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51. 发明授权

US4638087A 6-substituted naphthalene-2-carboxylic acids and process for producing the same 失效
标题翻译： 6-取代萘-2-羧酸及其制备方法
公开(公告)号：US4638087A
公开(公告)日：1987-01-20
申请号：US838525
申请日：1986-03-11
申请人： Akira Iizuka , Yutaka Konai , Takashi Yamauchi , Shoichiro Hayashi
发明人： Akira Iizuka , Yutaka Konai , Takashi Yamauchi , Shoichiro Hayashi
IPC分类号： C07C63/38 , B01J27/02 , C07B61/00 , C07C51/00 , C07C51/367 , C07C63/36 , C07C65/11 , C07C67/00 , C07C407/00 , C07C409/08 , C07C63/34
CPC分类号： C07C65/11 , C07C407/00 , C07C409/08 , C07C63/36
摘要： Disclosed herein are the novel 6-substituted naphthalene-2-carboxylic acids represented by the formula (I): ##STR1## wherein X represents a hydroperoxy group or a hydroxy group, and a process for producing the 6-substituted naphthalene-2-carboxylic acid represented by the formula (I) by reacting 6-isopropylnaphthalene-2-carboxylic acid with molecular oxygen under heating in the presence of a salt of persulfuric acid as a catalyst in an aqueous alkaline solution.
摘要翻译：本文公开了由式（I）表示的新颖的6-取代萘-2-羧酸：其中X表示氢过氧基或羟基，其中X取代的萘 - （I）表示的2-异丙基-2-羧酸，在过硫酸盐作为催化剂的存在下，在碱性水溶液中，使6-异丙基萘-2-羧酸与分子氧在加热下反应。

52. 发明授权

US3681461A 6-(3-diloweralkylamino-propyl)-7-(12h)-pleiadenones and salts thereof 失效
标题翻译： 6-（3-二甲基氨基丙基）-7-（12H） - 哌啶酮及其盐
公开(公告)号：US3681461A
公开(公告)日：1972-08-01
申请号：US3681461D
申请日：1970-08-12
申请人： SMITH KLINE FRENCH LAB
发明人： KAISER CARL , ZIRKLE CHARLES L
IPC分类号： C07C63/36 , C07D207/04 , C07D207/06 , C07D211/10 , C07D211/22 , C07D211/32 , C07C87/28
CPC分类号： C07D211/32 , C07C63/36 , C07D207/04 , C07D207/06 , C07D211/10 , C07D211/22
摘要： 7,12-Dihydropleiadenes in which the nucleus may have chloro, methyl, methoxy, methylthio or trifluoromethyl substituents and the 7-position is substituted by an aminopropylidene, aminopropyl, piperidylidene, piperidyl, pyrrolidylidene, pyrrolidyl, 2-piperidinylethylidene, 2-piperidinylethyl, 2pyrrolidinylethylidene or 2-pyrrolidinylethyl moiety are useful as tranquilizers and antidepressants. The compounds are generally prepared by reaction of the appropriate amino Grignard reagent with a 7(12H)-pleiadenone followed by acid dehydration of the 7hydroxy intermediate and subsequent reduction of the unsaturated derivative with phosphorus and hydroiodic acid. The 1,4-addition products also obtained via the Grignard reaction, namely 6substituted-7(12H)-pleiadenones, are also useful as tranquilizers and antidepressants.
摘要翻译： 7,12-二氢扁桃酸，其中核可以具有氯，甲基，甲氧基，甲硫基或三氟甲基取代基，并且7-位被氨基亚丙基，氨基丙基，哌啶基，哌啶基，吡咯烷亚基，吡咯烷基，2-哌啶子基亚乙基，2-哌啶基乙基， 2-吡咯烷基亚乙基或2-吡咯烷基乙基部分可用作镇定剂和抗抑郁药。这些化合物通常通过合适的氨基格氏试剂与7（12H） - ι-腺嘌呤反应，然后酸性脱水7-羟基中间体，随后用磷酸和氢碘酸还原不饱和衍生物来制备。还通过格利雅反应得到的1,4-加成产物，即6-取代-7（12H） - ple酮，也可用作镇定剂和抗抑郁剂。

53. 发明授权

US3557098A Substituted-7,12-dihydropleiadene derivatives 失效
标题翻译：取代的7,12-二氢蝶啶衍生物
公开(公告)号：US3557098A
公开(公告)日：1971-01-19
申请号：US3557098D
申请日：1968-03-04
申请人： SMITH KLINE FRENCH LAB
发明人： KAISER CARL , ZIRKLE CHARLES L
IPC分类号： C07C63/36 , C07D207/06 , C07D207/08 , C07D211/08 , C07D211/10 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70 , C07C87/28 , C07D51/70
CPC分类号： C07D207/08 , C07C63/36 , C07D207/06 , C07D211/08 , C07D211/10 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70
摘要： 7,12-DIHYDROPLEIADENES IN WHICH THE NUCLEUS MAY HAVE CHLORO, METHYL, METHOXY, METHYLTHIO OR TRIFLUOROMETHYL SUBSTITUTENTS AND THE 7-POSITON IS SUBSTITUTED BY AN AMINOPROPYLIDENE, AMINOPROPYL, PIPERIDYLIDENE, PIPERIDYL, PYRROLIDYLEDENE, PYRROLIDYL, 2-PIPERIDINYLETHYLIDENE, 2-PIPERINDINYLETHYL, 2-PYRROLIDINYLETHYLIDENE OR 2-PYRROLIDANYLETHYL MOIETY ARE USEFUL AS TRANQUILIZERS AND ANTIDEPRESSANTS. THE COMPOUNDS ARE GENERALLY PREPARED BY REACTION OF THE APPROPRIATE AMINO GRIGNARD REAGENT WITH A 7-(12H)-PLEIADENONE FOLLOWED BY ACID DEHYDRATION OF THE 7-HYDROXY INTERMEDIATE AND SUBSEQUENT REDUCTION OF THE UNSATURATED DERIVATIVE WITH PHORPHORUS AND HYDROIODIC ACID. THE 1,4-ADDITION PRODUCTS ALSO OBTAINED VIA THE GRIGNARD REACTION, NAMELY 6-SUBSTITUTED-7(12H)-PLEIADENONES, ARE ALSO USEFUL AS TRANQUILIZERS AND ANTIDEPRESSANTS.

54. 发明授权

US3335178A Process of controlled dichromate oxidation of alkyl naphthalenes 失效
标题翻译：受控重铬酸盐氧化烷基萘的工艺
公开(公告)号：US3335178A
公开(公告)日：1967-08-08
申请号：US54802666
申请日：1966-04-22
申请人： MARATHON OIL CO
发明人： TAUSSIG PETER R , ALLPHIN JR NYLEN L
IPC分类号： C07C51/16 , C07C51/38
CPC分类号： C07C51/16 , C07C51/38 , C07C63/36

55. 发明授权

US3184506A Preparation of carboxylic acid chlorides 失效
标题翻译：羧酸氯化物的制备
公开(公告)号：US3184506A
公开(公告)日：1965-05-18
申请号：US12508061
申请日：1961-07-19
申请人： DU PONT
发明人： PARKER STUART H , RUDY DENNIS D
IPC分类号： C07C51/60 , C07C205/57
CPC分类号： C07C201/12 , C07C51/60 , Y02P20/582 , C07C205/57 , C07C55/36 , C07C62/04 , C07C63/30 , C07C63/36 , C07C63/68

56. 发明授权

US1900649A Purification of crude dicarboxylic acids 失效
标题翻译：粗二羧酸的纯化
公开(公告)号：US1900649A
公开(公告)日：1933-03-07
申请号：US55207731
申请日：1931-07-20
申请人： SELDEN CO
发明人： JAEGER ALPHONS O
IPC分类号： C07C51/43
CPC分类号： C07C51/43 , C07C63/36 , C07C63/16 , C07C57/145

57. 发明申请

US20120316337A1 METHOD FOR PREPARING CHEMICAL COMPOUNDS OF INTEREST BY NUCLEOPHILIC AROMATIC SUBSTITUTION OF AROMATIC CARBOXYLIC ACID DERIVATIVES SUPPORTING AT LEAST ONE ELECTRO-ATTRACTIVE GROUP 审中-公开
标题翻译：用于制备支持最少一个电吸引组的芳香羧酸衍生物的核化学芳香取代化学化合物的方法
公开(公告)号：US20120316337A1
公开(公告)日：2012-12-13
申请号：US13578673
申请日：2011-02-17
申请人： Jacques Mortier , Anne-Sophie Castanet , Mickael Belaud-Rotureau
发明人： Jacques Mortier , Anne-Sophie Castanet , Mickael Belaud-Rotureau
IPC分类号： C07C227/08 , C07C51/353 , C07D237/30 , C07D215/48 , C07D217/00 , C07D295/155 , C07C51/367
CPC分类号： C07D295/155 , C07C51/353 , C07C51/367 , C07C227/08 , C07C63/36 , C07C63/66 , C07C65/24 , C07C229/56 , C07C229/58 , C07C229/64 , C07C229/68
摘要： Method for preparing carboxylic acid derivatives by aromatic nucleophilic substitution, in which a carboxylic acid derivative having a single carboxyl functional group, or one of the salts thereof, the carboxylic acid derivative having, in the ortho position of the carboxyl functional group, a leaving group, which is preferably an atom of fluorine or of chlorine or an alkoxy group, chiral or not, preferably a methoxy group, the carboxylic acid derivative not being substituted by an electro attractive group other than the leaving group if any; is reacted with a reactant MNu, where M is a metal and Nu is a nucleophile, chiral or not, the aromatic nucleophilic substitution reaction being carried out without a catalyst and without a step of protecting/deprotecting the acid functional group of the starting compound.
摘要翻译：通过芳族亲核取代制备羧酸衍生物的方法，其中具有单个羧基官能团的羧酸衍生物或其盐之一，羧酸官能团的邻位的羧酸衍生物为离去基团其优选为氟或氯或烷氧基的原子，手性或非甲氧基，优选甲氧基，不被离去基团以外的电吸引基团取代的羧酸衍生物; 与反应物MNu反应，其中M是金属，Nu是亲核试剂，手性或非手性的，芳族亲核取代反应在没有催化剂的情况下进行，而没有保护/去保护起始化合物的酸官能团的步骤。

58. 发明授权

US08188304B2 Process for the purification of lanthanide carboxylates 有权
标题翻译：镧系元素羧酸盐的纯化方法
公开(公告)号：US08188304B2
公开(公告)日：2012-05-29
申请号：US11689719
申请日：2007-03-22
申请人： Paolo Biagini , Mario Salvalaggio , Franco Cambisi , Lucia Bonoldi , Liliana Gila
发明人： Paolo Biagini , Mario Salvalaggio , Franco Cambisi , Lucia Bonoldi , Liliana Gila
IPC分类号： C07F13/00 , C07C63/36 , C07C53/00
CPC分类号： C07C51/47 , C07C51/48 , C08F36/04 , G01N21/3563 , G01N21/3577 , C07C53/126 , C07C53/128 , C07C63/36 , C08F4/545
摘要： A process is described for the purification of lanthanide carboxylates which comprises a step in which the hydrocarbon solution deriving from the synthesis of lanthanide carboxylate, containing said carboxylate and impurities of the corresponding carboxylic acid and/or water, is treated with an aqueous solution of a base in order to obtain a pH of the aqueous phase ranging from 9.0 to 12.2 and/or a step in which the hydrocarbon solution containing lanthanide carboxylate is treated with a solid selected from Na2SO4, MgSO4, Mg(ClO4)2, molecular sieves 3 Å, molecular sieves 4 Å, molecular sieves 5 Å and molecular sieves 13 X. Analytical methods are also described, which allow the purity of the lanthanide carboxylates to be non-destructively measured.
摘要翻译：描述了用于纯化镧系元素羧酸盐的方法，其包括将含有所述羧酸盐的镧系元素羧酸盐的衍生物的烃溶液和相应的羧酸和/或水的杂质用水溶液处理的步骤碱，以获得9.0-12.2的水相的pH值和/或其中含有镧系元素羧酸盐的烃溶液用选自Na 2 SO 4，MgSO 4，Mg（ClO 4）2，分子筛3的固体处理的步骤分子筛4，分子筛5和分子筛13 X.还描述了分析方法，其允许非腐蚀性地测量镧系元素羧酸盐的纯度。

59. 发明授权

US07592478B2 Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof 有权
标题翻译： RAR受体的配体拮抗剂及其药物/化妆品应用
公开(公告)号：US07592478B2
公开(公告)日：2009-09-22
申请号：US11978623
申请日：2007-10-30
申请人： Philippe Diaz , Catherine Raffin , Thibaud Biadatti
发明人： Philippe Diaz , Catherine Raffin , Thibaud Biadatti
IPC分类号： C07C69/74 , C07C69/76 , A01N37/10 , A01N37/30
CPC分类号： C07D213/79 , C07B2200/07 , C07C63/36 , C07C63/64 , C07C63/66 , C07C65/11 , C07C65/19 , C07C65/28 , C07C65/34 , C07C65/38 , C07C69/76 , C07C229/18 , C07C229/38 , C07C229/52 , C07C233/54 , C07C235/38 , C07C235/42 , C07C235/78 , C07C259/10 , C07C271/28 , C07C323/62 , C07C391/02 , C07C2602/10 , C07D213/30 , C07D213/80 , C07D333/16
摘要： Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):
摘要翻译： RAR受体的新型配体拮抗剂具有以下结构式（I）：其中A是CH 2，CHOH，C-O或C-N-OH基或硫或硒原子; B为选自式（a）〜（f）的基团：Ar为选自式（g）〜（i）的基团：

60. 发明申请

US20070232794A1 PROCESS FOR THE PURIFICATION OF LANTHANIDE CARBOXYLATES 有权
标题翻译：柠檬酸二羧酸酯的纯化方法
公开(公告)号：US20070232794A1
公开(公告)日：2007-10-04
申请号：US11689719
申请日：2007-03-22
申请人： Paolo Biagini , Mario Salvalaggio , Franco Cambisi , Lucia Bonoldi , Liliana Gila
发明人： Paolo Biagini , Mario Salvalaggio , Franco Cambisi , Lucia Bonoldi , Liliana Gila
IPC分类号： C07F5/00
CPC分类号： C07C51/47 , C07C51/48 , C08F36/04 , G01N21/3563 , G01N21/3577 , C07C53/126 , C07C53/128 , C07C63/36 , C08F4/545
摘要： A process is described for the purification of lanthanide carboxylates which comprises a step in which the hydrocarbon solution deriving from the synthesis of lanthanide carboxylate, containing said carboxylate and impurities of the corresponding carboxylic acid and/or water, is treated with an aqueous solution of a base in order to obtain a pH of the aqueous phase ranging from 9.0 to 12.2 and/or a step in which the hydrocarbon solution containing lanthanide carboxylate is treated with a solid selected from Na2SO4, MgSO4, Mg(ClO4)2, molecular sieves 3 Å, molecular sieves 4 Å, molecular sieves 5 Å and molecular sieves 13 X. Analytical methods are also described, which allow the purity of the lanthanide carboxylates to be non-destructively measured.
摘要翻译：描述了用于纯化镧系元素羧酸盐的方法，其包括将含有所述羧酸盐的镧系元素羧酸盐的衍生物的烃溶液和相应的羧酸和/或水的杂质用水溶液处理的步骤碱，以获得9.0-12.2的水相的pH值和/或其中含有镧系元素羧酸盐的烃溶液用选自Na 2 SO 4的固体处理的步骤 MgSO 4，Mg（ClO 4）2，分子筛3，分子筛4，分子筛5 还描述了分析方法，其允许非腐蚀性地测量镧系元素羧酸盐的纯度。

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