专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08685216B2 Apparatus and method for improved electrostatic drop merging and mixing 有权
标题翻译：改进静电滴合并和混合的装置和方法
公开(公告)号：US08685216B2
公开(公告)日：2014-04-01
申请号：US11018757
申请日：2004-12-21
申请人： Dirk De Bruyker , Michael I. Recht , Jürgen H. Daniel
发明人： Dirk De Bruyker , Michael I. Recht , Jürgen H. Daniel
IPC分类号： B03C5/02
CPC分类号： B01F13/0076 , B01F13/0071 , B01L3/5027 , B41J2002/14395
摘要： An apparatus for merging and mixing two droplets using electrostatic forces includes a substrate on which are disposed a first originating electrode, a center electrode, and a second originating electrode. The electrodes are disposed such that a first gap is formed between the first originating electrode and the center electrode and a second gap is formed between the second originating electrode and the center electrode. A dielectric material surrounds the electrodes on the substrate. A first droplet is deposited asymmetrically across the first gap, and a second droplet is deposited asymmetrically across the second gap. Voltage potentials are placed across the first gap and second gap, respectively, whereby each droplet is moved toward the other such that they collide together, causing the droplets to merge and mix, and causing oscillations within the collided droplet.
摘要翻译：一种用于使用静电力并入和混合两个液滴的装置包括其上布置有第一起始电极，中心电极和第二起始电极的基板。电极被布置成使得在第一起始电极和中心电极之间形成第一间隙，并且在第二起始电极和中心电极之间形成第二间隙。电介质材料围绕衬底上的电极。第一液滴不对称地沉积在第一间隙上，并且第二液滴不对称地沉积穿过第二间隙。电压电位分别放置在第一间隙和第二间隙之间，由此每个液滴向另一个间隙移动，使得它们碰撞在一起，导致液滴合并和混合，并引起碰撞液滴内的振荡。

2. 发明授权

US08617899B2 Enhanced drop mixing using magnetic actuation 有权
标题翻译：使用磁力驱动增强液滴混合
公开(公告)号：US08617899B2
公开(公告)日：2013-12-31
申请号：US12031519
申请日：2008-02-14
申请人： Dirk De Bruyker , Ali Asgar Saleem Bhagat , Alan G. Bell , Michael I. Recht , Francisco E. Torres
发明人： Dirk De Bruyker , Ali Asgar Saleem Bhagat , Alan G. Bell , Michael I. Recht , Francisco E. Torres
IPC分类号： G01N25/20 , G01N27/00 , G01N25/00 , C12M1/02
CPC分类号： B01F13/0818 , B01F13/0071 , B01F13/0076 , B01F13/0077 , B01F2015/0221 , G01N25/48 , Y10T137/0318 , Y10T137/87652 , Y10T436/25 , Y10T436/2575
摘要： A method and device for merging and mixing at least two separate and distinct fluid drops on a substrate, includes a drop merging area on the surface, where a first magnetic material is placed at a first location. A first drop of fluid is then placed at the first location on the surface, resulting in the first magnetic material being at least partially positioned within the first drop of fluid. A second drop of fluid is then placed at a second location on the surface of the drop merging area. A magnetic field is applied by a varying magnetic field generator to at least a portion of the drop merge area of the substrate, which includes at least the first location on the substrate. The varying magnetic field will act on the first magnetic material to move the first magnetic material within the first drop of fluid, causing a stirring of the fluid. A drop merging force from a drop merging mechanism is applied to at least one of the first drop of fluid and the second drop of fluid within the drop merge area. This causes at least one of the first drop of fluid and the second drop of fluid to move toward the other and make contact. The internal stirring of the fluid in the first drop of fluid by the movement of the magnetic material enhances the mixing of the constituents of the first drop of fluid and the constituents of the second drop of fluid.
摘要翻译：用于在衬底上合并和混合至少两个独立且不同的液滴的方法和装置包括在表面上的液滴合并区域，其中第一磁性材料放置在第一位置。然后将第一滴流体放置在表面上的第一位置处，导致第一磁性材料至少部分地定位在第一液滴内。然后将第二滴流体放置在滴液合并区域的表面上的第二位置。通过变化的磁场发生器将磁场施加到衬底的下落合并区域的至少一部分，其至少包括衬底上的第一位置。变化的磁场将作用在第一磁性材料上以使第一磁性材料在第一液滴内移动，引起流体的搅拌。来自液滴合并机构的液滴合并力被施加到液滴合并区域中的第一液体流体和第二液体流中的至少一个。这使得第一液体流体和第二液体液滴中的至少一个朝向另一个流体移动并进行接触。通过磁性材料的运动在第一滴流体中内部流体的内部搅拌增强了第一滴流体的组分与第二滴流体的组分的混合。

3. 发明申请

US20100045993A1 METHOD OF DETECTING ANALYTE 有权
标题翻译：检测分析仪的方法
公开(公告)号：US20100045993A1
公开(公告)日：2010-02-25
申请号：US12195997
申请日：2008-08-21
申请人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
发明人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
IPC分类号： G01N21/00
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. The method comprises detecting an optical property of a first region of two or more regions in a system, the first region located in a container having a reservoir for one or more modifiers of one or more optical properties of the first region. The movement of the one or more modifiers is responsive to changes in concentration of the analyte. A next step detects an optical property of a second region of the two or more regions in the system, the second region located in a container having a reservoir for one or more modifiers of one or more optical properties of the second region. The movement of the one or more modifiers is responsive to changes in concentration of a compound, where the compound is something other than the analyte. The detected optical property of the first region and the detected optical property of the second region are used in embodiments to separate the effect of the analyte on the detected optical property of the first region from the effect of the compound, where the compound is an interfering compound.
摘要翻译：提供了用于检测流体中分析物的浓度的系统和方法。该方法包括检测系统中两个或更多个区域的第一区域的光学性质，位于容器中的第一区域具有用于一个或多个第一区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应于分析物浓度的变化。下一步骤检测系统中两个或更多个区域的第二区域的光学性质，位于容器中的第二区域具有用于一个或多个第二区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应化合物浓度的变化，其中化合物是除分析物以外的物质。检测到的第一区域的光学特性和第二区域的检测光学特性用于实施例中以将分析物对第一区域的检测光学性质的影响与化合物的影响分开，其中化合物是干扰复合。

4. 发明申请

US20100049015A1 SPECIFICITY OF ANALYTE DETECTION IN ETALONS 有权
标题翻译： ETALON分析检测的特异性
公开(公告)号：US20100049015A1
公开(公告)日：2010-02-25
申请号：US12195942
申请日：2008-08-21
申请人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
发明人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
IPC分类号： A61B5/00 , G01N21/01 , G01N33/487 , G01N21/59
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. A first container includes (i) an optical cavity detection region, (ii) a reservoir for one or more modifiers of one or more optical properties of the optical cavity detection region, and (iii) a set of one or more bounding regions through which objects in the fluid can transfer into the container. The optical cavity detection region and the reservoir define separate areas of the first container. The movement of the one or more modifiers between the reservoir and the optical cavity detection region is responsive to changes in concentration of the analyte. A second container includes an optical cavity detection region, and a set of one or more bounding regions through which objects in the fluid can transfer into the container. Also provided are optical components for guiding light into the optical cavity detection regions of the first and second containers.
摘要翻译：提供了用于检测流体中分析物的浓度的系统和方法。第一容器包括（i）光腔检测区域，（ii）用于一个或多个光腔检测区域的一个或多个光学特性的修改器的储存器，以及（iii）一组或多个边界区域，流体中的物体可以转移到容器中。光腔检测区域和储存器限定第一容器的分开的区域。储存器和光腔检测区域之间的一个或多个改性剂的运动响应于分析物浓度的变化。第二容器包括光学腔检测区域和一组一个或多个界限区域，流体中的物体可通过该区域传送到容器中。还提供了用于将光引导到第一和第二容器的光学腔检测区域中的光学部件。

5. 发明授权

US07632008B2 Ranking fragment types with calorimetry 有权
标题翻译：用量热法排列片段类型
公开(公告)号：US07632008B2
公开(公告)日：2009-12-15
申请号：US11760236
申请日：2007-06-08
申请人： Michael I. Recht , Francisco E. Torres , Richard H. Bruce , Alan G. Bell
发明人： Michael I. Recht , Francisco E. Torres , Richard H. Bruce , Alan G. Bell
IPC分类号： G01K17/00
CPC分类号： G01N25/48
摘要： Test and reference groups of samples can be provided and concurrently combined and output signals can be provided. Each sample can have a volume not exceeding approximately 100 microliters, and each group can be provided in a region, such as in a cell of an array calorimeter. Each test group can include at least one fragment sample and one target sample, and its reference group can include similar samples. The output signals can include information about heat of reaction due to combining the fragment and target samples. For each target type, the output signals can be used to rank fragment types. For example, a subset of fragment types that react with the target type can be identified; an equilibrium constant or ligand efficiency can be obtained for each such fragment type; or a rank ordering can be obtained of such fragment types.
摘要翻译：样品的测试和参考组可以提供并同时组合，并且可以提供输出信号。每个样品可以具有不超过约100微升的体积，并且每个组可以设置在诸如阵列量热计的单元格的区域中。每个测试组可以包括至少一个片段样品和一个目标样品，其参考组可以包括相似的样品。输出信号可以包括由于组合片段和目标样品而引起的反应热的信息。对于每种目标类型，输出信号可用于对片段类型进行排序。例如，可以识别与目标类型反应的片段类型的子集; 可以获得每种这样的片段类型的平衡常数或配体效率; 或者可以获得这样的片段类型的等级排序。

6. 发明申请

US20080304541A1 Ranking Fragment Types with Calorimetry 有权
标题翻译：使用量热法排列片段类型
公开(公告)号：US20080304541A1
公开(公告)日：2008-12-11
申请号：US11760236
申请日：2007-06-08
申请人： Michael I. Recht , Francisco E. Torres , Richard H. Bruce , Alan G. Bell
发明人： Michael I. Recht , Francisco E. Torres , Richard H. Bruce , Alan G. Bell
IPC分类号： G01K17/00
CPC分类号： G01N25/48
摘要： Test and reference groups of samples can be provided and concurrently combined and output signals can be provided. Each sample can have a volume not exceeding approximately 100 microliters, and each group can be provided in a region, such as in a cell of an array calorimeter. Each test group can include at least one fragment sample and one target sample, and its reference group can include similar samples. The output signals can include information about heat of reaction due to combining the fragment and target samples. For each target type, the output signals can be used to rank fragment types. For example, a subset of fragment types that react with the target type can be identified; an equilibrium constant or ligand efficiency can be obtained for each such fragment type; or a rank ordering can be obtained of such fragment types.
摘要翻译：样品的测试和参考组可以提供并同时组合，并且可以提供输出信号。每个样品可以具有不超过约100微升的体积，并且每个组可以设置在诸如阵列量热计的单元格的区域中。每个测试组可以包括至少一个片段样品和一个目标样品，其参考组可以包括相似的样品。输出信号可以包括由于组合片段和目标样品而引起的反应热的信息。对于每种目标类型，输出信号可用于对片段类型进行排序。例如，可以识别与目标类型反应的片段类型的子集; 可以获得每种这样的片段类型的平衡常数或配体效率; 或者可以获得这样的片段类型的等级排序。

7. 发明授权

US07961326B2 Method of detecting the concentration of an analyte 有权
标题翻译：检测分析物浓度的方法
公开(公告)号：US07961326B2
公开(公告)日：2011-06-14
申请号：US12195997
申请日：2008-08-21
申请人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
发明人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
IPC分类号： A61B5/00 , G01J3/46
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. The method comprises detecting an optical property of a first region of two or more regions in a system, the first region located in a container having a reservoir for one or more modifiers of one or more optical properties of the first region. The movement of the one or more modifiers is responsive to changes in concentration of the analyte. A next step detects an optical property of a second region of the two or more regions in the system, the second region located in a container having a reservoir for one or more modifiers of one or more optical properties of the second region. The movement of the one or more modifiers is responsive to changes in concentration of a compound, where the compound is something other than the analyte. The detected optical property of the first region and the detected optical property of the second region are used in embodiments to separate the effect of the analyte on the detected optical property of the first region from the effect of the compound, where the compound is an interfering compound.
摘要翻译：提供了用于检测流体中分析物的浓度的系统和方法。该方法包括检测系统中两个或更多个区域的第一区域的光学性质，位于容器中的第一区域具有用于一个或多个第一区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应于分析物浓度的变化。下一步骤检测系统中两个或更多个区域的第二区域的光学性质，位于容器中的第二区域具有用于一个或多个第二区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应化合物浓度的变化，其中化合物是除分析物以外的物质。检测到的第一区域的光学特性和第二区域的检测光学特性用于实施例中以将分析物对第一区域的检测光学性质的影响与化合物的影响分开，其中化合物是干扰复合。

8. 发明授权

US09161714B2 Specificity of analyte detection in etalons 有权
标题翻译：标准具中分析物检测的特异性
公开(公告)号：US09161714B2
公开(公告)日：2015-10-20
申请号：US12195942
申请日：2008-08-21
申请人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
发明人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
IPC分类号： A61B5/00 , A61B5/1459 , A61B5/145 , G01N21/33 , G01N21/359
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. A first container includes (i) an optical cavity detection region, (ii) a reservoir for one or more modifiers of one or more optical properties of the optical cavity detection region, and (iii) a set of one or more bounding regions through which objects in the fluid can transfer into the container. The optical cavity detection region and the reservoir define separate areas of the first container. The movement of the one or more modifiers between the reservoir and the optical cavity detection region is responsive to changes in concentration of the analyte. A second container includes an optical cavity detection region, and a set of one or more bounding regions through which objects in the fluid can transfer into the container. Also provided are optical components for guiding light into the optical cavity detection regions of the first and second containers.
摘要翻译：提供了用于检测流体中分析物的浓度的系统和方法。第一容器包括（i）光腔检测区域，（ii）用于一个或多个光腔检测区域的一个或多个光学特性的修改器的储存器，以及（iii）一组或多个边界区域，流体中的物体可以转移到容器中。光腔检测区域和储存器限定第一容器的分开的区域。储存器和光腔检测区域之间的一个或多个改性剂的运动响应于分析物浓度的变化。第二容器包括光学腔检测区域和一组一个或多个界限区域，流体中的物体可通过该区域传送到容器中。还提供了用于将光引导到第一和第二容器的光学腔检测区域中的光学部件。

9. 发明申请

US20110263464A1 ENHANCED DROP MIXING USING MAGNETIC ACTUATION 有权
标题翻译：使用磁力驱动的增强液压混合
公开(公告)号：US20110263464A1
公开(公告)日：2011-10-27
申请号：US12031519
申请日：2008-02-14
申请人： Dirk De Bruyker , Ali Asgar Bhagat , Alan G. Bell , Michael I. Recht , Francisco E. Torres
发明人： Dirk De Bruyker , Ali Asgar Bhagat , Alan G. Bell , Michael I. Recht , Francisco E. Torres
IPC分类号： C40B60/14 , F15D1/00
CPC分类号： B01F13/0818 , B01F13/0071 , B01F13/0076 , B01F13/0077 , B01F2015/0221 , G01N25/48 , Y10T137/0318 , Y10T137/87652 , Y10T436/25 , Y10T436/2575
摘要： A method and device for merging and mixing at least two separate and distinct fluid drops on a substrate, includes a drop merging area on the surface, where a first magnetic material is placed at a first location. A first drop of fluid is then placed at the first location on the surface, resulting in the first magnetic material being at least partially positioned within the first drop of fluid. A second drop of fluid is then placed at a second location on the surface of the drop merging area. A magnetic field is applied by a varying magnetic field generator to at least a portion of the drop merge area of the substrate, which includes at least the first location on the substrate. The varying magnetic field will act on the first magnetic material to move the first magnetic material within the first drop of fluid, causing a stirring of the fluid. A drop merging force from a drop merging mechanism is applied to at least one of the first drop of fluid and the second drop of fluid within the drop merge area. This causes at least one of the first drop of fluid and the second drop of fluid to move toward the other and make contact. The internal stirring of the fluid in the first drop of fluid by the movement of the magnetic material enhances the mixing of the constituents of the first drop of fluid and the constituents of the second drop of fluid.
摘要翻译：用于在衬底上合并和混合至少两个独立且不同的液滴的方法和装置包括在表面上的液滴合并区域，其中第一磁性材料放置在第一位置。然后将第一滴流体放置在表面上的第一位置处，导致第一磁性材料至少部分地定位在第一液滴内。然后将第二滴流体放置在滴液合并区域的表面上的第二位置。通过变化的磁场发生器将磁场施加到衬底的下落合并区域的至少一部分，其至少包括衬底上的第一位置。变化的磁场将作用在第一磁性材料上，以使第一磁性材料在第一液滴内移动，引起流体的搅拌。来自液滴合并机构的液滴合并力被施加到液滴合并区域中的第一液体流体和第二液体流中的至少一个。这使得第一液体流体和第二液体液滴中的至少一个朝向另一个流体移动并进行接触。通过磁性材料的运动在第一滴流体中内部流体的内部搅拌增强了第一滴流体的组分与第二滴流体的组分的混合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式