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1. 发明申请

WO2007133710A3 MICROFLUIDIC DEVICES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2007133710A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/011462
申请日：2007-05-11
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
IPC分类号： B01F13/00 , B01J19/00 , B01L3/00 , G01N15/14 , G01N33/50
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

2. 发明申请

WO2007081385A3 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 审中-公开
公开(公告)号：WO2007081385A3
公开(公告)日：2007-07-19
申请号：PCT/US2006/021280
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： G01N33/536 , C12Q1/68 , B01J19/00 , C07B61/00 , C07K1/04 , G01N33/68
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.

3. 发明申请

WO2015103367A1 SYSTEM AND METHOD FOR DETECTION OF RNA SPECIES 审中-公开
标题翻译：用于检测RNA物种的系统和方法
公开(公告)号：WO2015103367A1
公开(公告)日：2015-07-09
申请号：PCT/US2014/072947
申请日：2014-12-31
申请人： RAINDANCE TECHNOLOGIES, INC.
发明人： SAMUELS, Michael , LINK, Darren, R. , BANERJEE, Sirshendu, Roopom
IPC分类号： C12Q1/68 , C12Q1/70 , C12P19/34
CPC分类号： C12Q1/702 , C12Q1/70 , C12Q2563/159
摘要： The invention includes methods for determining the presence of a latent viral population by analyzing an RNA population from the virus with digital techniques, such as digital PCR or by sequencing cDNA produced from the RNA. The invention additional includes methods for determining the presence of latent viral populations by detecting and/or quantifying enzymes that are uniquely associated with the virus, e.g., reverse transcriptases.
摘要翻译：本发明包括通过使用数字技术（例如数字PCR）或通过测序从RNA产生的cDNA来分析来自病毒的RNA群来确定潜伏病毒群体的存在的方法。本发明另外包括通过检测和/或定量与病毒唯一相关的酶（例如逆转录酶）来确定潜伏病毒种群的存在的方法。

4. 发明申请

WO2007081387A1 MICROFLUIDIC DEVICES, METHODS OF USE, AND KITS FOR PERFORMING DIAGNOSTICS 审中-公开
标题翻译：微流体装置，使用方法和用于执行诊断的工具
公开(公告)号：WO2007081387A1
公开(公告)日：2007-07-19
申请号：PCT/US2006/021380
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： G01N33/536 , C12Q1/68 , B01J19/00 , C07B61/00 , C07K1/04 , G01N33/68
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices, kits, and methods that are useful for performing high-throughput screening assays and diagnostics. Such diagnostic methods can include emulsifying an aqueous library of compounds with a set of uniquely dyecoded-labeled droplets in an inert fluorocarbon medium, thereby forming an interactor library, emulsifying an aqueous sample from a subject in an inert fluorocarbon medium, wherein said sample contains a compound that will react with at least one interactor molecule from the interactor library, coalescing the emulsions to form a nanoreactor, and screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, herein one or more steps are performed on a microfluidic device, which can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了用于进行高通量筛选测定和诊断的新型微流体装置，试剂盒和方法。这样的诊断方法可以包括用惰性碳氟介质中的一组独特的经编码标记的液滴乳化化合物的水性文库，从而形成相互作用文库，在惰性碳氟介质中乳化来自受试者的含水样品，其中所述样品含有将与来自相互作用文库的至少一个相互作用分子反应的化合物，聚合乳液以形成纳米反应器，并筛选纳米反应器以获得纳米反应器内容物之间所需的反应，这里，一个或多个步骤在微流体装置上进行，其可以包括整体地布置在微加工基板上的多个可电寻址的通道支承流体模块，从而为不混溶流体的流动提供连续通道。

5. 发明申请

WO2014165762A1 RARE CELL ANALYSIS AFTER NEGATIVE SELECTION 审中-公开
标题翻译：负面选择后的稀有细胞分析
公开(公告)号：WO2014165762A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/032983
申请日：2014-04-04
申请人： RAINDANCE TECHNOLOGIES, INC.
发明人： SAMUELS, Michael , LINK, Darren, R.
IPC分类号： C12Q1/68 , C12Q1/00
CPC分类号： C12N15/1075 , C12Q1/6806 , C12Q2563/159
摘要： The invention generally relates to rare cell analysis after negative selection.
摘要翻译：本发明一般涉及阴性选择后的稀有细胞分析。

6. 发明申请

WO2014165559A2 SYSTEMS AND METHODS FOR HANDLING MICROFLUIDIC DROPLETS 审中-公开
标题翻译：用于处理微流感滴液的系统和方法
公开(公告)号：WO2014165559A2
公开(公告)日：2014-10-09
申请号：PCT/US2014/032614
申请日：2014-04-02
申请人： RAINDANCE TECHNOLOGIES, INC.
发明人： LINK, Darren, R.
IPC分类号： G01N1/38 , C12Q1/68
CPC分类号： B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/028 , B01L2200/0673 , B01L2300/0645 , B01L2300/0867 , B01L2400/0487 , G01N35/085
摘要： The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel.
摘要翻译：本发明一般涉及用于从容器移动液滴的组件，其有助于液滴的收集和转移，同时最小化样品损失。在某些方面，组件包括至少一个液滴形成模块，其中模块被配置成形成由不混溶流体包围的液滴。组件还包括至少一个包括出口的室，其中室被构造成接收液滴和不混溶的流体，并且其中出口构造成仅基本上容纳液滴。组件还包括通道，其被构造成使得液滴形成模块和腔室经由通道彼此流体连通。在其他方面，组件包括多个中空构件，其中中空构件是通道，构件中构件与容器相互作用。多个中空构件包括构造成排出与容器中的液滴不混溶的流体的第一构件和构造成基本上仅从容器中滴下的第二构件。组件还包括主通道，其中第二构件与主通道流体连通。组件还包括连接到主通道的至少一个分析模块。

7. 发明申请

WO2008063227A2 MICROFLUIDIC DEVICES 审中-公开
标题翻译： MICROFLUIDIC设备
公开(公告)号：WO2008063227A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/011460
申请日：2007-05-11
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , WEINER, Michael , MARREN, David , ROTHBERG, Jonathan, M.
CPC分类号： B01F3/0807 , B01F13/0062 , B01J19/0093 , B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/565 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/086 , B03C5/005 , B03C5/026 , C12N15/1068 , C12N15/1086 , C12Q1/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6844 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/628 , C12Q2565/629 , G01N15/147 , G01N21/05 , G01N21/64 , G01N27/3275 , G01N35/08 , G01N2021/0346 , G01N2035/00237 , G01N2035/00326 , G01N2201/024 , Y10T137/87571 , Y10T137/87619 , Y10T137/87652 , C12Q2525/191 , C12Q2563/159 , C12Q2535/101 , C12Q2563/149 , C12Q2531/113
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了用于进行生物学，化学和诊断测定的新型微流体底物和方法。衬底可以包括多个电可寻址的，通道轴承流体模块整体布置，使得提供连续通道用于不混溶流体的流动。

8. 发明申请

WO2007081386A3 MICROFLUIDIC DEVICES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007081386A3
公开(公告)日：2007-07-19
申请号：PCT/US2006/021286
申请日：2006-06-01
申请人： RAINDANCE TECHNOLOGIES, INC. , LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
发明人： LINK, Darren, R. , BOITARD, Laurent , BRANCIFORTE, Jeffrey , CHARLES, Yves , FEKE, Gilbert , LU, John, Q. , MARRAN, David , TABATABAI, Ahmadali , WEINER, Michael , HINZ, Wolfgang , ROTHBERG, Jonathan, M.
IPC分类号： B01L3/00 , B01F13/00 , G01N15/14
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The device can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids.

9. 发明公开

EP2981349A2 SYSTEMS AND METHODS FOR HANDLING MICROFLUIDIC DROPLETS 审中-公开
标题翻译：用于处理微流体液滴的系统和方法
公开(公告)号：EP2981349A2
公开(公告)日：2016-02-10
申请号：EP14778430.0
申请日：2014-04-02
申请人： Raindance Technologies Inc.
发明人： LINK, Darren, R.
IPC分类号： B01F5/06 , B01J2/02 , B81B1/00 , G01N35/08
CPC分类号： B01L3/502715 , B01L3/502784 , B01L2200/027 , B01L2200/028 , B01L2200/0673 , B01L2300/0645 , B01L2300/0867 , B01L2400/0487 , G01N35/085
摘要： The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel.
摘要翻译：本发明总体上涉及用于从容器中排出液滴的组件，其促进了液滴的收集和转移，同时使样品损失最小化。在某些方面，组件包括至少一个液滴形成模块，其中模块被配置为形成被不混溶流体包围的液滴。该组件还包括至少一个腔室，该腔室包括出口，腔室构造成接收液滴和不混溶流体，并且其中出口构造成基本上仅接收液滴。该组件还包括通道，该通道被构造成使得液滴形成模块和腔室经由通道彼此流体连通。在其他方面，组件包括多个中空构件，其中中空构件是通道并且其中构件被构造成与容器相互作用。多个中空构件包括构造成排出与容器中的液滴不混溶的流体的第一构件和构造成基本上仅从容器中滴落的第二构件。该组件还包括主通道，其中第二构件与主通道流体连通。该组件还包括连接到主通道的至少一个分析模块。

10. 发明公开

EP3090063A1 SYSTEM AND METHOD FOR DETECTION OF RNA SPECIES 有权转让
标题翻译：系统采用VERFAHREN ZUR DETEKTION VON RNA-SPEZIES
公开(公告)号：EP3090063A1
公开(公告)日：2016-11-09
申请号：EP14876167.9
申请日：2014-12-31
申请人： Raindance Technologies Inc.
发明人： SAMUELS, Michael , LINK, Darren, R. , BANERJEE, Sirshendu, Roopom
IPC分类号： C12Q1/68 , C12Q1/70 , C12P19/34
摘要： The invention includes methods for determining the presence of a latent viral population by analyzing an RNA population from the virus with digital techniques, such as digital PCR or by sequencing cDNA produced from the RNA. The invention additional includes methods for determining the presence of latent viral populations by detecting and/or quantifying enzymes that are uniquely associated with the virus, e.g., reverse transcriptases.
摘要翻译：本发明包括通过用数字技术（例如数字PCR）或通过测序从RNA产生的cDNA来分析来自病毒的RNA群体来确定潜伏病毒群体的存在的方法。本发明另外包括通过检测和/或定量与病毒唯一相关的酶（例如逆转录酶）来确定潜在病毒种群的存在的方法。

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