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    • 4. 发明授权
    • Asymmetric capillary for capillary-flow cytometers
    • 毛细管流式细胞仪不对称毛细血管
    • US07564542B2
    • 2009-07-21
    • US11784939
    • 2007-04-10
    • Fedor A. Ilkov
    • Fedor A. Ilkov
    • G01N21/00
    • G01N15/1404G01N2015/0053G01N2015/1415
    • The present invention provides improved capillaries that lead to increased resolution in conventional capillary-flow cytometers. The cross-sectional shape of capillaries made according to the present invention lack a center of symmetry. In some embodiments, capillaries have inner side walls that are tilted at angles with respect to the collection-system optical axis so that the widest dimension of the inner bore is closest to the collection optical system and have an outer wall closest to the collection optical system with a dimension large enough to minimize the contribution of outer-wall refraction to the collected light signal. Exemplary capillary embodiments include tubes with a rectangular outer wall and a trapezoidal inner wall, a rectangular outer wall and a triangular inner wall, triangular outer and inner walls, a triangular outer wall with a trapezoidal inner wall, and a hemispherical or rhomboid outer wall and trapezoidal or triangular inner wall.
    • 本发明提供改进的毛细血管,其导致常规毛细血管流式细胞仪中分辨率的提高。 根据本发明制造的毛细管的横截面形状缺乏对称中心。 在一些实施例中,毛细管具有相对于收集系统光轴以角度倾斜的内侧壁,使得内孔的最宽尺寸最靠近收集光学系统,并且具有最靠近收集光学系统的外壁 其尺寸足够大以最小化外壁折射对所收集的光信号的贡献。 示例性毛细管实施例包括具有矩形外壁和梯形内壁,矩形外壁和三角形内壁,三角形外壁和内壁,具有梯形内壁的三角形外壁和半球形或菱形外壁的管,以及 梯形或三角形内壁。
    • 6. 发明授权
    • Asymmetric capillary for capillary-flow cytometers
    • 毛细管流式细胞仪不对称毛细血管
    • US07978318B2
    • 2011-07-12
    • US12484815
    • 2009-06-15
    • Fedor A. Ilkov
    • Fedor A. Ilkov
    • G01N21/00
    • G01N15/1404G01N2015/0053G01N2015/1415
    • The present invention provides improved capillaries that lead to increased resolution in conventional capillary-flow cytometers. The cross-sectional shape of capillaries made according to the present invention lack a center of symmetry. In some embodiments, capillaries have inner side walls that are tilted at angles with respect to the collection-system optical axis so that the widest dimension of the inner bore is closest to the collection optical system and have an outer wall closest to the collection optical system with a dimension large enough to minimize the contribution of outer-wall refraction to the collected light signal. Exemplary capillary embodiments include tubes with a rectangular outer wall and a trapezoidal inner wall, a rectangular outer wall and a triangular inner wall, triangular outer and inner walls, a triangular outer wall with a trapezoidal inner wall, and a hemispherical or rhomboid outer wall and trapezoidal or triangular inner wall.
    • 本发明提供改进的毛细血管,其导致常规毛细血管流式细胞仪中分辨率的提高。 根据本发明制造的毛细管的横截面形状缺乏对称中心。 在一些实施例中,毛细管具有相对于收集系统光轴以角度倾斜的内侧壁,使得内孔的最宽尺寸最靠近收集光学系统,并且具有最靠近收集光学系统的外壁 其尺寸足够大以最小化外壁折射对所收集的光信号的贡献。 示例性毛细管实施例包括具有矩形外壁和梯形内壁,矩形外壁和三角形内壁,三角形外壁和内壁,具有梯形内壁的三角形外壁和半球形或菱形外壁的管,以及 梯形或三角形内壁。
    • 7. 发明申请
    • Asymmetric capillary for capillary-flow cytometers
    • 毛细管流式细胞仪不对称毛细血管
    • US20070236681A1
    • 2007-10-11
    • US11784939
    • 2007-04-10
    • Fedor A. Ilkov
    • Fedor A. Ilkov
    • G01N21/00
    • G01N15/1404G01N2015/0053G01N2015/1415
    • The present invention provides improved capillaries that lead to increased resolution in conventional capillary-flow cytometers. The cross-sectional shape of capillaries made according to the present invention lack a center of symmetry. In some embodiments, capillaries have inner side walls that are tilted at angles with respect to the collection-system optical axis so that the widest dimension of the inner bore is closest to the collection optical system and have an outer wall closest to the collection optical system with a dimension large enough to minimize the contribution of outer-wall refraction to the collected light signal. Exemplary capillary embodiments include tubes with a rectangular outer wall and a trapezoidal inner wall, a rectangular outer wall and a triangular inner wall, triangular outer and inner walls, a triangular outer wall with a trapezoidal inner wall, and a hemispherical or rhomboid outer wall and trapezoidal or triangular inner wall.
    • 本发明提供改进的毛细血管,其导致常规毛细血管流式细胞仪中分辨率的提高。 根据本发明制造的毛细管的横截面形状缺乏对称中心。 在一些实施例中,毛细管具有相对于收集系统光轴以角度倾斜的内侧壁,使得内孔的最宽尺寸最靠近收集光学系统,并且具有最靠近收集光学系统的外壁 其尺寸足够大以最小化外壁折射对所收集的光信号的贡献。 示例性毛细管实施例包括具有矩形外壁和梯形内壁,矩形外壁和三角形内壁,三角形外壁和内壁,具有梯形内壁的三角形外壁和半球形或菱形外壁的管,以及 梯形或三角形内壁。