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1. 发明授权

US5777200A Chemically regulatable and anti-pathogenic DNA sequences and uses thereof 失效
标题翻译：化学上可调节的和抗病原性的DNA序列及其用途
公开(公告)号：US5777200A
公开(公告)日：1998-07-07
申请号：US455416
申请日：1995-05-31
申请人： John A. Ryals , Danny C. Alexander , Robert M. Goodman , Jeffrey R. Stinson
发明人： John A. Ryals , Danny C. Alexander , Robert M. Goodman , Jeffrey R. Stinson
IPC分类号： C07D285/14 , C07K14/415 , C12N9/02 , C12N9/08 , C12N9/24 , C12N9/36 , C12N15/29 , C12N15/56 , C12N15/62 , C12N15/82 , C12N15/00 , C12Q1/68
CPC分类号： C12N9/2462 , C07D285/14 , C07K14/415 , C12N15/625 , C12N15/8238 , C12N15/8239 , C12N15/8274 , C12N15/8282 , C12N15/8286 , C12N9/0065 , C12N9/0073 , C12N9/2442 , C12Y114/13001 , C12Y302/01014 , C12Y302/01039 , C12Y302/01058 , C12Y302/01073 , C07K2319/00 , C07K2319/02 , C07K2319/55 , C07K2319/61
摘要： The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease. Also provided is a method for the exogenous regulation of gene expression in plants, which comprises obtaining a plant incapable of regulating at least one gene or gene family, or at least one heterologous gene, due to the deactivation of at least one endogenous signal transduction cascade which regulates the gene in the plant, and applying a chemical regulator to the plant at a time when expression of the gene is desired. A novel signal peptide sequence and corresponding DNA coding sequence is also provided. Further provided are assays for the identification and isolation of additional chemically regulatable DNA sequences and cDNAs encoding PR proteins and assays for identifying chemicals capable of exogenously regulating the chemically regulatable DNA sequences of the invention.
摘要翻译：本发明提供能够调节植物或植物组织中相关DNA序列转录的化学可调节DNA序列，含有此类序列的嵌合构建体，含有此类序列的载体和嵌合构建体，以及含有这些嵌合构建体的转基因植物和植物组织。在一个方面，本发明的化学可调节DNA序列衍生自编码发病相关（PR）蛋白的基因的5'区域。本发明还提供衍生自编码PR蛋白的新cDNA的抗病原性序列，其可以被遗传工程化并转化成植物以赋予增强的抗病性。还提供了外源调节植物中基因表达的方法，其包括获得不能调节至少一个基因或基因家族或至少一个异源基因的植物，因为至少一种内源性信号转导级联失活其调节植物中的基因，并且在需要表达基因的时候将化学调节剂施用于植物。还提供了新的信号肽序列和相应的DNA编码序列。进一步提供用于鉴定和分离另外的化学可调节DNA序列和编码PR蛋白的cDNA和用于鉴定能够外源调节本发明的化学可调节DNA序列的化学品的测定。

2. 发明授权

US5767369A DNA sequences encoding SAR8.2 proteins and uses thereof 失效
标题翻译：编码SAR8.2蛋白的DNA序列及其用途
公开(公告)号：US5767369A
公开(公告)日：1998-06-16
申请号：US456265
申请日：1995-05-31
申请人： John A. Ryals , Danny C. Alexander , Robert M. Goodman , Jeffrey R. Stinson
发明人： John A. Ryals , Danny C. Alexander , Robert M. Goodman , Jeffrey R. Stinson
IPC分类号： C07D285/14 , C07K14/415 , C12N9/02 , C12N9/08 , C12N9/24 , C12N9/36 , C12N15/29 , C12N15/56 , C12N15/62 , C12N15/82 , A01H5/00 , C12N5/04
CPC分类号： C12N9/2462 , C07D285/14 , C07K14/415 , C12N15/625 , C12N15/8238 , C12N15/8239 , C12N15/8274 , C12N15/8282 , C12N15/8286 , C12N9/0065 , C12N9/0073 , C12N9/2442 , C12Y114/13001 , C12Y302/01014 , C12Y302/01039 , C12Y302/01058 , C12Y302/01073 , C07K2319/00 , C07K2319/02 , C07K2319/55 , C07K2319/61
摘要： The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease. Also provided is a method for the exogenous regulation of gene expression in plants, which comprises obtaining a plant incapable of regulating at least one gene or gene family, or at least one heterologous gene, due to the deactivation of at least one endogenous signal transduction cascade which regulates the gene in the plant, and applying a chemical regulator to the plant at a time when expression of the gene is desired. A novel signal peptide sequence and corresponding DNA coding sequence is also provided Further provided are assays for the identification and isolation of additional chemically regulatable DNA sequences and cDNAs encoding PR proteins and assays for identifying chemicals capable of exogenously regulating the chemically regulatable DNA sequences of the invention.
摘要翻译：本发明提供能够调节植物或植物组织中相关DNA序列转录的化学可调节DNA序列，含有此类序列的嵌合构建体，含有此类序列的载体和嵌合构建体，以及含有这些嵌合构建体的转基因植物和植物组织。在一个方面，本发明的化学可调节DNA序列衍生自编码发病相关（PR）蛋白的基因的5'区域。本发明还提供衍生自编码PR蛋白的新cDNA的抗病原性序列，其可以被遗传工程化并转化成植物以赋予增强的抗病性。还提供了用于外源调节植物中基因表达的方法，其包括获得不能调节至少一个基因或基因家族或至少一个异源基因的植物，这是由于至少一种内源性信号转导级联失活其调节植物中的基因，并且在需要表达基因的时候将化学调节剂施用于植物。还提供了新的信号肽序列和相应的DNA编码序列。进一步提供了用于鉴定和分离另外的化学可调节DNA序列和编码PR蛋白的cDNA和用于鉴定能够外源调节本发明的化学可调节DNA序列的化学物质的测定法。

3. 发明授权

US07949475B2 System and method for analyzing metabolomic data 有权
标题翻译：用于分析代谢组学数据的系统和方法
公开(公告)号：US07949475B2
公开(公告)日：2011-05-24
申请号：US12245862
申请日：2008-10-06
申请人： Thomas Henry Barrett, Jr. , Corey Donald DeHaven , Danny C. Alexander , Sarada Tanikella
发明人： Thomas Henry Barrett, Jr. , Corey Donald DeHaven , Danny C. Alexander , Sarada Tanikella
IPC分类号： G01N31/00
CPC分类号： G06F19/703 , G06F19/12 , G06F19/708
摘要： The present invention generates a visual display of metabolomic data compiled by a database and associated processor. More particularly, the present invention provides a database for automatically receiving a three-dimensional spectrometry data set for a group of samples. The present invention also provides a processor device for manipulating the data sets to produce plots that are directly comparable to a plurality of characteristic plots corresponding to a plurality of selected metabolites. Furthermore, the processor device may generate a visual display indicating the presence of the selected metabolites across the group of samples. Thus, the present invention enables a user to analyze a series of complex data sets in a visual display that may indicate the presence of the selected metabolites across the group of samples. Furthermore, the visual display generated by embodiments of the present invention also expedites the subjective analysis of the spectrometry data sets.
摘要翻译：本发明生成由数据库和相关联的处理器编译的代谢组学数据的视觉显示。更具体地，本发明提供一种用于自动接收一组样本的三维光谱数据集的数据库。本发明还提供了一种用于操纵数据集以产生与对应于多个选择的代谢物的多个特征图直接相比的图的处理器装置。此外，处理器设备可以生成指示所选择的代谢物在整个样本组中的存在的视觉显示。因此，本发明使得用户能够分析视觉显示中的一系列复杂数据集，其可以指示所选择的代谢物在整个样本组中的存在。此外，由本发明的实施例产生的视觉显示也加速了对光谱测定数据集的主观分析。

4. 发明申请

US20110307180A1 SYSTEM AND METHOD FOR ANALYZING METABOLOMIC DATA 有权
标题翻译：用于分析代谢数据的系统和方法
公开(公告)号：US20110307180A1
公开(公告)日：2011-12-15
申请号：US13084999
申请日：2011-04-12
申请人： Thomas Henry Barrett, JR. , Corey Donald Dehaven , Danny C. Alexander , Sarada Tanikella
发明人： Thomas Henry Barrett, JR. , Corey Donald Dehaven , Danny C. Alexander , Sarada Tanikella
IPC分类号： G06F19/10 , G06F19/26 , G06F19/12
CPC分类号： G06F19/703 , G06F19/12 , G06F19/708
摘要： The present invention generates a visual display of metabolomic data compiled by a database and associated processor. More particularly, the present invention provides a database for automatically receiving a three-dimensional spectrometry data set for a group of samples. The present invention also provides a processor device for manipulating the data sets to produce plots that are directly comparable to a plurality of characteristic plots corresponding to a plurality of selected metabolites. Furthermore, the processor device may generate a visual display indicating the presence of the selected metabolites across the group of samples. Thus, the present invention enables a user to analyze a series of complex data sets in a visual display that may indicate the presence of the selected metabolites across the group of samples. Furthermore, the visual display generated by embodiments of the present invention also expedites the subjective analysis of the spectrometry data sets.
摘要翻译：本发明生成由数据库和相关联的处理器编译的代谢组学数据的视觉显示。更具体地，本发明提供一种用于自动接收一组样本的三维光谱数据集的数据库。本发明还提供了一种用于操纵数据集以产生与对应于多个选择的代谢物的多个特征图直接相比的图的处理器装置。此外，处理器设备可以生成指示所选择的代谢物在整个样本组中的存在的视觉显示。因此，本发明使得用户能够分析视觉显示中的一系列复杂数据集，其可以指示所选择的代谢物在整个样本组中的存在。此外，由本发明的实施例产生的视觉显示也加速了对光谱测定数据集的主观分析。

5. 发明申请

US20090093971A1 System and Method for Analyzing Metabolomic Data 有权
标题翻译：用于分析代谢组学数据的系统和方法
公开(公告)号：US20090093971A1
公开(公告)日：2009-04-09
申请号：US12245862
申请日：2008-10-06
申请人： Thomas Henry Barrett, JR. , Corey Donald DeHaven , Danny C. Alexander , Sarada Tanikella
发明人： Thomas Henry Barrett, JR. , Corey Donald DeHaven , Danny C. Alexander , Sarada Tanikella
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , G06F19/12 , G06F19/708
摘要： The present invention generates a visual display of metabolomic data compiled by a database and associated processor. More particularly, the present invention provides a database for automatically receiving a three-dimensional spectrometry data set for a group of samples. The present invention also provides a processor device for manipulating the data sets to produce plots that are directly comparable to a plurality of characteristic plots corresponding to a plurality of selected metabolites. Furthermore, the processor device may generate a visual display indicating the presence of the selected metabolites across the group of samples. Thus, the present invention enables a user to analyze a series of complex data sets in a visual display that may indicate the presence of the selected metabolites across the group of samples. Furthermore, the visual display generated by embodiments of the present invention also expedites the subjective analysis of the spectrometry data sets.
摘要翻译：本发明生成由数据库和相关联的处理器编译的代谢组学数据的视觉显示。更具体地，本发明提供一种用于自动接收一组样本的三维光谱数据集的数据库。本发明还提供了一种用于操纵数据集以产生与对应于多个选择的代谢物的多个特征图直接相比的图的处理器装置。此外，处理器设备可以生成指示所选择的代谢物在整个样本组中的存在的视觉显示。因此，本发明使得用户能够分析视觉显示中的一系列复杂数据集，其可以指示所选择的代谢物在整个样本组中的存在。此外，由本发明的实施例产生的视觉显示也加速了对光谱测定数据集的主观分析。

6. 发明授权

US5856154A Method of protecting plants from oomycete pathogens 失效
标题翻译：保护植物从卵菌病原体的方法
公开(公告)号：US5856154A
公开(公告)日：1999-01-05
申请号：US456240
申请日：1995-05-31
申请人： John A. Ryals , Danny C. Alexander , Robert M. Goodman , Eric R. Ward
发明人： John A. Ryals , Danny C. Alexander , Robert M. Goodman , Eric R. Ward
IPC分类号： C07D285/14 , C07K14/415 , C12N9/02 , C12N9/08 , C12N9/24 , C12N9/36 , C12N15/29 , C12N15/56 , C12N15/62 , C12N15/82 , C12N5/04 , A01H5/00
CPC分类号： C12N9/2462 , C07D285/14 , C07K14/415 , C12N15/625 , C12N15/8238 , C12N15/8239 , C12N15/8274 , C12N15/8282 , C12N15/8286 , C12N9/0065 , C12N9/0073 , C12N9/2442 , C12Y114/13001 , C12Y302/01014 , C12Y302/01039 , C12Y302/01058 , C12Y302/01073 , C07K2319/00 , C07K2319/02 , C07K2319/55 , C07K2319/61
摘要： The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease. Also provided is a method for the exogenous regulation of gene expression in plants, which comprises obtaining a plant incapable of regulating at least one gene or gene family, or at least one heterologous gene, due to the deactivation of at least one endogenous signal transduction cascade which regulates the gene in the plant, and applying a chemical regulator to the plant at a time when expression of the gene is desired. A novel signal peptide sequence and corresponding DNA coding sequence is also provided Further provided are assays for the identification and isolation of additional chemically regulatable DNA sequences and cDNAs encoding PR proteins and assays for identifying chemicals capable of exogenously regulating the chemically regulatable DNA sequences of the invention.
摘要翻译：本发明提供能够调节植物或植物组织中相关DNA序列转录的化学可调节DNA序列，含有此类序列的嵌合构建体，含有此类序列的载体和嵌合构建体，以及含有这些嵌合构建体的转基因植物和植物组织。在一个方面，本发明的化学可调节DNA序列衍生自编码发病相关（PR）蛋白的基因的5'区域。本发明还提供衍生自编码PR蛋白的新cDNA的抗病原性序列，其可以被遗传工程化并转化成植物以赋予增强的抗病性。还提供了用于外源调节植物中基因表达的方法，其包括获得不能调节至少一个基因或基因家族或至少一个异源基因的植物，这是由于至少一种内源性信号转导级联失活其调节植物中的基因，并且在需要表达基因的时候将化学调节剂施用于植物。还提供了新的信号肽序列和相应的DNA编码序列。进一步提供了用于鉴定和分离另外的化学可调节DNA序列和编码PR蛋白的cDNA和用于鉴定能够外源调节本发明的化学可调节DNA序列的化学物质的测定法。

7. 发明授权

US5650505A Chemically regulatable and anti-pathogenic DNA sequences and uses thereof 失效
标题翻译：化学上可调节的和抗病原性的DNA序列及其用途
公开(公告)号：US5650505A
公开(公告)日：1997-07-22
申请号：US449315
申请日：1995-05-24
申请人： John A. Ryals , Danny C. Alexander , James J. Beck , John H. Duesing , Robert M. Goodman , Leslie B. Friedrich , Christian Harms , Frederich Meins, Jr. , Alice Montoya, deceased , Mary B. Moyer , Jean-Marc Neuhaus , George B. Payne , Christoph Sperisen , Jeffrey R. Stinson , Scott J. Uknes , Eric R. Ward , Shericca C. Williams
发明人： John A. Ryals , Danny C. Alexander , James J. Beck , John H. Duesing , Robert M. Goodman , Leslie B. Friedrich , Christian Harms , Frederich Meins, Jr. , Alice Montoya, deceased , Mary B. Moyer , Jean-Marc Neuhaus , George B. Payne , Christoph Sperisen , Jeffrey R. Stinson , Scott J. Uknes , Eric R. Ward , Shericca C. Williams
IPC分类号： C07D285/14 , C07K14/415 , C12N9/02 , C12N9/08 , C12N9/24 , C12N9/36 , C12N15/29 , C12N15/56 , C12N15/62 , C12N15/82 , A01H5/00
CPC分类号： C12N9/2462 , C07D285/14 , C07K14/415 , C12N15/625 , C12N15/8238 , C12N15/8239 , C12N15/8274 , C12N15/8282 , C12N15/8286 , C12N9/0065 , C12N9/0073 , C12N9/2442 , C12Y114/13001 , C12Y302/01014 , C12Y302/01039 , C12Y302/01058 , C12Y302/01073 , C07K2319/00 , C07K2319/02 , C07K2319/55 , C07K2319/61
摘要： The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease. Also provided is a method for the exogenous regulation of gene expression in plants, which comprises obtaining a plant incapable of regulating at least one gene or gene family, or at least one heterologous gene, due to the deactivation of at least one endogenous signal transduction cascade which regulates the gene in the plant, and applying a chemical regulator to the plant at a time when expression of the gene is desired. A novel signal peptide sequence and corresponding DNA coding sequence is also provided. Further provided are assays for the identification and isolation of additional chemically regulatable DNA sequences and cDNAs encoding PR proteins and assays for identifying chemicals capable of exogenously regulating the chemically regulatable DNA sequences of the invention.
摘要翻译：本发明提供能够调节植物或植物组织中相关DNA序列转录的化学可调节DNA序列，含有此类序列的嵌合构建体，含有此类序列的载体和嵌合构建体，以及含有这些嵌合构建体的转基因植物和植物组织。在一个方面，本发明的化学可调节DNA序列衍生自编码发病相关（PR）蛋白的基因的5'区域。本发明还提供衍生自编码PR蛋白的新cDNA的抗病原性序列，其可以被遗传工程化并转化成植物以赋予增强的抗病性。还提供了外源调节植物中基因表达的方法，其包括获得不能调节至少一个基因或基因家族或至少一个异源基因的植物，因为至少一种内源性信号转导级联失活其调节植物中的基因，并且在需要表达基因的时候将化学调节剂施用于植物。还提供了新的信号肽序列和相应的DNA编码序列。进一步提供用于鉴定和分离另外的化学可调节DNA序列和编码PR蛋白的cDNA和用于鉴定能够外源调节本发明的化学可调节DNA序列的化学品的测定。

8. 发明授权

US5614395A Chemically regulatable and anti-pathogenic DNA sequences and uses thereof 失效
标题翻译：化学上可调节的和抗病原性的DNA序列及其用途
公开(公告)号：US5614395A
公开(公告)日：1997-03-25
申请号：US181271
申请日：1994-01-13
申请人： John A. Ryals , Danny C. Alexander , James J. Beck , John H. Duesing , Robert M. Goodman , Leslie B. Friedrich , Christian Harms , Frederich Meins, Jr. , Alice Montoya, deceased , Mary B. Moyer , Jean-Marc Neuhaus , George B. Payne , Christoph Sperisen , Jeffrey R. Stinson , Scott J. Uknes , Eric R. Ward , Shericca C. Williams
发明人： John A. Ryals , Danny C. Alexander , James J. Beck , John H. Duesing , Robert M. Goodman , Leslie B. Friedrich , Christian Harms , Frederich Meins, Jr. , Alice Montoya, deceased , Mary B. Moyer , Jean-Marc Neuhaus , George B. Payne , Christoph Sperisen , Jeffrey R. Stinson , Scott J. Uknes , Eric R. Ward , Shericca C. Williams
IPC分类号： C07D285/14 , C07K14/415 , C12N9/02 , C12N9/08 , C12N9/24 , C12N9/36 , C12N15/29 , C12N15/56 , C12N15/62 , C12N15/82 , C12N15/09
CPC分类号： C12N9/2462 , C07D285/14 , C07K14/415 , C12N15/625 , C12N15/8238 , C12N15/8239 , C12N15/8274 , C12N15/8282 , C12N15/8286 , C12N9/0065 , C12N9/0073 , C12N9/2442 , C12Y114/13001 , C12Y302/01014 , C12Y302/01039 , C12Y302/01058 , C12Y302/01073 , C07K2319/00 , C07K2319/02 , C07K2319/55 , C07K2319/61
摘要： The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease. Also provided is a method for the exogenous regulation of gene expression in plants, which comprises obtaining a plant incapable of regulating at least one gene or gene family, or; at least one heterologous gene, due to the deactivation of at least one endogenous signal transduction cascade which regulates the gene in the plant, and applying a chemical regulator to the plant at a time when expression of the gene is desired. A novel signal peptide sequence and corresponding DNA coding sequence is also provided. Further provided are assays for the identification and isolation of additional chemically regulatable DNA sequences and cDNAs encoding PR proteins and assays for identifying chemicals capable of exogenously regulating the chemically regulatable DNA sequences of the invention.
摘要翻译：本发明提供能够调节植物或植物组织中相关DNA序列转录的化学可调节DNA序列，含有此类序列的嵌合构建体，含有此类序列的载体和嵌合构建体，以及含有这些嵌合构建体的转基因植物和植物组织。在一个方面，本发明的化学可调节DNA序列衍生自编码发病相关（PR）蛋白的基因的5'区域。本发明还提供衍生自编码PR蛋白的新cDNA的抗病原性序列，其可以被遗传工程化并转化成植物以赋予增强的抗病性。还提供了一种用于外源调节植物中基因表达的方法，其包括获得不能调节至少一个基因或基因家族的植物，或; 至少一种异源基因，由于至少一种调节植物中基因的内源性信号转导级联的失活，以及在需要基因表达时将化学调节剂施用于植物。还提供了新的信号肽序列和相应的DNA编码序列。进一步提供用于鉴定和分离另外的化学可调节DNA序列和编码PR蛋白的cDNA和用于鉴定能够外源调节本发明的化学可调节DNA序列的化学品的测定。

9. 发明申请

US20120138249A1 Method for improving paper and board's resistance to the penetration of liquids 审中-公开
标题翻译：提高纸张和纸张对液体渗透性的抵抗力的方法
公开(公告)号：US20120138249A1
公开(公告)日：2012-06-07
申请号：US12928057
申请日：2010-12-02
申请人： Patrick Sundholm , Danny C. Alexander
发明人： Patrick Sundholm , Danny C. Alexander
IPC分类号： D21H23/50
CPC分类号： D21H21/16 , D21H17/16 , D21H17/17 , D21H19/84 , D21H23/50
摘要： This invention brings a new aspect in papermaking by spraying hydrophobic chemical directly onto the paper surface in the dryer section of the paper machine, as a two-step process where high solids starch is sprayed on the paper to seal the sheet's surface and thereafter the hydrophobic chemical is sprayed on the paper surface. This invention is a completely new method of hydrophobic sizing, spraying a small amount of a suitable hydrophobic chemical on the moving web in the dryer section, instead of adding hydrophobic chemical in the wet-end of the paper machine, or mixing it in with starch at a size press. This invention reduces the amount of hydrophobic chemical used compared to any of the other processes, it simplifies wet-end chemistry, and it puts the hydrophobic sizing exactly where it is needed, on the paper's surface, which in many cases will be a single side of the paper.
摘要翻译：本发明通过将造纸机的干燥部中的疏水化学品直接喷涂到纸表面上作为两步法，其中将高固体淀粉喷在纸上以密封片材的表面，然后疏水性的方式在造纸中带来了新的方面化学品喷在纸面上。本发明是一种全新的疏水施胶方法，将少量合适的疏水化学品喷洒在干燥部分的移动纤维网上，而不是在造纸机的湿端添加疏水化学品，或将其与淀粉混合在大小新闻。本发明减少了与任何其它方法相比所使用的疏水化学品的用量，它简化了湿端化学，并且将疏水尺寸精确地置于需要的地方，在纸的表面上，其在许多情况下将是单面的论文。

10. 发明授权

US07433787B2 System, method, and computer program product using a database in a computing system to compile and compare metabolomic data obtained from a plurality of samples 有权
标题翻译：使用计算系统中的数据库来编制和比较从多个样本获得的代谢组学数据的系统，方法和计算机程序产品
公开(公告)号：US07433787B2
公开(公告)日：2008-10-07
申请号：US11462838
申请日：2006-08-07
申请人： Thomas Henry Barrett, Jr. , Corey Donald DeHaven , Danny C. Alexander
发明人： Thomas Henry Barrett, Jr. , Corey Donald DeHaven , Danny C. Alexander
IPC分类号： G01N24/00 , G06F19/00
CPC分类号： G06F19/26 , G06F19/18 , G06F19/28
摘要： The present invention generates a visual display of metabolomic data compiled by a database and associated processor. More particularly, the present invention provides a database for automatically receiving a three-dimensional spectrometry data set for a group of samples. The present invention also provides a processor device for manipulating the data sets to produce plots that are directly comparable to a plurality of characteristic plots corresponding to a plurality of selected metabolites. Furthermore, the processor device may generate a visual display indicating the presence of the selected metabolites across the group of samples. Thus, the present invention enables a user to analyze a series of complex data sets in a visual display that may indicate the presence of the selected metabolites across the group of samples. Furthermore, the visual display generated by embodiments of the present invention also expedites the subjective analysis of the spectrometry data sets.
摘要翻译：本发明生成由数据库和相关联的处理器编译的代谢组学数据的视觉显示。更具体地，本发明提供一种用于自动接收一组样本的三维光谱数据集的数据库。本发明还提供了一种用于操纵数据集以产生与对应于多个选择的代谢物的多个特征图直接相比的图的处理器装置。此外，处理器设备可以生成指示所选择的代谢物在整个样本组中的存在的视觉显示。因此，本发明使得用户能够分析视觉显示中的一系列复杂数据集，其可以指示所选择的代谢物在整个样本组中的存在。此外，由本发明的实施例产生的视觉显示也加速了对光谱测定数据集的主观分析。

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