专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

US20060199774A1 Remedies 审中-公开
标题翻译：补救措施
公开(公告)号：US20060199774A1
公开(公告)日：2006-09-07
申请号：US11408946
申请日：2006-04-24
申请人： Hiromu Ohnogi , Masahiro Shiraga , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Masahiro Shiraga , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K31/366 , A61K31/7048
CPC分类号： A61K31/7048 , A23K20/116 , A23K20/163 , A23L33/105 , A61K31/366 , A61K31/37 , C07H17/04 , C07H17/075
摘要： The present invention relates to a medicament, a food, a beverage or a feed, each comprising as an effective ingredient a compound having an enhancing action for NGF production, which is effective for a treatment, an amelioration of symptom, prevention or the like of a disease requiring enhancement of NGF production, wherein the compound has a coumarin and/or chroman backbone. Since no toxicity is especially found in the effective ingredient of the present invention, and there is no risk of incidence of adverse actions, the treatment or the like of the above disease can be safely and appropriately carried out.
摘要翻译：本发明涉及一种药物，食品，饮料或饲料，其各自包含作为有效成分的具有NGF生产增强作用的化合物，其有效治疗，改善症状，预防等需要增强NGF生产的疾病，其中所述化合物具有香豆素和/或色胺骨架。由于在本发明的有效成分中没有特别的毒性，并且不存在不良反应的发生风险，所以可以安全，适当地进行上述疾病的治疗等。

62. 发明申请

US20060147558A1 Remedies 审中-公开
标题翻译：补救措施
公开(公告)号：US20060147558A1
公开(公告)日：2006-07-06
申请号：US11258163
申请日：2005-10-26
申请人： Hiromu Ohnogi , Masahiro Shiraga , Tuo-Ping Li , Eiji Kobayashi , Kaori Nishimura , Hiroaki Sagawa , Ikunoshin Kato
发明人： Hiromu Ohnogi , Masahiro Shiraga , Tuo-Ping Li , Eiji Kobayashi , Kaori Nishimura , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K36/899 , A61K36/16 , A61K36/8962 , A61K36/31 , A61K36/906 , A61K36/28 , A61K36/23
CPC分类号： C12G3/06 , A23F3/163 , A23K20/00 , A23K20/10 , A23L2/02 , A23L2/52 , A23L33/105 , A61K31/12 , A61K31/192 , A61K31/216 , A61K31/7048 , A61K36/16 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/31 , A61K36/48 , A61K36/60 , A61K36/73 , A61K36/896 , A61K36/899 , A61K36/906 , A61K2300/00
摘要： The present invention provides a composition for enhancing growth factor production, comprising a plant-derived enhancer for growth factor production; a therapeutic agent or prophylactic agent for a disease requiring enhancement of growth factor production and a food, beverage or feed for enhancing growth factor production, each comprising the above composition. In addition, the present invention relates to a functional food, beverage or feed excellent in health enhancement.
摘要翻译：本发明提供一种用于增强生长因子生产的组合物，其包含用于生长因子生产的植物来源的增强剂; 用于需要增强生长因子产生的疾病的治疗剂或预防剂和用于增强生长因子产生的食品，饮料或饲料，每种包含上述组合物。此外，本发明涉及健康增强优异的功能性食品，饮料或饲料。

63. 发明授权

US06548543B1 Remedies or preventives containing cyclopentenone compounds as the active ingredient 失效
标题翻译：含环戊烯酮化合物作为活性成分的补救措施或预防措施
公开(公告)号：US06548543B1
公开(公告)日：2003-04-15
申请号：US09763244
申请日：2001-02-20
申请人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Eiji Kobayashi , Hiromu Ohnogi , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31215
CPC分类号： A61K31/215 , A61K31/22 , C07C69/013 , C07C2601/10 , Y02A50/411
摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.
摘要翻译：需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要调节细胞的疾病含有作为活性成分的至少一种选自通式[I]表示的环戊烯酮衍生物的化合物，其光学活性异构体和盐，其中R 1和R 2为相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。

64. 发明授权

US6165749A Plasmid 失效
标题翻译：质粒
公开(公告)号：US6165749A
公开(公告)日：2000-12-26
申请号：US952089
申请日：1997-11-10
申请人： Hiroaki Sagawa , Harumi Ueno , Atsushi Oshima , Ikunoshin Kato
发明人： Hiroaki Sagawa , Harumi Ueno , Atsushi Oshima , Ikunoshin Kato
IPC分类号： C12N15/09 , C12N1/21 , C12N9/10 , C12N9/16 , C12N9/22 , C12N15/55 , C12N15/69 , C12R1/19 , C12P21/06
CPC分类号： C12N15/69 , C12N9/1007 , C12N9/22
摘要： A plasmid vector characterized by comprising a promoter sequence that can be recognized by an RNA polymerase which is not inherent in a host and that controls the expression of desired genes and a replication origin that increases the number of copies under the induction by exogenous factors; methods for expression and isolation of target genes by using the vector; a polypeptide having the activity of an AccIII restriction endonuclease; and a DNA encoding the polypeptide. The invention provides for the first time a plasmid vector which can introduce an exogenous desired gene encoding proteins which are lethal or harmful to hosts into the hosts, a method for efficiently expressing the proteins by using the vector, and also a method for permitting a restriction endonuclease gene constituting a restriction-modification system to be isolated even in the absence of a modification enzyme gene, which has been difficult in the prior arts.
摘要翻译： PCT No.PCT / JP97 / 00748 Sec。 371日期：1997年11月10日 102（e）日期1997年11月10日PCT 1997年3月10日PCT公布。第WO97 / 34006号公报日期1997年9月18日一种质粒载体，其特征在于包含可由RNA聚合酶识别的启动子序列，其不是宿主中固有的并且控制所需基因的表达和增加诱导下拷贝数的复制起点由外生因素; 通过使用载体表达和分离靶基因的方法; 具有AccIII限制性内切核酸酶活性的多肽; 和编码该多肽的DNA。本发明首次提供能够将编码对宿主具有致死性或有害性的蛋白质的外源性所需基因导入宿主的质粒载体，使用该载体有效表达蛋白质的方法，以及允许限制的方法构成即使在不存在修饰酶基因的情况下分离的限制性修饰系统的核酸内切酶基因，这在现有技术中是困难的。

65. 发明授权

US6133238A Tetrahydrofurans 失效
标题翻译：四氢呋喃
公开(公告)号：US6133238A
公开(公告)日：2000-10-17
申请号：US347169
申请日：1999-07-02
申请人： Hiroaki Sagawa , Shinji Okuda , Nobuko Muraki , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
发明人： Hiroaki Sagawa , Shinji Okuda , Nobuko Muraki , Nobuto Koyama , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31/34 , A61K31/341 , A61P35/00 , C07D307/24 , A61K31/70 , C07D307/00 , C07D307/02
CPC分类号： C07D307/24
摘要： 2,5-dihydroxytetrahydro-2-furancarboxylic acid represented by the following formula [I], its optically active substance or salt thereof. ##STR1##
摘要翻译：由下式[I]表示的2,5-二羟基四氢-2-呋喃羧酸，其光学活性物质或其盐。

66. 发明授权

US08728811B2 Process for producing cytotoxic lymphocyte 有权
标题翻译：生产细胞毒性淋巴细胞的方法
公开(公告)号：US08728811B2
公开(公告)日：2014-05-20
申请号：US10509055
申请日：2003-03-25
申请人： Hiroaki Sagawa , Mitsuko Ideno , Ikunoshin Kato
发明人： Hiroaki Sagawa , Mitsuko Ideno , Ikunoshin Kato
IPC分类号： C12N5/071 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0638 , A61K2035/124 , C12N5/0636 , C12N2501/58 , C12N2510/00
摘要： The present invention relates to a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one of induction, maintenance and expansion of a cytotoxic lymphocyte in the presence of fibronectin, a fragment thereof or a mixture thereof.
摘要翻译：本发明涉及一种制备细胞毒性淋巴细胞的方法，其特征在于该方法包括在纤连蛋白，其片段或其混合物存在下，进行细胞毒性淋巴细胞的诱导，维持和扩增中的至少一种的步骤。

67. 发明申请

US20080096249A1 AGARASE AND GENE THEREOF 失效
标题翻译：其基因及其基因
公开(公告)号：US20080096249A1
公开(公告)日：2008-04-24
申请号：US11948650
申请日：2007-11-30
申请人： Jun TOMONO , Hiroaki Sagawa , Ikunoshin Kato
发明人： Jun TOMONO , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： C12N9/00 , C12N15/00 , C12N15/11 , C12P21/04 , C12N5/06
CPC分类号： C12Y302/01081 , C12N9/2468
摘要： Production of efficiently producing agaro-oligosaccharide; a polypeptide having an agarase activity which is usable in, for example, efficiently extracting a substance such as a nucleic acid from an agarose gel; the amino acid sequence of the polypeptide; a gene encoding the polypeptide; a process for producing the polypeptide; a process for producing agaro-oligosaccharide; and a process for extracting a substance such as a nucleic acid from an agarose gel.
摘要翻译：高效生产琼脂寡糖的生产; 具有琼脂糖酶活性的多肽，其可用于例如从琼脂糖凝胶中有效地提取诸如核酸的物质; 多肽的氨基酸序列; 编码该多肽的基因; 一种生产该多肽的方法; 制备琼脂寡糖的方法; 以及从琼脂糖凝胶中提取核酸等物质的方法。

68. 发明授权

US06673578B1 Method for synthesizing DNA 失效
标题翻译： DNA合成方法
公开(公告)号：US06673578B1
公开(公告)日：2004-01-06
申请号：US09786684
申请日：2001-05-22
申请人： Takashi Uemori , Yoshimi Sato , Mariko Okawa , Tomoko Fujita , Kazue Miyake , Osamu Takeda , Hiroaki Sagawa , Michio Hagiya , Hiroyuki Mukai , Kiyozo Asada , Ikunoshin Kato
发明人： Takashi Uemori , Yoshimi Sato , Mariko Okawa , Tomoko Fujita , Kazue Miyake , Osamu Takeda , Hiroaki Sagawa , Michio Hagiya , Hiroyuki Mukai , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12P1934
CPC分类号： C12N15/1003 , C12Q1/686 , C12Q2527/125
摘要： A DNA synthesis method with a shortened time period required for DNA synthesis by polymerase chain reaction (PCR), characterized in that a DNA polymerase is used in an amount effective for providing more than 10 ng of amplified DNA fragments of about 2 kb per 50 &mgr;l of a reaction mixture, when PCR is carried out under the following conditions (A) and (B): (A) reaction mixture: 50 &mgr;l volume of a reaction mixture comprising DNA polymerase, 1 ng of genomic DNA from Escherichia coli, and 10 pmol each of primers Eco-1 and Eco-2 (nucleotide sequences of the primers Eco-1 and Eco-2 being shown in SEQ ID NOs: 10 and 11 of Sequence Listing, respectively); and having a composition suitable for the DNA polymerase; and (B) reaction conditions: 35 cycles of PCR, wherein one cycle consists of 99° C., 1 second-66° C., 7 seconds; a kit for DNA synthesis usable for the DNA synthesis method; and an article of manufacture of a PCR agent. According to the present invention, the procedures in the genetic engineering studies and industries involved with PCR can be speeded up.
摘要翻译：一种DNA合成方法，其通过聚合酶链式反应（PCR）进行DNA合成所需的时间缩短，其特征在于使用DNA聚合酶，其量有效提供超过10ng每50ul约2kb的扩增DNA片段的反应混合物，当在以下条件（A）和（B）下进行PCR时：（A）反应混合物：将50体积的包含DNA聚合酶的反应混合物，1ng来自大肠杆菌的基因组DNA和10ng 各引物Eco-1和Eco-2（引物Eco-1和Eco-2的核苷酸序列分别示于序列表的SEQ ID NO：10和11中）并具有适合于DNA聚合酶的组合物; 和（B）反应条件：35个循环的PCR，其中一个循环由99℃，1秒-66℃，7秒; 用于DNA合成方法的DNA合成试剂盒; 以及PCR试剂的制造。根据本发明，可以加快基因工程研究和涉及PCR的行业的程序。

69. 发明申请

US20080206811A1 Process For Producing Polypeptide 审中-公开
标题翻译：生产多肽的方法
公开(公告)号：US20080206811A1
公开(公告)日：2008-08-28
申请号：US11597318
申请日：2005-08-19
申请人： Toshihiro Shodai , Hiroshi Kobori , Takehiro Sagara , Hiroshi Endo , Hikaru Takakura , Jun Tomono , Hiroaki Sagawa , Hiroyuki Mukai , Ikunoshin Kato
发明人： Toshihiro Shodai , Hiroshi Kobori , Takehiro Sagara , Hiroshi Endo , Hikaru Takakura , Jun Tomono , Hiroaki Sagawa , Hiroyuki Mukai , Ikunoshin Kato
IPC分类号： C12P21/04 , C12N15/00
CPC分类号： C12N15/70 , C12N9/1276 , C12N9/22 , C12P21/02
摘要： A process for producing a target protein at low temperature, comprising inducing expression of not only a vector having introduced therein a gene coding for the target protein but also a vector having a chaperone gene introduced therein.
摘要翻译：一种在低温下生产靶蛋白的方法，包括不仅引入其中引入了编码靶蛋白的基因的载体，还诱导其中引入伴侣伴侣基因的载体。

70. 发明申请

US20050124575A1 Remedies 审中-公开
标题翻译：补救措施
公开(公告)号：US20050124575A1
公开(公告)日：2005-06-09
申请号：US10507937
申请日：2003-04-14
申请人： Eiji Nishiyama , Nobuko Muraki , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
发明人： Eiji Nishiyama , Nobuko Muraki , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A23K1/16 , A23L1/0532 , A23L1/30 , A61K31/715 , A61K31/729 , A61P29/00 , C08B37/00 , A23G3/00 , A61K47/00
CPC分类号： C08B37/0039 , A23K20/163 , A23L29/256 , A23L33/10 , A23V2002/00 , A61K31/715 , A61K31/729 , A23V2250/5024 , A23V2250/1578 , A23V2250/5108 , A23V2250/616 , A23V2250/5118
摘要： Remedies or preventives, which are characterized by containing as the active ingredient at least one member selected from the group consisting of agar, agarose, high-molecular weight digestion products originating in agar and high-molecular weight digestion products originating in agarose, for diseases sensitive to the above active ingredients.
摘要翻译：其特征在于含有选自琼脂，琼脂糖，源自琼脂的高分子量消化产物和起源于琼脂糖的高分子量消化产物中的至少一种成分为活性成分，用于疾病敏感性的补救剂或预防剂以上活性成分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式