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61. 发明申请

WO2007133710A3 MICROFLUIDIC DEVICES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2007133710A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/011462
申请日：2007-05-11
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
IPC分类号： B01F13/00 , B01J19/00 , B01L3/00 , G01N15/14 , G01N33/50
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

62. 发明申请

WO2007133710A2 MICROFLUIDIC DEVICES AND METHODS OF USE THEREOF 审中-公开
标题翻译：微流体装置及其使用方法
公开(公告)号：WO2007133710A2
公开(公告)日：2007-11-22
申请号：PCT/US2007011462
申请日：2007-05-11
申请人： RAINDANCE TECHNOLOGIES INC , LINK DARREN R , WEINER MICHAEL , MARREN DAVID , ROTHBERG JONATHAN M
发明人： LINK DARREN R , WEINER MICHAEL , MARREN DAVID , ROTHBERG JONATHAN M
IPC分类号： B01F13/00 , B01J19/00 , B01L3/00 , G01N15/14 , G01N33/50
CPC分类号： B01F3/0807 , B01F13/0062 , B01J19/0093 , B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/565 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/086 , B03C5/005 , B03C5/026 , C12N15/1068 , C12N15/1086 , C12Q1/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6844 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/628 , C12Q2565/629 , G01N15/147 , G01N21/05 , G01N21/64 , G01N27/3275 , G01N35/08 , G01N2021/0346 , G01N2035/00237 , G01N2035/00326 , G01N2201/024 , Y10T137/87571 , Y10T137/87619 , Y10T137/87652 , C12Q2525/191 , C12Q2563/159 , C12Q2535/101 , C12Q2563/149
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了可用于进行生物学，化学和诊断测定的新型微流体底物和方法。基板可以包括多个可电寻址的通道支承流体模块，其一体地布置成使得提供用于不混溶流体流动的连续通道。

63. 发明申请

WO2014172288A2 DIGITAL ANALYTE ANALYSIS 审中-公开
标题翻译：数字分析分析
公开(公告)号：WO2014172288A2
公开(公告)日：2014-10-23
申请号：PCT/US2014/034037
申请日：2014-04-14
申请人： RAINDANCE TECHNOLOGIES, INC.
发明人： LINK, Darren, Roy , MILLER, Benjamin
IPC分类号： C12Q1/68
CPC分类号： G01N35/085 , B01L3/502784 , C12Q1/686 , C12Q2537/143 , C12Q2563/159 , C12Q2565/102 , C12Q2565/629
摘要： The invention generally relates to detecting target molecules.
摘要翻译：本发明一般涉及检测靶分子。

64. 发明申请

WO2013165748A1 DIGITAL ANALYTE ANALYSIS 审中-公开
标题翻译：数字分析分析
公开(公告)号：WO2013165748A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/037751
申请日：2013-04-23
申请人： RAINDANCE TECHNOLOGIES, INC
发明人： HUTCHISON, John, Brian , OLSON, Jeffrey, Charles , LINK, Darren, Roy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/686 , C12Q2563/107 , C12Q2563/159 , C12Q2535/122
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided. In one aspect, the invention provides a droplet that contains a single nucleic acid template and a plurality of primer pairs specific for multiple target sites on the template. The single nucleic acid template can be DNA or RNA. The template is amplified in the droplet for detection; and may preferably be amplified using a plurality of primer pairs as described herein. The ability to amplify and detect single nucleic acids in droplets enables digital PCR, detection, counting, and differentiation among nucleic acids, especially those present in heterogeneous samples. Thus, the invention applies to digital amplification techniques and, in specific embodiments enables multiplex PCR in droplets.
摘要翻译：本发明一般涉及基于液滴的数字PCR和使用其进行目标核酸分析的方法。在某些实施方案中，提供了用于测定样品的核酸组成的方法。在一个方面，本发明提供了包含单一核酸模板和对模板上多个靶位点特异的多个引物对的液滴。单个核酸模板可以是DNA或RNA。模板在液滴中被放大以便检测; 并且优选地可以使用如本文所述的多个引物对来扩增。在液滴中扩增和检测单个核酸的能力使得能够在核酸之间进行数字PCR，检测，计数和分化，特别是存在于异质样品中的核酸。因此，本发明适用于数字放大技术，并且在具体实施例中使得能够以液滴方式进行多重PCR。

65. 发明申请

WO2011079176A2 MICROFLUIDIC SYSTEMS AND METHODS FOR REDUCING THE EXCHANGE OF MOLECULES BETWEEN DROPLETS 审中-公开
标题翻译：微量流动系统和减少双歧杆菌分子交换的方法
公开(公告)号：WO2011079176A2
公开(公告)日：2011-06-30
申请号：PCT/US2010/061741
申请日：2010-12-22
申请人： RAINDANCE TECHNOLOGIES, INC. , UNIVERSITY OF STRASBOURG , KLEINSCHMIDT, Felix , GRIFFITHS, Andrew, D. , CARON, François , EL HARRAK, Abdeslam , BROUZES, Eric , LINK, Darren
发明人： KLEINSCHMIDT, Felix , GRIFFITHS, Andrew, D. , CARON, François , EL HARRAK, Abdeslam , BROUZES, Eric , LINK, Darren
IPC分类号： G01N35/08 , G01N33/48
CPC分类号： G01N1/38 , B01L3/502761 , B01L3/502784 , B01L7/52 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0424 , B01L2400/0469 , B01L2400/086 , C12M25/01 , G01N15/1459 , G01N33/5302 , G01N2015/1006 , G01N2015/149
摘要： The present invention generally relates to systems and methods to create stable emulsions with low rates of exchange of molecules between microdroplets.
摘要翻译：本发明一般涉及在微滴之间产生低分子交换速率的稳定乳液的系统和方法。

66. 发明申请

WO2011042564A1 LABELLED SILICA-BASED NANOMATERIAL WITH ENHANCED PROPERTIES AND USES THEREOF 审中-公开
标题翻译：具有增强性能的标记二氧化硅基纳米材料及其用途
公开(公告)号：WO2011042564A1
公开(公告)日：2011-04-14
申请号：PCT/EP2010/065188
申请日：2010-10-11
申请人： UNIVERSITE DE STRASBOURG , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , RAINDANCE TECHNOLOGIES, Inc. , EL HARRAK, Abdeslam , GOUST, Victoire , GRIFFITHS, Andrew David , MANGEAT, Thomas
发明人： EL HARRAK, Abdeslam , GOUST, Victoire , GRIFFITHS, Andrew David , MANGEAT, Thomas
IPC分类号： G01N33/543 , G01N33/58 , G01N33/552
CPC分类号： G01N33/54346 , G01N33/552 , G01N33/582 , Y10T428/2993
摘要： The present invention relates to labelled silica-based nanoparticles with enhanced properties, to process for preparing them and to uses thereof.
摘要翻译：本发明涉及具有增强性能的标记二氧化硅基纳米颗粒，其制备方法及其应用。

67. 发明申请

WO2014165762A1 RARE CELL ANALYSIS AFTER NEGATIVE SELECTION 审中-公开
标题翻译：负面选择后的稀有细胞分析
公开(公告)号：WO2014165762A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/032983
申请日：2014-04-04
申请人： RAINDANCE TECHNOLOGIES, INC.
发明人： SAMUELS, Michael , LINK, Darren, R.
IPC分类号： C12Q1/68 , C12Q1/00
CPC分类号： C12N15/1075 , C12Q1/6806 , C12Q2563/159
摘要： The invention generally relates to rare cell analysis after negative selection.
摘要翻译：本发明一般涉及阴性选择后的稀有细胞分析。

68. 发明申请

WO2014165559A2 SYSTEMS AND METHODS FOR HANDLING MICROFLUIDIC DROPLETS 审中-公开
标题翻译：用于处理微流感滴液的系统和方法
公开(公告)号：WO2014165559A2
公开(公告)日：2014-10-09
申请号：PCT/US2014/032614
申请日：2014-04-02
申请人： RAINDANCE TECHNOLOGIES, INC.
发明人： LINK, Darren, R.
IPC分类号： G01N1/38 , C12Q1/68
CPC分类号： B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/028 , B01L2200/0673 , B01L2300/0645 , B01L2300/0867 , B01L2400/0487 , G01N35/085
摘要： The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel.
摘要翻译：本发明一般涉及用于从容器移动液滴的组件，其有助于液滴的收集和转移，同时最小化样品损失。在某些方面，组件包括至少一个液滴形成模块，其中模块被配置成形成由不混溶流体包围的液滴。组件还包括至少一个包括出口的室，其中室被构造成接收液滴和不混溶的流体，并且其中出口构造成仅基本上容纳液滴。组件还包括通道，其被构造成使得液滴形成模块和腔室经由通道彼此流体连通。在其他方面，组件包括多个中空构件，其中中空构件是通道，构件中构件与容器相互作用。多个中空构件包括构造成排出与容器中的液滴不混溶的流体的第一构件和构造成基本上仅从容器中滴下的第二构件。组件还包括主通道，其中第二构件与主通道流体连通。组件还包括连接到主通道的至少一个分析模块。

69. 发明申请

WO2011100604A3 DIGITAL ANALYTE ANALYSIS 审中-公开
标题翻译：数字分析分析
公开(公告)号：WO2011100604A3
公开(公告)日：2014-03-27
申请号：PCT/US2011024615
申请日：2011-02-11
申请人： RAINDANCE TECHNOLOGIES INC , LARSON JONATHAN WILLIAM , ZHONG QUN , LINK DARREN ROY
发明人： LARSON JONATHAN WILLIAM , ZHONG QUN , LINK DARREN ROY
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
摘要翻译：本发明总体上涉及基于微滴的数字PCR和使用其分析靶核酸的方法。在某些实施方案中，本发明的方法涉及形成平均含有单个靶核酸的样品液滴，扩增液滴中的靶，排除含有来自靶的扩增子的微滴和来自靶变体的扩增子，并分析靶扩增子。

70. 发明申请

WO2012045012A3 SANDWICH ASSAYS IN DROPLETS 审中-公开
标题翻译：滴灌中的三重测定
公开(公告)号：WO2012045012A3
公开(公告)日：2012-07-19
申请号：PCT/US2011054353
申请日：2011-09-30
申请人： RAINDANCE TECHNOLOGIES INC , SAMUELS MICHAEL , LINK DARREN
发明人： SAMUELS MICHAEL , LINK DARREN
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/54366 , C12Q1/6874
摘要： Methods of performing sandwich assays in droplets are disclosed. Further disclosed are methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte; separating the complexes, and detecting the complexes, thereby detecting the target analyte.
摘要翻译：公开了以液滴形式进行夹心测定的方法。进一步公开的是用于检测目标分析物的方法，其包括形成包含疑似含有目标分析物的样品的一部分和样品标识符的流体的分隔部分，具有目标标识的第一结合剂和特异性的第二结合剂在产生第一和第二结合剂与目标分析物的复合物的条件下的目标分析物; 分离复合物，检测复合物，从而检测目标分析物。

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