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51. 发明申请

US20050004607A1 Cardiac stimulating and detecting device, system and method for identifying far field signals 有权
标题翻译：用于识别远场信号的心脏刺激和检测装置，系统和方法
公开(公告)号：US20050004607A1
公开(公告)日：2005-01-06
申请号：US10864064
申请日：2004-06-09
申请人： Anders Bjorling , Sven-Erik Hedberg , Nils Holmstrom
发明人： Anders Bjorling , Sven-Erik Hedberg , Nils Holmstrom
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/37 , A61N1/3627 , A61N1/3684 , Y10S128/901
摘要： In an implantable heart stimulating device, system and method, a control circuit has first and second circuits for sensing and pacing. The first circuit can be connected to a first electrode member suited to be positioned in or at a first ventricle of the heart. The second circuit can be connected to a second electrode member suited to be positioned in or at a second ventricle of the heart. The control circuit is able to detect whether signals sensed by the second circuit are likely to be far field signals. The control circuit performs this detection by at least determining whether, during a predetermined time (length, more signals are sensed by the second circuit than by the first circuit.
摘要翻译：在可植入心脏刺激装置，系统和方法中，控制电路具有用于感测和起搏的第一和第二电路。第一电路可以连接到适于定位在心脏的第一心室中或第一心室处的第一电极构件。第二电路可以连接到适于定位在心脏的第二心室中或第二心室处的第二电极构件。控制电路能够检测由第二电路感测的信号是否可能是远场信号。控制电路通过至少确定在预定时间（长度，由第二电路感测到的信号多于第一电路的信号）来执行该检测。

52. 发明授权

US06529777B1 Electrode for tissue stimulation 失效
标题翻译：电极组织刺激
公开(公告)号：US06529777B1
公开(公告)日：2003-03-04
申请号：US09622817
申请日：2000-08-23
申请人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
发明人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61N105
CPC分类号： A61N1/371 , A61N1/0565 , A61N1/362 , A61N1/36585
摘要： In an implantable electrode for an electrode lead for a stimulation device for stimulating tissue, the electrode is formed as a biocompatible piezoelectric electrode which is adapted to be in direct electrical contact with tissue for electrically and mechanically stimulating the tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. The stimulation device can include circuitry for making a diagnosis of a heart condition using signals received from the implantable electrode.
摘要翻译：在用于刺激组织的刺激装置的电极引线的可植入电极中，电极形成为生物相容性压电电极，其适于与组织直接电接触，用于电和机械刺激组织并检测电和机械诱发刺激组织的反应。刺激装置可以包括使用从可植入电极接收的信号进行心脏状况诊断的电路。

53. 发明授权

US5935158A Electrode lead and device for tissue stimulation and/or detection of tissue response 失效
标题翻译：用于组织刺激和/或检测组织反应的电极引线和装置
公开(公告)号：US5935158A
公开(公告)日：1999-08-10
申请号：US915756
申请日：1997-08-21
申请人： Nils Holmstrom , Sven-Erik Hedberg , Kenth Nilsson
发明人： Nils Holmstrom , Sven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61N1/05 , A61N1/362 , A61N1/39 , A61N1/04
CPC分类号： A61N1/0565
摘要： An implantable electrode for stimulating tissue has a piezoelectric electrode for electrically and mechanically stimulating tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. An implantable lead and an implantable stimulation device employing such an electrode are described including diagnostic circuitry for making a diagnosis of the heart condition using such an electrode.
摘要翻译：用于刺激组织的可植入电极具有用于电和机械刺激组织并用于检测受刺激组织的电和机械诱发反应的压电电极。描述了使用这种电极的可植入引线和可植入刺激装置，其包括使用这种电极进行心脏病症诊断的诊断电路。

54. 发明授权

US5464429A Apparatus for producing heart defibrillation sequences from stimulation pulses and defibrillation shocks 失效
标题翻译：用于从刺激脉冲和除颤电击产生心脏除颤序列的装置
公开(公告)号：US5464429A
公开(公告)日：1995-11-07
申请号：US114357
申请日：1993-09-01
申请人： Sven-Erik Hedberg , Martin Obel , Kurt Hoegnelid
发明人： Sven-Erik Hedberg , Martin Obel , Kurt Hoegnelid
IPC分类号： A61N1/39 , A61N1/362
CPC分类号： A61N1/3962
摘要： An apparatus for producing heart defibrillation sequences formed of stimulation pulses and defibrillation shocks contains a unit for delivering pulses through an intracardiac or epicardiac electrode, normally for cardiac pacing, and defibrillator circuitry for delivering defibrillation shocks through defibrillation electrodes. The unit for delivering pacing pulses has an output stage which is capable of generating a stimulation pulse, delivered to the heart via the pacing electrode, having a higher energy content than a pacing pulse, but considerably less energy than a conventional defibrillation shock. A control unit is connected to the unit for delivering stimulation pulses and to the defibrillator circuitry for forming a defibrillation sequence consisting of stimulation pulses and defibrillation shocks. The control unit determines the timing for delivering the stimulation pulses and the defibrillation shocks.
摘要翻译：用于产生由刺激脉冲和除颤电击形成的心脏除颤序列的装置包含用于通过心脏或心外膜电极（通常用于心脏起搏）输送脉冲的单元，以及用于通过除颤电极输送除颤电击的除颤器电路。用于输送起搏脉冲的单元具有输出级，其能够产生刺激脉冲，经由起搏电极传递到心脏，具有比起搏脉冲更高的能量含量，但是比传统除颤电击显着更少的能量。控制单元连接到用于递送刺激脉冲的单元和去纤颤器电路，用于形成由刺激脉冲和除颤电击组成的除颤序列。控制单元确定输送刺激脉冲和除颤电击的时间。

55. 发明授权

US4723551A Atrium-controlled heart pacemaker 失效
标题翻译：心房控制的心脏起搏器
公开(公告)号：US4723551A
公开(公告)日：1988-02-09
申请号：US910997
申请日：1986-09-24
申请人： Sven-Erik Hedberg , Anders Lindgren
发明人： Sven-Erik Hedberg , Anders Lindgren
IPC分类号： A61N1/37 , A61N1/362 , A61N1/365 , A61N1/36
CPC分类号： A61N1/3621
摘要： An atrium-controlled heart pacemaker has a monitoring circuit for interrupting tachycardia which may be generated by the pacemaker. The monitoring circuit includes a P-wave counter and a window generator connected thereto. The window generator prescribes a window for the P-wave counter within which a predetermined maximum number n of P-waves is allowed to appear. When the n.sup.th P-wave appears in the window, forwarding of the n+1.sup.th P-wave to the stimulation circuit is blocked.
摘要翻译：心房控制的心脏起搏器具有用于中断可由起搏器产生的心动过速的监测电路。监视电路包括P波计数器和与其连接的窗口发生器。窗口发生器规定了P波计数器的窗口，在该窗口中允许出现预定的最大数量n个P波。当第n个P波出现在窗口中时，第n + 1个P波到达刺激电路的转发被阻止。

56. 发明授权

US08620432B2 Identification of pacing site 有权
标题翻译：鉴定起搏部位
公开(公告)号：US08620432B2
公开(公告)日：2013-12-31
申请号：US13171952
申请日：2011-06-29
申请人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
发明人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译：可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。

57. 发明授权

US08346353B2 Implantable medical system for detecting incipient edema 有权
标题翻译：用于检测初期水肿的植入式医疗系统
公开(公告)号：US08346353B2
公开(公告)日：2013-01-01
申请号：US12531793
申请日：2007-04-24
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
IPC分类号： A61B5/05
CPC分类号： A61N1/05 , A61B5/0084 , A61B5/0086 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/7207 , A61N1/025 , A61N1/056 , A61N1/362
摘要： An implantable medical system for detecting incipient edema has an implantable medical lead including an optical sensor having a light source and a light detector. The medical system further has an edema detection circuit that activates the light source to emit light, the light being directed into lung tissue of a patient and that obtains a light intensity value corresponding to an intensity of light received by the light detector, and that evaluates the light intensity value to detect a consistency with incipient edema.
摘要翻译：用于检测初期水肿的可植入医疗系统具有包括具有光源和光检测器的光学传感器的可植入医疗引线。医疗系统还具有水肿检测电路，其激活光源发光，将光引导到患者的肺组织，并获得与由光检测器接收的光的强度对应的光强度值，并且评估光强值检测与初期水肿的一致性。

58. 发明授权

US08219194B2 Implantable cardiac stimulator, system, device and method for monitoring cardiac synchrony 有权
标题翻译：可植入式心脏刺激器，系统，装置和监测心脏同步的方法
公开(公告)号：US08219194B2
公开(公告)日：2012-07-10
申请号：US13271548
申请日：2011-10-12
申请人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
发明人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the first cardiac wall location and a second sensor is positioned at a second cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the second cardiac wall location. A lead arrangement conducts respective output signals from the first and second sensors to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译：在用于监测人心脏心脏同步的系统和方法中，第一传感器位于第一心脏壁位置，该第一心脏壁位置受到与心脏的纵向轴线的纵向瓣膜平面运动有关的运动，并且测量心脏壁移动在第一心脏壁位置处，并且第二传感器定位在第二心脏壁位置处，所述第二心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动相关的运动，并且测量第二心脏壁位置处的心脏壁运动。引线装置将来自第一和第二传感器的相应输出信号传导到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在第一和第二心脏壁位置处的各个阀平面运动中的同步。

59. 发明申请

US20120004700A1 IDENTIFICATION OF PACING SITE 有权
标题翻译：鉴定场地
公开(公告)号：US20120004700A1
公开(公告)日：2012-01-05
申请号：US13171952
申请日：2011-06-29
申请人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
发明人： Sven-Erik Hedberg , Nils Holmström , John Gustafsson , Andreas Blomqvist , Andreas Karlsson
IPC分类号： A61N1/368
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译：可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。

60. 发明申请

US20110144508A1 METHOD AND DEVICE FOR MONITORING ACUTE DECOMPENSATED HEART FAILURE 有权
标题翻译：用于监测急性脱发性心脏衰竭的方法和装置
公开(公告)号：US20110144508A1
公开(公告)日：2011-06-16
申请号：US12809255
申请日：2007-12-21
申请人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmström , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device has an impedance determiner for determining a cardiogenic impedance signal based on electric signals sensed by connected electrodes. A parameter calculator processes the impedance signal to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device for monitoring acute decompensated heart failure status of a subject.
摘要翻译：可植入医疗装置具有用于基于由连接电极感测的电信号确定心源阻抗信号的阻抗确定器。参数计算器处理阻抗信号以计算代表与心脏周期的舒张期相关的心源阻抗的阻抗参数。该参数随后被该装置用于监测受试者的急性失代偿性心力衰竭状态。

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