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    • 51. 发明授权
    • Medical device for detecting hemodynamic conditions of a heart
    • 用于检测心脏血液动力学状况的医疗装置
    • US5615684A
    • 1997-04-01
    • US429614
    • 1995-04-27
    • Pia HagelKjell NorenKurt Hoegnelid
    • Pia HagelKjell NorenKurt Hoegnelid
    • A61B5/022A61N1/362A61N1/365A61N1/39A61B5/021
    • A61N1/36564A61N1/3621A61N1/3956
    • A device for detecting hemodynamic conditions in a heart, in particular conditions corresponding to dangerous arrhythmias contains a sensing unit for a physiological variable, such as blood pressure, the unit emitting a signal on the basis of the variable having an average value, a signal conditioning unit connected to the sensing unit, a calculation unit connected to the signal conditioning unit and a comparator after the calculation unit. The calculation unit is devised to calculate a variability measure relative to the signal's average value, the variability measure being correlated to average blood pressure, and the variability measure is compared in the comparator to an adjustable threshold value corresponding to a specific hemodynamic condition, whereupon the comparator emits an indication signal when the variability measure falls below the threshold value.
    • 用于检测心脏中的血液动力学状况的装置,特别是与危险性心律失常相对应的条件包括用于生理变量例如血压的感测单元,该单元基于具有平均值的变量发出信号,信号调理 连接到感测单元的单元,连接到信号调节单元的计算单元和计算单元之后的比较器。 计算单元被设计为计算相对于信号平均值的可变性度量,可变性度量与平均血压相关,并且可变性度量在比较器中被比较到对应于特定血液动力学条件的可调阈值, 当可变性测量值低于阈值时,比较器发出指示信号。
    • 53. 发明申请
    • METHOD AND SYSTEM FOR STIMULATING A HEART OF A PATIENT
    • 用于刺激患者心脏的方法和系统
    • US20130158620A1
    • 2013-06-20
    • US13593334
    • 2012-08-23
    • Andreas BlomqvistKjell Noren
    • Andreas BlomqvistKjell Noren
    • A61N1/365
    • A61N1/00A61N1/3627A61N1/36514A61N1/36564A61N1/3682A61N1/3684
    • In an implantable medical device and a method for stimulating a heart of a patient, at least one left atrial pressure (LAP) signal over a cardiac cycle is obtained. The A-wave is identified using the LAP signal and a maximum positive rate of change of the A-wave of the LAP signal is determined. The maximum positive rate of change of the A-wave corresponds to the rate which the pressure in the atrium raises as the atria contraction forces more blood into the ventricle during the very last stage of diastole. Further, AV and/or VV delay is adjusted in response to the maximum positive rate of change of the A-wave, wherein a reduction of the maximum positive rate of change of the A-wave indicates an AV and/or VV delay providing an enhanced hemodynamic performance.
    • 在可植入医疗装置和刺激患者心脏的方法中,获得心动周期上的至少一个左心房压力(LAP)信号。 使用LAP信号识别A波,并确定LAP信号的A波的最大正比率。 A波的最大阳性变化率对应于心房收缩期间压力升高的速率,因为心房收缩在舒张期的最后阶段迫使更多的血液进入心室。 此外,AV和/或VV延迟响应于A波的最大正的变化速率而被调整,其中A波的最大正的变化率的减小表示AV和/或VV延迟提供 增强血液动力学性能。
    • 55. 发明授权
    • Implantable medical device with heart condition detection
    • 具有心脏状态检测的可植入医疗器械
    • US08133187B2
    • 2012-03-13
    • US12095216
    • 2005-12-16
    • Nils HolmströmKjell Noren
    • Nils HolmströmKjell Noren
    • A61B5/0255
    • A61B7/00A61B7/04A61N1/36514A61N1/36578
    • A method for detecting a condition of a heart of a patient using an implantable medical device, including the steps of sensing acoustic signals indicative of heart sounds of the heart of the patient; extracting signals corresponding to a first heart sound (S1) and a second heart sound (S2) from sensed signals; calculating an energy value corresponding to a signal corresponding to the first heart sound (S1) and an energy value corresponding to the second heart sound (S2); calculating a relation between the energy value corresponding to the first heart sound and the energy value corresponding to the second heart sound for successive cardiac cycles; and using at least one relation to detect the condition or a change of the condition. A medical device for determining the posture of a patient and a computer readable medium encoded with instructions are used to perform the inventive method.
    • 一种用于使用可植入医疗装置检测患者心脏状态的方法,包括以下步骤:感测指示患者心脏的心脏声音的声学信号; 从感测信号中提取对应于第一心音(S1)和第二心音(S2)的信号; 计算对应于对应于第一心音(S1)的信号的能量值和对应于第二心音(S2)的能量值; 计算对应于第一心音的能量值与对应于第二心音的能量值之间的关系,用于连续的心动周期; 并使用至少一个关系来检测条件或条件的变化。 用于确定患者姿势的医疗装置和用指令编码的计算机可读介质用于执行本发明的方法。
    • 57. 发明申请
    • Medical Device
    • 医疗装置
    • US20080294214A1
    • 2008-11-27
    • US12095241
    • 2005-12-16
    • Nils HolmstromKjell Noren
    • Nils HolmstromKjell Noren
    • A61N1/365
    • A61N1/36514A61N1/36578A61N1/368A61N1/3682
    • A method for operating an implantable medical device to control a stimulation therapy includes the steps of: sensing an acoustic energy; producing acoustic signals indicative of heart sounds of the heart of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles; extracting a signal corresponding to a first heart sound (S1) from a measured acoustic signal; calculating an energy value corresponding to the extracted signal; storing the energy value corresponding to the first heart sound; and initiating an optimization procedure, the optimization procedure comprising the steps of: iteratively controlling a delivery of the pacing pulses based on successive energy values corresponding to successive first heart sound signals and determining an optimal PV interval or AV interval with respect to the energy values. A medical device and a computer readable medium to implement the method.
    • 用于操作可植入医疗装置以控制刺激疗法的方法包括以下步骤:感测声能; 在连续心脏周期期间产生指示心脏周期的预定周期的患者心脏心脏的声音信号; 从测量的声信号中提取与第一心音(S1)对应的信号; 计算与所提取的信号相对应的能量值; 存储对应于第一心音的能量值; 并且启动优化过程,所述优化过程包括以下步骤:基于对应于连续的第一心音信号的连续能量值迭代地控制所述起搏脉冲的递送,并且相对于所述能量值确定最佳PV间隔或AV间隔。 一种用于实施该方法的医疗装置和计算机可读介质。
    • 59. 发明授权
    • Method and apparatus to remove data outliers, produced by external
disturbance, in internally measured signals in an implantable cardiac
stimulator
    • 在可植入式心脏刺激器内部测量的信号中消除由外部干扰产生的数据异常值的方法和装置
    • US5871509A
    • 1999-02-16
    • US53691
    • 1998-04-02
    • Kjell Noren
    • Kjell Noren
    • A61N1/37A61N1/362
    • A61N1/37A61N1/3718Y10S128/901
    • In a method and apparatus for removing data outliers in measured signals in an implanted medical apparatus, such as data outliers produced by GSM disturbance picked up by an implanted cardiac stimulator lead and superimposed on the sensed cardiac activity signal, the signal from the implanted lead is subjected to median filtering. The median filtering minimizes, or eliminates, the effect of highly aberrational data points in the incoming signal, without the necessity of actually removing the components in the signal produced by the disturbance from the incoming signal itself. Since no portion of the actual incoming signal is removed by the median filtering, the data integrity of the sensed cardiac signal is preserved. The signal processed by median filtering, possibly subjected to subsequent post filtering, is then supplied to a detector within the implanted stimulator, which performs the desired detection on the filtered signal, with the result of the detection then being used to control operation of the implanted stimulator.
    • 在用于去除植入的医疗装置中的测量信号中的数据异常值的方法和装置中,例如由植入式心脏刺激器引线拾取的GSM干扰产生的数据异常值并叠加在感测的心脏活动信号上,来自植入引线的信号是 进行中值滤波。 中值滤波最小化或消除了输入信号中高像差数据点的影响,而不需要实际去除由输入信号本身产生的干扰信号中的分量。 由于没有通过中值滤波去除实际输入信号的任何部分,因此保持感测到的心脏信号的数据完整性。 然后通过中值滤波处理的信号,可能进行后续滤波,然后将其提供给植入的刺激器内的检测器,该检测器对经滤波的信号执行所需的检测,其结果是用于控制植入的 刺激者