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51. 发明授权

US5733569A Galenic compositions comprising calcitonin and their use 失效
公开(公告)号：US5733569A
公开(公告)日：1998-03-31
申请号：US471118
申请日：1995-06-06
申请人： Moise Azria , Thomas Cavanak
发明人： Moise Azria , Thomas Cavanak
IPC分类号： A61K9/00 , A61K9/08 , A61K38/23 , A61K47/28 , A61K9/12
CPC分类号： A61K9/0043 , A61K38/23 , A61K47/28 , Y10S514/808 , Y10S514/97 , Y10S514/975
摘要： Pharmaceutical compositions for nasal administration comprising i) a calcitonin, and ii) benzalkonium chloride, and/or iv) a surfactant, suitable for application to the nasal mucosa, in iii) a liquid diluent or carrier, suitable for application to the nasal mucosa. The compositions are suitably adapted for administration in the form of a nasal spray.

52. 发明授权

US5731506A Inbred corn line CG00766 失效
标题翻译：近交玉米线CG00766
公开(公告)号：US5731506A
公开(公告)日：1998-03-24
申请号：US729889
申请日：1996-10-15
申请人： Robert L. Miller
发明人： Robert L. Miller
IPC分类号： A01H5/10 , A01H5/00 , A01H4/00 , C12N5/04
CPC分类号： A01H5/10 , Y10S47/01
摘要： According to the invention, there is provided an inbred corn line, designated CG00766. This invention thus relates to the plants and seeds of inbred corn line CG00766 and to methods for producing a corn plant produced by crossing the inbred line CG00766 with itself or with another corn line. This invention further relates to hybrid corn seeds and plants produced by crossing the inbred line CG00766 with another corn line.
摘要翻译：根据本发明，提供了一种称为CG00766的近交玉米品系。因此本发明涉及近交玉米品系CG00766的植物和种子以及通过将自交系CG00766与其他玉米品系交叉产生的玉米植物的生产方法。本发明还涉及通过将近交系CG00766与另一种玉米品系交叉而产生的杂交玉米种子和植物。

53. 发明授权

US5731503A Inbred corn line NP 948 失效
标题翻译：近交玉米线NP 948
公开(公告)号：US5731503A
公开(公告)日：1998-03-24
申请号：US716836
申请日：1996-08-22
申请人： Merl Krier
发明人： Merl Krier
IPC分类号： A01H5/10 , A01H5/00 , A01H4/00 , C12N5/04
CPC分类号： A01H5/10 , Y10S47/01
摘要： An inbred corn line, designated NP 948, is disclosed. The invention relates to the seeds of inbred corn line NP 948, to the plants of inbred corn line NP 948 and to methods for producing a corn plant produced by crossing inbred line NP 948 with itself or with another corn plant. The invention further relates to hybrid corn seeds and plants produced by crossing inbred line NP 948 with another corn line. Particularly the invention provides novel hybrid corn plants, designated N2555 and N3030, produced by crossing inbred NP 948 with another Northrup King proprietary inbred corn line.
摘要翻译：公开了一种称为NP 948的近交玉米品系。本发明涉及近交玉米品系NP 948的种子，近交玉米品系NP948的植物以及通过将自交系NP 948与其他玉米植物杂交而产生的玉米植物的方法。本发明还涉及通过将自交系NP948与另一个玉米品系交叉产生的杂交玉米种子和植物。特别地，本发明提供了通过将近交NP 948与另一个Northrup King专有的近交玉米品系交叉产生的新型杂种玉米植物，命名为N2555和N3030。

54. 发明授权

US5728875A Microbicides 失效
标题翻译：杀菌剂
公开(公告)号：US5728875A
公开(公告)日：1998-03-17
申请号：US703300
申请日：1996-08-26
申请人： Martin Zeller
发明人： Martin Zeller
IPC分类号： C07D275/02 , A01N41/06 , C07C303/36 , C07C307/06 , C07C311/06 , C07C311/07 , C07C311/11 , C07C311/14 , C07C311/20 , C07C313/06 , C07C313/20 , C07C317/04 , C07C323/60 , C07C323/65 , C07D295/26 , C07C233/76 , A61K31/18 , C07C303/40 , C07C303/35
CPC分类号： C07D295/26 , C07C307/06 , C07C311/06 , C07C311/07 , C07C311/11 , C07C311/14 , C07C313/06 , C07C313/20 , C07C317/04 , C07C323/60 , C07C2101/08 , C07C2101/14
摘要： .alpha.-Amino acid amides of the formula I ##STR1## in which n is the number zero or one; R.sub.1 is C.sub.1 -C.sub.12 alkyl, which is unsubstituted or can be substituted by C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.3 -C.sub.8 cycloalkyl, cyano, C.sub.1 -C.sub.6 alkoxycarbonyl, C.sub.3 -C.sub.6 alkenyloxycarbonyl or C.sub.3 -C.sub.6 alkynyloxycarbonyl; C.sub.3 -C.sub.8 cycloalkyl; C.sub.2 -C.sub.12 alkenyl; C.sub.2 -C.sub.12 alkynyl; C.sub.1 -C.sub.12 halogenoalkyl or a group NR.sub.13 R.sub.14 ; in which R.sub.13 and R.sub.14 independently of one another are hydrogen or C.sub.1 -C.sub.6 alkyl or together are tetra- or pentamethylene; R.sub.2 and R.sub.3 independently of one another are hydrogen; C.sub.1 -C.sub.8 alkyl; C.sub.1 -C.sub.8 alkyl which is substituted by hydroxyl, C.sub.1 -C.sub.4 alkoxy, mercapto or C.sub.1 -C.sub.4 alkylthio; C.sub.3 -C.sub.8 alkenyl; C.sub.3 -C.sub.8 alkynyl; C.sub.3 -C.sub.8 cycloalkyl or C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.4 alkyl, or in which the two groups R.sub.2 and R.sub.3, together with the carbon atom to which they are bonded, form a three- to eight-membered carbocyclic ring; R.sub.4 is hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.5 is hydrogen; C.sub.1 -C.sub.6 alkyl or phenyl, which is unsubstituted or can be substituted by halogen, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 halogenoalkyl, C.sub.1 -C.sub.4 alkoxy or C.sub.1 -C.sub.4 alkylthio; and R.sub.6 is a group G ##STR2## in which R.sub.7 and R.sub.8 independently of one another are hydrogen or C.sub.1 -C.sub.6 alkyl; p is the number zero or one; and R.sub.9, R.sub.10 and R.sub.11 independently of one another are hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 halogenoalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.1 -C.sub.6 alkoxy, C.sub.3 -C.sub.6 alkenyloxy, C.sub.3 -C.sub.6 alkynyloxy, C.sub.3 -C.sub.6 alkylthio, halogen or nitro are valuable microbicides. They can be employed in crop protection in the form of suitable compositions, for example for controlling fungal diseases.
摘要翻译： α型氨基酰胺，其中n是数字0或1; R 1是未被取代或可以被C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基磺酰基，C 3 -C 8环烷基，氰基，C 1 -C 6烷氧基羰基，C 3 -C 6烯氧基羰基或C 3 -C 6炔氧基羰基取代的C 1 -C 12烷基; C 3 -C 8环烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基或NR 13 R 14基团; 其中R 13和R 14彼此独立地是氢或C 1 -C 6烷基或一起是四或五亚甲基; R2和R3彼此独立地是氢; C1-C8烷基; 被羟基，C 1 -C 4烷氧基，巯基或C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8链烯基; C3-C8炔基; C 3 -C 8环烷基或C 3 -C 8环烷基-C 1 -C 4烷基，或其中两个基团R 2和R 3与它们所键合的碳原子一起形成三至八元碳环; R4是氢或C1-C6烷基; R5是氢; 硝基，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4烷氧基或C 1 -C 4烷硫基取代的C 1 -C 6烷基或苯基; 并且R 6是基团G G，其中R 7和R 8彼此独立地是氢或C 1 -C 6烷基; p是数字0或1; 并且R 9，R 10和R 11彼此独立地是氢，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 3 -C 6烯基，C 3 -C 6炔基，C 1 -C 6烷氧基，C 3 -C 6烯氧基，C 3 -C 6炔氧基，C 3 -C 6烷硫基，卤素或硝基是有价值的杀菌剂它们可以以合适的组合物的形式用于作物保护，例如用于防治真菌疾病。

55. 发明授权

US5705658A Azido containing tetrahydro furan compounds 失效
标题翻译：叠氮基四氢呋喃化合物
公开(公告)号：US5705658A
公开(公告)日：1998-01-06
申请号：US800671
申请日：1997-02-14
申请人： Richard Goschke , Jurgen Klaus Maibaum , Walter Schilling , Stefan Stutz , Pascal Rigollier , Yasuchika Yamaguchi , Nissim Claude Cohen , Peter Herold
发明人： Richard Goschke , Jurgen Klaus Maibaum , Walter Schilling , Stefan Stutz , Pascal Rigollier , Yasuchika Yamaguchi , Nissim Claude Cohen , Peter Herold
IPC分类号： C07D295/14 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/27 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4245 , A61K31/44 , A61K31/445 , A61K31/4468 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/20 , A61P27/02 , A61P43/00 , C07C213/00 , C07C229/36 , C07C235/34 , C07C235/36 , C07C237/20 , C07C237/22 , C07C237/24 , C07C255/13 , C07C255/16 , C07C255/60 , C07C271/16 , C07C271/18 , C07C271/22 , C07C311/30 , C07C311/32 , C07C317/18 , C07C317/28 , C07C317/44 , C07C323/10 , C07C323/12 , C07D207/27 , C07D207/40 , C07D211/32 , C07D211/88 , C07D213/30 , C07D213/40 , C07D213/65 , C07D213/89 , C07D233/64 , C07D233/76 , C07D239/10 , C07D241/08 , C07D257/04 , C07D263/20 , C07D263/26 , C07D263/38 , C07D265/30 , C07D271/06 , C07D277/14 , C07D277/18 , C07D277/28 , C07D295/13 , C07D295/18 , C07D295/22 , C07D307/32 , C07D307/33 , C07D317/64 , C07D319/18 , C07D319/20 , C07D413/06 , C07D521/00 , C07F7/18
CPC分类号： C07D307/33 , C07C229/36 , C07C237/20 , C07C255/13 , C07C271/16 , C07C271/18 , C07C271/22 , C07D241/08
摘要： .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
摘要翻译：式I（Ⅰ）的α-氨基-γ-羟基-ω-芳基 - 链烷酸酰胺及其盐具有肾素抑制性质，可用作抗高血压药用活性成分。

56. 发明授权

US5702920A DNAS encoding human macrophage migration inhibition factor related peptides 失效
标题翻译： DNAS编码人巨噬细胞迁移抑制因子相关肽
公开(公告)号：US5702920A
公开(公告)日：1997-12-30
申请号：US508142
申请日：1995-07-27
申请人： Karel Gerrit Odink , Roger Clerc , Nico Cerletti , Josef Bruggen , Lajos Tarcsay , Clemens Sorg , Walter Wiesendanger
发明人： Karel Gerrit Odink , Roger Clerc , Nico Cerletti , Josef Bruggen , Lajos Tarcsay , Clemens Sorg , Walter Wiesendanger
IPC分类号： G01N33/50 , A61K38/00 , A61P29/00 , C07H21/04 , C07K1/20 , C07K1/22 , C07K14/52 , C07K14/54 , C07K14/545 , C07K16/00 , C07K16/24 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12N15/85 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/865 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/24 , C07K14/52 , C12N15/85 , A61K38/00 , C12N2830/00 , C12N2830/002 , C12N2830/55 , C12N2830/702
摘要： The invention concerns polypeptides related to human macrophage migration inhibition factor, in particular the polypeptides called MRP-8 and MRP-14, processes for their preparation, mRNAs, DNAs and hybrid vectors coding for those polypeptides, hosts transformed with such a hybrid vector, monoclonal and polyclonal antibodies to those polypeptides, and diagnostic methods for inflammatory conditions and cystic fibrosis.
摘要翻译：本发明涉及与人巨噬细胞迁移抑制因子有关的多肽，特别是称为MRP-8和MRP-14的多肽，其制备方法，mRNA，DNA和编码那些多肽的杂交载体，用这种杂交载体转化的宿主，单克隆和多克隆抗体，以及炎性病症和囊性纤维化的诊断方法。

57. 发明授权

US5668158A Cyclic amino acid derivatives 失效
标题翻译：环状氨基酸衍生物
公开(公告)号：US5668158A
公开(公告)日：1997-09-16
申请号：US601626
申请日：1996-02-14
申请人： Cynthia Anne Fink
发明人： Cynthia Anne Fink
IPC分类号： A61K38/55 , A61K38/00 , A61P3/06 , A61P7/10 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , C07K5/065 , C07K5/078 , C07K14/81 , C07D213/02 , A61K31/44
CPC分类号： C07K5/06139 , C07K5/06078 , A61K38/00
摘要： Disclosed are the compounds of formula I ##STR1## wherein R represents hydrogen, lower alkyl, carbocyclic or heterocyclic aryl-lower alkyl or cycloalkyl-lower alkyl;R.sub.1 represents hydrogen, lower alkyl, cycloalkyl, carbocyclic aryl or heterocyclic aryl, or biaryl;R.sub.3 represents hydrogen or acyl;R.sub.4 represents hydrogen, lower alkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, biaryl or biaryl-lower alkyl;R.sub.5 represents hydrogen or lower alkyl; or R.sub.4 and R.sub.5 together with the carbon atom to which they are attached represent cycloalkylidene or benzo-fused cycloalkylidene;A together with the carbon atom to which it is attached represents 3 to 10 membered cycloalkylidene or 5 to 10 membered cycloalkenylidene radical which may be substituted by lower alkyl or aryl-lower alkyl or may be fused to a saturated or unsaturated carbocyclic 5-7-membered ring; or A together with the carbon to which it is attached represents 5 or 6 membered oxacycloalkylidene, thiacycloalkylidene or azacycloalkylidene optionally substituted by lower alkyl or aryl-lower alkyl; or A together with the carbon atom to which it is attached represents 2,2-norbornylidene;m is 0, 1, 2 or 3; andCOOR.sub.2 represents carboxyl or carboxyl derivatized in form of a pharmaceutically acceptable ester.
摘要翻译：公开了式I的化合物其中R表示氢，低级烷基，碳环或杂环芳基 - 低级烷基或环烷基 - 低级烷基; R 1表示氢，低级烷基，环烷基，碳环芳基或杂环芳基，或联芳基; R3代表氢或酰基; R 4表示氢，低级烷基，碳环或杂环芳基，碳环或杂环芳基 - 低级烷基，环烷基，环烷基 - 低级烷基，联芳基或联芳基 - 低级烷基; R5代表氢或低级烷基; 或R 4和R 5与它们所连接的碳原子一起代表亚环烷基或苯并稠合的环亚烷基; A与其连接的碳原子一起表示3至10元环亚烷基或5至10元环烯基，其可以被低级烷基或芳基 - 低级烷基取代，或可以与饱和或不饱和的碳环5-7- 元环或A与其连接的碳一起表示5或6元环亚烷基，硫代亚烷基或氮杂环烷叉基，其任选被低级烷基或芳基 - 低级烷基取代; 或A与连接的碳原子一起代表2,2-降冰片烯; m为0,1,2或3; COOR2表示以药学上可接受的酯形式衍生的羧基或羧基。

58. 发明授权

US5665840A Polymeric networks from water-soluble prepolymers 失效
标题翻译：来自水溶性预聚物的聚合物网络
公开(公告)号：US5665840A
公开(公告)日：1997-09-09
申请号：US552649
申请日：1995-11-03
申请人： Thomas Pohlmann , Achim Muller , Bernhard Seiferling
发明人： Thomas Pohlmann , Achim Muller , Bernhard Seiferling
IPC分类号： C08F8/12 , G02B1/04 , C08F26/10 , C08L39/06
CPC分类号： G02B1/043 , C08F8/44 , C08F2800/20 , C08F2810/50
摘要： The present invention describes a water-soluble crosslinkable prepolymer that comprises, in the copolymer chain, units derived from the following monomeric structural units: a vinyl lactam (a), vinyl alcohol (b), optionally a lower alkanecarboxylic acid vinyl ester (c), a vinylic crosslinking agent (d) and optionally a vinylic photoinitiator (e); a process for the preparation of the novel prepolymers; crosslinked water-insoluble polymeric networks therefrom; hydrogels and moulded articles made from the crosslinked water-insoluble polymeric networks, especially contact lenses; and a process for the manufacture of hydrogels and finished contact lenses using the mentioned crosslinkable water-soluble prepolymers.
摘要翻译：本发明描述了一种水溶性可交联预聚物，其在共聚物链中包含衍生自以下单体结构单元的单元：乙烯基内酰胺（a），乙烯醇（b），任选的低级链烷羧酸乙烯基酯（c）乙烯基交联剂（d）和任选的乙烯基光引发剂（e）; 一种制备新型预聚物的方法; 交联的水不溶性聚合物网络; 由交联的水不溶性聚合物网络制成的水凝胶和模塑制品，特别是隐形眼镜; 以及使用所述可交联水溶性预聚物制造水凝胶和成品隐形眼镜的方法。

59. 发明授权

US5650505A Chemically regulatable and anti-pathogenic DNA sequences and uses thereof 失效
标题翻译：化学上可调节的和抗病原性的DNA序列及其用途
公开(公告)号：US5650505A
公开(公告)日：1997-07-22
申请号：US449315
申请日：1995-05-24
申请人： John A. Ryals , Danny C. Alexander , James J. Beck , John H. Duesing , Robert M. Goodman , Leslie B. Friedrich , Christian Harms , Frederich Meins, Jr. , Alice Montoya, deceased , Mary B. Moyer , Jean-Marc Neuhaus , George B. Payne , Christoph Sperisen , Jeffrey R. Stinson , Scott J. Uknes , Eric R. Ward , Shericca C. Williams
发明人： John A. Ryals , Danny C. Alexander , James J. Beck , John H. Duesing , Robert M. Goodman , Leslie B. Friedrich , Christian Harms , Frederich Meins, Jr. , Alice Montoya, deceased , Mary B. Moyer , Jean-Marc Neuhaus , George B. Payne , Christoph Sperisen , Jeffrey R. Stinson , Scott J. Uknes , Eric R. Ward , Shericca C. Williams
IPC分类号： C07D285/14 , C07K14/415 , C12N9/02 , C12N9/08 , C12N9/24 , C12N9/36 , C12N15/29 , C12N15/56 , C12N15/62 , C12N15/82 , A01H5/00
CPC分类号： C12N9/2462 , C07D285/14 , C07K14/415 , C12N15/625 , C12N15/8238 , C12N15/8239 , C12N15/8274 , C12N15/8282 , C12N15/8286 , C12N9/0065 , C12N9/0073 , C12N9/2442 , C12Y114/13001 , C12Y302/01014 , C12Y302/01039 , C12Y302/01058 , C12Y302/01073 , C07K2319/00 , C07K2319/02 , C07K2319/55 , C07K2319/61
摘要： The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease. Also provided is a method for the exogenous regulation of gene expression in plants, which comprises obtaining a plant incapable of regulating at least one gene or gene family, or at least one heterologous gene, due to the deactivation of at least one endogenous signal transduction cascade which regulates the gene in the plant, and applying a chemical regulator to the plant at a time when expression of the gene is desired. A novel signal peptide sequence and corresponding DNA coding sequence is also provided. Further provided are assays for the identification and isolation of additional chemically regulatable DNA sequences and cDNAs encoding PR proteins and assays for identifying chemicals capable of exogenously regulating the chemically regulatable DNA sequences of the invention.
摘要翻译：本发明提供能够调节植物或植物组织中相关DNA序列转录的化学可调节DNA序列，含有此类序列的嵌合构建体，含有此类序列的载体和嵌合构建体，以及含有这些嵌合构建体的转基因植物和植物组织。在一个方面，本发明的化学可调节DNA序列衍生自编码发病相关（PR）蛋白的基因的5'区域。本发明还提供衍生自编码PR蛋白的新cDNA的抗病原性序列，其可以被遗传工程化并转化成植物以赋予增强的抗病性。还提供了外源调节植物中基因表达的方法，其包括获得不能调节至少一个基因或基因家族或至少一个异源基因的植物，因为至少一种内源性信号转导级联失活其调节植物中的基因，并且在需要表达基因的时候将化学调节剂施用于植物。还提供了新的信号肽序列和相应的DNA编码序列。进一步提供用于鉴定和分离另外的化学可调节DNA序列和编码PR蛋白的cDNA和用于鉴定能够外源调节本发明的化学可调节DNA序列的化学品的测定。

60. 发明授权

US6156923A Process for the preparation of pesticides 失效
标题翻译：农药制备工艺
公开(公告)号：US6156923A
公开(公告)日：2000-12-05
申请号：US762217
申请日：1996-12-06
申请人： Saleem Farooq , Stephan Trah , Hugo Ziegler , Rene Zurfluh
发明人： Saleem Farooq , Stephan Trah , Hugo Ziegler , Rene Zurfluh
IPC分类号： C07C249/04 , C07C249/12 , C07C251/48 , C07C251/60
CPC分类号： C07C249/12 , C07C251/48 , C07C251/60
摘要： The invention relates to a process for the preparation of compounds of the formula ##STR1## or, if appropriate, a tautomer thereof, in each case in the free form or in salt form, in whichA, X, Y, Z, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.7, R.sub.9 and n are as defined in claim 1 and the C.dbd.N double bond marked with E has the E configuration, which comprisesa1) reacting either a compound of the formula (II) mentioned above with a compound of the formula (III) mentioned above, in which X.sub.1 is a leaving group, ora2) a compound of the formula (IV) mentioned above, if appropriate in the presence of a base, with a compound of the formula (V) mentioned above, orb1) reacting a compound of the formula (VI) mentioned above with a compound of the formula R.sub.7 --A--X.sub.2 (VII), in which X.sub.2 is a leaving group, and either further reacting the compound thus obtainable, of the formula (IV), for example according to method a2), orb2) reacting it with hydroxylamine or a salt thereof, if appropriate in the presence of a basic or acid catalyst, and further reacting the compound thus obtainable, of the formula (II), for example according to method a1), orc) reacting a compound of the formula (VII), mentioned above with a C.sub.1 -C.sub.6 alkyl nitrite and further reacting the compound thus obtainable, of the formula (VI), for example according to method b), the E isomers of the compounds of the formulae (II), (IV) and (VI), a process for their preparation and their use for the preparation of compounds of the formula (I).
摘要翻译：本发明涉及一种制备下式的化合物或其合适的互变异构体的方法，其各自为游离形式或盐形式，其中A，X，Y，Z，R 2，R 3，R 4 ，R 5，R 7，R 9和n如权利要求1中所定义，并且用E标记的C = N双键具有E构型，其包括a1）使上述式（II）的化合物与上述式（III），其中X1是离去基团，或a2）上述式（Ⅳ）化合物，如果合适，在碱的存在下，与上述式（Ⅴ）化合物，或b1）使上述式（Ⅵ）化合物与式R7-A-X2（Ⅶ）化合物反应，其中X 2为离去基团，并进一步使由此得到的化合物（式（Ⅴ） IV），例如根据方法a2），或b2）如果合适，在碱性或酸性催化剂存在下，使其与羟胺或其盐反应，进一步使由式（II）得到的化合物，例如按照方法a1）进行反应，或c）使上述式（Ⅶ）化合物与亚硝酸C 1 -C 6烷基酯反应，然后进一步使化合物式（Ⅵ）化合物的E异构体，其制备方法及其制备方法（Ⅵ）的制备方法及其制备方法式（I）的化合物。

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