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1. 发明申请

US20140029002A1 ADJUSTABLE INTERSURFACE SPACING FOR SURFACE ENHANCED RAMAN SPECTROSCOPY 审中-公开
标题翻译：表面增强拉曼光谱的可调节的表面间距
公开(公告)号：US20140029002A1
公开(公告)日：2014-01-30
申请号：US13561561
申请日：2012-07-30
申请人： Shih-Yuan Wang , Zhiyong Li , Alexandre M. Bratkovski , Gary Gibson , Huei Pei Kuo , Zhang-Lin Zhou , Steven J. Barcelo , Ansoon Kim , R Stanley Williams
发明人： Shih-Yuan Wang , Zhiyong Li , Alexandre M. Bratkovski , Gary Gibson , Huei Pei Kuo , Zhang-Lin Zhou , Steven J. Barcelo , Ansoon Kim , R Stanley Williams
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00
摘要： A sensor for surface enhanced Raman spectroscopy (SERS) sensor includes surfaces and an actuator to adjust an intersurface spacing between the surfaces to contain an analyte and allow the analyte to be released from containment.
摘要翻译：用于表面增强拉曼光谱（SERS）传感器的传感器包括表面和致动器，以调节表面之间的表面间隔，以包含分析物并允许分析物从容纳物释放。

2. 发明申请

US20150241355A1 APPARATUS FOR PERFORMING SPECTROSCOPY HAVING A PARABOLIC REFLECTOR AND SERS ELEMENTS 审中-公开
标题翻译：用于执行具有抛物面反射器和元件元件的光谱的装置
公开(公告)号：US20150241355A1
公开(公告)日：2015-08-27
申请号：US14406653
申请日：2012-07-31
申请人： Shih-Yuan Wang , Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Steven Barcelo , Ansoon Kim , Mineo Yamakawa , Zhang-Lin Zhou , Huei Pei Kuo
发明人： Shih-Yuan Wang , Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Steven Barcelo , Ansoon Kim , Mineo Yamakawa , Zhang-Lin Zhou , Huei Pei Kuo
IPC分类号： G01N21/65 , A61F2/02 , A61F2/82 , G02B5/10
CPC分类号： G01N21/658 , A61F2/02 , A61F2/82 , G01N2201/068 , G02B5/10 , Y10T29/49826
摘要： According to an example, an apparatus for performing spectroscopy includes a parabolic reflector and a plurality of surface-enhanced Raman spectroscopy (SERS) elements spaced from the parabolic reflector and positioned substantially at a focal point of the parabolic reflector. The parabolic reflector is to reflect Raman scattered light emitted from molecules in a near field generated by the plurality of SERS elements to substantially increase the flux of the Raman scattered light emitted out of the apparatus.
摘要翻译：根据一个实例，用于执行光谱学的装置包括抛物面反射器和与抛物面反射器间隔开并且基本上位于抛物面反射器的焦点的多个表面增强拉曼光谱（SERS）元件。抛物面反射器是反射由多个SERS元件产生的近场中的分子发射的拉曼散射光，以大大增加从该装置发出的拉曼散射光的通量。

3. 发明申请

US20140036262A1 ELECTRONIC AND PLASMONIC ENHANCEMENT FOR SURFACE ENHANCED RAMAN SPECTROSCOPY 审中-公开
标题翻译：表面增强拉曼光谱的电子和等离子体增强
公开(公告)号：US20140036262A1
公开(公告)日：2014-02-06
申请号：US13562567
申请日：2012-07-31
申请人： Shih-Yuan Wang , Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Huei Pei Kuo , Zhang-Lin Zhou , R Stanley Williams
发明人： Shih-Yuan Wang , Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Huei Pei Kuo , Zhang-Lin Zhou , R Stanley Williams
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An apparatus for surface enhanced Raman spectroscopy includes a substrate, a nanostructure and a plasmonic material. The nanostructure and the plasmonic material are integrated together to provide electronic and plasmonic enhancement to a Raman signal produced by electromagnetic radiation scattering from an analyte.
摘要翻译：用于表面增强拉曼光谱的装置包括底物，纳米结构和等离子体激元材料。将纳米结构和等离子体激元材料集成在一起，以对由分析物的电磁辐射散射产生的拉曼信号提供电子和等离子体增强。

4. 发明授权

US09212997B2 Scattering spectroscopy nanosensor 有权
标题翻译：散射光谱纳米传感器
公开(公告)号：US09212997B2
公开(公告)日：2015-12-15
申请号：US14405334
申请日：2012-07-29
申请人： Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Shih-Yuan Wang , Huei Pei Kuo , Steven Barcelo , Zhang-Lin Zhou
发明人： Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Shih-Yuan Wang , Huei Pei Kuo , Steven Barcelo , Zhang-Lin Zhou
IPC分类号： G01J3/44 , G01N21/65 , B82Y15/00
CPC分类号： G01N21/658 , B82Y15/00 , G01J3/4412 , G01N2021/651 , G01N2201/06113 , Y10S977/902
摘要： A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.
摘要翻译：散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。通过暴露在入射到保护罩上的光束可选地去除保护罩。保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。

5. 发明申请

US20150103340A1 SCATTERING SPECTROSCOPY NANOSENSOR 有权
标题翻译：散射光谱纳米传感器
公开(公告)号：US20150103340A1
公开(公告)日：2015-04-16
申请号：US14405334
申请日：2012-07-29
申请人： Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Shih-Yuan Wang , Huei Pei Kuo , Steven Barcelo , Zhang-Lin Zhou
发明人： Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Shih-Yuan Wang , Huei Pei Kuo , Steven Barcelo , Zhang-Lin Zhou
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , B82Y15/00 , G01J3/4412 , G01N2021/651 , G01N2201/06113 , Y10S977/902
摘要： A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.
摘要翻译：散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。通过暴露在入射到保护罩上的光束可选地去除保护罩。保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。

6. 发明授权

US08559003B2 Electrically driven devices for surface enhanced raman spectroscopy 有权
标题翻译：用于表面增强拉曼光谱的电驱动装置
公开(公告)号：US08559003B2
公开(公告)日：2013-10-15
申请号：US13384456
申请日：2009-09-17
申请人： Huei Pei Kuo , Shih-Yuan Wang , Min Hu , Zhiyong Li , Alexandre M. Bratkovski
发明人： Huei Pei Kuo , Shih-Yuan Wang , Min Hu , Zhiyong Li , Alexandre M. Bratkovski
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00 , B82Y30/00
摘要： An electrically driven device for surface enhanced Raman spectroscopy includes a first electrode, a substrate positioned proximate to the first electrode, a plurality of cone shaped protrusions formed integrally with or on a substrate surface, a Raman signal-enhancing material coated on each protrusion, and a second electrode positioned relative to the first electrode at a predetermined distance. Each of the protrusions has a tip with a radius of curvature ranging from about 0.1 nm to about 100 nm. The second electrode is positioned relative to the first electrode such that the electrodes together produce an electric field when a voltage bias is applied therebetween. The electric field has a field distribution that creates a stronger field gradient at a region proximate to the tips than at other portions of the substrate.
摘要翻译：用于表面增强拉曼光谱的电驱动装置包括第一电极，靠近第一电极定位的基板，与基底表面一体地形成的多个锥形突起，涂覆在每个突起上的拉曼信号增强材料，以及相对于第一电极以预定距离定位的第二电极。每个突起具有具有约0.1nm至约100nm范围的曲率半径的尖端。第二电极相对于第一电极定位，使得当在其之间施加电压偏置时，电极一起产生电场。电场具有场分布，其在靠近尖端的区域处产生比在衬底的其它部分更强的场梯度。

7. 发明授权

US08208137B2 Molecule detection using Raman light detection 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US08208137B2
公开(公告)日：2012-06-26
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

8. 发明申请

US20110188033A1 MOLECULE DETECTION USING RAMAN LIGHT DETECTION 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US20110188033A1
公开(公告)日：2011-08-04
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

9. 发明授权

US08472018B2 Grating for multiple discrete wavelengths of Raman scattering 有权
标题翻译：用于多个离散波长的拉曼散射的光栅
公开(公告)号：US08472018B2
公开(公告)日：2013-06-25
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

10. 发明申请

US20120026493A1 GRATING FOR MULTIPLE DISCRETE WAVELENGTHS OF RAMAN SCATTERING 有权
标题翻译：用于拉曼散射的多个分辨波长的光刻
公开(公告)号：US20120026493A1
公开(公告)日：2012-02-02
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

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