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    • 53. 发明授权
    • miRNAs as therapeutic targets in cancer
    • miRNA作为癌症治疗靶点
    • US08927207B2
    • 2015-01-06
    • US12996249
    • 2009-06-05
    • Jingfang JuBo SongYuan Wang
    • Jingfang JuBo SongYuan Wang
    • C12Q1/68C12N15/113
    • C12N15/1137A61K31/7088A61K45/06C12N15/113C12N15/1135C12N2310/113C12N2310/14C12N2320/31C12Q1/6886C12Q2600/136C12Q2600/178
    • MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3′ untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
    • 微RNA(miRNA)是一类非编码小RNA分子,通过与其靶mRNA的3'非翻译区(UTR)相互作用,在转录后水平调节基因表达。 本发明涉及miR-192和miR-215的应用。 这两种miRNA通过p53-miRNA电路影响细胞增殖,并与二氢叶酸还原酶(DHFR)和胸苷酸合酶(TS)相互作用。 特别地,这些miRNA的上调减少细胞增殖。 本发明涉及这一发现。 例如,抑制miR-192和/或miR-215使肿瘤或具有肿瘤的受试者对化学治疗剂敏感。 此外,测量miR-192和/或miR-215的水平提供了关于肿瘤或受试者是否将对化学治疗剂作出反应的信息。 因此,本发明涉及与miR-192和miR-215的表达的鉴定,表征和调节相关的组合物和方法。
    • 57. 发明授权
    • Antenna assembly to reduce specific absorption rate
    • 天线组件降低比吸收率
    • US08659488B2
    • 2014-02-25
    • US13421890
    • 2012-03-16
    • Tiao-Hsing TsaiChi-Yin FangI-Ping YenChao-Hsu WuChun-Yuan Wang
    • Tiao-Hsing TsaiChi-Yin FangI-Ping YenChao-Hsu WuChun-Yuan Wang
    • H01Q1/24H01Q9/38
    • H01Q1/38H01Q1/48H01Q9/42H01Q21/30
    • An antenna assembly includes first and second antennas each generating a resonant mode to cover an operating bandwidth, and a transmission line. The first includes a first radiation unit with a feed-in portion coupled to a first feed portion in contact with a core wire of a coaxial cable and a first grounding portion. The second antenna includes a second radiation unit with a second feed-in portion coupled to a second feed portion in contact with a conductive shielding layer of the coaxial cable and a second grounding portion. The transmission line includes first and second connecting portions coupled respectively to the second feed portion of the second feed-in portion. When a signal within the operating bandwidth is transmitted through the coaxial cable, the energy of the signal is distributed among the first and second antennas.
    • 天线组件包括第一和第二天线,每个天线产生覆盖工作带宽的谐振模式和传输线。 第一辐射单元包括具有与第一馈电部分耦合的馈入部分的第一辐射单元,其与同轴电缆的芯线和第一接地部分接触。 第二天线包括具有第二馈入部分的第二辐射单元,第二馈入部分耦合到与同轴电缆的导电屏蔽层接触的第二馈电部分和第二接地部分。 传输线包括分别连接到第二馈入部分的第二馈送部分的第一和第二连接部分。 当通过同轴电缆传输工作带宽内的信号时,信号的能量分布在第一和第二天线之间。