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51. 发明申请

US20060024330A1 Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors 失效
标题翻译：可用作hiv整合酶抑制剂的二羟基吡啶并吡嗪-1,6-二酮化合物
公开(公告)号：US20060024330A1
公开(公告)日：2006-02-02
申请号：US10526275
申请日：2003-09-10
申请人： John Wai , Boyoung Kim , Thorsten Fisher , Linghang Zhuang , Peter Williams , Terry Lyle , H. Langford , Kyle Robinson
发明人： John Wai , Boyoung Kim , Thorsten Fisher , Linghang Zhuang , Peter Williams , Terry Lyle , H. Langford , Kyle Robinson
IPC分类号： A61P31/18 , A61K39/21 , C07D471/00 , C07D487/00
CPC分类号： C07D471/14 , C07D471/04
摘要： 8,9-Dihydroxydihydropyridopyrazine-1,6-diones and 8,9-dihydroxypyridopyrazine-1,6-diones are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the pyridopyrazinediones are of Formula (I): (I), wherein R1, R2, R3, R4 and R5 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.
摘要翻译： 8,9-二氢二氢吡啶并吡嗪-1,6-二酮和8,9-二羟基吡啶并吡嗪-1,6-二酮是HIV整合酶和HIV复制抑制剂的抑制剂。在一个实施方案中，吡啶并吡啶酮具有式（I）：（I），其中R 1，R 2，R 3，R 3， SUP> 4和R 5在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。描述了预防，治疗或延缓AIDS发病的方法以及预防或治疗HIV感染的方法。

52. 发明授权

US06918059B1 Method and system for handling errors in a distributed computer system 有权
标题翻译：用于处理分布式计算机系统中的错误的方法和系统
公开(公告)号：US06918059B1
公开(公告)日：2005-07-12
申请号：US09559849
申请日：2000-04-27
申请人： Albhy Galuten , Peter Williams
发明人： Albhy Galuten , Peter Williams
IPC分类号： G06F11/00 , G06F11/07 , H04L12/24
CPC分类号： G06F11/0793 , G06F11/0715 , G06F11/0748 , G06F11/0781 , G06F11/079 , H04L41/0604 , H04L43/0811
摘要： A method and system for tracking and processing errors in a distributed computer system. As an application encounters an error, a centralized system intercepts and assumes the processing of that error event. The central error processing may be used with a distributed network connecting the applications running on various user computers. Upon receipt of an error message from an application, the system creates an informative error package, propagates appropriate error alert to relevant subsystems, and attempts to resolve the error. The error may be resolved in various ways. For example, the system may select and dispatch appropriate help information to the user; or the system may locate an alternative resource to substitute for the failed resource. The system may prioritize errors when there is more than one error still unresolved at any given time. In addition, the system may filter errors that require different levels of response and the system may direct errors to resources capable of assisting in resolving the error.
摘要翻译：一种用于跟踪和处理分布式计算机系统中的错误的方法和系统。当应用程序遇到错误时，集中式系统将拦截并假定处理该错误事件。中央错误处理可以与连接在各种用户计算机上运行的应用的分布式网络一起使用。在从应用程序接收到错误消息后，系统将创建一个内容丰富的错误包，将相应的错误警报传播到相关子系统，并尝试解决错误。该错误可以以各种方式解决。例如，系统可以向用户选择和调度适当的帮助信息; 或者系统可以定位替代资源来替代故障资源。在任何给定的时间，当有多于一个错误仍然未解决时，系统可能对错误进行优先级排序。另外，系统可以过滤需要不同响应等级的错误，并且系统可能会将错误引导到能够帮助解决错误的资源。

53. 发明申请

US20050097763A1 Intrinsic Gauging For Tube Fittings 有权
标题翻译：管件的固有测量
公开(公告)号：US20050097763A1
公开(公告)日：2005-05-12
申请号：US10711353
申请日：2004-09-13
申请人： Peter Williams , Lonnie Johnston , John Karkosiak , Gerald Babuder , Sanjeev Moghe
发明人： Peter Williams , Lonnie Johnston , John Karkosiak , Gerald Babuder , Sanjeev Moghe
IPC分类号： F16L19/00 , F16L19/065 , F16L19/075 , F16L17/00
CPC分类号： F16L19/103 , F16L19/00 , F16L19/065 , F16L2201/10 , F16L2201/60
摘要： An intrinsic gauging device for a ferrule type tube fitting of the type having a coupling nut, a coupling body and at least one ferrule, includes a precisely formed marking on the coupling nut that is visually perceptible that indicates the pull-up position of the tube fitting assembly.
摘要翻译：用于具有联接螺母，联接主体和至少一个套圈的类型的套圈型管接头的固有测量装置包括在联接螺母上的精确形成的标记，其在视觉上可感知，指示管的上拉位置装配总成。

54. 发明授权

US06886256B2 Brush saw cutting head with integral herbicide applicator 失效
标题翻译：刷锯切割头与整体除草剂施药器
公开(公告)号：US06886256B2
公开(公告)日：2005-05-03
申请号：US10436148
申请日：2003-05-13
申请人： Bryan Marc Hobday , Peter Williams
发明人： Bryan Marc Hobday , Peter Williams
IPC分类号： A01D43/14 , B23D59/02
CPC分类号： A01D43/14
摘要： A chamber is formed in the upper end of a brush saw cutting head housing. The brush saw cutting element drive spindle's upper end projects into the chamber. The drive spindle's lower end projects beneath the housing and is drivingly couplable to the cutting element. A disc is mounted against the underside of the cutting element. A cavity is formed in the disc. At least one channel extends through the disc, between the cavity and the disc's external rim. An aperture extends through the drive spindle, between the chamber and the cavity. Herbicide supplied to the chamber flows from the chamber, through the drive spindle aperture, into the cavity. The drive spindle rotates the disc. Centrifugal force imposed on herbicide within the cavity forces the herbicide through the channel(s) onto the underside of the cutting element, for transfer onto the stumps of material cut by the element.
摘要翻译：在刷锯切割头壳体的上端形成有腔室。刷锯切割元件驱动主轴的上端突出到室内。驱动主轴的下端突出在壳体下方，并且可驱动地连接到切割元件。盘被安装在切割元件的下侧。在盘中形成空腔。至少一个通道延伸穿过盘，在腔和盘的外缘之间。孔在腔室和空腔之间延伸穿过驱动主轴。提供给室的除草剂从室流过驱动主轴孔流入空腔。驱动主轴旋转光盘。在空腔内施加的除草剂的离心力迫使除草剂通过通道到切割元件的下侧，以转移到由元件切割的材料的树脂上。

55. 发明申请

US20050032076A1 METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES 有权
标题翻译：确定寡核苷酸核苷酸序列和DNA分子的方法
公开(公告)号：US20050032076A1
公开(公告)日：2005-02-10
申请号：US10709436
申请日：2004-05-05
申请人： Peter Williams , Thomas Taylor , Daniel Williams , Ian Gould , Mark Hayes
发明人： Peter Williams , Thomas Taylor , Daniel Williams , Ian Gould , Mark Hayes
IPC分类号： C12N15/09 , C12Q1/68 , C12P19/34
CPC分类号： C12P19/34 , C12Q1/6816 , C12Q1/6869 , C12Q2565/629 , C12Q2533/101 , C12Q2565/301 , C12Q2563/107 , C12Q2563/103
摘要： The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA poly-merase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions.
摘要翻译：本发明涉及一种用于分析核酸序列的新方法，该方法基于实时检测将DNA微聚合酶催化的四个核苷酸碱基中的每一个（在微流体系统中单独提供和连续供应）并入到含有模板系统，其包含未知序列的DNA片段和寡核苷酸引物。将核苷酸碱基掺入模板系统可以通过多种方法中的任何一种检测，包括但不限于荧光和化学发光检测。或者，可以使用通过使用热电堆，热敏电阻和折射率测量将核苷酸并入扩展模板系统产生的热的微量热法测定来检测延伸反应。

56. 发明授权

US06714627B1 Collimator for radiotherapy apparatus 有权
标题翻译：放射治疗仪器准直仪
公开(公告)号：US06714627B1
公开(公告)日：2004-03-30
申请号：US09786065
申请日：2001-05-24
申请人： Kevin John Brown , Peter Williams , John Wong , Di Yan
发明人： Kevin John Brown , Peter Williams , John Wong , Di Yan
IPC分类号： G21K104
CPC分类号： G21K1/04 , A61N5/1042 , G21K1/046
摘要： A radiotherapy apparatus comprises a first collimator and a second collimator, the first collimator being a multi-leaf collimator, the second collimator comprising a plurality of slits having a width which is a fraction of the width of the leaves of the first collimator, the first and second collimators being aligned such that each slit of the second collimator is associated with a leaf of the first collimator. A first irradiation is made, during which the first collimator will define the outer edge of the irradiation pattern, and the second collimator will serve to narrow the effective width of each leaf of the first collimator. This narrowing is a simple function of the relative widths of the slits of the second collimator and the leaves of the first. This will leave gaps in between the slits of the second collimator, which can then be filled by moving one or more of the patient, first and second collimators, so as to irradiate an area omitted in the first irradiation. In this second irradiation, the positions of the leaves of the first collimator are adjusted as necessary. This process is then repeated until the entire target area has been irradiated. Suitable values for the fraction are {fraction (1/2, 1/3, 1/4)}, or ⅕.
摘要翻译：放射治疗装置包括第一准直器和第二准直器，所述第一准直器是多叶准直器，所述第二准直器包括多个狭缝，所述多个狭缝的宽度是所述第一准直仪叶片的宽度的一部分，并且第二准直器被对准，使得第二准直器的每个狭缝与第一准直仪的叶片相关联。进行第一次照射，在此期间第一准直器将限定照射图案的外边缘，并且第二准直器将用于缩小第一准直仪的每个叶片的有效宽度。这种变窄是第二准直器的狭缝和第一准直器的叶片的相对宽度的简单函数。这将在第二准直器的狭缝之间留下间隙，然后可以通过移动患者，第一和第二准直器中的一个或多个来填充，以便照射第一次照射中省略的区域。在该第二照射中，根据需要调整第一准直仪的叶片的位置。然后重复该过程直到整个目标区域被照射。分数的合适值为{分数（1/2，1/3，1/4）}或1/5。

57. 发明授权

US5741506A Use of active ingredients protected against degradation in the rumen as hepatoprotectors 失效
标题翻译：使用有保护作用的活性成分作为肝保护剂在瘤胃中降解
公开(公告)号：US5741506A
公开(公告)日：1998-04-21
申请号：US436115
申请日：1995-05-08
申请人： Dominique Bauchart , Yves Chilliard , Denys Durand , Dominique Gruffat , Alain Ollier , Jean-Claude Robert , Peter Williams
发明人： Dominique Bauchart , Yves Chilliard , Denys Durand , Dominique Gruffat , Alain Ollier , Jean-Claude Robert , Peter Williams
IPC分类号： A61K31/195 , A61K47/00 , A23K1/18
CPC分类号： A61K31/195 , Y10S426/807
摘要： The use of protected active ingredients, preferably methionine, protected against degradation in the rumen as a hepatoprotective agent is disclosed.
摘要翻译：公开了使用保护的活性成分，优选甲硫氨酸，作为肝保护剂在瘤胃中不被降解。

58. 发明授权

US4036983A Ferrocene compounds and pharmaceutical composition for use in treatment of iron deficiency in an animal 失效
标题翻译：二茂铁化合物和用于治疗动物缺铁的药物组合物
公开(公告)号：US4036983A
公开(公告)日：1977-07-19
申请号：US647133
申请日：1976-01-07
申请人： David Rutherford , Peter Williams , Richard Anthony Raphael
发明人： David Rutherford , Peter Williams , Richard Anthony Raphael
IPC分类号： A61K31/295 , C07F15/02 , C07F17/02 , A01N9/00
CPC分类号： C07F17/02
摘要： These are described compounds of formula I, ##STR1## in which R is a cycloalkyl group, N IS 0, 1 OR 2,R' is hydrogen, phenyl, alkyl C 1 to 6, cycloalkyl C 4 to 6, alkyl-cycloalkyl C 5 to 8, or phenyl-(alkyl C 1 to 6),x is a whole number from 0 to 8, andy is a whole number from 0 to 5.There are also described processes for making the compounds and pharmaceutical, e.g. haematinic, compositions containing the compounds.
摘要翻译：这些化合物是式Ⅰ化合物，其中R是环烷基，N是0,1或2，R'是氢，苯基，C 1-6的烷基，环烷基C 4〜6，烷基 - 环烷基 C 5〜8，或苯基 - （烷基C 1-6），X为0〜8的全数，Y为0〜5的整数。

59. 发明授权

US09261434B2 Tire uniformity testing system having a testing station for changing rim sets 有权
标题翻译：轮胎均匀性测试系统具有用于更换轮辋组的测试台
公开(公告)号：US09261434B2
公开(公告)日：2016-02-16
申请号：US13885850
申请日：2011-11-22
申请人： James Wollbrinck , Richard R. Matuszny , Barry Cargould , Peter Williams
发明人： James Wollbrinck , Richard R. Matuszny , Barry Cargould , Peter Williams
IPC分类号： G01M17/02 , B60C23/00 , B60C23/02 , B60C25/00
CPC分类号： G01M17/02 , B60C25/002 , G01M17/021 , Y10T29/49815 , Y10T29/49826
摘要： An apparatus for changing rim sets at a testing station of a tire uniformity testing system that includes a storage unit for storing a plurality of rim set assemblies. A transfer arm is reciprocally movable and includes a gripper mechanism for gripping a rim set assembly and moving it from a storage position to a position at which rims forming part of the rim set assembly are aligned with opposed spindles at the testing station. The rim set assembly includes a bracket having structure engageable by the transfer arm and at least one of the rims forming part of the assembly includes a locking member rotatable between a first position and a second position. The bracket includes a structure for immobilizing the rim to inhibit relative rotation between the rim and the bracket and further includes a lever mechanism for moving the locking member from its first position to its second position in order to engage retaining members forming part of the bracket. The lever mechanism moves the locking member from its second position to its first position when the rim is aligned with an associated spindle in order to engage other retaining members forming part of the spindle. The rim is released from the bracket as the locking member moves to engage the other retaining members. After release, the bracket moves to a remote position spaced from the testing station. To remove the rim sets, the steps for attaching rims to the spindles are reversed in order to release the rims from the spindles while simultaneously engaging the bracket. The resulting rim set assembly is moved to a remote position defined by a storage unit that stores a plurality of rim set assemblies. The disclosed locking member and associated rim can be used to facilitate the manual installation of a test rim to a spindle.
摘要翻译：一种用于在轮胎均匀性测试系统的测试站处改变轮辋组件的装置，其包括用于存储多个轮辋组件的存储单元。传送臂是可往复运动的，并且包括夹持机构，用于夹持轮圈组件并将其从存放位置移动到形成轮圈组件的一部分的轮缘与测试台处的相对的主轴对准的位置。轮辋组件包括具有可由传送臂接合的结构的支架，并且构成组件的一部分的至少一个轮辋包括可在第一位置和第二位置之间旋转的锁定构件。支架包括用于固定轮缘以阻止轮缘和支架之间的相对旋转的结构，并且还包括杠杆机构，用于将锁定构件从其第一位置移动到其第二位置，以便接合构成支架的一部分的保持构件。当边缘与相关联的主轴对准时，杠杆机构将锁定构件从其第二位置移动到其第一位置，以便接合形成主轴的一部分的其它保持构件。当锁定构件移动以与其它保持构件接合时，边缘从支架释放。释放后，支架移动到与测试站隔开的远程位置。为了拆下轮辋组，将轮辋连接到主轴上的步骤是相反的，以便在同时接合支架的同时将轮辋从主轴上松开。所得到的轮圈组件移动到由存储多个轮圈组件的存储单元限定的远程位置。所公开的锁定构件和相关联的边缘可以用于便于将试验轮辋手动安装到主轴。

60. 发明授权

US08537042B2 Multi-bit digital to analogue converter and a delta-sigma analogue to digital converter 有权
标题翻译：多位数模转换器和一个delta-sigma模数转换器
公开(公告)号：US08537042B2
公开(公告)日：2013-09-17
申请号：US13359741
申请日：2012-01-27
申请人： Hashem Zare-Hoseini , Peter Williams
发明人： Hashem Zare-Hoseini , Peter Williams
IPC分类号： H03M1/66 , H03M3/02
CPC分类号： H03M1/0665 , H03M1/74 , H03M3/464
摘要： The present invention relates to a multi-bit digital to analogue converter (DAC) and to a delta-sigma analogue to digital converter employing such a DAC. The DAC has a multi-bit input, a plurality of elements for processing an input signal received at the input and a selector for selecting, based on the input signal, one or more of the DAC elements to process the signal. The DAC has control means for controlling the selector such that if the input to the DAC is below a predetermined level for a predetermined period of time the selector is operative to select only a single one of the DAC elements to process the input signal. Also disclosed is a delta-sigma analogue to digital converter (ADC) employing such a DAC.
摘要翻译：本发明涉及一种多位数模转换器（DAC）以及采用这种DAC的Δ-Σ模数转换器。 DAC具有多位输入，用于处理在输入端接收的输入信号的多个元件和用于根据输入信号选择一个或多个DAC元件来处理该信号的选择器。 DAC具有用于控制选择器的控制装置，使得如果DAC的输入在预定时间段内低于预定电平，则选择器仅可操作以仅选择DAC单元中的一个来处理输入信号。还公开了采用这种DAC的Δ-Σ模数转换器（ADC）。

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