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61. 发明授权

US08014863B2 Heart attack or ischemia detector 有权
标题翻译：心脏病发作或缺血检测仪
公开(公告)号：US08014863B2
公开(公告)日：2011-09-06
申请号：US11625045
申请日：2007-01-19
申请人： Yi Zhang , Richard Fogoros , Julie Thompson , Bruce H. KenKnight , Michael J. Pederson , Abhilash Patangay , Tamara Colette Baynham , Yatheendhar D. Manicka , Scott T. Mazar
发明人： Yi Zhang , Richard Fogoros , Julie Thompson , Bruce H. KenKnight , Michael J. Pederson , Abhilash Patangay , Tamara Colette Baynham , Yatheendhar D. Manicka , Scott T. Mazar
IPC分类号： A61B5/02
CPC分类号： A61N1/365 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/0452 , A61B5/053 , A61B5/7203 , A61B7/023 , A61N1/36521 , A61N1/36542 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： A system including an implantable trigger event detector and an implantable ischemia detector. The implantable trigger event detector is adapted to detect at least one first condition and to output a responsive trigger signal including information about whether the first condition has been detected. The implantable ischemia detector is adapted to detect a second condition indicative of one or more physiologic cardiovascular events in a subject that are indicative of ischemia. The ischemia detector is coupled to the trigger event detector to receive the trigger signal, and the ischemia detector is enabled upon the trigger signal indicating that the first condition has been detected.
摘要翻译：一种包括可植入触发事件检测器和可植入缺血检测器的系统。可植入触发事件检测器适合于检测至少一个第一状态并输出包括关于是否检测到第一条件的信息的响应触发信号。可植入缺血检测器适于检测指示受试者中指示缺血的一种或多种生理性心血管事件的第二状态。缺血检测器耦合到触发事件检测器以接收触发信号，并且在触发信号指示已经检测到第一条件的情况下启用缺血检测器。

62. 发明申请

US20090228058A1 IMPLANTABLE MEDICAL DEVICE WITH VOICE RESPONDING AND RECORDING CAPACITY 有权
标题翻译：具有语音响应和记录能力的可植入医疗设备
公开(公告)号：US20090228058A1
公开(公告)日：2009-09-10
申请号：US12468648
申请日：2009-05-19
申请人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
发明人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
IPC分类号： A61N1/08 , A61N1/39
CPC分类号： A61N1/37217 , A61N1/3625 , A61N1/3627 , A61N1/37247
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.
摘要翻译：一种可植入医疗装置，例如心脏起搏器或植入式心律转复除颤器，具有以患者所说话语的形式接收通信的能力。声学换能器结合在该装置内，连同相关联的滤波电路使声音通信能够用于影响装置的操作或被记录以供稍后播放。

63. 发明申请

US20080234776A1 Demand-based cardiac function therapy 有权
公开(公告)号：US20080234776A1
公开(公告)日：2008-09-25
申请号：US12154746
申请日：2008-05-27
申请人： Bruce H. KenKnight , Qingsheng Zhu
发明人： Bruce H. KenKnight , Qingsheng Zhu
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A method and device for delivering cardiac function therapy on a demand basis. An implantable device for delivering cardiac function therapy is programmed to suspend such therapy at periodic intervals or upon command from an external programmer. Measurements related to hemodynamic performance are then taken using one or more sensing modalities incorporated into the device. Based upon these measurements, the device uses a decision algorithm to determine whether further delivery of the cardiac function therapy is warranted.

64. 发明授权

US07203540B2 Method and system for setting cardiac resynchronization therapy parameters 有权
标题翻译：设置心脏再同步治疗参数的方法和系统
公开(公告)号：US07203540B2
公开(公告)日：2007-04-10
申请号：US10744237
申请日：2003-12-22
申请人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
发明人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.
摘要翻译：提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

65. 发明授权

US06648881B2 Method for reducing arterial restenosis in the presence of an intravascular stent 失效
标题翻译：在血管内支架存在下减少动脉再狭窄的方法
公开(公告)号：US06648881B2
公开(公告)日：2003-11-18
申请号：US09940337
申请日：2001-08-27
申请人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
发明人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
IPC分类号： A61B1804
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
摘要翻译：第一电极位于植入的血管内支架附近的动脉内。第二电极相对于第一电极的位置定位在单独的位置。然后在第一和第二电极之间传递电能，以产生邻近植入的血管内支架的电场。当将血管内支架植入冠状动脉中时，电能的传递与在感测到的心脏信号中检测到的心脏周期协调，其中第一电极和第二电极之间的电能的传递发生在第一电极和第二电极的预定部分期间心动周期。

66. 发明授权

US06640135B1 Apparatus and method for spatially and temporally distributing cardiac electrical stimulation 有权
标题翻译：空间和时间分布心脏电刺激的装置和方法
公开(公告)号：US06640135B1
公开(公告)日：2003-10-28
申请号：US09544363
申请日：2000-04-06
申请人： Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
发明人： Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
IPC分类号： A61N1368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译：一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力。为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。

67. 发明授权

US06519488B2 Method and system for reducing arterial restenosis in the presence of an intravascular stent 失效
公开(公告)号：US06519488B2
公开(公告)日：2003-02-11
申请号：US09940336
申请日：2001-08-27
申请人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
发明人： Bruce H. KenKnight , Jay A. Warren , Stephen John Hahn
IPC分类号： A61B504
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.

68. 发明授权

US06453201B1 Implantable medical device with voice responding and recording capacity 有权
公开(公告)号：US06453201B1
公开(公告)日：2002-09-17
申请号：US09473466
申请日：1999-12-28
申请人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
发明人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
IPC分类号： A61N1362
CPC分类号： A61N1/37217 , A61N1/3625 , A61N1/3627 , A61N1/37247
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.

69. 发明授权

US06251125B1 Method and apparatus for treating ventricular fibrillation using electrogram features 失效
标题翻译：使用电描记图特征治疗心室颤动的方法和装置
公开(公告)号：US06251125B1
公开(公告)日：2001-06-26
申请号：US09053115
申请日：1998-04-01
申请人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
发明人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
IPC分类号： A61N139
CPC分类号： A61N1/3962
摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.
摘要翻译：通过以提高除颤休克成功概率的方式协调将感染的心室颤动复合物递送除颤电击的心室除颤的方法和系统。在心室纤维性颤动期间，在两个心室位置监测心室电活动，以检测心室心脏组织的粗略心室颤动复合物和收缩。伴随发生粗心室颤动复合物和心室心脏组织的收缩，特别是在其上坡部分发生除颤休克，以获得最佳的成功概率。

70. 发明授权

US06168801A Controlled release drug delivery 有权
标题翻译：控制释放药物递送
公开(公告)号：US06168801A
公开(公告)日：2001-01-02
申请号：US09272428
申请日：1999-03-19
申请人： Ronald W. Heil, Jr. , Bruce H. KenKnight
发明人： Ronald W. Heil, Jr. , Bruce H. KenKnight
IPC分类号： A61F202
CPC分类号： A61K9/0024
摘要： Biologically active materials are provided in a cylindrical carrier medium with better control over the rate of delivery and length of time of delivery by providing a carrier having dissolved or dispersed therein at least two compounds having a common biologically active nucleus, but with different solubility parameters. The combination of the two different variants of the same drug with different solubility parameters provides the material with control over the rate of release of the compounds (by varying the proportions of the variants) and most importantly, extending the useful life of the device by enabling release of effective levels of the compounds over a longer period of time. The cylindrical carrier medium, comprised of silicone, further includes a tail, a skirt, or a rate-limiting membrane.
摘要翻译：生物活性材料提供在圆柱形载体介质中，通过提供具有溶解或分散在其中的至少两种具有共同的生物活性核，但具有不同溶解度参数的化合物的载体，可以更好地控制输送速率和输送时间。具有不同溶解度参数的相同药物的两种不同变体的组合提供了材料对化合物释放速率的控制（通过改变变体的比例），最重要的是通过使得能够延长器件的使用寿命在更长的时间内释放有效含量的化合物。由硅树脂构成的圆柱形载体介质还包括尾部，裙部或限速膜。

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