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1. 发明授权

US08812109B2 Method and system for stimulating a heart of a patient 有权
标题翻译：刺激患者心脏的方法和系统
公开(公告)号：US08812109B2
公开(公告)日：2014-08-19
申请号：US13593334
申请日：2012-08-23
申请人： Andreas Blomqvist , Kjell Noren
发明人： Andreas Blomqvist , Kjell Noren
IPC分类号： A61N1/00
CPC分类号： A61N1/00 , A61N1/3627 , A61N1/36514 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： In an implantable medical device and a method for stimulating a heart of a patient, at least one left atrial pressure (LAP) signal over a cardiac cycle is obtained. The A-wave is identified using the LAP signal and a maximum positive rate of change of the A-wave of the LAP signal is determined. The maximum positive rate of change of the A-wave corresponds to the rate which the pressure in the atrium raises as the atria contraction forces more blood into the ventricle during the very last stage of diastole. Further, AV and/or VV delay is adjusted in response to the maximum positive rate of change of the A-wave, wherein a reduction of the maximum positive rate of change of the A-wave indicates an AV and/or VV delay providing an enhanced hemodynamic performance.
摘要翻译：在可植入医疗装置和刺激患者心脏的方法中，获得心动周期上的至少一个左心房压力（LAP）信号。使用LAP信号识别A波，并确定LAP信号的A波的最大正比率。 A波的最大阳性变化率对应于心房收缩期间压力升高的速率，因为心房收缩在舒张期的最后阶段迫使更多的血液进入心室。此外，AV和/或VV延迟响应于A波的最大正的变化速率而被调整，其中A波的最大正的变化率的减小表示AV和/或VV延迟提供增强血液动力学性能。

2. 发明申请

US20080091239A1 Cardiac assist device and method using epicardially placed microphone 审中-公开
标题翻译：使用心外膜放置麦克风的心脏辅助装置和方法
公开(公告)号：US20080091239A1
公开(公告)日：2008-04-17
申请号：US11582211
申请日：2006-10-16
申请人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
发明人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
IPC分类号： A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36514 , A61N1/3956
摘要： In a cardiac assist device and method, a microphone is placed in contact with the epicardium of the heart of a patient, and heart and lung sounds are simultaneously detected at the placement location of the microphone. The heart and lung sounds are automatically analyzed to set an appropriate cardiac therapy for the patient.
摘要翻译：在心脏辅助装置和方法中，将麦克风放置成与患者心脏的心外膜接触，并且在麦克风的放置位置同时检测心脏和肺部的声音。自动分析心脏和肺部声音，为患者设定适当的心脏治疗。

3. 发明申请

US20140257070A1 PROCESSING OF LAP SIGNALS 审中-公开
标题翻译： LAP信号的处理
公开(公告)号：US20140257070A1
公开(公告)日：2014-09-11
申请号：US13517009
申请日：2011-06-20
申请人： Andreas Blomqvist , Kjell Noren
发明人： Andreas Blomqvist , Kjell Noren
IPC分类号： A61B5/02 , A61B5/04 , A61B5/042 , A61B5/0215 , A61B5/0472
CPC分类号： A61B5/02028 , A61B5/0215 , A61B5/04012 , A61B5/0422 , A61B5/0472 , A61B5/7239 , A61N1/36514 , A61N1/36564
摘要： Cardiac valve events are monitored by recording a left atrial pressure (LAP) representing signal using an implantable pressure sensor (50). The LAP signal is processed in order to generate a derivative LAP signal representative of the first time derivative of the LAP signal. The opening of the aortic valve of the heart is then identified to coincide in time with a minimum in the derivative LAP signal following ventricular depolarization in a cardiac cycle.
摘要翻译：通过使用可植入压力传感器（50）记录表示信号的左心房压力（LAP）来监测心脏瓣膜事件。处理LAP信号以产生代表LAP信号的第一时间导数的导数LAP信号。然后心脏的主动脉瓣的开口在心脏周期的心室去极化之后被确定为在时间上与导数LAP信号中的最小值一致。

4. 发明申请

US20130158620A1 METHOD AND SYSTEM FOR STIMULATING A HEART OF A PATIENT 有权
标题翻译：用于刺激患者心脏的方法和系统
公开(公告)号：US20130158620A1
公开(公告)日：2013-06-20
申请号：US13593334
申请日：2012-08-23
申请人： Andreas Blomqvist , Kjell Noren
发明人： Andreas Blomqvist , Kjell Noren
IPC分类号： A61N1/365
CPC分类号： A61N1/00 , A61N1/3627 , A61N1/36514 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： In an implantable medical device and a method for stimulating a heart of a patient, at least one left atrial pressure (LAP) signal over a cardiac cycle is obtained. The A-wave is identified using the LAP signal and a maximum positive rate of change of the A-wave of the LAP signal is determined. The maximum positive rate of change of the A-wave corresponds to the rate which the pressure in the atrium raises as the atria contraction forces more blood into the ventricle during the very last stage of diastole. Further, AV and/or VV delay is adjusted in response to the maximum positive rate of change of the A-wave, wherein a reduction of the maximum positive rate of change of the A-wave indicates an AV and/or VV delay providing an enhanced hemodynamic performance.
摘要翻译：在可植入医疗装置和刺激患者心脏的方法中，获得心动周期上的至少一个左心房压力（LAP）信号。使用LAP信号识别A波，并确定LAP信号的A波的最大正比率。 A波的最大阳性变化率对应于心房收缩期间压力升高的速率，因为心房收缩在舒张期的最后阶段迫使更多的血液进入心室。此外，AV和/或VV延迟响应于A波的最大正的变化速率而被调整，其中A波的最大正的变化率的减小表示AV和/或VV延迟提供增强血液动力学性能。

5. 发明授权

US08700139B2 Late potential detection 有权
标题翻译：晚期电位检测
公开(公告)号：US08700139B2
公开(公告)日：2014-04-15
申请号：US13380933
申请日：2009-06-26
申请人： Andreas Blomqvist
发明人： Andreas Blomqvist
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/002 , A61B5/0031 , A61B5/0422 , A61B5/686 , A61B5/7242 , A61B5/7275 , A61B2505/07 , A61N1/362 , G06F19/00
摘要： A late potential detecting system has an implantable medical device connected to at least one cardiac lead having implantable electrodes positioned at different sites of a ventricle myocardium. A sampling unit of the implantable medical device records electrogram samples for the different implantable electrodes to get different sample sets. The electrogram samples of the sample sets are time synchronized and magnitude potential representations of the potential data of the electrogram samples are determined. The magnitude potential representations of the time synchronized electrogram samples are then co-processed and used for determining a parameter that is indicative of any late potentials of the monitored ventricle.
摘要翻译：晚期电位检测系统具有连接到至少一个具有位于心室心肌不同部位的可植入电极的心脏引线的可植入医疗装置。可植入医疗装置的采样单元记录不同可植入电极的电描记图样品以获得不同的样品组。样本集的电描记图样本是时间同步的，并且确定电描记图样本的潜在数据的幅度电位表示。然后对时间同步电描记图样本的幅度电位表示进行协处理，并用于确定指示所监测的心室的任何后期电位的参数。

6. 发明授权

US08679026B2 Medical device for detecting pulmonary artery pressure 有权
标题翻译：用于检测肺动脉压的医疗装置
公开(公告)号：US08679026B2
公开(公告)日：2014-03-25
申请号：US12679711
申请日：2007-11-08
申请人： Andreas Blomqvist
发明人： Andreas Blomqvist
IPC分类号： A61B5/0215 , A61B5/021
CPC分类号： A61B5/053 , A61B5/02028 , A61B5/0215 , A61B5/0538 , A61N1/36521 , A61N1/36564 , G06F19/00
摘要： In a medical device and method to monitor pulmonary artery pressure of a patient, a first parameter related to the right ventricular straight volume of the patient's is detected, and a second parameter related to the right ventricular ejection rate of the patient's heart, or related to the workload of the patient's heart, is also determined. A pulmonary pressure index is determined by combining the first and second parameters, with variations of the pulmonary pressure index indicating variations in the pulmonary artery pressure. Pulmonary artery hypertension can be monitored with such a device and method.
摘要翻译：在用于监测患者的肺动脉压力的医疗装置和方法中，检测与患者的右心室直线容积相关的第一参数，以及与患者心脏的右心室射血率相关的第二参数，病人心脏的工作量也是确定的。通过组合第一和第二参数来确定肺压力指数，肺动脉压指数的变化指示肺动脉压力的变化。可以用这种装置和方法监测肺动脉高血压。

7. 发明授权

US08386041B2 Medical device and system for determining a hemodynamic parameter using intracardiac impedance 有权
标题翻译：使用心内阻抗确定血液动力学参数的医疗设备和系统
公开(公告)号：US08386041B2
公开(公告)日：2013-02-26
申请号：US12307970
申请日：2006-06-21
申请人： Andreas Blomqvist , Johan Svahn
发明人： Andreas Blomqvist , Johan Svahn
IPC分类号： A61N1/365 , A61B5/05
CPC分类号： A61N1/36521 , A61B5/0031 , A61B5/02028 , A61B5/053
摘要： In implantable medical devices such a pacemaker or cardioverter/defibrillators (ICDs) and systems including such a device and an external programmer a measure of a hemodynamic parameter such as the cardiac output, the stroke volume, or the contractility of a patient is used to trend heart failure or in an AV/VV optimization scheme. The implantable medical device is adapted to measure the cardiac impedance and the cardiac impedance data is used to determine impedance morphology curves, which, in turn, are used to compute a measure of the hemodynamic parameter.
摘要翻译：在诸如起搏器或心脏复律器/除颤器（ICD）和包括这种装置和外部程序员的系统的可植入医疗装置中，使用诸如心输出量，行程体积或患者的收缩性的血液动力学参数的度量趋势心力衰竭或AV / VV优化方案。可植入医疗装置适于测量心脏阻抗，并且心脏阻抗数据用于确定阻抗形态曲线，其又用于计算血液动力学参数的度量。

8. 发明申请

US20120059272A1 MEDICAL DEVICE AND METHOD FOR DETERMINING A DYSSYNCHRONICITY MEASURE TECHNICAL FIELD 有权
标题翻译：医疗装置及其测定方法技术领域
公开(公告)号：US20120059272A1
公开(公告)日：2012-03-08
申请号：US13319776
申请日：2009-05-13
申请人： Andreas Blomqvist
发明人： Andreas Blomqvist
IPC分类号： A61B5/0452 , A61B5/053
CPC分类号： A61B5/1102 , A61B5/053 , A61B5/0538 , A61B5/6869 , A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： In an implantable medical device, such as a bi-ventricular pacemaker and a method for detecting and monitoring mechanical dyssynchronicity of the heart, a dyssynchronicity measure indicating a degree of mechanical dyssynchronicity of a heart of a patient is calculated. A first intracardiac impedance set is measured using electrodes placed such that the first intracardiac impedance set substantially reflects a mechanical activity of the left side of the heart and a second intracardiac impedance set is measure using electrodes placed such that the second intracardiac impedance set substantially reflects a mechanical activity of the right side of the heart. The measure of a dyssynchronicity is calculated based on a resulting parameter set from a comparison between at least a subset of the first and the second impedance sets, respectively, the subsets containing information of the mechanical systole, wherein a reduced dyssynchronicity measure corresponds to an improved synchronicity between the right side and the left side of the heart.
摘要翻译：在诸如双心室起搏器的可植入医疗装置和用于检测和监测心脏的机械不同步性的方法中，计算指示患者心脏的机械不同步程度的不同步性测量。使用放置使得第一心内阻抗设定基本上反映心脏左侧的机械活动的电极来测量第一心内阻抗集，并且使用放置的第二心内阻抗设定的电极来测量第二心内阻抗集，心脏右侧的机械活动。基于从第一和第二阻抗组的至少一个子集之间的比较的结果参数集计算包含机械收缩信息的子集，其中减少的不同步度测量对应于改进的心脏右侧和左侧的同步性。

9. 发明申请

US20100268102A1 IMPLANTABLE HEART MONITORING DEVICE, SYSTEM AND METHOD 有权
标题翻译：可植入心脏监测装置，系统和方法
公开(公告)号：US20100268102A1
公开(公告)日：2010-10-21
申请号：US12808041
申请日：2007-12-19
申请人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
发明人： Andreas Blomqvist , Nils Holmstöm , Sven-Erik Hedberg , Malin Öhlander
IPC分类号： A61B5/0472
CPC分类号： A61N1/36521 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61N1/3622 , A61N1/3684
摘要： In an implantable heart monitoring device and a monitoring method, an impedance is measured across at least part of an atrium, such that variation of the impedance is related to the volume change of the atrium. Values are stored at different occasions that indicate the rate of change of the measured impedance. The stored values are determined such that, when the device is used in a living being, the variation of the stored values will be related to the variation of the speed with which the atrium is filled with blood during the atrial diastole.
摘要翻译：在可植入心脏监测装置和监测方法中，跨越心房的至少一部分测量阻抗，使得阻抗的变化与心房的体积变化相关。值存储在指示测量阻抗的变化率的不同场合。确定所存储的值，使得当在生物体中使用该装置时，存储值的变化将与在心房舒张期期间心房充满血液的速度的变化相关。

10. 发明申请

US20100168812A1 METHOD AND DEVICE FOR COLLECTING REM SLEEP DATA 审中-公开
标题翻译：用于收集休眠数据的方法和装置
公开(公告)号：US20100168812A1
公开(公告)日：2010-07-01
申请号：US12663304
申请日：2007-06-27
申请人： Andreas Blomqvist , Michael Broomé
发明人： Andreas Blomqvist , Michael Broomé
IPC分类号： A61N1/365 , A61B5/00
CPC分类号： A61N1/3702 , A61B5/02405 , A61B5/053 , A61B5/076 , A61B5/4812 , A61B5/7275 , A61N1/36521 , A61N1/36585 , A61N1/37282 , G16H50/20 , G16H50/70
摘要： In a method and a device for trending and prediction of monitored conditions or diseases, an REM sleep detector is provided to allow data collected during REM sleep to be separated from other data so stable and uniform conditions for data collection are achieved. The REM sleep detector can advantageously be provided inside an implantable medical device.
摘要翻译：在用于趋势和预测监测的病症或疾病的方法和装置中，提供REM睡眠检测器以允许在REM睡眠期间收集的数据与其他数据分离，从而实现用于数据收集的稳定和均匀的条件。 REM睡眠检测器可以有利地设置在可植入医疗装置的内部。

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