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1. 发明申请

US20080263468A1 Graphical User Interface for Analysis and Comparison of Location-Specific Multiparameter Data Sets 有权
标题翻译：用于分析和比较位置特定多参数数据集的图形用户界面
公开(公告)号：US20080263468A1
公开(公告)日：2008-10-23
申请号：US12104234
申请日：2008-04-16
申请人： Amedeo Joseph Cappione , Ray Lefebvre , Neil Kilcoin , David Andrew King , George J. Dixon
发明人： Amedeo Joseph Cappione , Ray Lefebvre , Neil Kilcoin , David Andrew King , George J. Dixon
IPC分类号： G06F3/048 , G06F19/00
CPC分类号： G06F19/26 , G01N35/00722 , G01N2015/1402 , G01N2015/1477 , G01N2035/0091 , G06F3/04817
摘要： A graphical user interface on a computer provides for the analysis of location specific data and the presentation of analysis results for visual comparison by a user. Results of the analysis are visually presented as icons subdivided into regions and arranged in such a way that the user is able to associate each icon with a data location. A visual presentation of results in the icons and regions allows a user to visually compare the analysis results in two or more data sets according to location. The graphical user interface further provides for the definition and adjustment of an analysis through the interaction of a user with a graphical representation of the analysis. In some cases, the visual presentation of results tracks the analysis adjustments so the user can visually observe the effects that the adjustments have on the results. A method of interacting with the interface to define an analysis and represent results and a method of presenting two or more data sets using the interface are described. The interface can be used to analyze and visually compare the results of location specific data from a number of sources and is illustrated in a flow cytometry application.
摘要翻译：计算机上的图形用户界面提供对位置特定数据的分析和分析结果的呈现，以供用户视觉比较。分析结果以视觉方式呈现为按区域划分的图标，并以这样一种方式排列，使得用户能够将每个图标与数据位置相关联。在图标和区域中的视觉呈现结果允许用户根据位置在两个或多个数据集中视觉比较分析结果。图形用户界面还通过用户与分析的图形表示的交互来进一步提供对分析的定义和调整。在某些情况下，结果的视觉呈现跟踪分析调整，以便用户可以直观地观察调整对结果的影响。描述了与接口交互以定义分析并表示结果的方法以及使用该接口呈现两个或多个数据集的方法。界面可用于分析和视觉比较来自多个来源的位置特定数据的结果，并在流式细胞术应用中进行了说明。

2. 发明授权

US08959448B2 Graphical user interface for analysis and comparison of location-specific multiparameter data sets 有权
标题翻译：用于分析和比较位置特定多参数数据集的图形用户界面
公开(公告)号：US08959448B2
公开(公告)日：2015-02-17
申请号：US12104234
申请日：2008-04-16
申请人： Amedeo Joseph Cappione, III , Ray Lefebvre , Neil Kilcoin , David Andrew King , George J. Dixon
发明人： Amedeo Joseph Cappione, III , Ray Lefebvre , Neil Kilcoin , David Andrew King , George J. Dixon
IPC分类号： G06F3/048 , G01N35/00 , G06F19/26 , G01N15/14
CPC分类号： G06F19/26 , G01N35/00722 , G01N2015/1402 , G01N2015/1477 , G01N2035/0091 , G06F3/04817
摘要： A graphical user interface on a computer provides for the analysis of location specific data and the presentation of analysis results for visual comparison by a user. Results of the analysis are visually presented as icons subdivided into regions and arranged in such a way that the user is able to associate each icon with a data location. A visual presentation of results in the icons and regions allows a user to visually compare the analysis results in two or more data sets according to location. The graphical user interface further provides for the definition and adjustment of an analysis through the interaction of a user with a graphical representation of the analysis. In some cases, the visual presentation of results tracks the analysis adjustments so the user can visually observe the effects that the adjustments have on the results. A method of interacting with the interface to define an analysis and represent results and a method of presenting two or more data sets using the interface are described. The interface can be used to analyze and visually compare the results of location specific data from a number of sources and is illustrated in a flow cytometry application.
摘要翻译：计算机上的图形用户界面提供对位置特定数据的分析和分析结果的呈现，以供用户视觉比较。分析结果以视觉方式呈现为按区域划分的图标，并以这样一种方式排列，使得用户能够将每个图标与数据位置相关联。在图标和区域中的视觉呈现结果允许用户根据位置在两个或多个数据集中视觉比较分析结果。图形用户界面还通过用户与分析的图形表示的交互来进一步提供对分析的定义和调整。在某些情况下，结果的视觉呈现跟踪分析调整，以便用户可以直观地观察调整对结果的影响。描述了与接口交互以定义分析并表示结果的方法以及使用该接口呈现两个或多个数据集的方法。界面可用于分析和视觉比较来自多个来源的位置特定数据的结果，并在流式细胞术应用中进行了说明。

3. 发明授权

US06927382B2 Optical excitation/detection device and method for making same using fluidic self-assembly techniques 有权
标题翻译：光学激发/检测装置及其使用流体自组装技术的方法
公开(公告)号：US06927382B2
公开(公告)日：2005-08-09
申请号：US10153243
申请日：2002-05-22
申请人： David Andrew King , Richard J. Pittaro , Shahida Rana , Edward Verdonk , Frederick A. Stawitcke , Richard D. Pering
发明人： David Andrew King , Richard J. Pittaro , Shahida Rana , Edward Verdonk , Frederick A. Stawitcke , Richard D. Pering
IPC分类号： H01L21/98 , H01L25/16 , H01L27/146 , H01L31/00 , H01L31/12
CPC分类号： H01L24/95 , H01L25/167 , H01L25/50 , H01L27/14683 , H01L31/125 , H01L2224/95085 , H01L2924/01013 , H01L2924/01015 , H01L2924/01027 , H01L2924/01033 , H01L2924/01049 , H01L2924/10158 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/00
摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and separately formed photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array including a plurality of individual photoreceptors is selectively etched back between photoreceptor locations to reveal a plurality of recessed regions having a certain geographic profile. A plurality of semiconductor blocks, each having light emitting capability and each having a certain geometric profile that is complementary in size and shape to the certain geometric profile of the recessed regions, are separately fabricated. These blocks are included within a fluid to form a slurry. The slurry is then flowed over the CMOS fabricated photodetector array in accordance with a fluidic self-assembly technique, and the included semiconductor blocks are individually deposited within each of the plurality of recessed regions in the CMOS fabricated photodetector array. The deposited blocks are then attached within the recessed regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and separately formed photoemitters.
摘要翻译：本公开涉及一种光激励/检测装置，其包括阵列的多个光电检测器和单独形成的光电发生器，以及用于制造这种装置的方法。包括多个单独光感受器的CMOS制造的光检测器阵列被选择性地在感光体位置之间回蚀刻以露出具有一定地理轮廓的多个凹陷区域。分别制造多个半导体块，每个半导体块具有发光能力，并且各自具有与凹陷区域的某些几何轮廓尺寸和形状互补的一定几何轮廓。这些块被包含在流体中以形成浆料。然后根据流体自组装技术将浆料流过CMOS制造的光电检测器阵列，并且将所包含的半导体块分别沉积在CMOS制造的光电检测器阵列中的多个凹陷区域的每一个内。然后将沉积的块附接在凹陷区域内，以从阵列的多个光电检测器和单独形成的光电发生器形成光学激发/检测装置。

4. 发明授权

US07179654B2 Biochemical assay with programmable array detection 有权
标题翻译：具有可编程阵列检测的生化测定
公开(公告)号：US07179654B2
公开(公告)日：2007-02-20
申请号：US10100346
申请日：2002-03-18
申请人： Edward Verdonk , David Andrew King , Richard J. Pittaro
发明人： Edward Verdonk , David Andrew King , Richard J. Pittaro
IPC分类号： G01N21/76 , B32B5/02 , B32B27/12 , B32B27/04
CPC分类号： G01N21/6454 , G01N21/6428 , Y10T436/10
摘要： A biochemical sensor apparatus having an optical radiation source, a sensor array, and a photodetector array is disclosed. Each sensor of the sensor array includes fluorophores for fluorescence (generating response radiation) when mixed with analytes of interest and exposed to stimulus radiation. An array of photodetectors, such as a CMOS imaging array is used to detect the response radiation. The detected response radiation is converted to digital values and the digital values used to analyze various properties of the analytes present in the sensors.
摘要翻译：公开了一种具有光辐射源，传感器阵列和光电检测器阵列的生化传感器装置。传感器阵列的每个传感器包括与感兴趣的分析物混合并暴露于刺激辐射时用于荧光的荧光团（产生响应辐射）。使用诸如CMOS成像阵列的光电检测器阵列来检测响应辐射。检测到的响应辐射被转换为数字值，数字值用于分析传感器中存在的分析物的各种性质。

5. 发明授权

US06821793B2 Optical excitation/detection device and method for making same using discrete photoemitter devices 失效
标题翻译：光激励/检测装置及其使用离散光电发生器的方法
公开(公告)号：US06821793B2
公开(公告)日：2004-11-23
申请号：US10668435
申请日：2003-09-22
申请人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
发明人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
IPC分类号： H01L2100
CPC分类号： H01L27/14643 , H01L25/0753 , H01L25/167 , H01L2924/0002 , H01L2924/00
摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and discrete photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array includes an arrayed plurality of photoreceptor areas and photoemitter areas, wherein each photoreceptor area includes a CMOS integrated photoreceptor and each photoemitter area includes at least two buried electric contact pads. The CMOS array is selectively etched back at the locations of the photoemitter areas for regions to reveal the buried contact pads. A plurality of discrete semiconductor photoemitter devices (such as, for example, light emitting diodes) are inserted into, and mechanically retained within, the regions of the CMOS fabricated photodetector array. The inserted discrete semiconductor photoemitter devices make electrical contact with the buried electric contact pads that are revealed within each of the regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and discrete semiconductor photoemitters.
摘要翻译：本公开涉及包括阵列的多个光电探测器和分立光电发生器的光学激发/检测装置，以及用于制造这种装置的方法。 CMOS制造的光电检测器阵列包括阵列的多个感光体区域和光电发射器区域，其中每个感光体区域包括CMOS集成感光体，并且每个光电发射器区域包括至少两个埋入的电接触焊盘。 CMOS阵列在光电探测器区域的位置处被选择性地回蚀，用于区域以露出埋入的接触焊盘。多个分立的半导体光电探测器装置（例如，发光二极管）被插入并机械地保持在CMOS制造的光电检测器阵列的区域内。插入的分立半导体光电发生器装置与在每个区域内露出的掩埋电接触焊盘电接触，以从阵列的多个光电探测器和分立的半导体光电发生器形成光激发/检测装置。

6. 发明授权

US06657235B1 Optical excitation/detection device using discrete photoemitter devices 失效
标题翻译：光激励/检测装置采用离散光电发生器
公开(公告)号：US06657235B1
公开(公告)日：2003-12-02
申请号：US10153760
申请日：2002-05-22
申请人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
发明人： Edward Verdonk , Richard J. Pittaro , Shahida Rana , David Andrew King , Frederick A. Stawitcke , Richard D. Pering
IPC分类号： H01L2926
CPC分类号： H01L27/14643 , H01L25/0753 , H01L25/167 , H01L2924/0002 , H01L2924/00
摘要： The disclosure is directed toward an optical excitation/detection device that includes an arrayed plurality of photodetectors and discrete photoemitters, as well as a method for making such a device. A CMOS fabricated photodetector array includes an arrayed plurality of photoreceptor areas and photoemitter areas, wherein each photoreceptor area includes a CMOS integrated photoreceptor and each photoemitter area includes at least two buried electric contact pads. The CMOS array is selectively etched back at the locations of the photoemitter areas for regions to reveal the buried contact pads. A plurality of discrete semiconductor photoemitter devices (such as, for example, light emitting diodes) are inserted into, and mechanically retained within, the regions of the CMOS fabricated photodetector array. The inserted discrete semiconductor photoemitter devices make electrical contact with the buried electric contact pads that are revealed within each of the regions to form the optical excitation/detection device from an arrayed plurality of photodetectors and discrete semiconductor photoemitters.
摘要翻译：本公开涉及包括阵列的多个光电探测器和分立光电发生器的光学激发/检测装置，以及用于制造这种装置的方法。 CMOS制造的光电检测器阵列包括阵列的多个感光体区域和光电发射器区域，其中每个感光体区域包括CMOS集成感光体，并且每个光电发射器区域包括至少两个埋入的电接触焊盘。 CMOS阵列在光电探测器区域的位置处被选择性地回蚀，用于区域以露出埋入的接触焊盘。多个分立的半导体光电探测器装置（例如，发光二极管）被插入并机械地保持在CMOS制造的光电检测器阵列的区域内。插入的分立半导体光电发生器装置与在每个区域内露出的掩埋电接触焊盘电接触，以从阵列的多个光电探测器和分立的半导体光电发生器形成光激发/检测装置。

7. 发明授权

US06640197B2 Self aligning sensor array system 失效
标题翻译：自对准传感器阵列系统
公开(公告)号：US06640197B2
公开(公告)日：2003-10-28
申请号：US10072240
申请日：2002-02-08
申请人： Richard J. Pittaro , David Andrew King , Richard D. Pering , Shahida Rana , Frederick A. Stawitcke , Edward Verdonk
发明人： Richard J. Pittaro , David Andrew King , Richard D. Pering , Shahida Rana , Frederick A. Stawitcke , Edward Verdonk
IPC分类号： G01C2500
CPC分类号： G01N21/253
摘要： A sensor array is bonded to or molded together with a micro-lens array to form a sensor cartridge. The micro-lenses of the micro-lens array are configured to focus light incident on the sensors, into the sensors. An alignment structure has a mating profile that receives and engages one or more micro-lenses from the micro-lens array to laterally align the cartridge to enable repeatable precise positioning of the cartridge.
摘要翻译：传感器阵列与微透镜阵列结合或模制在一起以形成传感器盒。微透镜阵列的微透镜被配置为将入射到传感器上的光聚焦到传感器中。对准结构具有匹配轮廓，该配合轮廓接收并接合来自微透镜阵列的一个或多个微透镜以横向对准盒，以使得盒的可重复的精确定位。

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