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51. 发明申请

US20130015646A1 KNEE AIRBAG 有权
标题翻译： KNEE安全气囊
公开(公告)号：US20130015646A1
公开(公告)日：2013-01-17
申请号：US13579792
申请日：2011-02-02
申请人： Masakazu Okamoto , Akifumi Hanawa , Takashi Ohshima
发明人： Masakazu Okamoto , Akifumi Hanawa , Takashi Ohshima
IPC分类号： B60R21/231
CPC分类号： B60R21/2171 , B60R21/2346 , B60R21/237 , B60R2021/23169
摘要： An airbag in which no choking occurs and which can be rapidly deployed. A cushion section of the airbag internally accommodates a cylinder-type inflator that includes an insertion hole for inserting the inflator from an outside to an inside, and a diffuser into which the inflator is inserted, and a diffuser having a tubular portion obtained by folding back a section of cloth to form symmetrical portions with an upper base formed by the folded back part and a lower base formed by adjacent ends of the symmetrical portions. The cushion section is folded back at both lateral sides of the along first folding lines that are substantially orthogonal to a longitudinal direction of the diffuser.
摘要翻译：安全气囊，其中不发生窒息并且可以快速部署。气囊的缓冲部内部容纳有气缸式充气机，其包括用于将充气器从外部插入到内部的插入孔和充气器插入到其中的扩散器，以及具有通过折回获得的管状部分的扩散器形成对称部分的布的一部分与由折叠部分形成的上基部和由对称部分的相邻端形成的下基部。缓冲部分沿着与扩散器的纵向方向基本正交的第一折叠线的两侧的侧面折回。

52. 发明授权

US08319193B2 Charged particle beam apparatus, and method of controlling the same 有权
标题翻译：带电粒子束装置及其控制方法
公开(公告)号：US08319193B2
公开(公告)日：2012-11-27
申请号：US12999075
申请日：2009-06-10
申请人： Keigo Kasuya , Takashi Ohshima , Souichi Katagiri , Shigeru Kokubo , Hideo Todokoro
发明人： Keigo Kasuya , Takashi Ohshima , Souichi Katagiri , Shigeru Kokubo , Hideo Todokoro
IPC分类号： H01J27/26
CPC分类号： H01J1/304 , H01J37/073 , H01J37/265 , H01J2237/022 , H01J2237/06325 , H01J2237/0653 , H01J2237/0656
摘要： Provided is a charged particle beam apparatus, which can emit a stable electron beam, having high brightness and a narrow energy width. The charged particle beam apparatus comprises a field emission electron source, electrodes for applying an electric field to the field emission electron source, and a vacuum exhaust unit for keeping the pressure around the field emission electron source at 1 10−8 Pa or less. The apparatus is so constituted as to use such one of the electron beams emitted as has an electron-beam-center radiation angle of 1×10−2sr or less, and to use the electric current thereof, the second order differentiation of which is negative or zero with respect to the time, and which reduces at a rate of 10% or less per hour. The charged particle beam apparatus further comprises a heating unit for the field emission electron source, and a detection unit for the electric current of the electron beam. The field emission electron source is repeatedly heated to keep the electric current of the electron beam to be emitted, at a predetermined value or higher.
摘要翻译：提供一种带电粒子束装置，其能够发射具有高亮度和窄能量宽度的稳定电子束。带电粒子束装置包括场发射电子源，用于向场发射电子源施加电场的电极和用于将场致发射电子源周围的压力保持在10×10 8 Pa以下的真空排气单元。该装置构成为使用发射的电子束中心辐射角为1×10-2sr以下的电子束，并使用其电流，其二阶微分为负或相对于时间为零，并以每小时10％或更少的速率减少。带电粒子束装置还包括用于场发射电子源的加热单元和用于电子束电流的检测单元。重复加热场致发射电子源以使电子束的电流保持在规定值以上。

53. 发明申请

US20120119086A1 GAS FIELD ION SOURCE, CHARGED PARTICLE MICROSCOPE, AND APPARATUS 有权
标题翻译：气体离子源，充电颗粒显微镜和装置
公开(公告)号：US20120119086A1
公开(公告)日：2012-05-17
申请号：US13355104
申请日：2012-01-20
申请人： Hiroyasu Shichi , Shinichi Matsubara , Takashi Ohshima , Satoshi Tomimatsu , Tomihiro Hashizume , Tohru Ishitani
发明人： Hiroyasu Shichi , Shinichi Matsubara , Takashi Ohshima , Satoshi Tomimatsu , Tomihiro Hashizume , Tohru Ishitani
IPC分类号： H01J37/26
CPC分类号： H01J27/26 , H01J37/08 , H01J2237/0805 , H01J2237/0807 , H01J2237/182
摘要： A gas field ion source that can simultaneously increase a conductance during rough vacuuming and reduce an extraction electrode aperture diameter from the viewpoint of the increase of ion current. The gas field ion source has a mechanism to change a conductance in vacuuming a gas molecule ionization chamber. That is, the conductance in vacuuming a gas molecule ionization chamber is changed in accordance with whether or not an ion beam is extracted from the gas molecule ionization chamber. By forming lids as parts of the members constituting the mechanism to change the conductance with a bimetal alloy, the conductance can be changed in accordance with the temperature of the gas molecule ionization chamber, for example the conductance is changed to a relatively small conductance at a relatively low temperature and to a relatively large conductance at a relatively high temperature.
摘要翻译：一种气体离子源，其可以在粗吸真空中同时增加电导，并且从离子电流的增加的角度降低提取电极的孔直径。气体离子源具有改变真空气体分子离子化室中的电导的机理。也就是说，根据是否从气体分子离子化室抽出离子束，改变对气体分子离子化室进行抽真空的电导。通过将盖子形成为构成用双金属合金改变电导的机构的部件的部分，可以根据气体分子离子化室的温度来改变电导率，例如，电导率变为相对较小的电导率相对较低的温度和相对高的温度下的相对较大的电导率。

54. 发明申请

US20110098479A1 CONDENSATION REACTION BY METAL CATALYST 审中-公开
标题翻译：金属催化剂冷凝反应
公开(公告)号：US20110098479A1
公开(公告)日：2011-04-28
申请号：US12980502
申请日：2010-12-29
申请人： KAZUSHI MASHIMA , Takashi Ohshima , Takanori Iwasaki , Hironori Maeda , Kenya Ishida
发明人： KAZUSHI MASHIMA , Takashi Ohshima , Takanori Iwasaki , Hironori Maeda , Kenya Ishida
IPC分类号： C07F7/10 , C07D263/12 , C07D263/10 , C07D263/14 , C07D263/52
CPC分类号： C07D263/12 , B01J31/2226 , B01J2531/26 , C07C53/18 , C07C231/02 , C07C253/30 , C07D263/10 , C07D263/14 , C07D263/52 , C07D413/06 , C07F3/003 , C07F7/1892 , C07F9/5022 , C07K1/088 , C07K1/10
摘要： The invention relates to a method for producing an azoline compound represented by the general formula (3): wherein R1 represents an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; R3, R4, R5 and R6 may be the same or different and each represents a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted alkoxy group, an optionally substituted alkoxycarbonyl group, a halogen atom, a substituted amino group, a substituted carbamoyl group or an optionally substituted heterocyclic group; two arbitrary groups selected from R3, R4, R5 and R6 may bond to each other to form a ring; and Z1 represents an oxygen atom, a sulfur atom or a selenium atom;comprising reacting a carboxylic acid or a carboxylic acid derivative represented by the general formula (1): R1CO2R2 (1) wherein R1 is as defined above; R2 represents a hydrogen atom, an optionally substituted alkyl group or an optionally substituted aryl group; and R1 and R2 may bond to each other to form a ring;with an aminochalcogenide represented by the general formula (2): wherein R3, R4, R5, R6 and Z1 are as defined above; in the presence of a compound containing a group 12 metal element in the periodic table.
摘要翻译：本发明涉及一种制备由通式（3）表示的唑啉化合物的方法：其中R1表示任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基，取代的氨基甲酰基或任选取代的杂环基; R3，R4，R5和R6可以相同或不同，各自表示氢原子，任选取代的烃基，任选取代的烷氧基，任选取代的烷氧基羰基，卤素原子，取代的氨基，取代的氨基甲酰基基团或任选取代的杂环基团; 选自R3，R4，R5和R6中的两个任意基团可以彼此键合形成环; Z1表示氧原子，硫原子或硒原子; 包括使由通式（1）表示的羧酸或羧酸衍生物：R1CO2R2（1）其中R1如上定义; R2表示氢原子，任选取代的烷基或任选取代的芳基; 并且R 1和R 2可以彼此键合形成环; 与通式（2）表示的氨基硫族化物：其中R3，R4，R5，R6和Z1如上定义; 在含有元素周期表中第12族金属元素的化合物存在下进行。

55. 发明授权

US07755046B2 Transmission electron microscope 有权
标题翻译：透射电子显微镜
公开(公告)号：US07755046B2
公开(公告)日：2010-07-13
申请号：US12010702
申请日：2008-01-29
申请人： Teruo Kohashi , Takashi Ohshima , Takao Matsumoto , Hirokazu Nishida
发明人： Teruo Kohashi , Takashi Ohshima , Takao Matsumoto , Hirokazu Nishida
IPC分类号： G01N23/00 , G21K7/00
CPC分类号： H01J37/266 , H01J37/265 , H01J2237/06383 , H01J2237/1514 , H01J2237/24557 , H01J2237/2588 , H01J2237/2614
摘要： Chirality distribution in the molecular structure of protein or the like and magnetic domain structure are analyzed with high resolution less than 10 nm. A transmission electron microscope equipped with a spin-polarized electron source is used for holography observation. The phase of transmission spin-polarized electrons changes due to the existence of chirality structure or magnetization in a sample, which is observed as an interference pattern phase shift in holography measurement.
摘要翻译：蛋白质等分子结构中的手性分布和磁畴结构以高分辨率小于10nm进行分析。配备有自旋极化电子源的透射电子显微镜用于全息观察。透射自旋极化电子的相位由于样品中手性结构或磁化的存在而改变，在全息测量中被观察为干涉图案相移。

56. 发明申请

US20090294697A1 Charged particle beam apparatus 有权
标题翻译：带电粒子束装置
公开(公告)号：US20090294697A1
公开(公告)日：2009-12-03
申请号：US12453986
申请日：2009-05-28
申请人： Souichi Katagiri , Takashi Ohshima , Sho Takami , Makoto Ezumi , Takashi Doi , Yuji Kasai
发明人： Souichi Katagiri , Takashi Ohshima , Sho Takami , Makoto Ezumi , Takashi Doi , Yuji Kasai
IPC分类号： A61N5/00 , G21F5/02
CPC分类号： H01J37/18 , H01J2237/06341 , H01J2237/182 , H01J2237/188
摘要： The present invention provides a charged particle beam apparatus that keeps the degree of vacuum in the vicinity of the electron source to ultra-high vacuum such as 10−8 to 10−9 Pa even in the state where electron beams are emitted using a non-evaporable getter pump and is not affected by dropout foreign particles.The present invention includes a vacuum vessel in which a charged particle source (electron source, ion source, etc.) is disposed and a non-evaporable getter pump disposed at a position that does not directly face electron beams and includes a structure that makes the non-evaporable getter pump upward with respect to a horizontal direction to drop out foreign particles into a bottom in a groove, so that the foreign particles dropped out from the non-evaporable getter pump do not face an electron optical system. Or, the present invention includes a structure that is covered by a shield means, or a means that is disposed immediately on a surface of the non-evaporable getter pump but at a position where the electron beams are not seen and has a concave structure capable of trapping the dropout foreign particles on a lower portion of the non-evaporable getter pump.
摘要翻译：本发明提供了一种带电粒子束装置，其将电子源附近的真空度保持为10-8至10-9Pa的超高真空度，即使在使用非电子束发射电子束的状态下，可蒸发吸气泵，不受脱落异物的影响。本发明包括设置有带电粒子源（电子源，离子源等）的真空容器和设置在不直接面向电子束的位置的非蒸发性吸气泵，并且包括使不可蒸发的吸气剂相对于水平方向向上泵送以将异物排出到槽中的底部，使得从非蒸发性吸气泵排出的异物不面向电子光学系统。或者，本发明包括被屏蔽装置覆盖的结构，或者立即设置在不可蒸发的吸气泵的表面上，但是在不能看到电子束的位置处并具有凹形结构的装置在非蒸发性吸气泵的下部捕获脱落的异物。

57. 发明申请

US20070236143A1 Small electron gun 审中-公开
公开(公告)号：US20070236143A1
公开(公告)日：2007-10-11
申请号：US11806196
申请日：2007-05-30
申请人： Soichi Katagiri , Takashi Ohshima
发明人： Soichi Katagiri , Takashi Ohshima
IPC分类号： H01J17/24
CPC分类号： H01J37/18 , H01J7/16 , H01J7/18 , H01J37/07 , H01J2237/022 , H01J2237/062 , H01J2237/06316 , H01J2237/1825 , H01J2237/188
摘要： To provide a small electron gun capable of keeping a high vacuum pressure used for an electron microscope and an electron-beam drawing apparatus. An electron gun constituted by a nonevaporative getter pump, a heater, a filament, and an electron-source positioning mechanism is provided with an opening for rough exhausting and its automatically opening/closing valve, and means for ionizing and decomposing an inert gas or a compound gas for the nonevaporative getter pump. It is possible to keep a high vacuum pressure of 10−10 Torr without requiring an ion pump by using a small electron gun having a height and a width of approximately 15 cm while emitting electrons from the electron gun.

58. 发明授权

US06888138B2 Absorption current image apparatus in electron microscope 有权
标题翻译：吸收电流图像设备在电子显微镜下
公开(公告)号：US06888138B2
公开(公告)日：2005-05-03
申请号：US10868907
申请日：2004-06-17
申请人： Takashi Ohshima , Hiroshi Makino , Hiroshi Toyama , Hiroyuki Shinada
发明人： Takashi Ohshima , Hiroshi Makino , Hiroshi Toyama , Hiroyuki Shinada
IPC分类号： G01N23/225 , G01Q30/02 , H01J37/04 , H01J37/244 , H01J37/28
CPC分类号： H01J37/244 , H01J37/28 , H01J2237/2605
摘要： It was hard for conventional SEMs to take measurements at a high speed and take accurate measurements when an insulator exists between an object to probe and the detector, because the conventional SEMs used a continuous electron beam. Also, it was impossible to apply voltage to the sample during the measurement of current. By pulse-modulating the electron beam and extracting a high-frequency signal component from the sample, new SEM equipment disclosed herein detects electrons absorbed in the sample at a high speed and with precision. Precise and high-speed absorption current measurements can be achieved. High-functionality inspection apparatus can be provided.
摘要翻译：传统的扫描电镜很难在高速下进行测量，并且当物体与探针和检测器之间存在绝缘体时进行精确的测量，因为传统的扫描电镜使用连续的电子束。此外，在测量电流期间不可能对样品施加电压。通过脉冲调制电子束并从样品中提取高频信号分量，本文公开的新的SEM设备以高速和精确的方式检测样品中吸收的电子。可以实现精确和高速吸收电流测量。可以提供高功能检查装置。

59. 发明申请

US20050045820A1 ABSORPTION CURRENT IMAGE APPARATUS IN ELECTRON MICROSCOPE 有权
标题翻译：电子显微镜中的吸收电流图像装置
公开(公告)号：US20050045820A1
公开(公告)日：2005-03-03
申请号：US10868907
申请日：2004-06-17
申请人： Takashi Ohshima , Hiroshi Makino , Hiroshi Toyama , Hiroyuki Shinada
发明人： Takashi Ohshima , Hiroshi Makino , Hiroshi Toyama , Hiroyuki Shinada
IPC分类号： G01N23/225 , G01Q30/02 , H01J37/04 , H01J37/244 , H01J37/28
CPC分类号： H01J37/244 , H01J37/28 , H01J2237/2605
摘要： It was hard for conventional SEMs to take measurements at a high speed and take accurate measurements when an insulator exists between an object to probe and the detector, because the conventional SEMs used a continuous electron beam. Also, it was impossible to apply voltage to the sample during the measurement of current. By pulse-modulating the electron beam and extracting a high-frequency signal component from the sample, new SEM equipment disclosed herein detects electrons absorbed in the sample at a high speed and with precision. Precise and high-speed absorption current measurements can be achieved. High-functionality inspection apparatus can be provided.
摘要翻译：传统的扫描电镜很难在高速下进行测量，并且当物体与探针和检测器之间存在绝缘体时进行精确的测量，因为传统的扫描电镜使用连续的电子束。此外，在测量电流期间不可能对样品施加电压。通过脉冲调制电子束并从样品中提取高频信号分量，本文公开的新的SEM设备以高速和精确的方式检测样品中吸收的电子。可以实现精确和高速吸收电流测量。可以提供高功能检查装置。

60. 发明授权

US5965718A Analogs of sarcodictyin and eleutherobin 失效
标题翻译：讽刺素和eleutherobin的类似物
公开(公告)号：US5965718A
公开(公告)日：1999-10-12
申请号：US145376
申请日：1998-09-01
申请人： Kyriacos C. Nicolaou , Floris VanDelft , Seijiro Hosokawa , Sanghee Kim , Tianhu Li , Takashi Ohshima , Jeff Pfefferkorn , Dionisios Vourloumis , Jin-You Xu , Nicolas Winssinger
发明人： Kyriacos C. Nicolaou , Floris VanDelft , Seijiro Hosokawa , Sanghee Kim , Tianhu Li , Takashi Ohshima , Jeff Pfefferkorn , Dionisios Vourloumis , Jin-You Xu , Nicolas Winssinger
IPC分类号： C07H15/26 , A61K31/34 , A61K31/4164 , A61K31/422 , A61K31/427 , A61K31/443 , A61K31/7028 , A61K31/7048 , A61P35/00 , A61P43/00 , C07D493/08 , C07F7/18 , C07H15/24 , A61K31/70 , C07D307/77
CPC分类号： C07D493/08
摘要： Sarcodictyin A and B, eleutherobin, and bioactive analogs thereof synthesized using solid phase and solution phase chemistries. The synthetic method employs an attachment of common precursors, e.g., compounds 1880 or 200, on a solid support for generating conjugates 230 and 240, followed by standard chemical manipulations. A combinatorial library of sarcodictyins and eletherobin analogs was constructed with modified C-8 ester, C-15 ester and C-4 ketal functionalities and was screened for activity with respect to tubulin polymerization and cytotoxic activity against tumor cells, including Taxol-resistant lines. Compounds 600, 610, 630, 660-700, 730, 760, 850, and 920 were identified to be of equal or superior biological activities as compared to their corresponding natural product.
摘要翻译： Sarcodictyin A和B，eleutherobin及其使用固相和溶液相化学合成的生物活性类似物。合成方法使用常用前体（例如化合物1880或200）在固体支持物上的附着，用于产生共轭物230和240，随后进行标准化学操作。用修饰的C-8酯，C-15酯和C-4缩酮官能团构建了链霉菌素和eletherobin类似物的组合文库，并筛选了关于微管蛋白聚合和抗肿瘤细胞（包括耐紫杉醇系）的细胞毒活性的活性。与其相应的天然产物相比，化合物600,610,630,660-700,730,760,850和920被鉴定为具有相同或优异的生物活性。

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