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61. 发明授权

US5882334A Balloon/delivery catheter assembly with adjustable balloon positioning 失效
标题翻译：气球/输送导管组件，可调节气球定位
公开(公告)号：US5882334A
公开(公告)日：1999-03-16
申请号：US566606
申请日：1995-12-04
申请人： Ivan Sepetka , Erik T. Engelson
发明人： Ivan Sepetka , Erik T. Engelson
IPC分类号： A61F2/958 , A61M25/01 , A61M25/12 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61M25/01 , A61M2025/1015 , A61M25/1011
摘要： This is a catheter assembly having an expandable balloon adjustably positionable over a polymeric delivery catheter shaft.
摘要翻译：这是具有可调节地定位在聚合物输送导管轴上的可膨胀气囊的导管组件。

62. 发明授权

US5855578A Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas 失效
公开(公告)号：US5855578A
公开(公告)日：1999-01-05
申请号：US801795
申请日：1997-02-14
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/00 , A61B17/00 , A61B17/12 , A61B18/12 , A61B18/14 , A61B19/00 , A61M25/00 , A61B17/38
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B18/1492 , A61B2017/00292 , A61B2017/12063 , A61B2017/12095 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61B90/39 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

63. 发明授权

US5826587A Ultrasoft embolism coils and process for using them 失效
标题翻译：超声波栓塞线圈及其使用过程
公开(公告)号：US5826587A
公开(公告)日：1998-10-27
申请号：US864317
申请日：1997-05-28
申请人： Alejandro Berenstein , Ivan Sepetka
发明人： Alejandro Berenstein , Ivan Sepetka
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/02 , A61M25/095 , A61M25/14
CPC分类号： A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/1214 , A61B17/1215 , A61B17/12163 , A61B2017/00526 , A61B2017/00539 , A61B2017/12063 , A61B2017/1209 , A61B90/39
摘要： This invention is an exceptionally flexible, ultrasoft vaso-occlusive or embolism forming device. It is made of a radiopaque material which may be braided or coiled to form a long, thin threadlike device having little rigidity or column strength. The diameter of the device may be less than about 0.010 inches. The device is sufficiently flexible and small that it may be hydraulically delivered to a site within the vasculature of the human body using an injected drug or fluid flush through a catheter. The device assumes a loose, random mass of threadlike material after being ejected from the catheter tip at the chosen vascular site. The device (whether coil or braid) may be used alone or in conjunction with larger coils or braids to achieve a denser occlusion or as a substrate to localize the subsequent infusion of tissue adhesives, particulate embolization devices, or chemotherapeutic agents in abnormal blood vessels and tissues or for the temporary occlusion of blood vessels during types of diminished blood flow testing. The invention also include processes for introducing the devices into the human body.
摘要翻译：本发明是一种非常灵活的超软血管闭塞或栓塞形成装置。它由不透射线材料制成，其可以被编织或卷绕以形成具有很小刚度或柱强度的长而细的线状装置。设备的直径可以小于约0.010英寸。该装置具有足够的柔性和小度，使得其可以使用注射的药物或通过导管冲洗的液体液压地输送到人体脉管系统内的部位。该装置在选定的血管部位从导管尖端喷射后呈现松散随机的线状材料质量。该装置（无论是线圈还是编织物）可以单独使用或与更大的线圈或编织物结合使用以实现更致密的闭塞或作为基底以定位随后在异常血管中输注组织粘合剂，微粒栓塞装置或化学治疗剂，组织或用于在减少血液流动测试的类型期间暂时闭塞血管。本发明还包括将装置引入人体内的方法。

64. 发明授权

US5718711A Ultrasoft embolism devices and process for using them 失效
标题翻译：超声波栓塞装置及其使用过程
公开(公告)号：US5718711A
公开(公告)日：1998-02-17
申请号：US436282
申请日：1995-05-15
申请人： Alejandro Berenstein , Ivan Sepetka , Uriel Hiram Chee , Wendy J. Zenzen
发明人： Alejandro Berenstein , Ivan Sepetka , Uriel Hiram Chee , Wendy J. Zenzen
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/02 , A61M25/095 , A61M25/14
CPC分类号： A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/1214 , A61B17/1215 , A61B17/12163 , A61B2017/00526 , A61B2017/00539 , A61B2017/12063 , A61B2017/1209 , A61B90/39
摘要： An exceptionally flexible, ultrasoft vaso-occlusive or embolism forming device made of a material which may be a braid, coil, or chain which forms a long, thin thread-like device having little rigidity or column strength. The device is sufficiently flexible and small that it may be hydraulically delivered to a site within the vasculature of a human body using an injected drug or fluid flush through a catheter.
摘要翻译： PCT No.PCT / US93 / 09914 Sec。 371日期：1996年4月26日 102（e）日期1996年4月26日PCT提交1993年10月15日PCT公布。出版物WO94 / 10936 PCT 日期1994年5月26日一种非常灵活的超软血管闭塞或栓塞形成装置，其由可能是编织物，线圈或链的材料制成，其形成具有很小刚度或柱强度的长而细的线状装置。该装置具有足够的柔性和小度，使得其可以使用注射的药物或通过导管冲洗的流体液压递送到人体脉管系统内的部位。

65. 发明授权

US5228453A Catheter guide wire 失效
标题翻译：导管导丝
公开(公告)号：US5228453A
公开(公告)日：1993-07-20
申请号：US952206
申请日：1992-09-28
申请人： Ivan Sepetka
发明人： Ivan Sepetka
IPC分类号： A61M25/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09166 , A61M2025/09175 , A61M25/0054
摘要： A catheter guide wire comprising: a flexible, torqueable proximal wire section, a more flexible intermediate section with a flexible polymer tube covering, and a most flexible distal end section. A helical ribbon coil is wrapped about the intermediate core segment between the wire core and the polymer tube covering to increase radiopacity and improve torque transmission while retaining flexibility.
摘要翻译：导管导丝，其包括：柔性的，可扭转的近侧线段，具有柔性聚合物管覆盖的更柔性的中间部分和最柔性的远端部分。螺旋带状线圈围绕中心芯段缠绕在线芯和聚合物管覆盖物之间以增加不透射线性，并且在保持柔性的同时提高转矩传递。

66. 发明授权

US08409215B2 Systems, methods and devices for removing obstructions from a blood vessel 有权
公开(公告)号：US08409215B2
公开(公告)日：2013-04-02
申请号：US12583599
申请日：2009-08-20
申请人： Ivan Sepetka , Emily Vu , Dan Nguyen , John Miller , Ryan Pierce , Tiffany Tran Ngo , Norman Fung
发明人： Ivan Sepetka , Emily Vu , Dan Nguyen , John Miller , Ryan Pierce , Tiffany Tran Ngo , Norman Fung
IPC分类号： A61B17/22
CPC分类号： A61B17/22031 , A61B17/221 , A61B17/320725 , A61B18/1492 , A61B2017/00287 , A61B2017/22034 , A61B2017/22035 , A61B2017/22067 , A61B2017/2212 , A61B2017/2217 , A61B2017/320716 , A61B2018/00214 , A61B2018/00898
摘要： Devices and methods for removing an obstruction from a blood vessel are described. The devices are deployed in a collapsed condition and are then expanded within the body. The devices are then manipulated to engage and remove the obstruction.

67. 发明申请

US20110230830A1 METHODS AND DEVICES FOR PROTECTING A PASSAGEWAY IN A BODY WHEN ADVANCING DEVICES THROUGH THE PASSAGEWAY 审中-公开
标题翻译：在通过通讯方式提升设备时保护身体的方法和设备
公开(公告)号：US20110230830A1
公开(公告)日：2011-09-22
申请号：US13149886
申请日：2011-05-31
申请人： Hanson S. Gifford, III , Ivan Sepetka , Mark E. Deem , Douglas S. Sutton , Allan R. Will , Martin S. Dieck , Sunmi Chew
发明人： Hanson S. Gifford, III , Ivan Sepetka , Mark E. Deem , Douglas S. Sutton , Allan R. Will , Martin S. Dieck , Sunmi Chew
IPC分类号： A61M25/10
CPC分类号： A61F2/07 , A61F2/0095 , A61F2/013 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2/97 , A61F2002/018 , A61F2002/061 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2002/9511 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/0078 , A61F2250/0098
摘要： A liner is advanced through a narrowed region in a vessel such as the internal carotid artery. The liner is advanced through the narrowed region in a collapsed position. A stent is then advanced through the liner and expanded to open the narrowed region. The liner may also have an anchor, which expands an end of the liner before the stent is introduced.
摘要翻译：衬垫穿过诸如颈内动脉的血管中的狭窄区域前进。衬里在折叠位置前进通过狭窄区域。然后将支架推进穿过衬垫并膨胀以打开变窄的区域。衬垫还可以具有锚固件，其在引入支架之前扩张衬套的端部。

68. 发明授权

US07727243B2 Systems, methods and devices for removing obstructions from a blood vessel 失效
公开(公告)号：US07727243B2
公开(公告)日：2010-06-01
申请号：US11046563
申请日：2005-01-28
申请人： Ivan Sepetka , Emily Vu , Dan Nguyen , John Miller , Ryan Pierce , Tiffany Tran Ngo , Norman Fung
发明人： Ivan Sepetka , Emily Vu , Dan Nguyen , John Miller , Ryan Pierce , Tiffany Tran Ngo , Norman Fung
IPC分类号： A61B17/22
CPC分类号： A61B17/22031 , A61B17/221 , A61B17/320725 , A61B18/1492 , A61B2017/22034 , A61B2017/2217 , A61B2017/320716 , A61B2018/00214 , A61B2018/00898
摘要： Devices and methods for removing an obstruction from a blood vessel are described. The devices are deployed in a collapsed condition and are then expanded within the body. The devices are then manipulated to engage and remove the obstruction.

69. 发明申请

US20090318941A1 Self-Expandable Endovascular Device For Aneurysm Occlusion 审中-公开
标题翻译：用于动脉瘤闭塞的自扩张血管内装置
公开(公告)号：US20090318941A1
公开(公告)日：2009-12-24
申请号：US12294210
申请日：2007-03-23
申请人： Ivan Sepetka , Maria G. Aboytes , Hong Thu Doan , Ricardo Aboytes , Steven Hochberg , Peter Costantino , Craig F. Friedman , Arindam Datta
发明人： Ivan Sepetka , Maria G. Aboytes , Hong Thu Doan , Ricardo Aboytes , Steven Hochberg , Peter Costantino , Craig F. Friedman , Arindam Datta
IPC分类号： A61B17/08 , A61M25/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12172 , A61B17/12181 , A61B90/39 , A61B2017/00526 , A61B2017/00867 , A61B2017/00893 , A61B2017/12095
摘要： The self-expandable endovascular apparatus for aneurysm occlusion of the invention comprises a deformable shape memory frame with at least a partial segment covering comprised of a matrix implant material. The device can be folded and/or stretched to adopt a narrow profile for loading into a coaxial delivery device and expands in place as it adopts its original shape on release from the device into an aneurysm. A method of treating an aneurysm, comprises the steps of: (a) providing the self-expandable endovascular apparatus inserted into a lumen of a delivery device comprising a proximal end and a distal end, the distal end having a distal tip; (b) advancing the distal tip of the delivery device into an opening in an aneurysm having an interior sac; (c) advancing the apparatus through the lumen into the opening; and (d) withdrawing the delivery device, whereby the apparatus expands into the sac and covers the opening.
摘要翻译：本发明的用于动脉瘤闭塞的自扩张型血管内装置包括具有由基质植入材料构成的至少部分段覆盖物的可变形形状记忆框架。该装置可以被折叠和/或拉伸以采用窄的轮廓以装载到同轴输送装置中，并且在从装置释放到动脉瘤中时采用其原始形状而扩展就位。一种治疗动脉瘤的方法，包括以下步骤：（a）提供插入到包括近端和远端的输送装置的内腔中的自扩张型血管内装置，所述远端具有远端; （b）将输送装置的远端前进到具有内囊的动脉瘤的开口中; （c）使设备通过内腔进入开口; 和（d）取出输送装置，从而使装置膨胀成囊并覆盖开口。

70. 再颁专利

USRE41029E1 Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas 有权
标题翻译：动脉，静脉，动脉瘤，血管畸形和动静脉瘘中血栓形成的血管内电解可分离线和尖端
公开(公告)号：USRE41029E1
公开(公告)日：2009-12-01
申请号：US11377895
申请日：2006-03-15
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/04 , A61B17/12 , A61B18/14 , A61B18/12 , A61B17/00
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B18/1402 , A61B18/1492 , A61B90/39 , A61B2017/00292 , A61B2017/12054 , A61B2017/12063 , A61B2017/12095 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61M2025/09175
摘要： An artery, vein, aneurysms vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.REEAXMINATION RESULTS The questions raised in reexamination request 90/007,231, filed Oct. 4, 2004 have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CFR 1.570(e), for ex parte reexaminations, or the reexamination certificate required by 35 U.S.C. 316 as provided in 37 CFR 1.99(e) for inter partes reexaminations.
摘要翻译：动脉，静脉，动脉瘤血管畸形或动脉瘘通过血管内插入铂丝和/或尖端进入血管腔而通过血管内闭塞而闭塞。血管腔填充有尖端以阻止血液流动或进入腔中的血液，使得腔中的血块凝块和形成闭塞。尖端可以是细长的和柔性的，使得其通过在其自身上折叠多次来包装空腔，或者可以通过尖端的丝状或模糊结构来包装空腔。然后将尖端机械地从线分离，或者通过电极将电极与线分离。之后取出线和微导管，留下尖端嵌入形成在血管腔内的血栓。通过在微导管上提供不透射线的近端标记物和线上的相应指示标记，更容易跟踪导线在微导管中的移动。通过将接地电极放置在微导管的远端并在微导管电极和尖端之间流动电流来促进血栓形成。审议结果2004年10月4日提交的复审请求90 / 007,231中提出的问题已被考虑，其结果反映在该重新颁发专利中，该专利构成了35U.S.C.所要求的复审证书。根据第37 CFR 1.570（e）条规定，单方面复审或35 U.S.C.所要求的复审证书。 316，如第37 CFR 1.99（e）条所述，用于跨部门复审。

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