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51. 发明授权

US09107585B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
标题翻译：使用可植入引导系统的心内阻抗的组织表征
公开(公告)号：US09107585B1
公开(公告)日：2015-08-18
申请号：US11684664
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu
IPC分类号： A61N1/18 , A61B5/02 , A61B5/053 , A61N1/37 , A61B5/029 , A61B5/08 , A61B5/00
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.
摘要翻译：可植入系统采用可植入引线系统获得心内阻抗。在一个实现中，该系统产生提供净零电荷和净零电压的富频率，低能量，多相波形。当应用于身体组织时，具有多相波形的电流脉冲或电压脉冲在探测组织中提供增加的特异性和灵敏度。所施加的脉冲的影响被感测为对应的波形。施加和感测的脉冲的波形可以被积分，以获得表示频谱范围内的电流和电压的相应面积值。可以比较这些区域以获得组织的可靠的阻抗值。还可以测量频率响应，相位延迟和对调制脉冲宽度的响应，以确定组织的相对电容，指示梗死组织，血液与组织之比，水肿程度和其他生理参数。

52. 发明授权

US08634902B2 Cardiac analysis system for comparing clinical and induced ventricular tachycardia events 有权
标题翻译：用于比较临床和诱导性室性心动过速事件的心脏分析系统
公开(公告)号：US08634902B2
公开(公告)日：2014-01-21
申请号：US12820879
申请日：2010-06-22
申请人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
发明人： Michael E. Benser , Gene A. Bornzin , Euljoon Park , Kyungmoo Ryu , Michael Hardage
IPC分类号： A61B5/04
CPC分类号： A61B5/0422 , A61B5/0031 , A61B5/0464 , A61B18/1492 , A61N1/3621
摘要： A cardiac analysis system is provided that includes an implantable medical device (IMD), at least one sensor, and an external device. The IMD has electrodes positioned proximate to a heart that sense first cardiac signals of the heart and associated with a clinical ventricular tachycardia (VT) event and second cardiac signals associated with an induced VT event. The sensor measures first and second cardiac parameters of the heart associated with the clinical and induced VT events, respectively. The external device is configured to receive the first and second cardiac signals associated with the clinical and the induced VT events and the first and second cardiac parameters associated with the clinical and the induced VT events. The external device compares the first and second cardiac signals and compares the first and second cardiac parameters to determine if the clinical and induced VT events are a common type of VT event.
摘要翻译：提供了包括可植入医疗装置（IMD），至少一个传感器和外部装置的心脏分析系统。 IMD具有位于心脏附近的电极，其感测心脏的第一心脏信号并与临床心室性心动过速（VT）事件和与诱导的VT事件相关联的第二心脏信号相关联。该传感器分别测量与临床和诱导VT事件相关的心脏的第一和第二心脏参数。外部设备被配置为接收与临床和诱导的VT事件相关联的第一和第二心脏信号以及与临床和诱导的VT事件相关联的第一和第二心脏参数。外部设备比较第一和第二心脏信号，并比较第一和第二心脏参数以确定临床和诱导的VT事件是否是常见类型的VT事件。

53. 发明授权

US07945314B1 System and method for emulating a surface EKG for use with transtelephonic monitoring of an implantable medical device 有权
标题翻译：用于模拟表面EKG的系统和方法，用于可植入医疗装置的经耳监测
公开(公告)号：US07945314B1
公开(公告)日：2011-05-17
申请号：US11432636
申请日：2006-05-10
申请人： Jeffery D. Snell , Jong Gill , Gene A. Bornzin , Peter Boileau , Euljoon Park
发明人： Jeffery D. Snell , Jong Gill , Gene A. Bornzin , Peter Boileau , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0402 , A61B5/0006 , A61N1/3702 , A61N1/37235 , A61N1/37282
摘要： A surface electrocardiogram (EKG) is emulated using signals detected by internal leads of an implanted device. In one example, emulation is performed using a technique that concatenates portions of signals sensed using different electrodes, such as by combining far-field ventricular signals sensed in the atria with far-field atrial signals sensed in the ventricles. In another example, emulation is performed using a technique that selectively amplifies or attenuates portions of a single signal, such as by attenuating near-field portions of an atrial unipolar signal relative to far-field portions of the same signal. The surface EKG emulation may be performed by the implanted device itself or by an external programmer based on cardiac signals transmitted thereto. A transtelephonic monitoring network is also described, wherein the emulated surface EKG (or raw data used to emulate the EKG) is relayed from an implanted device to a remote monitor, typically installed in a physician's office.
摘要翻译：使用由植入装置的内部引线检测的信号来模拟表面心电图（EKG）。在一个示例中，使用将使用不同电极感测的信号的部分连接的技术来执行仿真，例如通过将在心房中感测到的远场心室信号与在心室中感测到的远场心房信号组合。在另一示例中，使用选择性地放大或衰减单个信号的部分的技术来执行仿真，例如通过衰减相对于相同信号的远场部分的心房单极信号的近场部分。表面EKG仿真可以由植入装置本身或外部编程器基于发送到其上的心脏信号执行。还描述了一种跨耳监测网络，其中仿真表面EKG（或用于模拟EKG的原始数据）从植入装置中继到通常安装在医师办公室中的远程监视器。

54. 发明授权

US07925349B1 Tissue characterization using intracardiac impedances with an implantable lead system 有权
公开(公告)号：US07925349B1
公开(公告)日：2011-04-12
申请号：US11684681
申请日：2007-03-12
申请人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia
发明人： Louis Wong , Cem Shaquer , Gene A. Bornzin , Euljoon Park , Andre Walker , Dorin Panescu , Jiong Xia
IPC分类号： A61N1/37
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/029 , A61B5/0538 , A61B5/08 , A61B5/4878 , A61N1/3627 , A61N1/36521 , A61N1/3702
摘要： An implantable system acquires intracardiac impedance with an implantable lead system. In one implementation, the system generates frequency-rich, low energy, multi-phasic waveforms that provide a net-zero charge and a net-zero voltage. When applied to bodily tissues, current pulses or voltage pulses having the multi-phasic waveform provide increased specificity and sensitivity in probing tissue. The effects of the applied pulses are sensed as a corresponding waveform. The waveforms of the applied and sensed pulses can be integrated to obtain corresponding area values that represent the current and voltage across a spectrum of frequencies. These areas can be compared to obtain a reliable impedance value for the tissue. Frequency response, phase delay, and response to modulated pulse width can also be measured to determine a relative capacitance of the tissue, indicative of infarcted tissue, blood to tissue ratio, degree of edema, and other physiological parameters.

55. 发明授权

US07725181B1 Apnea burden minimizing cardiac stimulation device 有权
标题翻译：呼吸暂停负担最小化心脏刺激装置
公开(公告)号：US07725181B1
公开(公告)日：2010-05-25
申请号：US11291310
申请日：2005-11-30
申请人： Gene A. Bornzin , Euljoon Park
发明人： Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61B5/113 , A61B5/4818 , A61N1/36514 , A61N1/3682
摘要： An implantable cardiac device minimizes apnea burden. In one implementation, the device administers a series of cardiac pacing trials using a different value for a pacing parameter in each trial and then measures an apnea burden corresponding to each trial in order to determine a value which reduces apnea burden when used for ongoing cardiac pacing. In one implementation the implantable cardiac device performs series of trials in cycles, during which a first series of trials determines a value for a first pacing parameter for reducing apnea burden while other pacing parameters are held constant. Subsequent series of trials subject the other pacing parameters, in turn, to their own series of pacing trials while holding the non-subjected pacing parameters constant. Through multiple cycles, the device optimizes each parameter in turn based on continually improving values for the other pacing parameters.
摘要翻译：可植入的心脏装置使呼吸暂停负担最小化。在一个实施方案中，该装置使用每个试验中的起搏参数使用不同的值进行一系列心脏起搏试验，然后测量与每次试验相对应的呼吸暂停负担，以便确定当用于持续心脏起搏时减少呼吸暂停负担的值。在一个实施方案中，可植入心脏装置以周期执行一系列试验，在此期间，第一系列试验确定第一起搏参数的值以减少呼吸暂停负担，而其他起搏参数保持恒定。随后的一系列试验将其他起搏参数反过来归因于其自己的一系列起搏试验，同时保持不受起搏的起搏参数不变。通过多个循环，设备会根据其他起搏参数的持续改进值轮流优化每个参数。

56. 发明授权

US07349732B1 System and method for emulating a surface EKG using internal cardiac signals sensed by an implantable medical device 有权
公开(公告)号：US07349732B1
公开(公告)日：2008-03-25
申请号：US10735944
申请日：2003-12-12
申请人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
发明人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
IPC分类号： A61B5/0402
CPC分类号： A61B5/042 , A61B5/04011
摘要： A surface electrocardiogram (EKG) is emulated using signals detected by the internal leads of an implanted device. In one example, the emulation is performed using a technique that concatenates portions of signals sensed using different electrodes, such as by combining far-field ventricular signals sensed in the atria with far-field atrial signals sensed in the ventricles or by combining near-field signals sensed in the atria with near-field signals sensed in the ventricles. In another example, the emulation is performed using a technique that selectively amplifies or attenuates portions of a single signal sensed using a single pair of electrodes, such as by attenuating near-field portions of an atrial unipolar signal relative to far-field portions of the same signal or by attenuating atrial portions of a cross-chamber signal relative to ventricular portions to the same signal. The surface EKG emulation may be performed by the implanted device itself or by an external programmer based on cardiac signals transmitted thereto.

57. 发明授权

US07286875B1 Monitoring ventricular contractions using an implantable stimulation device 有权
公开(公告)号：US07286875B1
公开(公告)日：2007-10-23
申请号：US10838947
申请日：2004-05-03
申请人： Euljoon Park , Gene A. Bornzin , Robert G. Turcott
发明人： Euljoon Park , Gene A. Bornzin , Robert G. Turcott
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/36585
摘要： An implantable cardiac stimulation device is configured to measure selected ventricular contraction parameters and possibly apply stimulation therapy based on the ventricular contraction parameters. In accordance with one aspect, the ventricular contraction parameters include impedance values that correspond to the volume of fluid in the right ventricle and the left ventricle. In accordance with another aspect, the ventricular contraction parameters include motion values that correspond to heart sounds/motion in the right ventricle and the left ventricle. The ventricular contraction parameters can be used to form pseudo P-V loop from which treatment decisions can be made.

58. 发明授权

US07272443B2 System and method for predicting a heart condition based on impedance values using an implantable medical device 有权
标题翻译：基于使用可植入医疗装置的阻抗值来预测心脏病的系统和方法
公开(公告)号：US07272443B2
公开(公告)日：2007-09-18
申请号：US11014276
申请日：2004-12-15
申请人： Xiaoyi Min , Gene A. Bornzin , Euljoon Park
发明人： Xiaoyi Min , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0538 , A61N1/3627 , A61N1/371
摘要： Techniques are provided for predicting the onset of a heart condition within a patient based on impedance measurements. Briefly, overloads in fluid levels in the thorax and in ventricular myocardial mass within the patient are detected based on impedance signals sensed using implanted electrodes. The onset of certain heart conditions is then predicted based on the overloads. For example, pulmonary edema arising due to diastolic heart failure is predicted based on the detection of on-going overloads in both fluid levels and ventricular mass. Ventricular hypertrophy is detected based on an on-going ventricular mass overload without a sustained fluid overload. Various other heart conditions may also be predicted based on specific combinations of recent or on-going overloads. Evoked response is exploited to corroborate the predictions. Appropriate warning signals are generated and preemptive therapy is initiated.
摘要翻译：提供了基于阻抗测量来预测患者心脏病状发作的技术。简单地说，基于使用植入电极感测到的阻抗信号来检测患者胸部液位水平和心室心肌质量的过载。然后基于过载来预测某些心脏状况的发作。例如，由于舒张性心力衰竭引起的肺水肿基于检测流体水平和心室质量中的持续过载而被预测。基于正在进行的心室质量超载而无持续的流体超载检测出心室肥大。还可以基于最近或正在进行的过载的特定组合来预测各种其他心脏状况。被诱发的反应被利用来证实预测。产生适当的警告信号并开始抢先治疗。

59. 发明授权

US06466821B1 AC/DC multi-axis accelerometer for determining patient activity and body position 失效
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06466821B1
公开(公告)日：2002-10-15
申请号：US09457451
申请日：1999-12-08
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1362
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

60. 发明授权

US06269264B1 Method for measuring impedance in the body 有权
标题翻译：测量身体阻抗的方法
公开(公告)号：US06269264B1
公开(公告)日：2001-07-31
申请号：US09325312
申请日：1999-06-03
申请人： Robert R. Weyant , Jason A. Sholder , Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Said Mortazavi
发明人： Robert R. Weyant , Jason A. Sholder , Euljoon Park , Gene A. Bornzin , Joseph J. Florio , Said Mortazavi
IPC分类号： A61B505
CPC分类号： A61N1/36521
摘要： Methods and apparatus are provided for measuring the impedance of a patient's body. Pulse generating circuitry within a rate-responsive pacemaker is used to generate an impedance measurement signal that is applied to the body of the patient with conventional pacemaker leads. The impedance measurement signal contains a series of multiphasic impedance measurement waveforms, which have no net DC value and zero value after second integration. The impedance measurement signal allows the impedance of the body to be measured without interfering with external cardiac monitoring equipment such as electrocardiogram machines.
摘要翻译：提供了用于测量患者身体阻抗的方法和装置。速率响应起搏器内的脉冲发生电路用于产生用常规起搏器引线施加到患者身体的阻抗测量信号。阻抗测量信号包含一系列多相阻抗测量波形，其在第二次积分后不具有净DC值和零值。阻抗测量信号允许测量身体的阻抗，而不会干扰外部心脏监测设备，如心电图仪。

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