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71. 发明申请

WO1989004339A1 FIBROIN MOLDINGS, PROCESS FOR THEIR PREPARATION, HEPARIN-IMMOBILIZING CARRIER, AND PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：纤维素模型，其制备方法，肝素固定载体及其制备方法
公开(公告)号：WO1989004339A1
公开(公告)日：1989-05-18
申请号：PCT/JP1988001099
申请日：1988-10-28
申请人： TERUMO KABUSHIKI KAISHA , HIRABAYASHI, Kiyoshi
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： C08H01/00
CPC分类号： B01J20/28023 , A61L33/0011 , B01D71/74 , B01J20/28014 , B01J20/28033 , B01J20/28042 , C08H1/00 , C08L89/00
摘要： A fibroin molding is obtained by treating fibroin with a crosslinking or coupling agent such as carbodiimide or glutaraldehyde. This molding can be formed into any desired form such as cast film, regenerated fibers, permeable membrane, coating membrane, porous material, microbeads, etc. They can be prepared by adding the coupling agent to a fibroin solution and solidifying fibroin, or by solidifying and molding fibroin from a fibroin solution and treating the product with the coupling agent. The above-described molding can be used by immobilizing thereon heparin or the like.

72. 发明申请

WO1989004308A1 PYRAZINE DERIVATIVES AND MEDICINAL PREPARATION CONTAINING SAME 审中-公开
标题翻译：吡嗪衍生物和含有其的药物制剂
公开(公告)号：WO1989004308A1
公开(公告)日：1989-05-18
申请号：PCT/JP1988001141
申请日：1988-11-11
申请人： TERUMO KABUSHIKI KAISHA , SUWABE, Yasushi , USHIJIMA, Hideto , HIJIKURO, Kohshi , SAKURAGI, Shiho , SUZUKI, Tadahiko , AKITA, Yasuo , OHTA, Akihiro
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： C07D241/12
CPC分类号： C07D241/12 , C07D241/16 , C07D241/24 , C07D241/42
摘要： Pyrazine derivatives represented by general formula (I), wherein X represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a cyano group, R1 represents a hydrogen atom, a lower alkyl group or a group of (a) (wherein X is as defined above), R2 represents a hydrogen atom, a halogen atom or (a) (wherein X is as defined above), R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a cyano group, a naphthylmethyl group, a benzyl group or (b) (wherein R4 represents a hydrogen atom, a halogen atom or a lower alkylamino group), a carboxyl group or a lower alkoxycarbonyl group or, when taken together, R2 and R3 represent a cyclohexane ring or a benzene ring together with the carbon atoms to which they are bound, provided that the case where X represents a hydrogen atom, R1 represents (a) (wherein X represents a hydrogen atom), and R2 and R3 represent hydrogen atoms and the case where X represents a hydrogen atom, R1 represents a hydrogen atom, R2 represents (a) (wherein X represents a hydrogen atom), and R3 represents a methyl group are excluded. The pyrazine derivatives have a strong blood platelet agglutination depressing effect and a cyclooxygenase inhibiting effect. The above-described compounds are used as blood platelet agglutination inhibitor or anti-inflammatory agents.

73. 发明申请

WO1989003402A1 ULTRAVIOLET-ABSORBING POLYMER MATERIAL AND PHOTOETCHING PROCESS 审中-公开
标题翻译：超紫外线吸收聚合物材料和光泽化过程
公开(公告)号：WO1989003402A1
公开(公告)日：1989-04-20
申请号：PCT/JP1988001028
申请日：1988-10-07
申请人： TERUMO KABUSHIKI KAISHA , MURAHARA, Masataka , SHIMOMURA, Takeshi , TAKAHASHI, Toru
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： C08F220/12
CPC分类号： G03F7/2043 , C08F220/12 , G03F7/0041 , G03F7/039 , G03F7/36
摘要： An ultraviolet-absorbing polymer material which comprises a copolymer between a (meth)acrylic ester monomer and a monomer having at least one fluorine atom as the substituent is disclosed. Also disclosed is a photoetching process which comprises forming a resist membrane on a base, irradiating it with a light beam of a first wavelength through a photomask, optionally conducting development of the resist, and irradiating it with a light beam of a second wavelength in a photodissociable gas atmosphere to conduct etching with reactive radicals generated by the dissociation.

74. 发明申请

WO1989003375A1 ISOPRENOID DERIVATIVES AND PHARMACEUTICAL PREPARATION CONTAINING SAME 审中-公开
标题翻译：异噻吩衍生物和含有其的药物制剂
公开(公告)号：WO1989003375A1
公开(公告)日：1989-04-20
申请号：PCT/JP1988001046
申请日：1988-10-14
申请人： TERUMO KABUSHIKI KAISHA , ONISHI, Hiroyuki , KOYAMA, Shingo , NANBA, Ryoichi , MIYAOKA, Syozo , MASUDA, Akira , SHIKATA, Yoshiyuki , USHIJIMA, Hideto , MUROTA, Seiitsu
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： C07C49/248
CPC分类号： C07C235/34 , C07C45/66 , C07C45/673 , C07C45/72 , C07C49/248 , C07C49/255
摘要： Isoprenoid derivatives represented by general formula (I), wherein R represents a hydrogen atom or a lower alkyl group, X represents -CH2-, -O- or -NH-, n represents 1 or 2, the number of double bonds of trans configuration, and m represents an integer of 0 to 3. The compounds have the activity of inhibiting the action of 5-lipoxygenase and are useful as drugs for treating allergy, nephritis, hepatitis, rheumatism, gastric ulcer, etc.

75. 发明申请

WO1989002305A1 LEUCOCYTE-SEPARATING FILTER 审中-公开
标题翻译：荧光分离过滤器
公开(公告)号：WO1989002305A1
公开(公告)日：1989-03-23
申请号：PCT/JP1988000943
申请日：1988-09-16
申请人： TERUMO KABUSHIKI KAISHA , NAOI, Keiji
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： B01D13/00
CPC分类号： B01D71/34 , A61M1/3633 , A61M2202/0439 , B01D39/1676 , B01D39/1692 , B01D69/02 , A61M2202/005
摘要： A leucocyte-separating filter is disclosed, which has a porous membrane having fine pores with substantially an oblong form of 3 to 30 mu m in average shorter diameter and a long diameter-to-short diameter ratio (average) of 1.5 or more. Leucocytes contained in a leucocyte suspension are collected without passing through the fine pores since the short diameter of the porous membrane is small enough, whereas since the pores have an oblong form, suspension-passing rate is comparatively great to effectively separate leucocytes. In addition, since matrix of the porous membrane is of a continuous structure, it is stable, and problems of run-off of foreign matters from the porous body or channeling of flow path during the procedure do not substantially arise.
摘要翻译：公开了一种白细胞分离过滤器，其具有多孔膜，该多孔膜具有细孔，其平均短径为3〜30μm，长径比比（平均）为1.5以上。由于多孔膜的短径足够小，所以白细胞悬浮液中含有的白细胞被收集而不通过细孔，而由于孔具有长圆形形状，因此悬浮通过率相对较高以有效分离白细胞。此外，由于多孔膜的基体是连续的结构，因此其稳定，而且在实施过程中不会引起异物从多孔体流出或流路的流出问题。

76. 发明申请

WO1989002304A1 LEUCOCYTE-SEPARATING FILTER 审中-公开
标题翻译：荧光分离过滤器
公开(公告)号：WO1989002304A1
公开(公告)日：1989-03-23
申请号：PCT/JP1988000942
申请日：1988-09-16
申请人： TERUMO KABUSHIKI KAISHA , NAOI, Keiji
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： B01D13/00
CPC分类号： B01D39/1676 , A61M1/3633 , A61M2202/0439 , B01D69/02 , A61M2202/005
摘要： A leucocyte-separating filter is disclosed, which comprises a polyvinyl formal porous body of a three-dimensional network continuous structure having continuous open pores of 5 to 60 mum in average pore size. Leucocytes contained in a leucocyte suspension can be effectively adsorbed onto the inside surface of pores and collected during the suspension being passed through complicated path of flow composed of the continuous open pores formed in the matrix of the porous body. Since the flow path in the filter is formed of porous matrix, a step of assembling a haemocyte-removing filter is conducted in an extremely simple manner, and scattering of the performance of products is few. In addition, since the porous matrix is of a continuous structure, it is stable, and problems of run-off of foreign matters from the porous body or channeling of flow path during the procedure substantially do not arise.

77. 发明申请

WO1989001755A1 CATHETER TUBE 审中-公开
标题翻译：导管管
公开(公告)号：WO1989001755A1
公开(公告)日：1989-03-09
申请号：PCT/JP1988000860
申请日：1988-08-30
申请人： TERUMO KABUSHIKI KAISHA , HONDA, Hiroaki
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： A61B01/00
CPC分类号： A61B1/018 , A61B1/00082 , A61B1/00135 , A61B1/00165
摘要： This invention relates to a catheter tube to be inserted into and allowed to stay in a body cavity having a relatively small diameter as typified by the blood vessel and used for observation or medical treatment of the interior of the body cavity. The catheter tube of the present invention has a structure wherein a linear inspection or medical instrument in the form of an optical fiber bundle is stored in a lumen formed in a tube body and is characterized in that the tip of the inspection or medical instrument is bent by moving the instrument in the longitudinal direction of the tube without bending substantially the tip of the catheter tube. Accordingly, the inspection and medical treatment of the inner wall of the body cavity can be conducted with a simple structure and the diameter of the catheter tube can be reduced.
摘要翻译：本发明涉及一种导管管，其用于插入并保持在体腔中具有相对小的直径，如通常的血管和其目的是被用于观察或医疗体腔内部。所述导管管包括其中的线性检查仪或光学纤维束的形式的医疗设备来代替在形成于管体的内腔保持的结构，并且其特征在于以下事实通过沿管的纵向方向移动检查器械或医疗器械的尖端而弯曲，而基本不弯曲导管管的尖端。因此，能够以简单的结构进行体腔内壁的检查和医疗处理，并且能够缩小导管的直径。

78. 发明申请

WO1989001351A1 CATHETER 审中-公开
标题翻译：导管
公开(公告)号：WO1989001351A1
公开(公告)日：1989-02-23
申请号：PCT/JP1988000803
申请日：1988-08-12
申请人： TERUMO KABUSHIKI KAISHA , HARADA, Fumiaki
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： A61M29/00
CPC分类号： A61F2/95 , A61F2/0004 , A61F2/88 , A61F2210/0019 , A61F2210/0023 , A61F2250/0098
摘要： This invention relates to a catheter equipped detachably at the tip thereof with a cylindrical expansion holding member of expanding the inner diameter of the lumen of the blood vessel or other tubular organ and for holding it in an expanded state either temporarily or permanently. The tip of the catheter which supports this member has a sufficiently smaller outer diameter than those of the other portions and the outer diameter of the expansion holding member is equal to, or smaller than, the outer diameters of the rest of portions of the catheter even when the expansion holding member is supported at the tip. The expansion holding member is made of a shape memory alloy so that it can expand or contract in the radial direction with a temperature change. Expansion or contraction of this member is made by causing the outflow of a heated or cooled liquid from a side hole bored at said tip of the catheter and bringing it into contact with the expansion holding member.
摘要翻译：本发明涉及一种在其前端可拆卸地配置有圆柱形膨胀保持构件的导管，该圆柱形膨胀保持构件使血管或其它管状器官的内腔的内径扩大并且暂时或永久地将其保持在展开状态。支撑该构件的导管的前端具有比其他部分小的外径足够小的外径，并且膨胀保持构件的外径等于或小于导管的其余部分的外径，甚至当膨胀保持构件被支撑在尖端时。膨胀保持构件由形状记忆合金制成，使得其能够随着温度变化沿径向膨胀或收缩。该构件的膨胀或收缩通过使来自在导管的所述尖端处钻孔的侧孔的加热或冷却的液体流出并使其与膨胀保持构件接触而进行。

79. 发明申请

WO1989001144A1 APPARATUS FOR MEASURING CONCENTRATION AND OXYGEN SATURATION OF HEMOGLOBIN 审中-公开
标题翻译：用于测量血红蛋白浓度和氧气饱和度的装置
公开(公告)号：WO1989001144A1
公开(公告)日：1989-02-09
申请号：PCT/JP1988000742
申请日：1988-07-22
申请人： TERUMO KABUSHIKI KAISHA , KOHNO, Hiromasa , HONDA, Hiroaki , NUDESHIMA, Masahiro
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： G01N21/31
CPC分类号： G01N21/3151 , A61B5/0059 , A61B5/14557 , G01N2021/3144 , Y10S435/808
摘要： A light beam having a first wavelength ( lambda 1) is applied to the blood from a first light radiation section, while a light beam having a second wavelength ( lambda 2) is applied from second and third light radiation sections different in positions from the first radiation section and from each other to the blood and the respective reflected light intensity (I1, I2, I3) is detected. A first correction value (X) for correcting the reflected light intensity ratio (I2/I3) is calculated by a first correction value operation section (40) and a second correction value (C1) is calculated by a second correction value operation section (42) by use of this first correction value and the reflected light intensity (I3). The reflected light intensity ratio (I1/I2) is corrected by use of this second correction value and an oxygen saturation in the blood is operated based on correlation function by use of the corrected reflected light intensity ratio (Rs). The reflected light intensity ratio (I2/I3) is corrected by the coefficient of correction thus operated and the hemoglobin concentration in the blood is operated based on correlation function by use of the reflected light intensity ratio thus corrected.
摘要翻译：具有第一波长（λ1）的光束被施加到来自第一光辐射部分的血液，而具有第二波长（λ2）的光束从与第一波长（λ1）不同的位置的第二和第三光辐射部分施加辐射部分和彼此相对于血液，并且检测各自的反射光强度（I1，I2，I3）。通过第一校正值运算部（40）计算用于校正反射光强度比（I2 / I3）的第一校正值（X），第二校正值（C1）由第二校正值运算部）通过使用该第一校正值和反射光强度（I3）。通过使用该第二校正值校正反射光强度比（I1 / I2），并且通过使用校正的反射光强度比（Rs），基于相关函数来操作血液中的氧饱和度。反射光强度比（I2 / I3）由这样操作的校正系数校正，并且通过使用如此校正的反射光强度比，基于相关函数来操作血液中的血红蛋白浓度。

80. 发明申请

WO1989000878A1 HYDROPHILIC POROUS MEMBRANE, PROCESS FOR ITS PRODUCTION AND PLASMA-SEPARATING APPARATUS 审中-公开
标题翻译：疏水多孔膜，其生产工艺及等离子体分离装置
公开(公告)号：WO1989000878A1
公开(公告)日：1989-02-09
申请号：PCT/JP1988000779
申请日：1988-08-05
申请人： TERUMO KABUSHIKI KAISHA , ONISHI, Makoto , FUJII, Tatsuya
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： B01D13/00
CPC分类号： B01D67/0093 , B01D63/084 , B01D2323/38
摘要： A hydrophilic porous membrane useful as plasma-separating hydrophilic membrane, a process for its production, and a plasma-separating apparatus containing this membrane in housing are disclosed. The membrane comprises a hydrophobic porous membrane containing a hydrophobic polymer, -(X)m-, as base material having at least on the surface thereof hydrophilic polymer, -(Y)n-, grafted to the base material, with the molar ratio of monomer units Y to monomer units X (Y/X) on the membrane surface being 0.2 to 2.0 and weight ratio of -(Y)n-/-(X)m- in the total membrane being 0.03 to 0.3.
摘要翻译：公开了用作等离子体分离亲水膜的亲水性多孔膜，其制造方法以及在壳体中含有该膜的等离子体分离装置。该膜包括含有疏水性聚合物的疏水性多孔膜 - （X）m-作为至少在其表面上具有亲水性聚合物的基材，（Y）n-接枝到基材上，摩尔比为单体单元Y与膜表面上的单体单元X（Y / X）的比例为0.2〜2.0，总膜中的 - （Y）n - / - （X）m-的重量比为0.03〜0.3。

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