专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US3686335A 5-vinyl-5h-di benzo(a,d)cycloheptenes 失效
标题翻译： 5-乙烯基-5H-二苯并（A，D）环烯醇
公开(公告)号：US3686335A
公开(公告)日：1972-08-22
申请号：US3686335D
申请日：1970-12-21
申请人： SMITH KLINE FRENCH LAB
发明人： KAISER CARL , ZIRKLE CHARLES L
IPC分类号： C07C61/40 , C07C25/00 , C07C25/18
CPC分类号： C07C61/40
摘要： 5-Vinyl-5H-dibenzo(a,d)cyclo-heptenes are useful in the preparation of cyclopropanecarboxylic acid derivatives. The latter are useful as intermediates for the preparation of corresponding aminocyclopropane derivatives of 5H-dibenzo(a, d)cycloheptenes which have antidepressant, tranquilizing and anorectic activity.
摘要翻译： 5-乙烯基-5H-二苯并[a，d]环庚烯可用于制备环丙烷羧酸衍生物。后者可用作制备相应的具有抗抑郁，镇静和厌食活性的5H-二苯并[a，d]环庚烯的氨基环丙烷衍生物的中间体。

2. 发明授权

US3681461A 6-(3-diloweralkylamino-propyl)-7-(12h)-pleiadenones and salts thereof 失效
标题翻译： 6-（3-二甲基氨基丙基）-7-（12H） - 哌啶酮及其盐
公开(公告)号：US3681461A
公开(公告)日：1972-08-01
申请号：US3681461D
申请日：1970-08-12
申请人： SMITH KLINE FRENCH LAB
发明人： KAISER CARL , ZIRKLE CHARLES L
IPC分类号： C07C63/36 , C07D207/04 , C07D207/06 , C07D211/10 , C07D211/22 , C07D211/32 , C07C87/28
CPC分类号： C07D211/32 , C07C63/36 , C07D207/04 , C07D207/06 , C07D211/10 , C07D211/22
摘要： 7,12-Dihydropleiadenes in which the nucleus may have chloro, methyl, methoxy, methylthio or trifluoromethyl substituents and the 7-position is substituted by an aminopropylidene, aminopropyl, piperidylidene, piperidyl, pyrrolidylidene, pyrrolidyl, 2-piperidinylethylidene, 2-piperidinylethyl, 2pyrrolidinylethylidene or 2-pyrrolidinylethyl moiety are useful as tranquilizers and antidepressants. The compounds are generally prepared by reaction of the appropriate amino Grignard reagent with a 7(12H)-pleiadenone followed by acid dehydration of the 7hydroxy intermediate and subsequent reduction of the unsaturated derivative with phosphorus and hydroiodic acid. The 1,4-addition products also obtained via the Grignard reaction, namely 6substituted-7(12H)-pleiadenones, are also useful as tranquilizers and antidepressants.
摘要翻译： 7,12-二氢扁桃酸，其中核可以具有氯，甲基，甲氧基，甲硫基或三氟甲基取代基，并且7-位被氨基亚丙基，氨基丙基，哌啶基，哌啶基，吡咯烷亚基，吡咯烷基，2-哌啶子基亚乙基，2-哌啶基乙基， 2-吡咯烷基亚乙基或2-吡咯烷基乙基部分可用作镇定剂和抗抑郁药。这些化合物通常通过合适的氨基格氏试剂与7（12H） - ι-腺嘌呤反应，然后酸性脱水7-羟基中间体，随后用磷酸和氢碘酸还原不饱和衍生物来制备。还通过格利雅反应得到的1,4-加成产物，即6-取代-7（12H） - ple酮，也可用作镇定剂和抗抑郁剂。

3. 发明授权

US3679693A N-pyridylalkyl-{62 -alkoxy-{62 -trifluoromethyl-phenalkylamines 失效
标题翻译： N-吡啶基 - {62-羟基 - {62-三氟甲基 - 戊基]
公开(公告)号：US3679693A
公开(公告)日：1972-07-25
申请号：US3679693D
申请日：1970-09-15
申请人： SMITH KLINE FRENCH LAB
发明人： ROSS STEPHEN T , ZIRKLE CHARLES L
IPC分类号： C07D213/38 , C07D31/42
CPC分类号： C07D213/38 , Y10S514/91
摘要： N-Pyridylalkyl- Beta -alkoxy- Beta trifluoromethylphenalkylamines having anorectic activity are prepared by the condensation of an N-pyridylalkylamine with a Beta -alkoxytrifluoromethylphenakyl halide.
摘要翻译：通过N-吡啶基烷基胺与β-烷氧基三氟甲基苯甲酰卤的缩合制备具有厌氧活性的N-吡啶基烷基-β-烷氧基-β-三氟甲基苯烷基胺。

4. 发明授权

US3576853A Cyclopropanecarboxylic acid derivatives of 5h-dibenzo(a,d)cycloheptenes 失效
标题翻译： 5H-二苯并（A，D）环烯酸的环丙烷基羧酸衍生物
公开(公告)号：US3576853A
公开(公告)日：1971-04-27
申请号：US3576853D
申请日：1968-12-27
申请人： SMITH KLINE FRENCH LAB
发明人： KAISER CARL , ZIRKLE CHARLES L
IPC分类号： C07C61/39 , C07C61/40 , C07C63/44
CPC分类号： C07C61/40 , C07C61/39
摘要： CYCLOPROPANECARBOXYLIC ACID AND AMIDE DERIVATIVES OF 5H-DIBENZO (A,D) CYCLOHEPTENES WHEREIN THE TRICYCLIC NUCLEUS MAY BE SUBSTITUTED BY CHLORINE, BROMINE, TRIFLUOROMETHYL, METHYL, METHOXY OR METHYLTHIO, AS WELL AS 10,11DIHYDRO DERIVATIVES, AND THE AMIDES ARE N-MONO OR N,NDISUBSTITUTED LOWER ALKYL OR INCLUDE A CYCLIC AMIDO MOIETY, ARE USEFUL AS INTERMEDIATES FOR THE PREPARATION OF CORRESPONDING AMINOCYCLOPROPANE DERIVATIVES. THE LATTER HAVE ANTIDEPRESSANT, TRANQUILIZING AND ANORECTIC ACITIVITY. THE ACIDS AND AMIDES ARE GENERALLY PREPARED FROM APPROPRIATE 5H-DIBENZO (A,D) CYCLOHEPTENES BY ALKYLATION WITH A BROMOCYCLOPROPANECARBOXYLATE OR A BROMOCYCLOPROPANE CARBOXAMIDE, RESPECTIVELY. ALSO USEFUL IN THE PREPARATION OF THE ACIDS ARE 5-VINYL-5H-DIBENZO (A,D) CYCLOHEPTENES.

5. 发明授权

US3557098A Substituted-7,12-dihydropleiadene derivatives 失效
标题翻译：取代的7,12-二氢蝶啶衍生物
公开(公告)号：US3557098A
公开(公告)日：1971-01-19
申请号：US3557098D
申请日：1968-03-04
申请人： SMITH KLINE FRENCH LAB
发明人： KAISER CARL , ZIRKLE CHARLES L
IPC分类号： C07C63/36 , C07D207/06 , C07D207/08 , C07D211/08 , C07D211/10 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70 , C07C87/28 , C07D51/70
CPC分类号： C07D207/08 , C07C63/36 , C07D207/06 , C07D211/08 , C07D211/10 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/70
摘要： 7,12-DIHYDROPLEIADENES IN WHICH THE NUCLEUS MAY HAVE CHLORO, METHYL, METHOXY, METHYLTHIO OR TRIFLUOROMETHYL SUBSTITUTENTS AND THE 7-POSITON IS SUBSTITUTED BY AN AMINOPROPYLIDENE, AMINOPROPYL, PIPERIDYLIDENE, PIPERIDYL, PYRROLIDYLEDENE, PYRROLIDYL, 2-PIPERIDINYLETHYLIDENE, 2-PIPERINDINYLETHYL, 2-PYRROLIDINYLETHYLIDENE OR 2-PYRROLIDANYLETHYL MOIETY ARE USEFUL AS TRANQUILIZERS AND ANTIDEPRESSANTS. THE COMPOUNDS ARE GENERALLY PREPARED BY REACTION OF THE APPROPRIATE AMINO GRIGNARD REAGENT WITH A 7-(12H)-PLEIADENONE FOLLOWED BY ACID DEHYDRATION OF THE 7-HYDROXY INTERMEDIATE AND SUBSEQUENT REDUCTION OF THE UNSATURATED DERIVATIVE WITH PHORPHORUS AND HYDROIODIC ACID. THE 1,4-ADDITION PRODUCTS ALSO OBTAINED VIA THE GRIGNARD REACTION, NAMELY 6-SUBSTITUTED-7(12H)-PLEIADENONES, ARE ALSO USEFUL AS TRANQUILIZERS AND ANTIDEPRESSANTS.

6. 发明授权

US3075977A Ethers of 3-oxa- and 3-thia-9-azabicyclo-[3.3.1]-nonan-7-ol 失效
标题翻译： 3-氧杂 - 和3-硫杂-9-氮杂双环 - [3.3.1] - 壬子-7-醇的醚
公开(公告)号：US3075977A
公开(公告)日：1963-01-29
申请号：US2055760
申请日：1960-04-07
申请人： SMITH KLINE FRENCH LAB
发明人： ZIRKLE CHARLES L
IPC分类号： C07D498/08 , C07D513/08
CPC分类号： C07D513/08

7. 发明授权

US2970144A Esters of 9-alkyl-3-oxa and 3-thia-9-azabicyclo [3. 3. 1]-nonan-7-ol 失效
标题翻译： 9-烷基-3-氧杂和3-硫杂-9-氮杂双环[3。 1] - 壬-7-醇
公开(公告)号：US2970144A
公开(公告)日：1961-01-31
申请号：US70197557
申请日：1957-12-11
申请人： SMITH KLINE FRENCH LAB
发明人： ZIRKLE CHARLES L
IPC分类号： C07D498/08 , C07D513/08
CPC分类号： C07D513/08

8. 发明授权

US3655667A 1-(2-benzoylcyclopropylmethyl)-4-phenylpiperazines 失效
标题翻译： 1-（2-苯甲酰基环戊基甲基）-4-苯基哌啶
公开(公告)号：US3655667A
公开(公告)日：1972-04-11
申请号：US3655667D
申请日：1970-08-12
申请人： SMITH KLINE FRENCH LAB
发明人： KAISER CARL , ZIRKLE CHARLES L
IPC分类号： C07D211/52 , C07D295/112 , C07D51/70
CPC分类号： C07D295/112 , C07D211/52
摘要： 1-(2-BENZOYLCYCLOPROPYLMETHY) - 4 - PHENYL-1,2,5,6-TETRAHYDROPYRIDINES AND RELATED 4-PHENYLPIPERAZINES IN WHICH THE BENZOYL GROUP AND/OR THE PHENYL MOIETY MAY BE SUBSTITUTED BY CHLORO, BROMO-FLUORO, TRIFLUOROMETHYL, METHYL OR METHOXY, AS WELL AS THE ETHYLENE KETALS THEREOF, HAVE TRANQUILIZING ACTIVITY. THE COMPOUNDS ARE GENERALLY PREPARED FROM A 2-BENZOCYCLYCLOPROPANECARBOXYLIC ACID VIA REACTION OF THE TRIEHYLAMINE SALT WITH ETHYL CHLOROFORMATE TO GIVE THE MIXED ANHYDRIDE WHICH IS CONDENSED WITH A 4-PHENYL-4-PIPERIDINOL OR 1-PHENYLPIPERZINE TO GIVE A CORRESPONDING AMIDE. THE ETHYLENE KETAL OF THE AMIDE IS REDUCED TO THE CYCLOPROPYLMETHYL DERIVATIVE WHICH IS HYDROLYZED WITH ACID TO THE FREE PRODUCT.

9. 发明授权

US3597479A Substituted anilino benzyl alcohols 失效
标题翻译：取代苯胺苄醇
公开(公告)号：US3597479A
公开(公告)日：1971-08-03
申请号：US3597479D
申请日：1970-02-05
申请人： SMITH KLINE FRENCH LAB
发明人： ROSS STEPHEN T , ZIRKLE CHARLES L
IPC分类号： C07C311/37 , C07C143/80
CPC分类号： C07C311/37
摘要： 2-(SUBSTITUTED ANILINO)-BENZYL ALCOHOLS, THE SUBSTITUENTS BEING CHLORINE AND N,N-DILOWERALKYLSULFAMOYL, ARE USEFUL AS ANTIPYRETIC AND ANTI-INFLAMMATORY AGENTS. THE COMPOUNDS ARE GENERALLY PREPARED BY REDUCTION OF THE CORRESPONDING N-(SUBSTITUTED PHENYL)-ANTHRANILIC ACIDS.

10. 发明授权

US3590079A 10',11'-dihydrospiro(cyclopropane - 1,5' -5h-dibenzo(a,d)cycloheptene) - 2-carboxylic acids 失效
标题翻译： 10'，11'-DIHYDROSPIRO（环丙基 - 1,5'-5H-二苯并（A，D）环烯基）-2-羧酸
公开(公告)号：US3590079A
公开(公告)日：1971-06-29
申请号：US3590079D
申请日：1968-08-23
申请人： SMITH KLINE FRENCH LAB
发明人： KAISER CARL , ZIRKLE CHARLES L
IPC分类号： C07C49/683 , C07C49/697 , C07C57/50 , C07C61/39 , C07C61/40 , C07C245/14 , C07C63/44
CPC分类号： C07C61/39 , C07C49/683 , C07C49/697 , C07C57/50 , C07C61/40 , C07C245/14 , C07C2601/02 , C07C2603/18 , C07C2603/94
摘要： 10'',11''-DIHYDROSPIRO(CYCLOPROPANE - 1,5'' - 5H - DIBENZO (A,D)CYCLOHEPTENE) - 2 - CARBOCYLIC ACIDS WHEREIN THE DIBENZOCYCLOHEPTENE RING MAY BE SUBSTITUTED BY HALOGEN, TRIFLUOROMETHYL, LOWER, ALKYL, LOWER ALKOXY OR LOWER ALKYLTHIO ARE USEFUL AS INTERMEDIATES FOR THE PREPARATION OF CORRESPONDING 2-AMINO DERIVATIVES. THE LATTER HAVE ANTIDEPRESSANT ACTIVITY. THE ACIDS ARE GENERALLY PREPARED FORM APPROPRIATE DIBENZO(A,D)CYCLOHEPTEN-5-ONES BY CONVERSION TO THE 5-METHYL-5-OL, DEHYDRATION TO THE 5-METHYLENE DERIVATIVE, REACTION WITH ETHYL DIAZOACETATE AND HYDROLYSIS OF THE RESULTING ETHYL 2-CARBOXYLATE.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式