专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110112109A1 TRIAZOLONE DERIVATIVES 有权
标题翻译：三唑酮衍生物
公开(公告)号：US20110112109A1
公开(公告)日：2011-05-12
申请号：US13006004
申请日：2011-01-13
申请人： Richard CLARK , Fumiyoshi Matsuura , Kazunobu Kira , Shinsuke Hirota , Hiroshi Azuma , Tadashi Nagakura , Tatsuo Horizoe , Kimiyo Tabata , Kazutomi Kusano , Takao Omae , Atsushi Inoue
发明人： Richard CLARK , Fumiyoshi Matsuura , Kazunobu Kira , Shinsuke Hirota , Hiroshi Azuma , Tadashi Nagakura , Tatsuo Horizoe , Kimiyo Tabata , Kazutomi Kusano , Takao Omae , Atsushi Inoue
IPC分类号： A61K31/501 , A61K31/4196 , A61K31/506 , A61K31/4439 , A61K31/497 , A61K31/427 , A61K31/4245 , A61P7/02
CPC分类号： C07D249/12 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04
摘要： A compound represented by the following general formula (1) or salts thereof or hydrates of the foregoing: wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen.
摘要翻译：由下列通式（1）表示的化合物或其盐或上述的水合物：其中R1a，R1b，R1c和R1d各自独立地表示氢等; R2代表任选取代的苯基等; R3代表任选取代的C6-10芳基等; Z1和Z2各自独立地表示氢。

2. 发明申请

US20100190783A1 TRIAZOLONE DERIVATIVES 有权
标题翻译：三唑酮衍生物
公开(公告)号：US20100190783A1
公开(公告)日：2010-07-29
申请号：US12748806
申请日：2010-03-29
申请人： Richard CLARK , Fumiyoshi MATSUURA , Kazunobu KIRA , Shinsuke HIROTA , Hiroshi AZUMA , Tadashi NAGAKURA , Tatsuo HORIZOE , Kimiyo TABATA , Kazutomi KUSANO , Takao OMAE , Atsushi INOUE
发明人： Richard CLARK , Fumiyoshi MATSUURA , Kazunobu KIRA , Shinsuke HIROTA , Hiroshi AZUMA , Tadashi NAGAKURA , Tatsuo HORIZOE , Kimiyo TABATA , Kazutomi KUSANO , Takao OMAE , Atsushi INOUE
IPC分类号： A61K31/5377 , C07D249/12 , A61K31/4192 , C07D401/04 , A61K31/4439 , C07D403/04 , A61K31/506 , C07D401/14 , A61K31/444 , A61K31/501 , A61K31/497 , C07D413/14 , A61P7/02 , A61P9/10
CPC分类号： C07D249/12 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04
摘要： A Compound represented by the following general formula (1): wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen or salts thereof or hydrates of the foregoing.
摘要翻译：由以下通式（1）表示的化合物：其中R1a，R1b，R1c和R1d各自独立地表示氢等; R2代表任选取代的苯基等; R3代表任选取代的C6-10芳基等; 并且Z 1和Z 2各自独立地表示氢或其盐或前述的水合物。

3. 发明申请

US20080015199A1 Triazolone derivatives 有权
标题翻译：三唑酮衍生物
公开(公告)号：US20080015199A1
公开(公告)日：2008-01-17
申请号：US11723893
申请日：2007-03-22
申请人： Richard Clark , Fumiyoshi Matsuura , Kazunobu Kira , Shinsuke Hirota , Hiroshi Azuma , Tadashi Nagakura , Tatsuo Horizoe , Kimiyo Tabata , Kazutomi Kusano , Takao Omae , Atsushi Inoue
发明人： Richard Clark , Fumiyoshi Matsuura , Kazunobu Kira , Shinsuke Hirota , Hiroshi Azuma , Tadashi Nagakura , Tatsuo Horizoe , Kimiyo Tabata , Kazutomi Kusano , Takao Omae , Atsushi Inoue
IPC分类号： A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61P7/02 , A61P9/00 , C07D249/08 , C07D401/04 , C07D403/04 , C07D409/04 , C07D417/04
CPC分类号： C07D249/12 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04
摘要： A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen]
摘要翻译：由以下通式（1）表示的化合物，其盐或其前体的水合物是可用于治疗和/或预防与血栓形成有关的疾病的新型化合物，其具有合适的理化稳定性更安全。 [其中R 1a，R 1b，R 1c和R 1d各自独立地表示氢等。 R 2表示任选取代的苯基等; R 3表示任选取代的C 6-10芳基等; Z 1和Z 2各自独立地表示氢]

4. 发明申请

US20060111362A1 1,3-Dihydroimidazole ring compound 失效
标题翻译： 1,3-二氢咪唑环化合物
公开(公告)号：US20060111362A1
公开(公告)日：2006-05-25
申请号：US10537227
申请日：2003-12-02
申请人： Kazunobu Kira , Richard Clark , Seiji Yoshikawa , Taisuke Uehara
发明人： Kazunobu Kira , Richard Clark , Seiji Yoshikawa , Taisuke Uehara
IPC分类号： C07D473/12 , A61K31/522
CPC分类号： C07D473/18 , C07D471/04 , C07D473/16 , C07D473/24 , C07D473/32 , C07D473/40
摘要： The objective of this invention is to provide novel compounds that show excellent DPPIV-inhibiting activity. The present invention provides compounds represented by the general formula (I), salts thereof, or hydrates thereof, [wherein, T1 stands for a monocyclic or bicyclic 4 to 12-membered heterocycle having 1 or 2 nitrogen atoms in the ring, which may have substituents; in formula (I), the following formula represents a double bond or a single bond; X3 denotes an oxygen atom or a sulfur atom; X1 denotes a C2-6 alkyl group which may have substituents; Z1 denotes a nitrogen atom or the formula —CR3═; Z2 and Z3 each independently denote a nitrogen atom, the formula —CR1═, a carbonyl group, or the formula —NR2—; R1, R2, R3, and X2 each independently denote a C1-6 alkyl group which may have substituents, and such].
摘要翻译：本发明的目的是提供显示优异DPPIV抑制活性的新型化合物。本发明提供由通式（I）表示的化合物，其盐或其水合物[其中，T 1表示具有1或2个氮的单环或双环4至12元杂环环中的原子，其可以具有取代基; 在式（I）中，下式表示双键或单键; X 3表示氧原子或硫原子; X 1表示可以具有取代基的C 2-6烷基; Z 1表示氮原子或式-CR 3 O 3 - ; Z 2和Z 3各自独立地表示氮原子，式-CR 1 - ，羰基或式-NR 3 - SUP> 2 - ; R 1，R 2，R 3和X 2各自独立地表示C 1〜 6个可以具有取代基的烷基等。

5. 发明申请

US20060100199A1 Novel condensed imidazole derivatives 审中-公开
标题翻译：新型稠合咪唑衍生物
公开(公告)号：US20060100199A1
公开(公告)日：2006-05-11
申请号：US10516971
申请日：2003-06-03
申请人： Seiji Yoshikawa , Eita Emori , Eumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
发明人： Seiji Yoshikawa , Eita Emori , Eumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
IPC分类号： A61K31/551 , A61K31/522 , A61K31/503 , A61K31/4745 , C07D473/02 , C07D487/02
CPC分类号： C07D473/30 , C07D471/04 , C07D473/04 , C07D473/06 , C07D473/18 , C07D473/36 , C07D473/40 , C07D487/04 , C07D491/14
摘要： The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C1-6 alkyl group which may have one or more substituents, or such; Z1 and Z2 each independently represent a nitrogen atom or a group represented by the formula —CR2—; R1 and R2 independently represent a hydrogen atom, a C1-6 alkyl group which may have one or more substituents, or a C1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent
摘要翻译：本发明涉及由下式表示的化合物或其盐或水合物，其中T 1表示在环中含有一个或两个氮原子的4至12元杂环基，其中是可以具有一个或多个取代基的单环或双环结构; X表示可具有一个或多个取代基的C 1-6烷基; Z 1和Z 2各自独立地表示氮原子或由式-CR 2 -O 2 - 表示的基团。 R 1和R 2独立地表示氢原子，可以具有一个或多个取代基的C 1-6烷基或C 可以具有一个或多个取代基的烷基，等等。这些是显示出优异的新型化合物

6. 发明申请

US20060063787A1 Condensed imidazole derivatives 审中-公开
标题翻译：缩合咪唑衍生物
公开(公告)号：US20060063787A1
公开(公告)日：2006-03-23
申请号：US11212407
申请日：2005-08-26
申请人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
发明人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
IPC分类号： A61K31/522 , C07D473/02 , A61K31/4745 , C07D471/02
CPC分类号： C07D473/30 , C07D471/04 , C07D473/04 , C07D473/06 , C07D473/18 , C07D473/36 , C07D473/40 , C07D487/04 , C07D491/14
摘要： The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C1-6 alkyl group which may have one or more substituents, or such; Z1 and Z2 each independently represent a nitrogen atom or a group represented by the formula —CR2—; R1 and R2 independently represent a hydrogen atom, a C1-6 alkyl group which may have one or more substituents, or a C1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.
摘要翻译：本发明涉及由下式表示的化合物或其盐或水合物

7. 发明申请

US20090018331A1 CONDENSED IMIDAZOLE DERIVATIVES 失效
标题翻译：稠密咪唑衍生物
公开(公告)号：US20090018331A1
公开(公告)日：2009-01-15
申请号：US12199982
申请日：2008-08-28
申请人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
发明人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
IPC分类号： C07D498/14 , C07D473/04 , C07D487/04
CPC分类号： C07D473/30 , C07D471/04 , C07D473/04 , C07D473/06 , C07D473/18 , C07D473/36 , C07D473/40 , C07D487/04 , C07D491/14
摘要： The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C1-6 alkyl group which may have one or more substituents, or such; Z1 and Z2 each independently represent a nitrogen atom or a group represented by the formula —CR2—; R1 and R2 independently represent a hydrogen atom, a C1-6 alkyl group which may have one or more substituents, or a C1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.
摘要翻译：本发明涉及由下式表示的化合物或其盐或水合物，其中，T1表示在环中含有一个或两个氮原子的4至12元杂环基，其为单环或双环结构，其可以是具有一个或多个取代基; X表示可以具有一个或多个取代基的C 1-6烷基; Z 1和Z 2各自独立地表示氮原子或由式-CR 2表示的基团; R1和R2独立地表示氢原子，可以具有一个或多个取代基的C 1-6烷基或可以具有一个或多个取代基的C 1-6烷氧基等。这些是表现出优异的DPPIV抑制活性的新型化合物。

8. 发明申请

US20080132507A1 Hydrazide Derivatives 审中-公开
标题翻译：酰肼衍生物
公开(公告)号：US20080132507A1
公开(公告)日：2008-06-05
申请号：US11665385
申请日：2005-10-13
申请人： Richard Clark , Shinsuke Hirota , Hiroshi Azuma , Kazunobu Kira , Nobuhisa Watanabe , Tadashi Nagakura , Tatsuo Horizoe
发明人： Richard Clark , Shinsuke Hirota , Hiroshi Azuma , Kazunobu Kira , Nobuhisa Watanabe , Tadashi Nagakura , Tatsuo Horizoe
IPC分类号： A61K31/5375 , C07D213/02 , C07D239/24 , C07D333/02 , C07D307/02 , C07D215/00 , C07D295/00 , C07D249/04 , C07D241/10 , A61P9/10 , A61P11/00 , A61K31/4965 , A61K31/50 , A61K31/4192 , C07C63/00 , C07C57/00 , A61K31/19 , A61K31/44 , A61K31/505 , A61K31/381 , A61K31/47
CPC分类号： C07D209/48 , C07C257/18 , C07C311/49 , C07C317/14 , C07C317/44 , C07C337/06 , C07D209/08 , C07D213/30 , C07D213/54 , C07D213/71 , C07D213/77 , C07D213/80 , C07D213/82 , C07D213/86 , C07D213/87 , C07D213/89 , C07D215/38 , C07D233/90 , C07D237/20 , C07D239/28 , C07D239/42 , C07D249/18 , C07D257/04 , C07D295/32 , C07D307/68 , C07D333/24 , C07D471/04
摘要： A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic or prophylactic agents for diseases associated with thrombus formation. wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc., R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc., Z1, Z2 and Z3 each independently represent hydrogen, etc., Z4 represents hydrogen, etc. and X represents a single bond or —CO—, etc.
摘要翻译：由下列通式（1）表示的化合物或其盐或其水合物是安全的，同时具有合适的物理化学稳定性，并且可用作与血栓形成相关的疾病的治疗或预防剂。其中R 1a，R 1b，R 1c和R 1d各自独立地表示氢等， O 2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等，Z 1，Z 2， Z 3和Z 3各自独立地表示氢等，Z 4表示氢等，X表示单键或-CO-等。

9. 发明授权

US07816522B2 Triazolone derivatives 有权
标题翻译：三唑酮衍生物
公开(公告)号：US07816522B2
公开(公告)日：2010-10-19
申请号：US11723893
申请日：2007-03-22
申请人： Richard Clark , Fumiyoshi Matsuura , Kazunobu Kira , Shinsuke Hirota , Hiroshi Azuma , Tadashi Nagakura , Tatsuo Horizoe , Kimiyo Tabata , Kazutomi Kusano , Takao Omae , Atsushi Inoue
发明人： Richard Clark , Fumiyoshi Matsuura , Kazunobu Kira , Shinsuke Hirota , Hiroshi Azuma , Tadashi Nagakura , Tatsuo Horizoe , Kimiyo Tabata , Kazutomi Kusano , Takao Omae , Atsushi Inoue
IPC分类号： A61K31/41 , A61K31/415 , C07D233/00 , C07D249/00
CPC分类号： C07D249/12 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D413/14 , C07D417/04
摘要： A Compound represented by the following general formula (1), salts thereof or hydrates of the foregoing is a novel compound useful for treatment and/or prevention of diseases associated with thrombus formation, and which is safer with suitable physicochemical stability. [wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc.; R2 represents optionally substituted phenyl, etc.; R3 represents optionally substituted C6-10 aryl, etc.; and Z1 and Z2 each independently represent hydrogen]
摘要翻译：由以下通式（1）表示的化合物，其盐或其前体的水合物是可用于治疗和/或预防与血栓形成有关的疾病的新型化合物，其具有合适的理化稳定性更安全。 [其中R1a，R1b，R1c和R1d各自独立地表示氢等; R2代表任选取代的苯基等; R3代表任选取代的C6-10芳基等; 并且Z 1和Z 2各自独立地表示氢]

10. 发明申请

US20100240654A1 HYDRAZIDE DERIVATIVES 审中-公开
标题翻译：氢化衍生物
公开(公告)号：US20100240654A1
公开(公告)日：2010-09-23
申请号：US12791571
申请日：2010-06-01
申请人： Richard CLARK , Shinsuke HIROTA , Hiroshi AZUMA , Kazunobu KIRA , Nobuhisa WATANABE , Tadashi NAGAKURA , Tatsuo HORIZOE
发明人： Richard CLARK , Shinsuke HIROTA , Hiroshi AZUMA , Kazunobu KIRA , Nobuhisa WATANABE , Tadashi NAGAKURA , Tatsuo HORIZOE
IPC分类号： A61K31/5377 , C07C243/22 , A61K31/15 , C07D211/72 , A61K31/4402 , C07D215/38 , A61K31/47 , C07D239/32 , C07D295/28 , A61K31/5375 , C07D413/04 , A61P7/02 , A61P9/10 , A61P9/00 , A61P7/00
CPC分类号： C07D209/48 , C07C257/18 , C07C311/49 , C07C317/14 , C07C317/44 , C07C337/06 , C07D209/08 , C07D213/30 , C07D213/54 , C07D213/71 , C07D213/77 , C07D213/80 , C07D213/82 , C07D213/86 , C07D213/87 , C07D213/89 , C07D215/38 , C07D233/90 , C07D237/20 , C07D239/28 , C07D239/42 , C07D249/18 , C07D257/04 , C07D295/32 , C07D307/68 , C07D333/24 , C07D471/04
摘要： A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic or prophylactic agents for diseases associated with thrombus formation. wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc., R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc., Z1, Z2 and Z3 each independently represent hydrogen, etc., Z4 represents hydrogen, etc. and X represents a single bond or —CO—, etc.
摘要翻译：由下列通式（1）表示的化合物或其盐或其水合物是安全的，同时具有合适的物理化学稳定性，并且可用作与血栓形成相关的疾病的治疗或预防剂。其中R1a，R1b，R1c和R1d各自独立地表示氢等，R2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等，Z 1，Z 2和Z 3各自独立地表示氢等， Z4表示氢等，X表示单键或-CO-等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式