于目标样品的装置; 对所得离子进行质量分析的手段; 以及数据库，其存储信号强度对于每种目标化合物和加成化合物的特定基质成分的浓度的依赖性，其中所述数据库用于从源自目标化合物的信号校准目标化合物的浓度，以及来自加成化合物的信号，通过质量分析装置得到的各信号。与现有技术相比，本发明实现了使用低成本，高吞吐量质量分析的多分量分析仪。

4. 发明申请

US20090032697A1 MASS ANALYZER AND MASS ANALYZING METHOD 有权
标题翻译：质量分析仪和质量分析方法
公开(公告)号：US20090032697A1
公开(公告)日：2009-02-05
申请号：US12039306
申请日：2008-02-28
申请人： Masuyuki SUGIYAMA , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
发明人： Masuyuki SUGIYAMA , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
IPC分类号： B01D59/44
CPC分类号： H01J49/0045
摘要： There has been a problem that both detection sensitivity and throughput cannot be improved simultaneously by a conventional MS/MS analysis method.A mass analyzer having an ion trap for ejecting ions in a specific mass range, a collisional dissociation part for causing ions ejected from the ion trap to be dissociated, a mass analyzing part for performing a mass analysis of ions ejected from the collisional dissociation part, and a control part including a list in which measurement conditions for each ion are stored selectively resonance-ejects ions introduced into and accumulated in the ion trap based on masses. A scanning operation is a repetition of an operation of ejecting specific precursor ions in a direction of the collisional dissociation part and an operation of ejecting nothing, and each ion can be measured under optimal measurement conditions by controlling an output voltage of each part with reference to list information, realizing a mass analyzer that can perform an MS/MS measurement with high throughput and high sensitivity.
摘要翻译：存在通过常规MS / MS分析方法不能同时改善检测灵敏度和通过量的问题。 1.一种质量分析装置，具有用于在特定质量范围内排出离子的离子阱，用于使从离子阱排出的离子离解的碰撞解离部，对从碰撞解离部喷出的离子进行质量分析的质量分析部，以及包括其中存储每个离子的测量条件的列表的控制部分选择性地基于质量共振 - 喷射引入和积聚在离子阱中的离子。扫描操作是重复在碰撞解离部分的方向上排出特定的前体离子的操作和不喷射的操作，并且可以在最佳测量条件下测量每个离子，通过参考每个部分的输出电压列表信息，实现能够以高吞吐量和高灵敏度执行MS / MS测量的质量分析器。

5. 发明申请

US20120112059A1 MASS SPECTROMETER AND MASS SPECTROMETRY METHOD 有权
标题翻译：质谱仪和质谱方法
公开(公告)号：US20120112059A1
公开(公告)日：2012-05-10
申请号：US13383371
申请日：2010-07-09
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hisashi Nagano , Hideki Hasegawa , Yasuaki Takada , Masuyoshi Yamada
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hisashi Nagano , Hideki Hasegawa , Yasuaki Takada , Masuyoshi Yamada
IPC分类号： H01J49/26
CPC分类号： H01J49/004
摘要： An object is to measure both cations and anions with high duty cycle. In a mass spectrometer comprising an ion source (1), an ion guide part (31), and an ion trap (32), while ions are being mass-selectively ejected from the ion trap, ions having a polarity reverse to that of the ions trapped in the ion trap are introduced into the ion guide part.
摘要翻译：一个目标是测量阳离子和阴离子高占空比。在离子源（1），离子引导部（31）和离子阱（32）的质谱仪中，离子从离子阱中质量选择性地喷出时，具有与捕获在离子阱中的离子被引入离子引导部。

6. 发明申请

US20090179149A1 MASS SPECTROMETER AND MASS SPECTROMETRIC ANALYSIS METHOD 有权
标题翻译：质谱仪和质谱分析方法
公开(公告)号：US20090179149A1
公开(公告)日：2009-07-16
申请号：US12354245
申请日：2009-01-15
申请人： Masuyuki SUGIYAMA , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
发明人： Masuyuki SUGIYAMA , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
IPC分类号： B01D59/44 , H01J49/26
CPC分类号： H01J49/0045
摘要： An MS/MS spectrometric analysis method obtains throughput and mass resolving power of precursor ions. In a mass spectrometer, ions, which are introduced and accumulated in an ion trap unit, are resonance-extracted mass-selectively. A profile of precursor ions at the m/z axis of the ion trap and a profile at the mass analyzer portion, which performs mass analysis of the ions extracted from a collision induced dissociation portion, is obtained by performing a measurement when the injection energy to the collision induced dissociation portion is low, and when the injection energy to the collision induced dissociation portion is high. The profile at the m/z axis of the ion trap of the obtained two-dimensional spectrum is substituted with the profile at the m/z axis of the mass analyzer portion. In this way, the m/z of both the precursor ions and the fragment ions can be determined with high mass resolving power.
摘要翻译： MS / MS光谱分析方法获得前体离子的通量和质量分辨能力。在质谱仪中，离子阱单元中引入和积聚的离子是质量选择性共振提取的。在离子阱的m / z轴处的前体离子的轮廓和质量分析器部分的轮廓，其进行从碰撞诱导的解离部分提取的离子的质量分析，通过在将注入能量碰撞诱导的解离部分低，并且当碰撞诱导解离部分的注入能量高时。所获得的二维光谱的离子阱的m / z轴的轮廓被质量分析器部的m / z轴的轮廓所取代。以这种方式，可以以高质量分辨能力确定前体离子和碎片离子两者的m / z。

7. 发明申请

US20080277575A1 Ion mobility spectrometer and ion-mobility-spectrometry/mass-spectrometry hybrid spectrometer 有权
标题翻译：离子迁移光谱仪和离子迁移光谱/质谱混合光谱仪
公开(公告)号：US20080277575A1
公开(公告)日：2008-11-13
申请号：US12149737
申请日：2008-05-07
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
IPC分类号： H01J49/10
CPC分类号： G01N27/622
摘要： A low-cost and high-ion-transmission-ratio ion-mobility spectrometry filter, including an ion source, a first drift region in which a gas flow direction and a DC electric-field direction are opposite to each other, a second drift region in which a gas flow direction is provided, the gas flow direction being different from the gas flow direction in the first drift region, and being opposite to a DC electric-field application direction in the second drift region, an intermediate region having an electric field for causing ions to travel between the first drift region and the second drift region, and a detector for detecting ions which have passed through the first drift region and the second drift region.
摘要翻译：一种低成本和高离子透射比的离子迁移谱分析滤光器，包括离子源，气流方向和DC电场方向彼此相反的第一漂移区，第二漂移区其中设置有气体流动方向，气体流动方向与第一漂移区域中的气体流动方向不同，并且与第二漂移区域中的DC电场施加方向相反，具有电场的中间区域用于使离子在第一漂移区域和第二漂移区域之间行进;以及检测器，用于检测已经通过第一漂移区域和第二漂移区域的离子。

8. 发明授权

US08835834B2 Mass spectrometer and mass spectrometry method 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US08835834B2
公开(公告)日：2014-09-16
申请号：US13383371
申请日：2010-07-09
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hisashi Nagano , Hideki Hasegawa , Yasuaki Takada , Masuyoshi Yamada
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hisashi Nagano , Hideki Hasegawa , Yasuaki Takada , Masuyoshi Yamada
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/004
摘要： An object is to measure both cations and anions with high duty cycle. In a mass spectrometer comprising an ion source (1), an ion guide part (31), and an ion trap (32), while ions are being mass-selectively ejected from the ion trap, ions having a polarity reverse to that of the ions trapped in the ion trap are introduced into the ion guide part.
摘要翻译：一个目标是测量阳离子和阴离子高占空比。在离子源（1），离子引导部（31）和离子阱（32）的质谱仪中，离子从离子阱中质量选择性地喷出时，具有与捕获在离子阱中的离子被引入离子引导部。

9. 发明授权

US07956322B2 Mass spectrometer and mass spectrometric analysis method 有权
标题翻译：质谱仪和质谱分析方法
公开(公告)号：US07956322B2
公开(公告)日：2011-06-07
申请号：US12354245
申请日：2009-01-15
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0045
摘要： An MS/MS spectrometric analysis method obtains throughput and mass resolving power of precursor ions. In a mass spectrometer, ions, which are introduced and accumulated in an ion trap unit, are resonance-extracted mass-selectively. A profile of precursor ions at the m/z axis of the ion trap and a profile at the mass analyzer portion, which performs mass analysis of the ions extracted from a collision induced dissociation portion, is obtained by performing a measurement when the injection energy to the collision induced dissociation portion is low, and when the injection energy to the collision induced dissociation portion is high. The profile at the m/z axis of the ion trap of the obtained two-dimensional spectrum is substituted with the profile at the m/z axis of the mass analyzer portion. In this way, the m/z of both the precursor ions and the fragment ions can be determined with high mass resolving power.
摘要翻译： MS / MS光谱分析方法获得前体离子的通量和质量分辨能力。在质谱仪中，离子阱单元中引入和积聚的离子是质量选择性共振提取的。在离子阱的m / z轴处的前体离子的轮廓和质量分析器部分的轮廓，其进行从碰撞诱导的解离部分提取的离子的质量分析，通过在将注入能量碰撞诱导的解离部分低，并且当碰撞诱导解离部分的注入能量高时。所获得的二维光谱的离子阱的m / z轴的轮廓被质量分析器部的m / z轴的轮廓所取代。以这种方式，可以以高质量分辨能力确定前体离子和碎片离子两者的m / z。

10. 发明授权

US07829846B2 Analytical system and method utilizing the dependence of signal intensity on matrix component concentration 有权
标题翻译：利用信号强度对基质成分浓度的依赖性的分析系统和方法
公开(公告)号：US07829846B2
公开(公告)日：2010-11-09
申请号：US12037148
申请日：2008-02-26
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
IPC分类号： H01J49/40 , G06F19/00 , G01N31/00
CPC分类号： H01J49/0036
摘要： The present invention achieves accurate quantitative determination without reducing measurement throughput and also without having to add a multi-component reference standard. An analytical instrument of the present invention for determining the concentration of a target compound contained in a target sample includes: a means for ionizing a mixture having a specific compound added to the target sample; a means for performing mass analysis on resulting ions; and a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, wherein the database is used to calibrate the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means. The present invention achieves a multi-component analyzer using low-cost, high-throughput mass analysis, as compared to conventional technique.
摘要翻译：本发明可以在不降低测量吞吐量的情况下实现准确的定量测定，而且不必添加多组分参考标准。本发明的用于测定目标样品中包含的目标化合物的浓度的分析仪包括：将具有特定化合物的混合物电离于目标样品的装置; 对所得离子进行质量分析的手段; 以及数据库，其存储信号强度对于每种目标化合物和加成化合物的特定基质成分的浓度的依赖性，其中所述数据库用于从源自目标化合物的信号校准目标化合物的浓度，以及来自加成化合物的信号，通过质量分析装置得到的各信号。与现有技术相比，本发明实现了使用低成本，高吞吐量质量分析的多分量分析仪。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式