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1. 发明授权

US5487755A Methods for displaying a sequential series of pacing events 失效
标题翻译：显示顺序一系列起搏事件的方法
公开(公告)号：US5487755A
公开(公告)日：1996-01-30
申请号：US328218
申请日：1994-10-25
申请人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
发明人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
IPC分类号： A61N1/37 , A61N1/372
CPC分类号： A61N1/37247 , A61N1/37
摘要： An implantable pacemaker continuously records pacing events and their respective rates of occurrence in sequence, as they occur, into an Event Record stored in a circular buffer. The circular buffer always contains the most recent events and rates collected. The recording of the pacing events selectively occurs at every event, or at sampling rates of one event per fixed sample interval. A programming device, coupled to the implantable pacemaker through a telemetry link, selectively retrieves the recorded pacing events and rates from the Event Record and reports subsets thereof in condensed or summarized form using numerical and/or graphical formats. The pacing event data collected in the Event Record is three-dimensional in that each pacing event includes a pacemaker event, an associated pacemaker or heart rate, and a real time interval. The programming device also calculates and reports statistical information from the data collected in the Event Record. The Event Record provides a base recording that establishes the behavior of the pacemaker in a particular patient under ascertainable conditions.
摘要翻译：植入式起搏器将发生的起搏事件及其各自发生的发生顺序连续记录到存储在循环缓冲器中的事件记录中。循环缓冲区总是包含最近收集的事件和速率。起搏事件的记录选择性地发生在每个事件或每个固定采样间隔的一个事件的采样率。通过遥测链路耦合到可植入心脏起搏器的编程设备选择性地从事件记录中检索所记录的起搏事件和速率，并使用数字和/或图形格式以浓缩或概括形式报告子集。事件记录中收集的起搏事件数据是三维的，因为每个起搏事件包括起搏器事件，相关起搏器或心率以及实时间隔。编程设备还根据事件记录中收集的数据计算和报告统计信息。事件记录提供基准记录，确定特定病人在确定条件下的起搏器的行为。

2. 发明授权

US5431691A Method and system for recording and displaying a sequential series of pacing events 失效
标题翻译：用于记录，报告和显示一系列连续的起搏事件的方法和系统
公开(公告)号：US5431691A
公开(公告)日：1995-07-11
申请号：US846460
申请日：1992-03-02
申请人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
发明人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
IPC分类号： A61N1/37 , A61N1/372
CPC分类号： A61N1/37247 , A61N1/37
摘要： An implantable pacemaker continuously records pacing events and their respective rates of occurrence in sequence, as they occur, into an Event Record stored in a circular buffer. The circular buffer always contains the most recent events and rates collected. The recording of the pacing events selectively occurs at every event, or at sampling rates of one event per fixed sample interval. A programming device, coupled to the implantable pacemaker through a telemetry link, selectively retrieves the recorded pacing events and rates from the Event Record and reports subsets thereof in condensed or summarized form using numerical and/or graphical formats. The pacing event data collected in the Event Record is three-dimensional in that each pacing event includes a pacemaker event, an associated pacemaker or heart rate, and a real time interval. The programming device also calculates and reports statistical information from the data collected in the Event Record. The Event Record provides a base recording that establishes the behavior of the pacemaker in a particular patient under ascertainable conditions.
摘要翻译：植入式起搏器将发生的起搏事件及其各自发生的发生顺序连续记录到存储在循环缓冲器中的事件记录中。循环缓冲区总是包含最近收集的事件和速率。起搏事件的记录选择性地发生在每个事件或每个固定采样间隔的一个事件的采样率。通过遥测链路耦合到可植入心脏起搏器的编程设备选择性地从事件记录中检索所记录的起搏事件和速率，并使用数字和/或图形格式以浓缩或概括形式报告子集。事件记录中收集的起搏事件数据是三维的，因为每个起搏事件包括起搏器事件，相关起搏器或心率以及实时间隔。编程设备还根据事件记录中收集的数据计算和报告统计信息。事件记录提供基准记录，确定特定病人在确定条件下的起搏器的行为。

3. 发明授权

US5309919A Method and system for recording, reporting, and displaying the distribution of pacing events over time and for using same to optimize programming 失效
标题翻译：方法和系统用于记录，报告和显示起搏事件随时间的分布以及使用它们来优化编程
公开(公告)号：US5309919A
公开(公告)日：1994-05-10
申请号：US846461
申请日：1992-03-02
申请人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
发明人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
IPC分类号： A61N1/37 , A61N1/372 , A61B5/0452
CPC分类号： A61N1/37247 , A61N1/3702
摘要： A method and system for monitoring the behavior of an implanted pacemaker counts (records) the number of times that a given internal event or state change of the pacemaker occurs, and also determines the rate at which each event or state change thus counted occurs. The event counts and their associated rate are stored (recorded) in appropriate memory circuits housed within the pacemaker device. At an appropriate time, the stored event count and rate data are downloaded to an external programming device. The external programming device processes the event count and rate data, and displays a distribution of the event count data as a function of its rate of occurrence, as well as other statistical information derived therefrom. The displayed information, and its associated statistical information, allows a baseline recording to be made that establishes the implanted pacemaker's behavior for a given patient under known conditions. Such baseline recording of event counts in combination with the associated rate of occurrence of such event counts provides significant insight into the past behavior of the pacemaker as implanted in a particular patient. The past behavior of the pacemaker, in turn, may then be used to predict with a high degree of accuracy the future behavior of the pacemaker.
摘要翻译：用于监测植入式起搏器的行为的方法和系统计数（记录）发生起搏器的给定内部事件或状态改变的次数，并且还确定发生每个事件或状态改变的速率。事件计数及其相关速率被存储（记录）在安置在起搏器装置内的适当的存储器电路中。在适当的时间，存储的事件计数和速率数据被下载到外部编程设备。外部编程设备处理事件计数和速率数据，并且显示作为其发生速率的函数的事件计数数据的分布以及从其导出的其他统计信息。显示的信息及其相关的统计信息允许进行基线记录，以在已知条件下确定给定患者的植入式心脏起搏器的行为。事件计数的这种基线记录与这种事件计数的相关发生率相结合提供了对植入在特定患者中的起搏器的过去行为的显着了解。起搏器的过去行为反过来可能被用来高精度地预测起搏器未来的行为。

4. 发明授权

US5487754A Method and apparatus for reporting and displaying a sequential series of pacing events 失效
标题翻译：用于报告和显示一连串的起搏事件的方法和装置
公开(公告)号：US5487754A
公开(公告)日：1996-01-30
申请号：US328217
申请日：1994-10-25
申请人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
发明人： Jeffery D. Snell , Harold C. Schloss , Brian M. Mann , John W. Poore , Roy B. Medlin
IPC分类号： A61N1/37 , A61N1/372
CPC分类号： A61N1/37247 , A61N1/37
摘要： An implantable pacemaker continuously records pacing events and their respective rates of occurrence in sequence, as they occur, into an Event Record stored in a circular buffer. The circular buffer always contains the most recent events and rates collected. The recording of the pacing events selectively occurs at every event, or at sampling rates of one event per fixed sample interval. A programming device, coupled to the implantable pacemaker through a telemetry link, selectively retrieves the recorded pacing events and rates from the Event Record and reports subsets thereof in condensed or summarized form using numerical and/or graphical formats. The pacing event data collected in the Event Record is three-dimensional in that each pacing event includes a pacemaker event, an associated pacemaker or heart rate, and a real time interval. The programming device also calculates and reports statistical information from the data collected in the Event Record. The Event Record provides a base recording that establishes the behavior of the pacemaker in a particular patient under ascertainable conditions.
摘要翻译：植入式起搏器将发生的起搏事件及其各自发生的发生顺序连续记录到存储在循环缓冲器中的事件记录中。循环缓冲区总是包含最近收集的事件和速率。起搏事件的记录选择性地发生在每个事件或每个固定采样间隔的一个事件的采样率。通过遥测链路耦合到可植入心脏起搏器的编程设备选择性地从事件记录中检索记录的起搏事件和速率，并使用数字和/或图形格式以浓缩或概括形式报告其子集。事件记录中收集的起搏事件数据是三维的，因为每个起搏事件包括起搏器事件，相关起搏器或心率以及实时间隔。编程设备还根据事件记录中收集的数据计算和报告统计信息。事件记录提供基准记录，确定特定病人在确定条件下的起搏器的行为。

5. 发明授权

US4809697A Interactive programming and diagnostic system for use with implantable pacemaker 失效
标题翻译：与植入式起搏器一起使用的交互式编程和诊断系统
公开(公告)号：US4809697A
公开(公告)日：1989-03-07
申请号：US108842
申请日：1987-10-14
申请人： James D. Causey, III , Harold C. Schloss , Jeffery D. Snell
发明人： James D. Causey, III , Harold C. Schloss , Jeffery D. Snell
IPC分类号： A61N1/362 , A61N1/372 , A61N1/00
CPC分类号： A61N1/37235 , A61N1/362 , Y10S128/903
摘要： An analyzer-programmer system (30) for use with an implantable medical device, such as a cardiac pacemaker (20). The system facilitates non-invasive communications with the implantable device and makes analysis of the operation of the implantable device easier to understand and perform. The system includes conventional processor means (42) for processing a sequence of stored instructions stored in programmable read-only memory, or ROM (40). The ROM, although designed to be accessed through predefined page of information, and blocks within such pages, is configured to allow in-page addressing within any of a plurality of pages in a linear fashion. Programmed intervals to be sent to the implantable device are displayed by the system in tabular form or as scaled time-lines or bars (FIG. 9A), with each separate interval beginning and ending in proper timed sequence, thereby providing a prediction of the expected performance. Such programmed intervals can overlay or sidelay measured performance (FIG. 9B), thereby facilitating a comparison between predicted and measured performance. The system also includes telemetry head means (28) for sending and receiving control and data signals to and from the implanted medical device ( 20). The telemetry head means (28) includes processing circuitry (FIG. 4C) that greatly simplifies the other circuitry needed in order to effectuate such communication.
摘要翻译：一种用于可植入医疗装置的分析器编程器系统（30），例如心脏起搏器（20）。该系统促进与可植入装置的非侵入式通信，并且使得可植入装置的操作的分析更易于理解和执行。该系统包括用于处理存储在可编程只读存储器或ROM（40）中的存储指令序列的常规处理器装置（42）。 ROM虽然被设计为通过预定义的信息页被访问，并且在这样的页面中的块被配置为允许以线性方式在多个页面中的任何页面内进行页内寻址。要发送到可植入设备的程序间隔由系统以表格形式或缩放的时间线或条（图9A）显示，每个单独的间隔开始并以适当的定时顺序结束，从而提供预期的性能。这样的编程间隔可覆盖或测量性能（图9B），从而便于预测和测量性能之间的比较。该系统还包括遥测头装置（28），用于发送和接收来自植入医疗装置（20）的控制和数据信号。遥测头装置（28）包括大大简化为了实现这种通信所需的其它电路的处理电路（图4C）。

6. 发明授权

US06539260B1 Atrial sensing and pacing using a unipolar atrial electrode 有权
标题翻译：心房感应和起搏使用单极心房电极
公开(公告)号：US06539260B1
公开(公告)日：2003-03-25
申请号：US09514631
申请日：2000-02-28
申请人： Harold C. Schloss
发明人： Harold C. Schloss
IPC分类号： A61N1362
CPC分类号： A61N1/362 , A61N1/056
摘要： A system and method for performing bipolar sensing and pacing in a heart using a unipolar atrial electrode. The invention provides a lead system comprising an atrial electrode placed in the atrium of the heart and a defibrillation electrode placed in the heart. The defibrillation electrode may be placed in the ventricle, the superior vena cava, or the coronary sinus. Bipolar pacing and sensing in the atrium is achieved without the introduction of additional conductors into the atrium.
摘要翻译：使用单极心房电极在心脏中进行双极感测和起搏的系统和方法。本发明提供了一种引导系统，其包括置于心脏心房的心房电极和置于心脏中的除颤电极。除颤电极可以放置在心室，上腔静脉或冠状窦中。在心房中实现双极起搏和感应，而不需要将额外的导体引入心房。

7. 发明授权

US5549646A Periodic electrical lead intergrity testing system and method for implantable cardiac stimulating devices 失效
标题翻译：定期电引线整体测试系统及植入式心脏刺激装置的方法
公开(公告)号：US5549646A
公开(公告)日：1996-08-27
申请号：US349862
申请日：1994-12-06
申请人： Samuel M. Katz , Harold C. Schloss
发明人： Samuel M. Katz , Harold C. Schloss
IPC分类号： A61N1/39 , A61N1/08 , A61N1/37
CPC分类号： A61N1/3937 , A61N1/3706 , A61N2001/083
摘要： A periodic electrical lead integrity testing system is provided which periodically tests electrical leads used with an implantable cardiac stimulating device. The system is especially advantageous in multi-functional implantable cardiac stimulating devices. Lead integrity is evaluated by periodically comparing the impedance of the electrical leads to a reference impedance. A pass/fail algorithm is used to determine if electrical lead integrity has been compromised. The system improves the efficacy and safety of implantable cardiac stimulating devices by detecting electrical failures independent of the delivery of therapeutic shocks. The required circuitry adds only minimal complexity and cost to the implantable cardiac stimulating device.
摘要翻译：提供了周期性的电引线完整性测试系统，其周期性地测试与可植入的心脏刺激装置一起使用的电引线。该系统在多功能可植入心脏刺激装置中特别有利。通过定期比较电引线的阻抗与参考阻抗来评估引线完整性。通过/失败算法用于确定电线的完整性是否受到损害。该系统通过检测独立于治疗性休克的递送的电气故障来改善可植入心脏刺激装置的功效和安全性。所需的电路仅增加植入式心脏刺激装置的复杂性和成本。

8. 发明授权

US06456882B1 Implantable cardiac stimulation device having automatic capture/threshold capability using a dynamically adjustable safety margin 有权
标题翻译：可植入的心脏刺激装置具有自动捕获/阈值能力，使用动态可调安全裕度
公开(公告)号：US06456882B1
公开(公告)日：2002-09-24
申请号：US09684153
申请日：2000-10-06
申请人： Harold C. Schloss
发明人： Harold C. Schloss
IPC分类号： A61N118
CPC分类号： A61N1/3712
摘要： An improved system and method for performing automatic capture/threshold detection in an implantable cardiac stimulation device or any device capable of stimulating some organ or tissue in the body. In existing systems a threshold stimulation energy level is periodically determined and a working stimulation energy level is then set by increasing the threshold stimulation energy level by a fixed or preprogrammed safety margin, e.g., a fixed voltage level or a percentage safety margin. However, in certain circumstances this safety margin may not be sufficient, resulting in either frequent threshold level determinations or losses-of-capture. To avoid these situations which may be wasteful of battery energy or dangerous for the patient, embodiments of the present invention periodically increase and/or decrease the safety margin according to the performance of the stimulation device, i.e., based upon the frequency of capture.
摘要翻译：一种用于在可植入心脏刺激装置或能够刺激身体中的一些器官或组织的任何装置中执行自动捕获/阈值检测的改进的系统和方法。在现有系统中，周期性地确定阈值刺激能量水平，然后通过将固定的或预编程的安全裕度（例如固定电压电平或百分比安全裕度）增加阈值刺激能量级来设定工作刺激能级。然而，在某些情况下，该安全幅度可能不足，导致频繁的阈值水平确定或捕获损失。为了避免可能浪费电池能量或对患者危险的这些情况，本发明的实施例根据刺激装置的性能，即基于捕获的频率周期性地增加和/或降低安全裕度。

9. 发明授权

US5733312A System and method for modulating the output of an implantable medical device in response to circadian variations 失效
标题翻译：响应于昼夜变化而调制可植入医疗装置的输出的系统和方法
公开(公告)号：US5733312A
公开(公告)日：1998-03-31
申请号：US783936
申请日：1997-01-17
申请人： Harold C. Schloss , Gene A. Bornzin
发明人： Harold C. Schloss , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36585
摘要： An implantable cardiac pacemaker is provided for delivering pacing pulses to a patient, where the pacing pulses are defined by at least two parameters. The pacemaker allows for transitioning of the two parameters from first values to second values in response to the patient's circadian rhythms, such as in response to the beginning and ending of a sleep cycle. Also provided is an implantable pacemaker for delivering pacing pulses to a patient where the pacing pulses are defined by at least one parameter. The pacemaker allows for selective transitioning of the parameter from a first value to a second value in response to the patient's circadian rhythms.
摘要翻译：提供可植入心脏起搏器，用于将起搏脉冲输送到患者，其中起搏脉冲由至少两个参数限定。起搏器允许响应于患者的昼夜节律，例如响应于睡眠周期的开始和结束，将两个参数从第一值转换到第二值。还提供了一种可植入起搏器，用于将起搏脉冲发送到患者，其中起搏脉冲由至少一个参数限定。起搏器允许响应于患者的昼夜节律选择性地将参数从第一值转换到第二值。

10. 发明授权

US07010346B1 Implantable medical device having atrial tachyarrhythmia prevention therapy 失效
标题翻译：具有房性心律失常预防治疗的植入式医疗器械
公开(公告)号：US07010346B1
公开(公告)日：2006-03-07
申请号：US09931481
申请日：2001-08-15
申请人： Harold C. Schloss , Mark W. Kroll , Paul A. Levine
发明人： Harold C. Schloss , Mark W. Kroll , Paul A. Levine
IPC分类号： A61N1/18
CPC分类号： A61N1/3622
摘要： An implantable medical device provides atrial arrhythmia prevention pacing when an interatrial conduction disturbance is detected. The implantable medical device includes a signal processor that detects the interatrial conduction disturbance and a pulse generator circuit coupled to the detector that delivers the atrial arrhythmia prevention pacing pulses to the heart when the processor detects the interatrial conduction disturbance. The interatrial conduction disturbance may be a P-wave duration, a difference between odd and even P-waves, or a predetermined P-wave spectral energy distribution.
摘要翻译：当检测到房间传导障碍时，植入式医疗装置提供心律失常预防起搏。可植入医疗装置包括检测院内传导障碍的信号处理器和耦合到检测器的脉冲发生器电路，当处理器检测到房间传导障碍时，其将心律失常预防起搏脉冲传送到心脏。室间传导障碍可以是P波持续时间，奇数和偶数P波之间的差异或预定的P波频谱能量分布。

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