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1. 发明专利

MXPA06003963A ACIDOS CARBOXILICOS MACROCICLICOS Y ACILSULFONAMIDAS COMO INHIBIDORES DE REPLICACION DEL HCV. 未知
公开(公告)号：MXPA06003963A
公开(公告)日：2006-08-25
申请号：MXPA06003963
申请日：2004-10-13
申请人： INTERMUNE INC
发明人： BLATT LAWRENCE M , WENGLOWSKY STEVEN MARK , ANDREWS STEVEN WADE , JIANG YUTONG , KENNEDY APRIL LAYNE , CONDROSKI KEVIN RONALD , JOSEY JOHN ANTHONY , STENGEL PETER JOHN , MADDURU MACHENDER R , DOHERTY GEORGE ANDREW , WOODARD BENJAMIN T
IPC分类号： A61K38/00 , A61K20060101 , C07D487/04 , C08H1/00 , C08H01/00
摘要： La presente invencion proporciona compuestos de las formulas generales I-IX, asi como composiciones, que incluyen composiciones farmaceuticas, que comprenden un compuesto objetivo. La presente invencion proporciona ademas metodos de tratamiento, incluyendo metodos para tratar una infeccion por virus de hepatitis C y metodos para tratar fibrosis hepatica, involucrando generalmente los metodos la administracion a un individuo con necesidad del mismo de una cantidad efectiva de un compuesto o composicion objetivo.

2. 发明公开

EP0140640A3 Blood substitute 有权
标题翻译：血液替代品
公开(公告)号：EP0140640A3
公开(公告)日：1986-05-28
申请号：EP84307070
申请日：1984-10-16
申请人： FISONS plc
发明人： Wong, Jeffrey Tze-Fei
IPC分类号： C08B37/02 , C08H01/00 , A61K37/14
CPC分类号： C08H1/00 , C07F9/091 , C08B37/0021
摘要： There is described a water soluble compound having a molecular weight of from about 70,000 to about 2,000,000, and having the formula 1,
where PS represents a physiologically acceptable polysaccharide of molecular weight from about 2,000 to about 2,000,000,
X represents a covalently bonded chemical bridging group, HB represents a haemoglobin residue, and Z represents an oxygen affinity reducing ligand, containing 2 or more phosphate groups. There is also described haemoglobin linked to an oxygen affinity reducing ligand derived from inositol phosphate, and polymers of such linked haemoglobin. Processes for making the compounds, and their formulation and use as oxygen transporting agents, are also described.

3. 发明申请

WO1997030108A1 CHARACTERIZED BRCA1 AND BRCA2 PROTEINS AND SCREENING AND THERAPEUTIC METHODS BASED ON CHARACTERIZED BRCA1 AND BRCA2 PROTEINS 审中-公开
标题翻译：基于特征BRCA1和BRCA2蛋白的特征BRCA1和BRCA2蛋白和筛选和治疗方法
公开(公告)号：WO1997030108A1
公开(公告)日：1997-08-21
申请号：PCT/US1997003340
申请日：1997-02-19
申请人： VANDERBILT UNIVERSITY , UNIVERSITY OF WASHINGTON
发明人： VANDERBILT UNIVERSITY , UNIVERSITY OF WASHINGTON , HOLT, Jeffrey, T. , JENSEN, Roy, A. , CLAIRE-KING, Marie , PAGE, David, L. , SZABO, Csilla, I. , JETTON, Thomas, L. , ROBINSON-BENION, Cheryl, L. , THOMPSON, Marilyn, E.
IPC分类号： C08H01/00
CPC分类号： A61K49/0004 , A61K38/00 , A61K48/00 , C07K14/4703 , C07K2319/00
摘要： Genetic analysis of familial breast and ovarian cancer indicates that BRCA1 is a tumor suppressor gene. The BRCA1 gene encodes a 190 kDa protein with sequence homology and biochemical analogy to the granin family of proteins. Granins are secreted from endocrine cells via the regulated secretory pathway and are proteolytically cleaved to yield biologically active peptides. BRCA1 protein localises to secretory vesicles, and was demonstrated to be secreted. Gene transfer of BRCA1 inhibits growth and tumorigenesis of breast and ovarian cancer cells, but not colon or lung cancer cells or fibroplasts, suggesting that BRCA1 encodes a tissue-specific growth inhibitor. Thus, BRCA1 is a secreted growth inhibitor and functions by a mechanism not previously described for tumor suppressor genes. The BRCA2 breast and ovarian cancer gene encodes a protein that also includes a granin region, indicating that the BRCA2 protein is also a secreted tumor suppressor. Therapeutic methods using the BRCA1 and BRCA proteins and genes are also described. A method of screening for the receptors of the BRCA1 protein and BRCA2 proteins is also described.
摘要翻译：家族性乳腺癌和卵巢癌的遗传分析表明，BRCA1是肿瘤抑制基因。 BRCA1基因编码190 kDa的蛋白质，与蛋白质的大豆蛋白家族具有序列同源性和生物化学类比。通过经调节的分泌途径从内分泌细胞分泌颗粒，并被蛋白水解切割以产生生物活性肽。 BRCA1蛋白定位于分泌囊泡，并被证明是分泌的。 BRCA1的基因转移抑制乳腺和卵巢癌细胞的生长和肿瘤发生，但不抑制结肠或肺癌细胞或纤维板，这表明BRCA1编码组织特异性生长抑制剂。因此，BRCA1是分泌的生长抑制剂，并且通过以前未被描述用于肿瘤抑制基因的机制起作用。 BRCA2乳腺癌和卵巢癌基因编码的蛋白质也包括一个颗粒蛋白，表明BRCA2蛋白也是分泌的肿瘤抑制因子。还描述了使用BRCA1和BRCA蛋白和基因的治疗方法。还描述了筛选BRCA1蛋白和BRCA2蛋白的受体的方法。

4. 发明申请

WO1996003456A1 BIOCOMPATIBLE OPTICALLY TRANSPARENT POLYMERIC MATERIAL BASED UPON COLLAGEN AND METHOD OF MAKING 审中-公开
标题翻译：基于胶原的生物可溶性透明聚合材料及其制备方法
公开(公告)号：WO1996003456A1
公开(公告)日：1996-02-08
申请号：PCT/US1995009202
申请日：1995-07-21
申请人： FEINGOLD, Vladimir , OSSIPOV, Alexai, V.
IPC分类号： C08H01/00
CPC分类号： C08H1/06 , A61F2/16 , A61F2310/00365 , A61L27/16 , A61L27/24 , C08F289/00 , G02B1/043 , C08L51/00
摘要： The present invention is biocompatible polymer containing the copolymerization product of a mixture of hydrophobic and hydrophilic acrylic and/or allelic monomers, graft-polymerized with telo-collagen. The present material is useful in the production of deformable lenses, for example, intraocular lenses, refractive intraocular contact lenses, and standard contact lenses useful, for example, for correcting aphekia, myopia and hypermetropia.
摘要翻译：本发明是含有与端粒胶原蛋白接枝聚合的疏水和亲水的丙烯酸和/或等位基因单体的混合物的共聚产物的生物相容性聚合物。本发明的材料可用于生产可变形透镜，例如眼内透镜，屈光眼内隐形眼镜和用于例如矫正阿朴，近视和远视的标准隐形眼镜。

5. 发明公开

EP0194807A3 Hydrated adhesive gel and method for preparing the same 失效
标题翻译：水泥胶粘剂及其制备方法
公开(公告)号：EP0194807A3
公开(公告)日：1987-09-02
申请号：EP86301575
申请日：1986-03-06
申请人： NIPPON OIL AND FATS COMPANY, LIMITED
发明人： Doi, Hiroshi , Inoue, Masanori
IPC分类号： A61K47/00 , A61L25/00 , A61L15/03 , A61K07/48 , C08H01/00
CPC分类号： A61K8/042 , A61K8/64 , A61K8/645 , A61K8/65 , A61K47/42 , A61L15/20 , A61L15/58 , A61L26/0028 , A61L26/008 , A61Q19/00 , C08H1/00 , C08L89/00
摘要： This invention relates to a hydrated adhesive gel using a product which is obtained by reacting an aqueous solution essentially containing protein having amino groups at the side chains thereof, a gelling retarder, and a hydrophilic tackifier with a certain N-hydroxyimidoester compound.

6. 发明公开

EP0140596A3 Protein/polysaccharide complexes 有权
标题翻译：蛋白/多糖复合物
公开(公告)号：EP0140596A3
公开(公告)日：1985-06-12
申请号：EP84306742
申请日：1984-10-03
申请人： JOHNSON & JOHNSON
发明人： Easton, Ian Alexander , Gorham, Stephen Dudley
IPC分类号： C08H01/00 , C08H01/06 , A61L27/00 , A61L15/04
CPC分类号： C08H1/06 , A61F2310/00365 , A61L15/225 , A61L17/08 , A61L27/24 , A61L27/26 , C08B37/0084 , C08L89/06 , C08L5/04 , C08L89/00
摘要： @ Complexes of polyanionic plant polysaccharides with biodegradable proteins, or proteolytic degradation products thereof, are useful in the formation of wound dressings and surgical implants, such as sutures, blood vessel grafts, and artificial organs. The biodegradable protein is preferably collagen, and the polysaccharide is preferably sodium alginate. The complexes are preferably formed by combining the protein and the polysaccharide at a pH which is no higher than the isoelectric point of the protein. The complexes may be crosslinked, such as by dehydrothermal crosslinking or by the use of chemical crosslinking agents such as aldehydes or carbodiimides. Multivalent cations may also be incorporated in the complex in order to give added strength.

7. 发明申请

WO1996040817A1 CARBOXYL-MODIFIED SUPERABSORBENT PROTEIN HYDROGEL 审中-公开
标题翻译：羧甲基改性超吸附蛋白水凝胶
公开(公告)号：WO1996040817A1
公开(公告)日：1996-12-19
申请号：PCT/US1996007267
申请日：1996-05-20
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： WISCONSIN ALUMNI RESEARCH FOUNDATION , DAMODARAN, Srinivasan , HWANG, Der-Chyan
IPC分类号： C08H01/00
CPC分类号： C08H1/00 , A61L15/40 , A61L15/60 , C08L89/00
摘要： The present invention is a biodegradable, reversibly-swellable, polyvalent cation-binding, protein-based hydrogel which comprises an acyl-modified protein matrix in which the acyl-modified protein matrix is cross-linked with a bifunctional cross-linking reagent, and a method of making the same.
摘要翻译：本发明是可生物降解的可逆膨胀的多价阳离子结合蛋白质的水凝胶，其包含酰基修饰的蛋白质基质，其中酰基修饰的蛋白质基质与双功能交联剂交联，和制作相同的方法

8. 发明申请

WO1989004339A1 FIBROIN MOLDINGS, PROCESS FOR THEIR PREPARATION, HEPARIN-IMMOBILIZING CARRIER, AND PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：纤维素模型，其制备方法，肝素固定载体及其制备方法
公开(公告)号：WO1989004339A1
公开(公告)日：1989-05-18
申请号：PCT/JP1988001099
申请日：1988-10-28
申请人： TERUMO KABUSHIKI KAISHA , HIRABAYASHI, Kiyoshi
发明人： TERUMO KABUSHIKI KAISHA
IPC分类号： C08H01/00
CPC分类号： B01J20/28023 , A61L33/0011 , B01D71/74 , B01J20/28014 , B01J20/28033 , B01J20/28042 , C08H1/00 , C08L89/00
摘要： A fibroin molding is obtained by treating fibroin with a crosslinking or coupling agent such as carbodiimide or glutaraldehyde. This molding can be formed into any desired form such as cast film, regenerated fibers, permeable membrane, coating membrane, porous material, microbeads, etc. They can be prepared by adding the coupling agent to a fibroin solution and solidifying fibroin, or by solidifying and molding fibroin from a fibroin solution and treating the product with the coupling agent. The above-described molding can be used by immobilizing thereon heparin or the like.

9. 发明申请

WO1995015352A1 ALBUMIN BASED HYDROGEL 审中-公开
标题翻译：基于ALBUMIN的HYDROGEL
公开(公告)号：WO1995015352A1
公开(公告)日：1995-06-08
申请号：PCT/CA1994000650
申请日：1994-11-24
申请人： UNIVERSITE DU QUEBEC A MONTREAL
发明人： UNIVERSITE DU QUEBEC A MONTREAL , FORTIER, Guy
IPC分类号： C08H01/00
CPC分类号： G02B1/043 , A61L15/26 , A61L15/32 , A61L15/60 , C08H1/00 , C08J3/075 , C08L89/00 , C08L2666/02 , C08L71/02
摘要： Novel bioartificial hydrogels consisting of a three-dimensional crosslinked mixture of: (a) a bifunctionalized polyethylene oxide, activated with an activating agent, dissolved in an aqueous solution; and (b) albumin type protein. The novel hydrogels are based on the crosslinking of albumin type protein of various sources including, for example, bovine serum albumin, lactalbumin or ovalbumin, with a bifunctionalyzed polyethylene oxide, most proferably polyethylene glycol, or a mixture of bifunctionalyzed polyethylene oxides preferably polyethylene glycol, of various molecular masses (Mr 2,000 to 35,000), dissolved in aqueous solution in adequate proportions. Also provided is a method and conditions for preparing the novel hydrogels. Also divulged are a variety of biomedical applications for the novel hydrogels. Additionally, it has been found that the mechanical properties of the novel hydrogels can be improved by adding to the casting solution unreactive polyethylen glycol or other inert polymer of high molecular masses (Mr > 100,000). In general terms the novel hydrogels possess advantageous properties such as shape retention and shape memory, high water content (more than 94 % (w/w) based on the dry weight of the hydrogel), good mechanical and optical properties. The hydrogels exhibit additional charcteristics which may render them extremely useful in the pharmaceutic and medical areas due to other advantageous properties such as biocompatibility, resistance to proteases action, slow release of various drugs, hydrophillic surface, good oxygen permeability, controlled porosity.
摘要翻译：由以下三维交联混合物组成的新型生物人造水凝胶：（a）活化剂活化的双官能化聚环氧乙烷，溶解在水溶液中; 和（b）白蛋白型蛋白质。新型水凝胶基于各种来源的白蛋白型蛋白质的交联，包括例如牛血清白蛋白，乳白蛋白或卵清蛋白，具有双官能化聚环氧乙烷，最优选聚乙二醇，或双功能化聚环氧乙烷的混合物，优选聚乙二醇，的各种分子量（2,000至35,000），以足够的比例溶解在水溶液中。还提供了制备新颖水凝胶的方法和条件。还泄露了新型水凝胶的各种生物医学应用。此外，已经发现，通过向浇铸溶液中加入非反应性聚乙二醇或其它高分子量惰性聚合物（Mr> 100,000）可以改善新型水凝胶的机械性能。一般来说，新型水凝胶具有诸如形状保持和形状记忆等有益的特性，高水含量（基于水凝胶的干重大于94％（w / w）），良好的机械和光学性能。水凝胶呈现出额外的特征，由于其它有利的性质如生物相容性，抗蛋白酶作用，缓慢释放各种药物，亲水表面，良好的透氧性，受控的孔隙率，这些特征可能使它们在药物和医学领域中非常有用。

10. 发明申请

WO1993020130A1 APPARATUS FOR PROCESSING BIOPOLYMER-CONTAINING COLUMNS 审中-公开
标题翻译：用于加工包含生物聚合物的柱的装置
公开(公告)号：WO1993020130A1
公开(公告)日：1993-10-14
申请号：PCT/US1993003123
申请日：1993-03-29
申请人： BARRSKOGEN, INC. , CHOW, Flora
发明人： BARRSKOGEN, INC.
IPC分类号： C08H01/00
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00414 , B01J2219/00418 , B01J2219/00454 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , G01N30/06 , G01N30/24 , G01N30/466 , G01N30/82 , G01N30/88 , G01N2030/8804 , G01N2030/8813 , G01N2030/3007
摘要： An apparatus (10) has been designed that is useful for the automated or semi-automated removal, recovery, deprotection, and/or purification of biopolymers such as oligodeoxyribonucleotides, oligoribonucleotides, oligosaccharides and peptides from a solid support matrix (20) that is contained in a reaction chamber in the shape of a column (18).
摘要翻译：已经设计了可用于自动或半自动移除，回收，脱保护和/或纯化来自固体支持基质（20）的生物聚合物如寡脱氧核糖核苷酸，寡核糖核苷酸，寡糖和肽的装置（10）在柱（18）的形式的反应室中。

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