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1. 发明授权

US06795733B1 Methods and systems for automatically determining minute ventilation 有权
标题翻译：自动确定分钟通气的方法和系统
公开(公告)号：US06795733B1
公开(公告)日：2004-09-21
申请号：US10103605
申请日：2002-03-21
申请人： Richard Lu
发明人： Richard Lu
IPC分类号： A61N1368
CPC分类号： A61B5/0538 , A61B5/0535 , A61B5/0809 , A61N1/05 , A61N1/36185 , A61N1/36521 , A61N1/3686
摘要： Methods and systems for switching electrode configurations for measuring the transthoracic impedance of patient are described. Various embodiments provide stimulation devices and methods that can automatically adapt to different minute ventilation electrode configurations. This, in turn, permits minute ventilation functionality to continue, e.g. rate-responsive pacing, in spite of the fact that an electrode configuration has changed. Accordingly, minute ventilation functionality can automatically continue in a adaptive manner when a previously-available electrode configuration is no longer available for minute ventilation functionality.
摘要翻译：描述用于切换测量患者经胸阻抗的电极配置的方法和系统。各种实施例提供可以自动适应不同的分钟通气电极配置的刺激装置和方法。这反过来又允许分钟通气功能继续，例如。速率响应起搏，尽管电极配置已经改变。因此，当先前可用的电极配置不再可用于分钟通气功能时，分钟通气功能可以以自适应的方式自动继续。

2. 发明授权

US06760619B1 Two lead universal defibrillation, pacing and sensing system 失效
标题翻译：双引线通用除颤，起搏和感应系统
公开(公告)号：US06760619B1
公开(公告)日：2004-07-06
申请号：US09945449
申请日：2001-08-31
申请人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
发明人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1368
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3918 , A61N1/395
摘要： An implantable cardiac stimulation system senses electrical activity of all four chambers of the heart and delivers pacing and defibrillation pulses to all four chambers of the heart. The system includes a lead system consisting of first and second leads. The first lead includes a right ventricular pacing electrode, a right ventricular defibrillation electrode, and a right atrial defibrillation lead. The second lead is implantable in the coronary sinus of the heart and includes a left ventricular pacing electrode, a left ventricular defibrillation electrode, a left atrial pacing electrode, and a left atrial defibrillation electrode. A right atrial pacing electrode is carried by one of the first and second leads. The system further includes a cardiac stimulation device including a pulse generator that delivers defibrillation pulses between any combination of the defibrillation electrodes and pacing pulses to any one of the pacing electrodes and a sensing circuit that senses cardiac electrical activity with any one of the pacing electrodes.
摘要翻译：植入式心脏刺激系统感测心脏的所有四个腔室的电活动，并将心脏起搏和除颤脉冲输送到心脏的所有四个腔室。该系统包括由第一和第二引线组成的引导系统。第一个引线包括右心室起搏电极，右心室除颤电极和右心房除颤引线。第二引线可植入心脏的冠状窦内，包括左心室起搏电极，左心室除颤电极，左心房起搏电极和左心房除颤电极。右心房起搏电极由第一和第二引线之一承载。该系统还包括心脏刺激装置，其包括脉冲发生器，该脉冲发生器将除颤电极和起搏脉冲的任何组合之间的除颤脉冲传送到任何一个起搏电极，以及感测电路，其用任何一个起搏电极感测心脏电活动。

3. 发明授权

US06748268B1 Three lead universal pacing and shocking system 失效
标题翻译：三主控通用起搏和震动系统
公开(公告)号：US06748268B1
公开(公告)日：2004-06-08
申请号：US09945079
申请日：2001-08-31
申请人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
发明人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1368
CPC分类号： A61N1/0563 , A61N1/3918 , A61N1/395 , A61N2001/0585
摘要： A three lead implantable cardiac stimulation system is capable of delivering stimulation pulses to any one chamber or combination of chambers of a heart. The system includes a first lead for implant in the right ventricle and having a right ventricular defibrillation electrode, a second lead for implant in the coronary sinus and having a left ventricular defibrillation electrode, and a third lead for implant in the coronary sinus and having a left atrial defibrillation electrode. One of the leads further including a right atrial defibrillation electrode for placement in one of the right atrium and superior vena cava. The system further includes an implantable cardiac stimulation device including a programmable pulse generator that delivers defibrillation pulses to any one of the defibrillation electrodes or to any combination of the defibrillation electrodes. The leads may further provide at least one pacing electrode for each chamber of the heart and the device is programmable to provide pacing pulses to any one of the pacing electrodes.
摘要翻译：三引线可植入心脏刺激系统能够将刺激脉冲输送到心脏的任何一个腔室或腔室的组合。该系统包括用于植入右心室并具有右心室除颤电极的第一引线，用于在冠状窦内植入并具有左心室除颤电极的第二引线和用于植入在冠状窦中的第三引线，并具有左心房除颤电极。其中一个引线还包括右心房除颤电极，用于放置在右心房和上腔静脉中的一个。该系统还包括可植入心脏刺激装置，其包括将除颤脉冲输送到除颤电极中的任何一个或除颤电极的任何组合的可编程脉冲发生器。引线还可以为心脏的每个腔室提供至少一个起搏电极，并且该装置可编程以将起搏脉冲提供给任何一个起搏电极。

4. 发明授权

US06609027B2 His Bundle sensing device and associated method 有权
标题翻译：他的捆绑传感装置及相关方法
公开(公告)号：US06609027B2
公开(公告)日：2003-08-19
申请号：US09793640
申请日：2001-02-23
申请人： Mark W. Kroll , John R. Helland
发明人： Mark W. Kroll , John R. Helland
IPC分类号： A61N1368
CPC分类号： A61N1/3627 , A61N1/368
摘要： A cardiac stimulation device, a His Bundle lead, and an associated method for detecting a conduction signal from the His Bundle. Upon this detection, the stimulation device delivers ventricular stimulation to the right and/or left ventricles at an interval following the atrial depolarization. A sensing window is initiated following the sensing of the atrial depolarization. During the sensing windows, the His Bundle signal received through the His Bundle lead is sampled and a moving average is calculated to determine a signal peak. Detection of the His Bundle signal peak triggers ventricular stimulation, which may be delivered to the right ventricle, the left ventricle, or both ventricles.
摘要翻译：心脏刺激装置，His束引线，以及用于检测来自His束的传导信号的相关方法。在这种检测中，刺激装置在心房去极化之后的间隔向右心室和/或左心室递送心室刺激。在感觉到心房去极化之后启动感测窗口。在感测窗口期间，通过His Bundle引线接收的His Bundle信号被采样，并计算移动平均线以确定信号峰值。 His Bundle信号峰的检测触发心室刺激，可以将其传送到右心室，左心室或两个脑室。

5. 发明授权

US06606516B2 System and method for programmably controlling stimulation electrode configurations and activation sequence in a multi-site cardiac stimulation device 有权
公开(公告)号：US06606516B2
公开(公告)日：2003-08-12
申请号：US09904159
申请日：2001-07-11
申请人： Paul A. Levine
发明人： Paul A. Levine
IPC分类号： A61N1368
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3918
摘要： An implantable multi-chamber cardiac stimulation device includes flexibly programmable electrode stimulation configurations, and is capable of precisely controlling the stimulation sequence between multiple sites. The stimulation device provides a plurality of connection ports that allow independent connection of each electrical lead associated with a particular stimulation site in the heart. Each connection port further provides a unique terminal for making electrical contact with only one electrode such that no two electrodes are required to be electrically coupled. Furthermore, each electrode, whether residing on a unipolar, bipolar or multipolar lead, may be selectively connected or disconnected through programmable switching circuitry that determines the electrode configurations to be used for sensing and for stimulating at each stimulation site. The stimulation device possesses unique sensing and output configurations associated with each stimulation site, such that depolarizations occurring at each stimulation site can be detected independently of events occurring at other sites within the heart, and such that each site can be stimulated independently of other sites or on a precisely timed basis triggered by events occurring at other sites. The stimulation device is further capable of uniquely programming coupling intervals for precisely controlling the activation sequence of stimulated sites. Coupling intervals are selected so as to provide optimal hemodynamic benefit to the patient.

6. 发明授权

US06424865B1 Ventricular conduction delay trending system and method 有权
公开(公告)号：US06424865B1
公开(公告)日：2002-07-23
申请号：US09615588
申请日：2000-07-13
申请人： Jiang Ding
发明人： Jiang Ding
IPC分类号： A61N1368
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/365
摘要： A method and system for ascertaining the condition of the heart's conduction system in a patient treated for congestive heart failure with pacing therapy. In accordance with the invention, changes in ventricular activation patterns are monitored over time in order to detect changes in the heart's conduction system that may occur due to physiological regeneration of conduction pathways. The activation patterns are reflected by electrogram signals detected from different ventricular locations. By measuring the difference in conduction times of an excitation impulse traveling from the AV node to the different ventricular locations, a parameter representative of the heart's conduction system is obtained that may be used to adjust the pacing therapy in accordance therewith.

7. 发明授权

US06363278B1 Cardiac rhythm management system with staggered pulses for coordination therapy 有权
公开(公告)号：US06363278B1
公开(公告)日：2002-03-26
申请号：US09549862
申请日：2000-04-14
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Julio C. Spinelli
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1368
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3716
摘要： A cardiac rhythm management system for coordination therapy includes a pulse generator to generate pacing and discharging of recharge pulses. A pulse delivery controller coupled to the pulse generator, times the delivery of the pacing and discharging of recharge pulses in a desired sequence. A therapy circuit coupled to the pulse delivery controller, receives the timed pulses from the pulse delivery controller and delivers the timed pulses to one or more electrodes disposed in or around a heart to communicate the timed pacing and discharging of recharge pulses to different sites of a heart, to avoid any interactions resulting from the electric fields surrounding the electrodes during a multiple site pacing required by the coordination therapy.

8. 发明授权

US06738669B1 System and method for multichamber cardiac stimulation with ventricular capture verification using far-field evoked response 有权
标题翻译：多室心脏刺激的系统和方法，使用远场诱发反应进行心室捕获验证
公开(公告)号：US06738669B1
公开(公告)日：2004-05-18
申请号：US10011127
申请日：2001-10-24
申请人： Laurence S. Sloman , Kerry Bradley
发明人： Laurence S. Sloman , Kerry Bradley
IPC分类号： A61N1368
CPC分类号： A61N1/3712 , A61N1/3714
摘要： An implantable cardiac stimulation device and method automatically verify capture of one or both ventricular chambers by sensing a far-field signal in both atrial chambers. A far-field interval window is set following the delivery of the ventricular stimulation, during which a far-field signal is detected and compared to a signal representing a predetermined far-field R-wave that represents successful capture of one or both ventricular chambers. If the far-field signal is approximately equal to the predetermined far-field R-wave signal, then capture is verified. If capture is not verified, a threshold search is performed in the ventricle in which capture was lost.
摘要翻译：可植入心脏刺激装置和方法通过感测两个心房中的远场信号来自动验证一个或两个心室的捕获。远场间隔窗口设置在心室刺激传递之后，在此期间，检测到远场信号，并将其与表示成功捕获一个或两个心室的成像捕获的预定远场R波的信号进行比较。如果远场信号近似等于预定的远场R波信号，则验证捕获。如果没有验证捕获，则在捕获丢失的心室中执行阈值搜索。

9. 发明授权

US06618620B1 Apparatus for controlling thermal dosing in an thermal treatment system 有权
标题翻译：用于控制热处理系统中热量计量的装置
公开(公告)号：US06618620B1
公开(公告)日：2003-09-09
申请号：US09724670
申请日：2000-11-28
申请人： David Freundlich , Jacob Vortman , Roni Yagel , Shuki Vitek , Naama Brenner
发明人： David Freundlich , Jacob Vortman , Roni Yagel , Shuki Vitek , Naama Brenner
IPC分类号： A61N1368
CPC分类号： A61N7/02 , A61B34/10 , A61B2017/00084 , A61B2090/374
摘要： A thermal treatment system including a heat applying element for generating thermal doses for ablating a target mass in a patient, a controller for controlling thermal dose properties of the heat applying element, an imager for providing preliminary images of the target mass and thermal images during the treatment, and a planner for automatically constructing a treatment plan, comprising a series of treatment sites that are each represented by a set of thermal dose properties. The planner automatically constructs the treatment plan based on input information including one or more of a volume of the target mass, a distance from a skin surface of the patient to the target mass, a set of default thermal dose prediction properties, a set of user specified thermal dose prediction properties, physical properties of the heat applying elements, and images provided by the imager. The default thermal dose prediction properties are preferably based on a type of clinical application and include at least one of thermal dose threshold, thermal dose prediction algorithm, maximum allowed energy for each thermal dose, thermal dose duration for each treatment site, cooling time between thermal doses, and electrical properties for the heat applying element. The user specified thermal dose prediction properties preferably include at least one or more of overrides for any default thermal dose prediction properties, treatment site grid density; and thermal dose prediction properties not specified as default thermal dose prediction properties from the group comprised of thermal dose threshold, thermal dose prediction algorithm, maximum allowed energy for each thermal dose, thermal dose duration for each treatment site cooling time between thermal doses, and electrical properties for the heat applying element.
摘要翻译：一种热处理系统，包括用于产生热剂量以消除患者中的目标物质的热施加元件，用于控制加热元件的热剂量特性的控制器，用于在所述加热元件期间提供目标物质的预备图像和热图像的成像器治疗和用于自动构建治疗计划的计划者，其包括由一组热剂量特性表示的一系列治疗部位。计划者根据输入信息自动构建治疗计划，该输入信息包括一个或多个目标质量体积，从患者皮肤表面到目标质量的距离，一组默认热剂量预测属性，一组用户指定的热剂量预测性质，热施加元件的物理特性和由成像器提供的图像。默认的热剂量预测性质优选地基于一种临床应用，并且包括热剂量阈值，热剂量预测算法，每个热剂量的最大允许能量，每个治疗部位的热剂量持续时间，热量之间的冷却时间剂量和电气性能。用户指定的热剂量预测性质优选包括用于任何默认热剂量预测性质，治疗部位网格密度的至少一个或多个覆盖; 和热剂量预测性质未被指定为由热剂量阈值，热剂量预测算法，每个热剂量的最大允许能量，热剂量之间的每个处理部位冷却时间的热剂量持续时间和电热量的预定热剂量预测性质热施加元件的特性。

10. 发明授权

US06587721B1 Trigger-based regulation of excitable tissue control of the heart 有权
标题翻译：基于触发的心脏可兴奋组织控制的调节
公开(公告)号：US06587721B1
公开(公告)日：2003-07-01
申请号：US09831282
申请日：2001-09-10
申请人： David Prutchi , Yuval Mika , Ziv Belsky
发明人： David Prutchi , Yuval Mika , Ziv Belsky
IPC分类号： A61N1368
CPC分类号： A61N1/362 , A61N1/3627 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： A method and apparatus for modifying contractility of heart tissue. The method includes applying electrodes (34, 35, 38) to one or more sites in the heart (20) and making a determination at which of the sites, if any, to pace the heart. A parameter of an excitable tissue control (ETC) signal (50, 60) to be applied to the heart is set responsive to the determination, and the ETC signal is applied to at least one of the electrodes responsive to the parameter, so as to enhance contractility of the heart.
摘要翻译：一种改善心脏组织收缩性的方法和装置。该方法包括将电极（34,35,38）施加到心脏（20）中的一个或多个部位，并确定哪个部位（如果有的话）能够调节心脏。响应于该确定设置要施加到心脏的可兴奋组织控制（ETC）信号（E，F）信号（50,60）的参数，并且响应于参数将ETC信号施加到至少一个电极，以便增强心脏的收缩性。

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