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71. 发明申请

US20120122869A1 TRIZAOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：调节HSP90活性的TRIZAOLE化合物
公开(公告)号：US20120122869A1
公开(公告)日：2012-05-17
申请号：US13350296
申请日：2012-01-13
申请人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
发明人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/5377 , A61K31/4196 , A61P35/00 , C07D403/00 , A61K31/4709 , C07D249/12 , C07D413/10
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

72. 发明授权

US08053456B2 Triazole compounds that modulate Hsp90 activity 有权
标题翻译：调节Hsp90活性的三唑化合物
公开(公告)号：US08053456B2
公开(公告)日：2011-11-08
申请号：US11807327
申请日：2007-05-25
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D249/12
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

73. 发明申请

US20110105749A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
公开(公告)号：US20110105749A1
公开(公告)日：2011-05-05
申请号：US12815322
申请日：2010-06-14
申请人： Weiwen YING , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen YING , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： C07D403/10 , C07D417/10 , C07D413/10 , C07D405/10 , C07D401/10 , C07D249/14 , C07D249/12 , C07D473/34 , C07D413/12 , C07F9/6518
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

74. 发明申请

US20110009397A1 TRIAZONE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
标题翻译：调节HSP90活性的TRIAZONE化合物
公开(公告)号：US20110009397A1
公开(公告)日：2011-01-13
申请号：US12604970
申请日：2009-10-23
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , A61K31/4709 , A61K31/4439 , A61K31/4725 , A61K31/5377 , A61K31/538 , C12N5/00
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

75. 发明授权

US07662813B2 Triazole compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US07662813B2
公开(公告)日：2010-02-16
申请号：US11506185
申请日：2006-08-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard P Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
IPC分类号： A61K31/4196 , A61K31/4025 , A61K31/4523 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D249/08 , C07D207/04 , C07D401/02 , C07D403/02 , C07D413/02
CPC分类号： C07D249/08 , C07D403/10 , C07D403/12 , C07D413/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

76. 发明申请

US20080176840A1 Triazole compounds that modulate Hsp90 activity 有权
标题翻译：调节Hsp90活性的三唑化合物
公开(公告)号：US20080176840A1
公开(公告)日：2008-07-24
申请号：US11807327
申请日：2007-05-25
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , C07D401/14 , A61K31/4439 , C07D471/04 , A61K31/538 , A61K31/496 , A61P37/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61K31/5377 , C07D413/14 , A61K31/52 , A61K31/4709 , C07D403/02
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

77. 发明申请

US20080059214A1 Model-Based Policy Application 失效
标题翻译：基于模型的策略应用
公开(公告)号：US20080059214A1
公开(公告)日：2008-03-06
申请号：US11622978
申请日：2007-01-12
申请人： Anders Vinberg , Bruce Copeland , Robert Fries , Kevin Grealish , Jonathan Hardwick , Michael Healy , Galen Hunt , Aamer Hydrie , David James , Anand Lakshminarayanan , Edwin Lassettre , Raymond McCollum , Rob Mensching , Mazhar Mohammed , Rajagopalan Narayanan , Geoffrey Outhred , Zhengkai Pan , Efstathios Papaefstathiou , John Parchem , Vij Rajarajan , Ashvikumar Sanghvi , Bassam Tabbara , Rene Vega , Vitaly Voloshin , Robert Welland , John Wilson , Eric Winner , Jeffrey Woolsey
发明人： Anders Vinberg , Bruce Copeland , Robert Fries , Kevin Grealish , Jonathan Hardwick , Michael Healy , Galen Hunt , Aamer Hydrie , David James , Anand Lakshminarayanan , Edwin Lassettre , Raymond McCollum , Rob Mensching , Mazhar Mohammed , Rajagopalan Narayanan , Geoffrey Outhred , Zhengkai Pan , Efstathios Papaefstathiou , John Parchem , Vij Rajarajan , Ashvikumar Sanghvi , Bassam Tabbara , Rene Vega , Vitaly Voloshin , Robert Welland , John Wilson , Eric Winner , Jeffrey Woolsey
IPC分类号： G06Q10/00
CPC分类号： G06F21/6236 , G06F8/61 , G06F9/44505 , G06F2221/2101 , G06Q10/067
摘要： In accordance with certain aspects of the model-based policy application, each of a plurality of policies is associated with appropriate parts of a model of a heterogeneous system. A deployment agent is invoked to apply each of the plurality of policies to components associated with the parts of the model. An identification of a change to one of the plurality of policies is received, and the deployment agent is also invoked to apply the changed policy to selected ones of the components associated with the parts of the model.
摘要翻译：根据基于模型的策略应用的某些方面，多个策略中的每一个都与异构系统的模型的适当部分相关联。调用部署代理以将多个策略中的每一个应用于与模型的部分相关联的组件。接收到对多个策略中的一个策略的改变的标识，并且还调用部署代理以将改变的策略应用于与模型的部分相关联的选定的组件。

78. 发明申请

US20070213627A1 FETAL SURVEILLANCE 有权
标题翻译： FETAL监视
公开(公告)号：US20070213627A1
公开(公告)日：2007-09-13
申请号：US10595378
申请日：2004-10-13
申请人： David James , John Crowe , Barrie Hayes-Gill , Carl Barratt , Jean-Francois Pieri
发明人： David James , John Crowe , Barrie Hayes-Gill , Carl Barratt , Jean-Francois Pieri
IPC分类号： A61B5/0444
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/0444
摘要： Fetal behaviour is monitored by receiving ECG data from a set of electrodes attached to a materrial body. A waveform pre-processor identifies a succession of fetal ECG complex waveforms within the received data and a waveform processor determines differences in the processor succession of fetal ECG complex waveforms over time. An event logger determines from the determined differences a number of fetal movements during the period of time. Fetal spatial presentation and/or position within the uterus may also be determined from fetal ECG data acquired from a plurality of electrodes positioned on the maternal abdomen in a predetermined configuration. A number of fetal ECG complex waveforms are identified within the data, and each of the waveforms is compared with a set of predetermined fetal ECG complex templates ascribed to the predetermined electrode configuration to determine a template that best matches the identified fetal ECG waveforms.
摘要翻译：通过从连接到物质体的一组电极接收ECG数据来监测胎儿行为。波形预处理器识别接收到的数据中的一系列胎儿ECG复杂波形，并且波形处理器确定随着时间的推移，胎儿ECG复杂波形的处理器连续性的差异。事件记录器根据所确定的差异确定一段时间内的胎动。胎儿空间呈现和/或子宫内的位置也可以从以预定配置从位于母体腹部的多个电极获取的胎儿ECG数据确定。在数据内识别出许多胎儿ECG复杂波形，并且将每个波形与归因于预定电极配置的一组预定胎儿ECG复合模板进行比较，以确定与所识别的胎儿ECG波形最佳匹配的模板。

79. 发明申请

US20070195487A1 Energy storage device 有权
公开(公告)号：US20070195487A1
公开(公告)日：2007-08-23
申请号：US11790374
申请日：2007-04-25
申请人： David James , Stephen Wilson , Alina Sloan , Richard Stephens
发明人： David James , Stephen Wilson , Alina Sloan , Richard Stephens
IPC分类号： H01G9/00
CPC分类号： H01G9/155 , H01G2/06 , H01G9/016 , H01G9/10 , H01G11/52 , H01G11/74 , H01G11/82 , H01M2/0207 , H01M2/30 , H01M6/10 , H01M6/42 , H01M10/04 , H01M10/0436 , Y02E60/13 , Y10T29/41 , Y10T29/417
摘要： A surface mount energy storage device in the form of a supercapacitor (1) includes a generally rectangular folded prismatic housing (2) and two energy storage elements (not shown) that are sealingly contained within the housing (2) and which are connected in series. A mount, in the form of an integrally formed tinned metal frame (3), extends about and captively retains housing (2) in the folded configuration shown. Two terminals, in the form of elongate contacts (4, 5) extend from the energy storage elements and terminate outside housing (2) for allowing external electrical connection to the elements.

80. 发明申请

US20070155809A1 Triazole compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US20070155809A1
公开(公告)日：2007-07-05
申请号：US11506185
申请日：2006-08-17
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Elena Kostik , Junghyun Chae , Howard Ng , Zhenjian Du , James Barsoum , Dinesh Chimmanamada , Chi-Wan Lee , Kevin Foley
IPC分类号： A61K31/4196 , C07D249/08 , C07D403/02
CPC分类号： C07D249/08 , C07D403/10 , C07D403/12 , C07D413/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

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