专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007133710A3 MICROFLUIDIC DEVICES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2007133710A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/011462
申请日：2007-05-11
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
IPC分类号： B01F13/00 , B01J19/00 , B01L3/00 , G01N15/14 , G01N33/50
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

2. 发明申请

WO2008063227A2 MICROFLUIDIC DEVICES 审中-公开
标题翻译： MICROFLUIDIC设备
公开(公告)号：WO2008063227A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/011460
申请日：2007-05-11
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
CPC分类号： B01F3/0807 , B01F13/0062 , B01J19/0093 , B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/565 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/086 , B03C5/005 , B03C5/026 , C12N15/1068 , C12N15/1086 , C12Q1/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6844 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/628 , C12Q2565/629 , G01N15/147 , G01N21/05 , G01N21/64 , G01N27/3275 , G01N35/08 , G01N2021/0346 , G01N2035/00237 , G01N2035/00326 , G01N2201/024 , Y10T137/87571 , Y10T137/87619 , Y10T137/87652 , C12Q2525/191 , C12Q2563/159 , C12Q2535/101 , C12Q2563/149 , C12Q2531/113
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了用于进行生物学，化学和诊断测定的新型微流体底物和方法。衬底可以包括多个电可寻址的，通道轴承流体模块整体布置，使得提供连续通道用于不混溶流体的流动。

3. 发明申请

WO2007081387A1 MICROFLUIDIC DEVICES, METHODS OF USE, AND KITS FOR PERFORMING DIAGNOSTICS 审中-公开
标题翻译：微流体装置，使用方法和用于执行诊断的工具
公开(公告)号：WO2007081387A1
公开(公告)日：2007-07-19
申请号：PCT/US2006/021380
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： G01N33/536 , C12Q1/68 , B01J19/00 , C07B61/00 , C07K1/04 , G01N33/68
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices, kits, and methods that are useful for performing high-throughput screening assays and diagnostics. Such diagnostic methods can include emulsifying an aqueous library of compounds with a set of uniquely dyecoded-labeled droplets in an inert fluorocarbon medium, thereby forming an interactor library, emulsifying an aqueous sample from a subject in an inert fluorocarbon medium, wherein said sample contains a compound that will react with at least one interactor molecule from the interactor library, coalescing the emulsions to form a nanoreactor, and screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, herein one or more steps are performed on a microfluidic device, which can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了用于进行高通量筛选测定和诊断的新型微流体装置，试剂盒和方法。这样的诊断方法可以包括用惰性碳氟介质中的一组独特的经编码标记的液滴乳化化合物的水性文库，从而形成相互作用文库，在惰性碳氟介质中乳化来自受试者的含水样品，其中所述样品含有将与来自相互作用文库的至少一个相互作用分子反应的化合物，聚合乳液以形成纳米反应器，并筛选纳米反应器以获得纳米反应器内容物之间所需的反应，这里，一个或多个步骤在微流体装置上进行，其可以包括整体地布置在微加工基板上的多个可电寻址的通道支承流体模块，从而为不混溶流体的流动提供连续通道。

4. 发明申请

WO2007081385A3 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 审中-公开
公开(公告)号：WO2007081385A3
公开(公告)日：2007-07-19
申请号：PCT/US2006/021280
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： G01N33/536 , C12Q1/68 , B01J19/00 , C07B61/00 , C07K1/04 , G01N33/68
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.

5. 发明申请

WO2007081386A3 MICROFLUIDIC DEVICES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007081386A3
公开(公告)日：2007-07-19
申请号：PCT/US2006/021286
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： B01L3/00 , B01F13/00 , G01N15/14
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The device can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids.

6. 发明申请

WO2005021151A1 ELECTRONIC CONTROL OF FLUIDIC SPECIES 审中-公开
标题翻译：流体物种的电子控制
公开(公告)号：WO2005021151A1
公开(公告)日：2005-03-10
申请号：PCT/US2004/027912
申请日：2004-08-27
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LINK, Darren, R. , WEITZ, David, A. , CRISTOBAL-AZKARTE, Glader , CHENG, Zhengdong , AHN, Keunho
发明人： LINK, Darren, R. , WEITZ, David, A. , CRISTOBAL-AZKARTE, Glader , CHENG, Zhengdong , AHN, Keunho
IPC分类号： B01J19/00
CPC分类号： B01L3/5027 , B01F5/0256 , B01F5/0646 , B01F5/0655 , B01F5/0682 , B01F5/0689 , B01F13/0069 , B01F13/0071 , B01F13/0074 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00862 , B01L3/0241 , B01L3/502761 , B01L3/502776 , B01L3/502784 , B01L3/502792 , B01L3/5088 , B01L2200/0636 , B01L2200/0652 , B01L2200/0673 , B01L2300/0864 , B01L2300/0867 , B01L2300/161 , B01L2400/0415 , B01L2400/0439 , B01L2400/0487 , C12Q2563/159 , C12Q2565/629 , G01N15/10 , G01N15/14 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/149 , Y10S436/807 , Y10T436/118339 , Y10T436/2525 , Y10T436/2575
摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles, etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.
摘要翻译：本发明的各个方面涉及流体物质的控制和操作，例如在微流体系统中。一方面，本发明涉及使用例如电场，机械改变，中间流体等的添加来制造由液体包围的流体液滴的系统和方法。在一些情况下，液滴可以各自具有其中的实体数量基本一致。例如，95％或更多的液滴可以各自包含相同数量的特定物种的实体。另一方面，本发明涉及用于将流体液滴分成两个液滴的系统和方法，例如通过与电场的电荷和/或偶极相互作用。本发明还涉及根据本发明另一方面的用于熔融液滴的系统和方法，例如通过电荷和/或偶极相互作用。在一些情况下，液滴的融合可引发或确定反应。在本发明的相关方面，还提供了允许在液滴内进行流体混合的系统和方法。在另一方面，本发明涉及用于分选液滴的系统和方法，例如通过使液滴移动到流体系统内的某些区域。实例包括使用电相互作用（例如电荷，偶极子等）或机械系统（例如，流体位移）来对液滴进行分类。在一些情况下，流体液滴可以以相对较高的速率进行分选，例如每秒约10个液滴或更多。本发明的另一方面提供了例如使用荧光和/或其他光学技术（例如显微镜）或诸如电介质感测的电传感技术来确定液滴或其组分的能力。

7. 发明申请

WO2004091763A2 FORMATION AND CONTROL OF FLUIDIC SPECIES 审中-公开
标题翻译：流体物种的形成与控制
公开(公告)号：WO2004091763A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/010903
申请日：2004-04-09
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LINK, Darren, R. , WEITZ, David, A. , MARQUEZ-SANCHEZ, Manuel , CHENG, Zhengdong
发明人： LINK, Darren, R. , WEITZ, David, A. , MARQUEZ-SANCHEZ, Manuel , CHENG, Zhengdong
IPC分类号： B01F13/00
CPC分类号： B01L3/502784 , B01F5/0682 , B01F13/0062 , B01F13/0071 , B01F13/0076 , B01F2215/0431 , B01J2/04 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2300/0867 , B01L2400/02 , B01L2400/0415 , B01L2400/0424 , B05B5/03 , B05B7/061
摘要： This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.
摘要翻译：本发明一般涉及用于形成和/或控制流体物质的系统和方法，以及由这些系统和方法生产的制品。在一些情况下，本发明涉及独特的流体通道，系统，控制和/或限制及其组合。在某些实施方案中，本发明允许流体流（其可以是连续的或不连续的，即液滴）以各种尺度形成和/或组合，包括微流体尺度。在一组实施例中，流体流可以从通道产生，其中流体流的横截面尺寸小于通道的横截面尺寸，例如通过使用结构元件，其它流体和/或应用外场等。在某些情况下，可能产生泰勒锥。在另一组实施例中，可以以某种方式操纵流体流，例如以产生管（其可以是中空或固体），液滴，嵌套管或液滴，管或液滴阵列，管的网格等。在一些情况下，使用本发明的某些实施方案产生的液滴可能被充电或基本上带电，这可能允许它们进一步操作，例如使用外部应用场。这种操作的非限制性实例包括产生带电液滴，聚集液滴（特别是微量级），同步液滴形成，使液滴中的分子对齐等。在一些情况下，液滴和/或流体流可包括胶体，细胞，治疗剂等。

8. 发明申请

WO2015103367A1 SYSTEM AND METHOD FOR DETECTION OF RNA SPECIES 审中-公开
标题翻译：用于检测RNA物种的系统和方法
公开(公告)号：WO2015103367A1
公开(公告)日：2015-07-09
申请号：PCT/US2014/072947
申请日：2014-12-31
申请人： RAINDANCE TECHNOLOGIES, INC.
发明人： SAMUELS, Michael , LINK, Darren, R. , BANERJEE, Sirshendu, Roopom
IPC分类号： C12Q1/68 , C12Q1/70 , C12P19/34
CPC分类号： C12Q1/702 , C12Q1/70 , C12Q2563/159
摘要： The invention includes methods for determining the presence of a latent viral population by analyzing an RNA population from the virus with digital techniques, such as digital PCR or by sequencing cDNA produced from the RNA. The invention additional includes methods for determining the presence of latent viral populations by detecting and/or quantifying enzymes that are uniquely associated with the virus, e.g., reverse transcriptases.
摘要翻译：本发明包括通过使用数字技术（例如数字PCR）或通过测序从RNA产生的cDNA来分析来自病毒的RNA群来确定潜伏病毒群体的存在的方法。本发明另外包括通过检测和/或定量与病毒唯一相关的酶（例如逆转录酶）来确定潜伏病毒种群的存在的方法。

9. 发明申请

WO2014165762A1 RARE CELL ANALYSIS AFTER NEGATIVE SELECTION 审中-公开
标题翻译：负面选择后的稀有细胞分析
公开(公告)号：WO2014165762A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/032983
申请日：2014-04-04
申请人： RAINDANCE TECHNOLOGIES, INC.
发明人： SAMUELS, Michael , LINK, Darren, R.
IPC分类号： C12Q1/68 , C12Q1/00
CPC分类号： C12N15/1075 , C12Q1/6806 , C12Q2563/159
摘要： The invention generally relates to rare cell analysis after negative selection.
摘要翻译：本发明一般涉及阴性选择后的稀有细胞分析。

10. 发明申请

WO2014165559A2 SYSTEMS AND METHODS FOR HANDLING MICROFLUIDIC DROPLETS 审中-公开
标题翻译：用于处理微流感滴液的系统和方法
公开(公告)号：WO2014165559A2
公开(公告)日：2014-10-09
申请号：PCT/US2014/032614
申请日：2014-04-02
申请人： RAINDANCE TECHNOLOGIES, INC.
发明人： LINK, Darren, R.
IPC分类号： G01N1/38 , C12Q1/68
CPC分类号： B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/028 , B01L2200/0673 , B01L2300/0645 , B01L2300/0867 , B01L2400/0487 , G01N35/085
摘要： The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel.
摘要翻译：本发明一般涉及用于从容器移动液滴的组件，其有助于液滴的收集和转移，同时最小化样品损失。在某些方面，组件包括至少一个液滴形成模块，其中模块被配置成形成由不混溶流体包围的液滴。组件还包括至少一个包括出口的室，其中室被构造成接收液滴和不混溶的流体，并且其中出口构造成仅基本上容纳液滴。组件还包括通道，其被构造成使得液滴形成模块和腔室经由通道彼此流体连通。在其他方面，组件包括多个中空构件，其中中空构件是通道，构件中构件与容器相互作用。多个中空构件包括构造成排出与容器中的液滴不混溶的流体的第一构件和构造成基本上仅从容器中滴下的第二构件。组件还包括主通道，其中第二构件与主通道流体连通。组件还包括连接到主通道的至少一个分析模块。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式