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1. 发明申请

US20080306566A1 Implantable Medical Device with Heart Condition Detection 有权
标题翻译：具有心脏状态检测的植入式医疗器械
公开(公告)号：US20080306566A1
公开(公告)日：2008-12-11
申请号：US12095216
申请日：2005-12-16
申请人： Nils Holmstrom , Kjell Noren
发明人： Nils Holmstrom , Kjell Noren
IPC分类号： A61N1/365
CPC分类号： A61B7/00 , A61B7/04 , A61N1/36514 , A61N1/36578
摘要： A method for detecting a condition of a heart of a patient using an implantable medical device including the steps of sensing acoustic signals indicative of heart sounds of the heart of the patient; extracting signals corresponding to a first heart sound (S1) and a second heart sound (S2) from sensed signals; calculating an energy value corresponding to a signal corresponding to the first heart sound (S1) and an energy value corresponding to the second heart sound (S2); calculating a relation between the energy value corresponding to the first heart sound and the energy value corresponding to the second heart sound for successive cardiac cycles; and using at least one relation to detect the condition or a change of the condition. A medical device for determining the posture of a patient and a computer readable medium encoded with instructions are used to perform the inventive method.
摘要翻译：一种使用可植入医疗装置检测患者心脏状况的方法，包括以下步骤：感测指示患者心脏心脏的声音的声信号; 从感测信号中提取对应于第一心音（S1）和第二心音（S2）的信号; 计算对应于对应于第一心音（S1）的信号的能量值和对应于第二心音（S2）的能量值; 计算对应于第一心音的能量值与对应于第二心音的能量值之间的关系，用于连续的心动周期; 并使用至少一个关系来检测条件或条件的变化。用于确定患者姿势的医疗装置和用指令编码的计算机可读介质用于执行本发明的方法。

2. 发明申请

US20080294214A1 Medical Device 有权
标题翻译：医疗装置
公开(公告)号：US20080294214A1
公开(公告)日：2008-11-27
申请号：US12095241
申请日：2005-12-16
申请人： Nils Holmstrom , Kjell Noren
发明人： Nils Holmstrom , Kjell Noren
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/36578 , A61N1/368 , A61N1/3682
摘要： A method for operating an implantable medical device to control a stimulation therapy includes the steps of: sensing an acoustic energy; producing acoustic signals indicative of heart sounds of the heart of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles; extracting a signal corresponding to a first heart sound (S1) from a measured acoustic signal; calculating an energy value corresponding to the extracted signal; storing the energy value corresponding to the first heart sound; and initiating an optimization procedure, the optimization procedure comprising the steps of: iteratively controlling a delivery of the pacing pulses based on successive energy values corresponding to successive first heart sound signals and determining an optimal PV interval or AV interval with respect to the energy values. A medical device and a computer readable medium to implement the method.
摘要翻译：用于操作可植入医疗装置以控制刺激疗法的方法包括以下步骤：感测声能; 在连续心脏周期期间产生指示心脏周期的预定周期的患者心脏心脏的声音信号; 从测量的声信号中提取与第一心音（S1）对应的信号; 计算与所提取的信号相对应的能量值; 存储对应于第一心音的能量值; 并且启动优化过程，所述优化过程包括以下步骤：基于对应于连续的第一心音信号的连续能量值迭代地控制所述起搏脉冲的递送，并且相对于所述能量值确定最佳PV间隔或AV间隔。一种用于实施该方法的医疗装置和计算机可读介质。

3. 发明申请

US20080306565A1 Medical Device 审中-公开
标题翻译：医疗装置
公开(公告)号：US20080306565A1
公开(公告)日：2008-12-11
申请号：US12095212
申请日：2005-12-16
申请人： Nils Holmstrom , Kjell Noren
发明人： Nils Holmstrom , Kjell Noren
IPC分类号： A61N1/00 , A61F2/02
CPC分类号： A61B7/00 , A61B7/04 , A61N1/3627 , A61N1/36514
摘要： In an implantable medical device and a method and computer-readable medium for operating the medical device to detect a condition of a heart of a patient, activity level of a patient and acoustic energy in a patient are sensed, and acoustic signals are generated that are indicative of heart sounds of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles. A signal corresponding to a first sound is extracted from the sensed acoustic signal of a cardiac cycle. A relation is calculated between a first signal corresponding to the first heart sound in a first activity range, and a second signal corresponding to the first heart sound in a second predetermined activity level range. The calculated relation is compared with at least one reference value to detect the condition or a change of the condition.
摘要翻译：在可植入医疗装置和用于操作医疗装置以检测患者心脏状况的方法和计算机可读介质中，感测患者的活动水平和患者的声能，并且生成声信号指示在连续心脏周期期间心脏周期的预定时间段的患者的心脏声音。从感测到的心律周期的声信号中提取对应于第一声音的信号。在与第一活动范围内的第一心音相对应的第一信号与对应于第二预定活动水平范围中的第一心音的第二信号之间计算关系。将计算的关系与至少一个参考值进行比较以检测条件或状况的变化。

4. 发明申请

US20070293771A1 Method for extracting timing parameters using a cardio-mechanical sensor 有权
标题翻译：使用心机械传感器提取定时参数的方法
公开(公告)号：US20070293771A1
公开(公告)日：2007-12-20
申请号：US11455518
申请日：2006-06-19
申请人： Kjell Noren , Nils Holmstrom
发明人： Kjell Noren , Nils Holmstrom
IPC分类号： A61B5/02
CPC分类号： A61B5/02416 , A61B5/0031 , A61B5/0452 , A61B5/083 , A61B5/1116 , A61B5/686 , A61B5/7239 , A61N1/36514 , A61N1/36578
摘要： In a method and apparatus for measuring the ejection fraction in a mammalian heart, the opening and closing of a heart valve is sensed with an implanted sensor, and a pre-ejection period is measured as a function of the sensed opening and closing of the heart valve. The ventricular ejection time also is measured, and the ejection fraction is determined as a function of the measured pre-ejection period and the ejection time.
摘要翻译：在用于测量哺乳动物心脏中的射血分数的方法和装置中，用植入的传感器感测心脏瓣膜的打开和关闭，并且根据检测到的心脏的开启和关闭来测量预喷射周期阀。也测量心室射血时间，并且将射血分数确定为所测量的预喷射时间和喷射时间的函数。

5. 发明申请

US20080294213A1 Implantable Medical Device with Therapy Control 有权
标题翻译：具有治疗控制的植入式医疗器械
公开(公告)号：US20080294213A1
公开(公告)日：2008-11-27
申请号：US12094534
申请日：2005-11-30
申请人： Nils Holmstrom , Kjell Noren
发明人： Nils Holmstrom , Kjell Noren
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B7/04 , A61N1/3627 , A61N1/36578 , A61N1/3684
摘要： A method for operating an implantable medical device to obtain substantially synchronized closure of the mitral and tricuspid valves based on sensed heart sounds includes sensing an acoustic energy; producing signals indicative of heart sounds of the heart of the patient over predetermined periods of a cardiac cycle during successive cardiac cycles; calculating a pulse width of such a signal; and iteratively controlling a delivery of the ventricular pacing pulses based on calculated pulse widths of successive heart sound signals to identify an RV interval or VV interval that causes a substantially synchronized closure of the mitral and tricuspid valve. A medical device for optimizing an RV interval or VV interval based on sensed heart sounds implements such a method and a computer readable medium encoded with instructions causes a computer to perform such a method.
摘要翻译：用于操作可植入医疗装置以基于感测到的心脏声音获得二尖瓣和三尖瓣的基本上同步闭合的方法包括感测声能; 在连续心脏周期期间产生指示心脏周期的预定周期的患者心脏的心脏声音的信号; 计算这种信号的脉冲宽度; 并且基于计算的连续心脏声音信号的脉冲宽度迭代地控制心室起搏脉冲的递送，以识别导致二尖瓣和三尖瓣的基本上同步闭合的RV间隔或VV间隔。基于感测到的心脏声音优化RV间隔或VV间隔的医疗装置实现了这样的方法，并且用指令编码的计算机可读介质使得计算机执行这种方法。

6. 发明申请

US20080091239A1 Cardiac assist device and method using epicardially placed microphone 审中-公开
标题翻译：使用心外膜放置麦克风的心脏辅助装置和方法
公开(公告)号：US20080091239A1
公开(公告)日：2008-04-17
申请号：US11582211
申请日：2006-10-16
申请人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
发明人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
IPC分类号： A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36514 , A61N1/3956
摘要： In a cardiac assist device and method, a microphone is placed in contact with the epicardium of the heart of a patient, and heart and lung sounds are simultaneously detected at the placement location of the microphone. The heart and lung sounds are automatically analyzed to set an appropriate cardiac therapy for the patient.
摘要翻译：在心脏辅助装置和方法中，将麦克风放置成与患者心脏的心外膜接触，并且在麦克风的放置位置同时检测心脏和肺部的声音。自动分析心脏和肺部声音，为患者设定适当的心脏治疗。

7. 发明申请

US20060235325A1 Congestive heart failure monitor 审中-公开
标题翻译：充血性心力衰竭监测仪
公开(公告)号：US20060235325A1
公开(公告)日：2006-10-19
申请号：US10524196
申请日：2003-06-23
申请人： Nils Holmstrom , Martin Obel , Anna Norlin , Kenneth Dahlberg , Anders Bjorling , Sven Kalling , Karin Ljungstrom , Kjell Noren
发明人： Nils Holmstrom , Martin Obel , Anna Norlin , Kenneth Dahlberg , Anders Bjorling , Sven Kalling , Karin Ljungstrom , Kjell Noren
IPC分类号： A61B5/05 , A61B5/02
CPC分类号： A61B5/0538 , A61B5/053 , A61N1/3627
摘要： A congestive heart failure monitor has an impedance measuring unit that measures the impedance between at least two electrodes implanted in a patient, to use a detected change of the measured impedance as an indication of a change in the left atrium volume. Any analyzing unit analyzes the measured impedance and detects insipient congestive heart failure dependent on a quotient of a maximum value of the measured impedance and a minimum value of the measured impedance during a cardiac cycle.
摘要翻译：充血性心力衰竭监测器具有阻抗测量单元，其测量植入患者中的至少两个电极之间的阻抗，以使用检测到的测量阻抗的变化作为左心房体积变化的指示。任何分析单元分析所测量的阻抗，并根据所测量的阻抗的最大值和心动周期内所测量的阻抗的最小值来检测不利的充血性心力衰竭。

8. 发明授权

US08600497B1 Systems and methods to monitor and treat heart failure conditions 有权
标题翻译：监测和治疗心力衰竭病症的系统和方法
公开(公告)号：US08600497B1
公开(公告)日：2013-12-03
申请号：US11558088
申请日：2006-11-09
申请人： Weiqun Yang , Malin Ohlander , Louis Wong , Nils Holmstrom , Cem Shaquer , Euljoon Park , Dorin Panescu , Shahrooz Shahparnia , Andre Walker , Ajit Pillai , Mihir Naware
发明人： Weiqun Yang , Malin Ohlander , Louis Wong , Nils Holmstrom , Cem Shaquer , Euljoon Park , Dorin Panescu , Shahrooz Shahparnia , Andre Walker , Ajit Pillai , Mihir Naware
IPC分类号： A61B5/05 , A61N1/00
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable device monitors and treats heart failure, pulmonary edema, and hemodynamic conditions and in some cases applies therapy. In one implementation, the implantable device applies a high-frequency multi-phasic pulse waveform over multiple-vectors through tissue. The waveform has a duration less than the charging time constant of electrode-electrolyte interfaces in vivo to reduce intrusiveness while increasing sensitivity and specificity for trending parameters. The waveform can be multiplexed over multiple vectors and the results cross-correlated or subjected to probabilistic analysis or thresholding schemata to stage heart failure or pulmonary edema. In one implementation, a fractionation morphology of a sensed impedance waveform is used to trend intracardiac pressure to stage heart failure and to regulate cardiac resynchronization therapy. The waveform also provides unintrusive electrode integrity checks and 3-D impedancegrams.
摘要翻译：植入式装置监测和治疗心力衰竭，肺水肿和血液动力学状况，并且在某些情况下应用治疗。在一个实施方案中，可植入装置通过组织在多个向量上施加高频多相脉冲波形。该波形的持续时间小于体内电极 - 电解质界面的充电时间常数，以降低侵入性，同时增加趋势参数的灵敏度和特异性。波形可以在多个载体上进行复用，并且结果相互关联或进行概率分析或阈值模式以分步心脏衰竭或肺水肿。在一个实施方案中，使用感测阻抗波形的分级形态来趋向心脏内压力来分级心力衰竭并调节心脏再同步治疗。该波形还提供非侵入式电极完整性检查和3-D阻抗图。

9. 发明申请

US20130190582A1 ISCHEMIC REGION DETECTION 审中-公开
标题翻译：分离区域检测
公开(公告)号：US20130190582A1
公开(公告)日：2013-07-25
申请号：US13358063
申请日：2012-01-25
申请人： Nils Holmstrom , Michael Broome
发明人： Nils Holmstrom , Michael Broome
IPC分类号： A61B5/145 , A61B5/02
CPC分类号： A61B5/14503 , A61B5/1118 , A61B5/1455 , A61B5/1459 , A61B5/686
摘要： An ischemia detecting system has an implantable medical device connectable to an LV cardiac catheter with sensors for generating sensor signals representative of the concentration of a constituent in coronary venous blood at different sites in the coronary venous system. The sensor signals are co-processed by the system to detect an ischemic region of the subject's heart based on a relation between the sensor signals. The detection of the particular ischemic cardiac region is possible by conducting the concentration monitoring on either sides of a branching vein in the coronary venous system and co-processing the sensor signals.
摘要翻译：缺血检测系统具有可连接到具有传感器的LV心导管的可植入医疗装置，所述传感器用于产生代表冠状静脉系统不同部位冠状静脉血中成分浓度的传感器信号。传感器信号由系统共同处理，以基于传感器信号之间的关系检测受试者心脏的缺血区域。通过在冠状静脉系统中的分支静脉的两侧进行浓度监测并共同处理传感器信号，可以检测特定的缺血性心脏区域。

10. 发明申请

US20110257696A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MONITORING SYNCHRONICITY OF THE VENTRICLES OF A HEART 审中-公开
标题翻译：用于监测心脏通气道的同步性的可植入医疗装置和方法
公开(公告)号：US20110257696A1
公开(公告)日：2011-10-20
申请号：US13140119
申请日：2008-12-17
申请人： Nils Holmstrom , Karin Ljungstrom , Michael Broome , Cecilia Emanuelsson
发明人： Nils Holmstrom , Karin Ljungstrom , Michael Broome , Cecilia Emanuelsson
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61B5/0538 , A61B5/0816 , A61B5/11 , A61B5/7239 , A61B5/7289 , A61N1/36521 , A61N1/36578 , A61N1/3684 , A61N1/3686
摘要： In an implantable medical device and a method for monitoring ventricular synchronicity of a heart, impedance signals are measured that reflect septal wall movements and impedance amplitude peaks in the impedance signal are detected. A synchronicity index indicating a degree of synchronicity is determined based on detected impedance peaks, with at least two impedance peaks detected within a predetermined time window including a cardiac cycle or a part of a cardiac cycle indicating an increased dyssynchronicity in the ventricular contractions.
摘要翻译：在可植入医疗装置和用于监测心脏心室同步性的方法中，测量阻抗信号，其反映了隔膜壁运动，并且检测阻抗信号中的阻抗幅度峰值。基于检测到的阻抗峰值确定表示同步度的同步性指标，其中在包括心动周期的预定时间窗口或心跳周期的一部分中检测到至少两个阻抗峰值，指示心室收缩中的不同步性增加。

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