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51. 发明授权

US07745161B2 Amplification of enzymatic reactions for use with an enthalpy array 有权
标题翻译：扩增用于焓阵列的酶反应
公开(公告)号：US07745161B2
公开(公告)日：2010-06-29
申请号：US10740776
申请日：2003-12-19
申请人： Francisco E. Torres , Richard H. Bruce , James R. Williamson , Peter Kuhn , Ray Stevens
发明人： Francisco E. Torres , Richard H. Bruce , James R. Williamson , Peter Kuhn , Ray Stevens
IPC分类号： G01N33/53
CPC分类号： G01N25/4846 , G01N25/4866
摘要： Provided is a method of detecting characteristics of a reaction of interest, including instituting the reaction of interest, obtaining an amplified heat related to the reaction of interest, measuring the amplified heat, and determining the characteristics of the reaction of interest, using the signal obtained in the step of measuring.
摘要翻译：本发明提供一种检测感兴趣特征的方法，包括进行感兴趣的反应，获得与感兴趣的反应相关的放大热，测量放大的热量，并使用获得的信号确定感兴趣的特性在测量的步骤。

52. 发明申请

US20100045993A1 METHOD OF DETECTING ANALYTE 有权
标题翻译：检测分析仪的方法
公开(公告)号：US20100045993A1
公开(公告)日：2010-02-25
申请号：US12195997
申请日：2008-08-21
申请人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
发明人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
IPC分类号： G01N21/00
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. The method comprises detecting an optical property of a first region of two or more regions in a system, the first region located in a container having a reservoir for one or more modifiers of one or more optical properties of the first region. The movement of the one or more modifiers is responsive to changes in concentration of the analyte. A next step detects an optical property of a second region of the two or more regions in the system, the second region located in a container having a reservoir for one or more modifiers of one or more optical properties of the second region. The movement of the one or more modifiers is responsive to changes in concentration of a compound, where the compound is something other than the analyte. The detected optical property of the first region and the detected optical property of the second region are used in embodiments to separate the effect of the analyte on the detected optical property of the first region from the effect of the compound, where the compound is an interfering compound.
摘要翻译：提供了用于检测流体中分析物的浓度的系统和方法。该方法包括检测系统中两个或更多个区域的第一区域的光学性质，位于容器中的第一区域具有用于一个或多个第一区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应于分析物浓度的变化。下一步骤检测系统中两个或更多个区域的第二区域的光学性质，位于容器中的第二区域具有用于一个或多个第二区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应化合物浓度的变化，其中化合物是除分析物以外的物质。检测到的第一区域的光学特性和第二区域的检测光学特性用于实施例中以将分析物对第一区域的检测光学性质的影响与化合物的影响分开，其中化合物是干扰复合。

53. 发明申请

US20090156917A1 Controlling Transfer of Objects Affecting Optical Characteristics 有权
标题翻译：控制影响光学特性的物体的传输
公开(公告)号：US20090156917A1
公开(公告)日：2009-06-18
申请号：US11957610
申请日：2007-12-17
申请人： Jorg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
发明人： Jorg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/03 , G01N21/39 , G01N21/8507
摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.
摘要翻译：诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。该产品还可以包括流体组件，例如过滤器组件，其控制影响或移动光谱特征或特性的物体的转移，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中等强度宽度，作为全宽半最大值（FWHM）。分析物，例如葡萄糖分子可以主要包括在一组物体中，其比其它物体更快地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。因此，来自容器的输出光包括关于分析物的信息。

54. 发明申请

US20080186483A1 Implanting optical cavity structures 有权
标题翻译：植入光腔结构
公开(公告)号：US20080186483A1
公开(公告)日：2008-08-07
申请号：US11702329
申请日：2007-02-05
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
IPC分类号： G01N1/10
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译：可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。第二部分包括封闭的容器并且包含参考流体。可植入产品还可以包括光源组件和感光组件中的一个或两个。可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

55. 发明授权

US07277569B2 Apparatus and method for detecting and locating rare cells 有权
标题翻译：用于检测和定位稀有细胞的装置和方法
公开(公告)号：US07277569B2
公开(公告)日：2007-10-02
申请号：US10616366
申请日：2003-07-09
申请人： Richard H. Bruce , Douglas N. Curry , Robert T. Krivacic , Huangpin B. Hsieh
发明人： Richard H. Bruce , Douglas N. Curry , Robert T. Krivacic , Huangpin B. Hsieh
IPC分类号： G06K9/00
CPC分类号： B82Y20/00 , B82Y5/00 , B82Y10/00 , G01N15/1468 , G01N2015/0065
摘要： In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample. A photodetector is arranged to detect the light signal at the distal bundle end, and a processor processes the detected light signals.
摘要翻译：根据本申请的一个方面，公开了一种用于检测和定位样品中的稀有细胞的成像器和方法。成像器台支持样品。光纤束具有布置成限定观察平移台上的样品的输入孔的第一光纤端的近端束端。光纤束还具有设置成限定与输入孔不同的形状的输出孔并远离成像器台设置的第二纤维端的远端束端。扫描辐射源被布置在与输入孔相对的固定相对位置。扫描辐射源在输入孔的观察区域内扫描样品上的辐射束。辐射束与样品相互作用以产生被信号反射，散射，透射，再发射或以其它方式收集和接收的光信号，并通过光纤束传输到输出孔。扫描辐射源将辐射束照射在样品的选定区域上。光检测器被设置为检测远端束端处的光信号，并且处理器处理检测到的光信号。

56. 发明授权

US06623700B1 Level sense and control system for biofluid drop ejection devices 失效
标题翻译：生物流体喷射装置的液位感应和控制系统
公开(公告)号：US06623700B1
公开(公告)日：2003-09-23
申请号：US09721386
申请日：2000-11-22
申请人： David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , Scott A. Elrod
发明人： David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , Scott A. Elrod
IPC分类号： B01L302
CPC分类号： B41J2/17566 , B41J2/1714 , Y10T436/2575
摘要： A level control mechanism is provided for a biofluid drop ejection device which ejects biofluid drops in small volumes. The biofluid drop device includes a drop ejection mechanism having a transducer which generates energy used to emit the biofluid drops. A reagent cartridge or biofluid holding area holds a biofluid, isolated from the drop ejection mechanism to avoid contamination between the biofluid drop ejection mechanism and the reagent cartridge. The reagent cartridge is connected to the drop ejection mechanism such that upon operation of the mechanism, the biofluid is emitted in controlled biofluid drops. A level sensor is positioned to sense a height of the biofluid within the cartridge. Upon sensing the height of the biofluid below a certain level, an adjustment is made to the height by providing at least one of additional biofluid to the cartridge, and raising the level of the entire reagent cartridge.
摘要翻译：为生物流体液滴喷射装置提供液面控制机构，其以小体积喷射生物流体液滴。生物流体液滴装置包括液滴喷射机构，其具有产生用于发射生物流体滴的能量的换能器。试剂盒或生物流体保持区域保持与液滴喷射机构隔离的生物流体，以避免生物流体液滴喷射机构和试剂盒之间的污染。试剂盒连接到液滴喷射机构，使得在机构操作时，生物流体在受控的生物流体滴下发射。水平传感器被定位成感测盒内的生物流体的高度。当感测到生物流体的高度低于一定水平时，通过向盒提供至少一种额外的生物流体，并提高整个试剂盒的水平来调节高度。

57. 发明授权

US06514704B2 Quality control mechanism and process for a biofluid multi-ejector system 失效
公开(公告)号：US06514704B2
公开(公告)日：2003-02-04
申请号：US09773804
申请日：2001-02-01
申请人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
发明人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
IPC分类号： C12Q168
CPC分类号： G01N35/10 , G01N35/00712 , G01N35/1009 , G01N2035/1037 , G06F19/00
摘要： A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay. A comparing operation is undertaken to compare the obtained signature output through the scanning operation, with the expected signature output signals for the biofluid loaded in the corresponding drop ejector. The biological material itself may also be tagged with a marker to ensure its inclusion in the biofluid. By the comparing operation, it is possible to verify the biofluids were loaded in the proper drop ejector, including the proper biological material, and that the drop ejectors are functioning properly.

58. 发明授权

US06503454B1 Multi-ejector system for ejecting biofluids 有权
标题翻译：用于喷射生物流体的多喷射器系统
公开(公告)号：US06503454B1
公开(公告)日：2003-01-07
申请号：US09721389
申请日：2000-11-22
申请人： Babur B. Hadimioglu , Scott A. Elrod , Richard H. Bruce , Jaan Noolandi , David A. Horine
发明人： Babur B. Hadimioglu , Scott A. Elrod , Richard H. Bruce , Jaan Noolandi , David A. Horine
IPC分类号： B01L302
CPC分类号： B01L3/0268 , G01N2035/1039 , Y10T436/2575
摘要： A multiple-ejector system for printing arrays of biofluids include a tooling plate having a plurality of sets of tooling pins extending outward from the surface of the tooling plate. A printed circuit board is provided having pairs of power connection pins and ground return pins extending from a surface of the circuit board. A plurality of biofluid drop ejection units are provided and include alignment grooves and at least a transducer. Each of the plurality of biofluid drop ejection units are connected to a corresponding one of a set of tooling pins by connection of the tooling pins and alignment grooves. The power connection pins of the pairs are in operational connection with respective transducers and the ground return connection pins of the pairs are in operational connection with a body portion of the drop ejection units. The different drop ejection units will contain different biofluids which are to be emitted onto a substrate. Verification of drop ejection units containing biofluids, may be obtained in one embodiment through the use of an optical scanner. Detection of drops at defined locations provides a verification that validates a properly formed spot is present on a substrate, and is in the correct position.
摘要翻译：用于打印生物流体阵列的多喷射器系统包括具有从工具板的表面向外延伸的多组工具销的工具板。提供一个印刷电路板，其具有从电路板的表面延伸的成对的电源连接引脚和接地返回引脚。提供多个生物流体液滴喷射单元，并且包括对准凹槽和至少一个换能器。多个生物流体滴落喷射单元中的每一个通过工具销和对准槽的连接连接到一组加工销中的对应的一个。成对的电源连接引脚与相应的换能器操作连接，并且对的接地返回连接引脚与液滴喷射单元的主体部分操作连接。不同的液滴喷射单元将包含将被发射到基底上的不同生物流体。通过使用光学扫描仪可以在一个实施例中获得包含生物流体的液滴喷射单元的验证。在限定位置处检测液滴提供验证，验证正确形成的斑点存在于基底上，并处于正确的位置。

59. 发明授权

US6078936A Presenting an image on a display as it would be presented by another image output device or on printing circuitry 失效
标题翻译：在显示器上呈现由另一图像输出设备或打印电路呈现的图像
公开(公告)号：US6078936A
公开(公告)日：2000-06-20
申请号：US679169
申请日：1996-07-12
申请人： Russel A. Martin , Richard H. Bruce , Alan G. Lewis , Kathryn M. Middo , Malcolm J. Thompson , William D. Turner
发明人： Russel A. Martin , Richard H. Bruce , Alan G. Lewis , Kathryn M. Middo , Malcolm J. Thompson , William D. Turner
IPC分类号： H04N1/00 , G06T11/80 , H04N1/60 , G06F3/147 , G06F3/12 , G06F17/21 , G06K15/00
CPC分类号： H04N1/6011
摘要： A display has sufficient resolution to present images as they would appear on other types of image output devices, such as types of printers or displays. In response to a user signal indicating a type of image output devices, data defining an image is used to automatically obtain version data defining a version of the image. The version can be presented on the display to show the image as it would appear when presented by an image output device of the indicated type. The user can indicate a type by selecting a menu item or a button or by providing a sequence of keystrokes. In response to a user signal indicating a parameter value, a version can be presented showing the image as it would appear when presented with the value. When a satisfactory image is displayed, the user can then request presentation of the image by a device of the indicated type. Either data defining the input image from which the displayed image is a version or data defining the currently displayed image can then be transformed to obtain a presentation version for the image output device. A copier or printer that includes the display can use it to perform print previewing.
摘要翻译：显示器具有足够的分辨率来呈现在其他类型的图像输出设备（例如打印机或显示器的类型）上显示的图像。响应于指示图像输出设备的类型的用户信号，定义图像的数据被用于自动获取定义图像版本的版本数据。该版本可以在显示器上呈现，以显示当由指定类型的图像输出设备呈现时将出现的图像。用户可以通过选择菜单项或按钮或通过提供一系列按键来指示类型。响应于指示参数值的用户信号，可以呈现当呈现该值时将出现的图像的版本。当显示令人满意的图像时，用户可以通过所指示类型的设备请求呈现图像。然后可以对定义所显示的图像是定义当前显示的图像的版本的数据的数据进行变换，以获得图像输出装置的呈现版本。包含显示器的复印机或打印机可以使用它来执行打印预览。

60. 发明授权

US5978880A Multi-segmented bus and method of operation 失效
标题翻译：多段总线和运行方式
公开(公告)号：US5978880A
公开(公告)日：1999-11-02
申请号：US447648
申请日：1995-05-23
申请人： Richard H. Bruce , Jean Gastinel , William F. Gunning , Michael Overton
发明人： Richard H. Bruce , Jean Gastinel , William F. Gunning , Michael Overton
IPC分类号： G06F13/36 , G06F13/40 , G06F13/42 , G06F13/00
CPC分类号： G06F13/409 , G06F13/4022
摘要： A multi-level hierarchical bus architecture implemented with a multi-chip package and a modular shared-bus provides high bandwidth. All IC components are mounted on standardized multi-chip packages. Each multi-chip package includes bus interface chips for providing communication from the integrated circuits to a board bus. One multi-chip package contains additional bus interface circuitry for providing communication from the board bus to a backplane bus.
摘要翻译：采用多芯片封装和模块化共享总线实现的多级分层总线结构提供了高带宽。所有IC组件均安装在标准化的多芯片封装上。每个多芯片封装包括用于提供从集成电路到板总线的通信的总线接口芯片。一个多芯片封装包含用于提供从板总线到背板总线的通信的附加总线接口电路。

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