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61. 发明授权

US07564542B2 Asymmetric capillary for capillary-flow cytometers 失效
标题翻译：毛细管流式细胞仪不对称毛细血管
公开(公告)号：US07564542B2
公开(公告)日：2009-07-21
申请号：US11784939
申请日：2007-04-10
申请人： Fedor A. Ilkov
发明人： Fedor A. Ilkov
IPC分类号： G01N21/00
CPC分类号： G01N15/1404 , G01N2015/0053 , G01N2015/1415
摘要： The present invention provides improved capillaries that lead to increased resolution in conventional capillary-flow cytometers. The cross-sectional shape of capillaries made according to the present invention lack a center of symmetry. In some embodiments, capillaries have inner side walls that are tilted at angles with respect to the collection-system optical axis so that the widest dimension of the inner bore is closest to the collection optical system and have an outer wall closest to the collection optical system with a dimension large enough to minimize the contribution of outer-wall refraction to the collected light signal. Exemplary capillary embodiments include tubes with a rectangular outer wall and a trapezoidal inner wall, a rectangular outer wall and a triangular inner wall, triangular outer and inner walls, a triangular outer wall with a trapezoidal inner wall, and a hemispherical or rhomboid outer wall and trapezoidal or triangular inner wall.
摘要翻译：本发明提供改进的毛细血管，其导致常规毛细血管流式细胞仪中分辨率的提高。根据本发明制造的毛细管的横截面形状缺乏对称中心。在一些实施例中，毛细管具有相对于收集系统光轴以角度倾斜的内侧壁，使得内孔的最宽尺寸最靠近收集光学系统，并且具有最靠近收集光学系统的外壁其尺寸足够大以最小化外壁折射对所收集的光信号的贡献。示例性毛细管实施例包括具有矩形外壁和梯形内壁，矩形外壁和三角形内壁，三角形外壁和内壁，具有梯形内壁的三角形外壁和半球形或菱形外壁的管，以及梯形或三角形内壁。

62. 发明申请

US20040036870A1 Method and apparatus for detecting microparticles in fluid samples 有权
公开(公告)号：US20040036870A1
公开(公告)日：2004-02-26
申请号：US10652665
申请日：2003-08-28
申请人： Guava Technologies, Inc.
发明人： Philippe J. Goix
IPC分类号： G01J003/30 , G01N021/64
CPC分类号： G01N15/1459 , C12Q1/04 , G01N21/05 , G01N33/1866 , G01N2015/1477 , G01N2015/1486 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421 , G02B2207/113
摘要： A method and apparatus for detecting a fluorescent substance tagged to a microparticle are described. The device comprises a single capillary flow carrier system for transporting the microparticle past a selected location, a source of electromagnetic radiation for irradiating the substance tagged to the microparticle, and a detection system for measuring fluorescent light emitted from the substance at the selected location. The method comprises transporting the microparticle to a selected location, irradiating a fluorescent substance tagged to the microparticle, and measuring the fluorescent light emitted from the fluorescent substance at the selected location.

63. 发明申请

US20080263468A1 Graphical User Interface for Analysis and Comparison of Location-Specific Multiparameter Data Sets 有权
标题翻译：用于分析和比较位置特定多参数数据集的图形用户界面
公开(公告)号：US20080263468A1
公开(公告)日：2008-10-23
申请号：US12104234
申请日：2008-04-16
申请人： Amedeo Joseph Cappione , Ray Lefebvre , Neil Kilcoin , David Andrew King , George J. Dixon
发明人： Amedeo Joseph Cappione , Ray Lefebvre , Neil Kilcoin , David Andrew King , George J. Dixon
IPC分类号： G06F3/048 , G06F19/00
CPC分类号： G06F19/26 , G01N35/00722 , G01N2015/1402 , G01N2015/1477 , G01N2035/0091 , G06F3/04817
摘要： A graphical user interface on a computer provides for the analysis of location specific data and the presentation of analysis results for visual comparison by a user. Results of the analysis are visually presented as icons subdivided into regions and arranged in such a way that the user is able to associate each icon with a data location. A visual presentation of results in the icons and regions allows a user to visually compare the analysis results in two or more data sets according to location. The graphical user interface further provides for the definition and adjustment of an analysis through the interaction of a user with a graphical representation of the analysis. In some cases, the visual presentation of results tracks the analysis adjustments so the user can visually observe the effects that the adjustments have on the results. A method of interacting with the interface to define an analysis and represent results and a method of presenting two or more data sets using the interface are described. The interface can be used to analyze and visually compare the results of location specific data from a number of sources and is illustrated in a flow cytometry application.
摘要翻译：计算机上的图形用户界面提供对位置特定数据的分析和分析结果的呈现，以供用户视觉比较。分析结果以视觉方式呈现为按区域划分的图标，并以这样一种方式排列，使得用户能够将每个图标与数据位置相关联。在图标和区域中的视觉呈现结果允许用户根据位置在两个或多个数据集中视觉比较分析结果。图形用户界面还通过用户与分析的图形表示的交互来进一步提供对分析的定义和调整。在某些情况下，结果的视觉呈现跟踪分析调整，以便用户可以直观地观察调整对结果的影响。描述了与接口交互以定义分析并表示结果的方法以及使用该接口呈现两个或多个数据集的方法。界面可用于分析和视觉比较来自多个来源的位置特定数据的结果，并在流式细胞术应用中进行了说明。

64. 发明授权

US07320775B2 Exchangeable flow cell assembly with a suspended capillary 有权
标题翻译：具有悬浮毛细管的可更换流通池组件
公开(公告)号：US07320775B2
公开(公告)日：2008-01-22
申请号：US10146019
申请日：2002-05-14
申请人： Thomas E. Kochy , Roger A. O'Neill , Terah W. Smiley , Vidal O. Smith
发明人： Thomas E. Kochy , Roger A. O'Neill , Terah W. Smiley , Vidal O. Smith
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , G01N1/10 , G01N21/01
CPC分类号： G01N15/1459 , G01N15/1434 , Y10T436/11 , Y10T436/117497
摘要： There is provided a flow cell assembly in which a shuttle supports and positions a capillary with its end extending beyond the shuttle. The flow cell assembly facilitates the replacement of a flow cell which is damaged or with flow cells having capillaries of different size or shape.
摘要翻译：提供了一种流动池组件，其中梭子支撑并定位毛细管，其端部延伸超过梭子。流动池组件有助于更换损坏的流动池或具有不同尺寸或形状的毛细管的流动池。

65. 发明授权

US07091348B2 Fluorescent dyes, energy transfer couples and methods 有权
标题翻译：荧光染料，能量转移对和方法
公开(公告)号：US07091348B2
公开(公告)日：2006-08-15
申请号：US10612297
申请日：2003-07-01
申请人： Roger O'Neill , Peter V. Fisher
发明人： Roger O'Neill , Peter V. Fisher
IPC分类号： C07D209/06 , C07D215/04 , C07D487/02
CPC分类号： C09B11/08 , C09B11/06 , C09B11/24 , C09B11/28 , C09B23/083 , G01N33/542
摘要： Fluorescent dyes, fluorescence energy transfer dye couples, multi-color dye sets, can be employed in art-recognized assays and certain novel methods, such as in proximity assays.
摘要翻译：荧光染料，荧光能量转移染料对，多色染料组，可以用于本领域公认的测定和某些新颖的方法，例如邻近测定。

66. 发明申请

US20020028434A1 Particle or cell analyzer and method 审中-公开
标题翻译：粒子或细胞分析仪和方法
公开(公告)号：US20020028434A1
公开(公告)日：2002-03-07
申请号：US09844080
申请日：2001-04-26
申请人： GUAVA TECHNOLOGIES, INC.
发明人： Philippe J. Goix , Paul J. Lingane , Janette T. Phi-Wilson
IPC分类号： C12Q001/00 , G01N033/48 , G01J003/00
CPC分类号： G01N15/1404 , G01N21/64
摘要： A particle analyzer in which tagged particles to be analyzed are drawn through a suspended capillary tube where a predetermined volume in the capillary tube is illuminated. The illumination scattered by said particles is detected by a detector to count all particles. The fluorescent illumination emitted by tagged particles is detected and the output signals from the fluorescent detectors and scatter detector are processed to provide an analysis of the particles.
摘要翻译：其中待分析的标记颗粒通过毛细管中的预定体积被照亮的悬浮毛细管吸取的颗粒分析仪。由所述颗粒散射的照明由检测器检测以计数所有颗粒。检测由标记的颗粒发射的荧光照明，并且处理来自荧光检测器和散射检测器的输出信号以提供颗粒的分析。

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