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61. 发明授权

US07660616B1 Implantable multi-wavelength oximeter sensor 有权
标题翻译：可植入多波长血氧计传感器
公开(公告)号：US07660616B1
公开(公告)日：2010-02-09
申请号：US11231555
申请日：2005-09-20
申请人： John W. Poore
发明人： John W. Poore
IPC分类号： A61B5/1455
CPC分类号： A61B5/14542 , A61B5/1459
摘要： Implantable multi-wavelength oximetry sensors, which can be used to monitor a patient's blood oxygen saturation level, are described. The sensor includes an implantable sensor housing within which are located a plurality of light sources that each transmits light of a different wavelength. Also within the sensor housing are one or more surfaces that are configured to combine the light from the plurality of light sources into a beam of light for transmission through a portion of the housing (e.g., a window) through which light can exit and enter the housing. Additionally, a light detector is located within the sensor housing, to detect light scattered by blood back into the housing. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.
摘要翻译：描述了可用于监测患者血氧饱和度水平的可植入多波长血氧测定传感器。该传感器包括可植入的传感器外壳，其中位于多个光源中，每个光源透射不同波长的光。在传感器壳体内还有一个或多个表面，其被配置为将来自多个光源的光组合成光束，以便通过壳体的一部分（例如，窗口）传输，光可以通过该部分离开并进入住房。此外，光检测器位于传感器壳体内，以检测由血液散射回到壳体内的光。本说明书不是对本发明的完整描述或限制本发明的范围。本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

62. 发明授权

US07630078B1 Calibrating implantable optical sensors 失效
标题翻译：校准植入光学传感器
公开(公告)号：US07630078B1
公开(公告)日：2009-12-08
申请号：US11683521
申请日：2007-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： G01B9/08
CPC分类号： A61B5/14542 , A61B5/02028 , A61B5/14535 , A61B5/1459 , A61B2560/0223 , A61N1/36557
摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.
摘要翻译：测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度光源。基于由校准光检测器产生的校准信号来补偿透射光强度的变化。本说明书不是对本发明的完整描述或限制本发明的范围。本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

63. 发明授权

US07347826B1 Packaging sensors for long term implant 有权
标题翻译：用于长期植入的包装传感器
公开(公告)号：US07347826B1
公开(公告)日：2008-03-25
申请号：US10688687
申请日：2003-10-16
申请人： Annapurna Karicherla , John W. Poore
发明人： Annapurna Karicherla , John W. Poore
IPC分类号： A61B5/00 , A61B5/04 , A61B5/02
CPC分类号： A61B5/0215 , A61B2562/242 , A61N1/375
摘要： According to this technique of packaging a sensor device implantable in a living body so as to provide protection of the sensor device and to the living body itself, an electrical conductor of the sensor device is sealed in an insulating substrate extending between proximal and distal ends. The distal end of the electrical conductor is externally connected to an external sensor on the sensor device and the proximal end of the electrical conductor is externally connected to a distal end of a lead wire extending proximally to a pulse generator and these connections are embedded in an insulative sheath. The external sensor, substrate, and insulative sheath are encapsulated in a thin film of hermetic material without interference with the lead wire. In another embodiment, a layer of insulating material may underlie the hermetic material to encapsulate the external sensor and the substrate.
摘要翻译：根据这种将植入生物体的传感器装置进行包装以提供对传感器装置和生物体本身的保护的技术，传感器装置的电导体被密封在在近端和远端之间延伸的绝缘基片中。电导体的远端外部连接到传感器装置上的外部传感器，并且电导体的近端外部连接到向近端延伸到脉冲发生器的引线的远端，并且这些连接被嵌入到绝缘护套。外部传感器，基板和绝缘护套被封装在密封材料的薄膜中，而不会干扰引线。在另一个实施例中，绝缘材料层可以位于密封材料的下面，以封装外部传感器和基板。

64. 发明授权

US07076301B1 Implantable cardiac stimulation device that minimizes parasitic muscle stimulation and method 失效
标题翻译：植入式心脏刺激装置，使寄生肌肉刺激和方法最小化
公开(公告)号：US07076301B1
公开(公告)日：2006-07-11
申请号：US10326746
申请日：2002-12-20
申请人： Mark W. Kroll , John W. Poore
发明人： Mark W. Kroll , John W. Poore
IPC分类号： A61N1/362 , A61N1/365
CPC分类号： A61N1/3704 , A61N1/3712
摘要： An implantable cardiac stimulation device provides capture of a chamber of a heart with pacing pulses while minimizing parasitic muscle tissue stimulation. A parasitic muscle stimulation detector detects if the application of pacing pulses result in parasitic muscle stimulation. If there is parasitic muscle stimulation resulting from the application of pacing pulses, a pulse generator control adjusts the pacing pulse amplitudes and durations until the pacing pulses capture the chamber of the heart without causing parasitic muscle stimulation.
摘要翻译：可植入的心脏刺激装置提供用起搏脉冲捕获心脏室，同时最小化寄生肌肉组织刺激。寄生肌肉刺激检测器检测起搏脉冲的应用是否导致寄生肌肉刺激。如果由施加起搏脉冲引起的寄生肌肉刺激，则脉冲发生器控制调节起搏脉冲幅度和持续时间，直到起搏脉冲捕获心脏室而不引起寄生肌肉刺激。

65. 发明授权

US06804556B1 Methods and apparatus for overdrive pacing heat tissue using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置的超速起搏热组织的方法和装置
公开(公告)号：US06804556B1
公开(公告)日：2004-10-12
申请号：US10036026
申请日：2001-12-21
申请人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
发明人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
IPC分类号： A61N1365
CPC分类号： A61N1/368
摘要： Techniques are described for overdrive pacing the heart using a pacemaker wherein the overdrive pacing rate only increases when at least two intrinsic beats are detected within a determined search period. In one specific technique, an increase in the pacing rate occurs only if two P-waves are detected within X cardiac cycles. In another specific technique, the overdrive pacing rate is increased only if at least two P-waves are detected within a block of N cardiac cycles. In both techniques, the overdrive pacing rate is decreased if no increase has occurred in the last Z cardiac cycles. By increasing the overdrive pacing rate only in response to detection of at least two P-waves within a determined number of cardiac cycles, an excessively high overdrive pacing rate is avoided. Other techniques are described for adaptively adjusting overdrive pacing parameters so as to achieve a determined target degree of pacing of, for example, 95% paced beats. By adaptively adjusting overdrive parameters to maintain a target degree of pacing, the average overdrive pacing rate is minimized while still maintaining a high number of paced beats, thereby reducing the risk of a tachyarrhythmia occurring within the patient.
摘要翻译：描述了使用起搏器超速起搏心脏的技术，其中在确定的搜索周期内检测到至少两个固有节拍时，超速起搏速率仅增加。在一种特定技术中，只有在X个心动周期内检测到两个P波时，起搏速率才会增加。在另一个具体技术中，只有在N个心动周期的块内检测到至少两个P波时，才能增加超速起搏速率。在两种技术中，如果在最后Z个心动周期中没有发生增加，则超速起搏速率将降低。通过仅在确定的心跳周期内响应于至少两个P波的检测来增加超速起搏速率，避免了过高的超速起搏速率。描述了用于自适应地调节过驱动起搏参数的其它技术，以便实现例如95％起搏节拍的确定的目标起搏程度。通过自适应地调整过驱动参数以保持目标起搏程度，平均超速起搏速度最小化，同时仍然保持大量的起搏节奏，从而降低患者内出现快速性心律失常的风险。

66. 发明授权

US06766195B1 Method and apparatus for detecting natural electrical coherence within the heart and for administering therapy based thereon 有权
标题翻译：用于检测心脏内的自然电相干性并用于基于其进行治疗的方法和装置
公开(公告)号：US06766195B1
公开(公告)日：2004-07-20
申请号：US09686630
申请日：2000-10-10
申请人： Gene A. Bornzin , Peter Boileau , Joseph J. Florio , John W. Poore , Kelly H. McClure
发明人： Gene A. Bornzin , Peter Boileau , Joseph J. Florio , John W. Poore , Kelly H. McClure
IPC分类号： A61N0118
CPC分类号： A61N1/3962 , A61N1/395
摘要： Techniques are provided for detecting natural electrical coherence within the heart and for administering or adjusting therapy based upon whether natural electrical coherence is detected. In one example, an implantable cardioverter defibrillator (ICD), upon detecting atrial fibrillation, delays administering an atrial defibrillation pulse until a period of natural electrical coherence is detected between the left and the right atria of the heart. The ICD may further delay the pulse until the ventricles of the heart are refractory so as to help prevent triggering ventricular fibrillation. The pulses are administered at a time selected based upon the period of electrical coherence to reduce the amount of electrical energy required within the pulse to reliably defibrillate the heart. Other types of therapy besides defibrillation therapy such as anti-tachycardia pacing pulses may also be timed based upon detection periods of natural electrical coherence. Method and apparatus embodiments are described.
摘要翻译：提供了用于检测心脏内的自然电连贯性的技术，并且用于基于是否检测到自然电连贯来施用或调整治疗。在一个实例中，在检测心房颤动时，植入式心律转复除颤器（ICD）延迟施用心房除颤脉冲，直到在心脏的左心房和右心房之间检测到自然电相干的时间段。 ICD可以进一步延迟脉冲，直到心脏的心室难以耐受，以便有助于防止触发心室颤动。在基于电相干周期选择的时间施加脉冲以减少脉冲内所需的电能量以可靠地除颤心脏。除了除颤疗法之外的其他类型的治疗，如抗心动过速起搏脉冲也可以基于自然电连续性的检测周期来计时。描述了方法和设备实施例。

67. 发明授权

US06731985B2 Implantable cardiac stimulation system and method for automatic capture verification calibration 有权
标题翻译：植入式心脏刺激系统和自动捕获验证校准方法
公开(公告)号：US06731985B2
公开(公告)日：2004-05-04
申请号：US09981555
申请日：2001-10-16
申请人： John W. Poore , Kerry Bradley , Laurence S. Sloman , Gene A. Bornzin , Joseph J. Florio
发明人： John W. Poore , Kerry Bradley , Laurence S. Sloman , Gene A. Bornzin , Joseph J. Florio
IPC分类号： A61N1362
CPC分类号： A61N1/3712
摘要： An implantable cardiac stimulation device and associated method perform an automatic calibration procedure for evaluating whether automatic capture verification can be recommended. The calibration procedure calculates and displays a number of variables for use by a medical practitioner in programming automatic capture operating parameters. An average paced depolarization integral (PDI) is determined from the cardiac signals following delivery of multiple stimulation pulse below and above capture threshold such that both pure lead polarization signals and evoked response signals may be analyzed. From the paced depolarization integral data, a capture threshold, a stimulation response curve, a minimum evoked response, a maximum lead polarization, an evoked response sensitivity, an evoked response safety margin, and a polarization safety margin are determined. Based on these variables, the calibration procedure determines if automatic capture verification can be recommended. If so, the stimulation device calculates a capture detection threshold. The automatic capture verification recommendation and the estimated calibration variables are displayed.
摘要翻译：可植入心脏刺激装置和相关方法执行自动校准程序，以评估是否可以推荐自动捕获验证。校准程序计算并显示许多变量，供医生在编程自动捕获操作参数时使用。平均节奏去极化积分（PDI）是在多次刺激脉冲传递后低于和高于捕获阈值的心脏信号确定的，以便可以分析纯铅极化信号和诱发响应信号。从起搏去极化积分数据中，确定捕获阈值，刺激响应曲线，最小诱发响应，最大引线极化，诱发响应灵敏度，诱发响应安全裕度和极化安全裕度。基于这些变量，校准过程确定是否可以推荐自动捕获验证。如果是，则刺激装置计算捕获检测阈值。显示自动捕获验证建议和估计的校准变量。

68. 发明授权

US06622045B2 System and method for remote programming of implantable cardiac stimulation devices 有权
公开(公告)号：US06622045B2
公开(公告)日：2003-09-16
申请号：US09823374
申请日：2001-03-29
申请人： Jeffery D. Snell , John W. Poore , Jason A. Sholder
发明人： Jeffery D. Snell , John W. Poore , Jason A. Sholder
IPC分类号： A61N108
CPC分类号： A61N1/37282
摘要： To permit remote programming of implantable cardiac stimulation devices such as pacemakers, a central device programmer is provided in conjunction with a network of remote telemetry units for use in patient homes or in remote clinics. To reprogram a device implanted within a patient, a physician enters programming commands within the central programmer which relays the programming commands to a remote telemetry unit in proximity to the patient. The remote telemetry unit, in turn, forwards the programming commands to the implanted device. In this manner, the patient need not return to the physician for reprogramming of the device. Remote telemetry units may be provided within patient homes, clinics, hospital emergency rooms, hospital patient rooms, and the like. Depending upon the implementation, different levels of programmability may be permitted depending upon the degree of supervision of the patient. For an unsupervised patient, limited programmability is permitted. For a nurse-supervised patient, a greater degree of programmability is permitted. Finally, for a physician-supervised patient, a full range of programmability is permitted. In a specific example described herein, each remote telemetry unit includes minimal hardware and software components necessary to relay programming commands, diagnostic information, and other signals between the central programmer and the implanted device.

69. 发明授权

US5697959A Method and system for analyzing and displaying complex pacing event records 失效
标题翻译：分析和显示复杂起搏事件记录的方法和系统
公开(公告)号：US5697959A
公开(公告)日：1997-12-16
申请号：US584574
申请日：1996-01-11
申请人： John W. Poore
发明人： John W. Poore
IPC分类号： A61N1/372 , G06F19/00 , A61N1/362 , A61N1/37
CPC分类号： A61N1/37247 , G06F19/3406 , G06F19/345 , G06F19/3487
摘要： A method and system for analyzing and displaying pacing event data of an implantable pacemaker using a programmer device comprises downloading the pacing event data from the implantable pacemaker to the programmer device and processing the pacing event data to produce an Event Record. The Event Record includes actual pacing event data obtained and stored by the implantable pacemaker over a prescribed period of time as well as various statistical information derived therefrom. Selected parametric data of the Event Record are then displayed to the physician or other user on a display screen of the programmer device in a simple and comprehensible graphical format.
摘要翻译：用于使用编程器装置分析和显示可植入起搏器的起搏事件数据的方法和系统包括将起搏事件数据从可植入起搏器下载到编程器装置并处理起搏事件数据以产生事件记录。事件记录包括在规定的时间段内由可植入心脏起搏器获得和存储的实际起搏事件数据以及从其导出的各种统计信息。事件记录的所选择的参数数据然后以简单且易于理解的图形格式显示给编程器设备的显示屏上的医生或其他用户。

70. 发明授权

US5431691A Method and system for recording and displaying a sequential series of pacing events 失效
标题翻译：用于记录，报告和显示一系列连续的起搏事件的方法和系统
公开(公告)号：US5431691A
公开(公告)日：1995-07-11
申请号：US846460
申请日：1992-03-02
申请人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
发明人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
IPC分类号： A61N1/37 , A61N1/372
CPC分类号： A61N1/37247 , A61N1/37
摘要： An implantable pacemaker continuously records pacing events and their respective rates of occurrence in sequence, as they occur, into an Event Record stored in a circular buffer. The circular buffer always contains the most recent events and rates collected. The recording of the pacing events selectively occurs at every event, or at sampling rates of one event per fixed sample interval. A programming device, coupled to the implantable pacemaker through a telemetry link, selectively retrieves the recorded pacing events and rates from the Event Record and reports subsets thereof in condensed or summarized form using numerical and/or graphical formats. The pacing event data collected in the Event Record is three-dimensional in that each pacing event includes a pacemaker event, an associated pacemaker or heart rate, and a real time interval. The programming device also calculates and reports statistical information from the data collected in the Event Record. The Event Record provides a base recording that establishes the behavior of the pacemaker in a particular patient under ascertainable conditions.
摘要翻译：植入式起搏器将发生的起搏事件及其各自发生的发生顺序连续记录到存储在循环缓冲器中的事件记录中。循环缓冲区总是包含最近收集的事件和速率。起搏事件的记录选择性地发生在每个事件或每个固定采样间隔的一个事件的采样率。通过遥测链路耦合到可植入心脏起搏器的编程设备选择性地从事件记录中检索所记录的起搏事件和速率，并使用数字和/或图形格式以浓缩或概括形式报告子集。事件记录中收集的起搏事件数据是三维的，因为每个起搏事件包括起搏器事件，相关起搏器或心率以及实时间隔。编程设备还根据事件记录中收集的数据计算和报告统计信息。事件记录提供基准记录，确定特定病人在确定条件下的起搏器的行为。

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