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1. 发明申请

US20160238335A1 SILENCER DEVICE 审中-公开
标题翻译：沉默器
公开(公告)号：US20160238335A1
公开(公告)日：2016-08-18
申请号：US15040845
申请日：2016-02-10
申请人： Werner Bertschinger , Hugo Ziegler
发明人： Werner Bertschinger , Hugo Ziegler
IPC分类号： F41A21/30
CPC分类号： F41A21/30
摘要： A silencer device for a firearm has a center portion including at least two substantially semi-circular chamber partition wall elements being spaced from one another in the longitudinal direction of the center portion, a housing portion into which the center portion is introduced, wherein between the at least two substantially semi-circular chamber partition wall elements and the inner wall of the housing portion at least one chamber is formed; and a positioning portion being at least connectable to the housing portion. The at least two substantially semi-circular chamber partition wall elements respectively comprise on their outer sides at least one chamfer, which form a lateral passage for explosive gases with the inner wall of the housing portion.
摘要翻译：用于枪支的消音装置具有中心部分，该中心部分包括沿中心部分的纵向方向彼此间隔开的至少两个基本上半圆形的室隔壁元件，其中引入中心部分的壳体部分，至少两个大致半圆形的室隔壁元件和壳体部分的内壁形成至少一个室; 并且至少可连接到所述壳体部分的定位部分。所述至少两个基本上为半圆形的室隔壁元件在其外侧分别包括至少一个倒角，其形成用于爆炸性气体的外部通道与壳体部分的内壁。

2. 发明申请

US20130012686A1 COSMETIC COMPOSITION FOR STIMULATING THE SYNTHESIS OF PROTEINS OF THE BASEMENT MEMBRANE 有权
标题翻译：用于刺激基底膜蛋白质合成的化妆品组合物
公开(公告)号：US20130012686A1
公开(公告)日：2013-01-10
申请号：US13614337
申请日：2012-09-13
申请人： Hugo ZIEGLER , Dominik IMFELD , Martin STOCKLI , Marc HEIDL
发明人： Hugo ZIEGLER , Dominik IMFELD , Martin STOCKLI , Marc HEIDL
IPC分类号： C07K5/11 , C07K5/09
CPC分类号： A61Q19/08 , A61K8/64 , C07K5/0815 , C07K5/1019
摘要： Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or ary1-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.
摘要翻译：可以局部应用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20烷基，环烷基或芳基，C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。

3. 发明授权

US08088921B2 Method for producing 3-amidinophenylalanine derivatives 有权
标题翻译：制备3-脒基苯丙氨酸衍生物的方法
公开(公告)号：US08088921B2
公开(公告)日：2012-01-03
申请号：US12905769
申请日：2010-10-15
申请人： Hugo Ziegler , Peter Wikstroem
发明人： Hugo Ziegler , Peter Wikstroem
IPC分类号： C07D295/00 , C07D213/00
CPC分类号： C07D295/205 , C07D211/60
摘要： The present invention describes a method for the synthesis of enantiomerically pure 3-amidinophenylalanine derivatives, which are used as pharmaceutically effective urokinase inhibitors, by starting from 3-cyanophenylalanine derivatives. The methods of manufacture comprising only one synthesis step lead to new intermediates, namely 3-hydroxyamidino- and 3-amidrazonophenylalanine derivatives. These intermediates or their acetyl derivatives can be reduced into the desired 3-amidino-phenylalanine derivatives under gentle conditions (H2 or ammonium formiate, Pd/C (approx. 10%), ethanol/water, room temperature, normal pressure or also H2, Pd/C, AcOH or HCl/ethanol, 1-3 bar) in excellent yields and in an enantiomeric excess of up to 99.9%.
摘要翻译：本发明描述了通过从3-氰基苯丙氨酸衍生物开始合成用作药物有效的尿激酶抑制剂的对映体纯的3-脒基苯丙氨酸衍生物的方法。仅包含一个合成步骤的制备方法导致新的中间体，即3-羟基脒基 - 和3-酰胺基苯丙氨酸衍生物。这些中间体或其乙酰基衍生物可以在温和的条件下（H2或甲酸铵，Pd / C（约10％），乙醇/水，室温，常压或还有H2），还原成所需的3-脒基 - 苯丙氨酸衍生物， Pd / C，AcOH或HCl /乙醇，1-3巴），产率高达99.9％，对映异构体过量。

4. 发明申请

US20110142895A1 TRIPEPTIDES AND DERIVATIVES THEREOF FOR COSMETIC APPLICATION IN ORDER TO IMPROVE SKIN STRUCTURE 有权
标题翻译：用于化妆品应用的TRIPEPTIDES及其衍生物以改善皮肤结构
公开(公告)号：US20110142895A1
公开(公告)日：2011-06-16
申请号：US12954142
申请日：2010-11-24
申请人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
发明人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
IPC分类号： A61K8/64 , A61Q19/08 , A61K38/06 , A61Q19/04 , A61P17/10 , A61P17/18 , A61P29/00 , A61Q19/06 , A61P31/00 , A61P17/00 , A61Q17/04 , A61K8/02 , B82Y5/00
CPC分类号： C07K7/08 , A61K8/64 , A61Q19/08
摘要： The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24)alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).
摘要翻译：本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6，-SO 2 -R 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2）n -NH 2或（CH 2）3 -NHC（NH）NH 2; n等于1 4; R3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选取代的（C 1 -C 24）烷基，任选取代的C 2 -C 24烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4烷基或9-芴基 - 甲基; X表示氧（-O-）或NH-; 或具有X = O的XR5也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R1和R5不表示氢，X不同时代表氧。本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

5. 发明授权

US07718406B2 Substrates for TAFI (A) 有权
标题翻译： TAFI基板（A）
公开(公告)号：US07718406B2
公开(公告)日：2010-05-18
申请号：US10530165
申请日：2002-12-06
申请人： Hugo Ziegler , Dagmar Prasa , Jörg Stürzebecher , Peter Wikstroem
发明人： Hugo Ziegler , Dagmar Prasa , Jörg Stürzebecher , Peter Wikstroem
IPC分类号： C12P13/04 , A61K38/00
CPC分类号： C07K5/06095 , C07K5/06086 , C07K5/06147 , C07K5/08 , C07K5/0802 , C12Q1/56
摘要： The invention relates to compounds of general formula (I) and acid addition salts thereof, where the various symbols have the meanings given in the description and claims, the production and use thereof as substrate for the detection of TAFIa, a fibrinolysis inhibiting enzyme. The detection occurs by using the absorption between 400 and 412 nm, arising as a result of the formation of 3-carboxy-4-nitrothiophenol from Ellman's reagent as a function of time.
摘要翻译：本发明涉及通式（I）的化合物及其酸加成盐，其中各种符号具有在说明书和权利要求书中给出的含义，其作为检测TAFIa，纤维蛋白溶解抑制酶的底物的生产和用途。通过使用400和412nm之间的吸收作为由Ellman试剂形成3-羧基-4-硝基苯硫酚作为时间的函数而产生的检测发生。

6. 发明授权

US07109197B2 N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives 失效
标题翻译： N-苯基-4-（4-吡啶基）-2-嘧啶胺衍生物
公开(公告)号：US07109197B2
公开(公告)日：2006-09-19
申请号：US10297737
申请日：2001-06-06
申请人： Martin Eberle , Daniel Stierli , Christian Pillonel , Hugo Ziegler
发明人： Martin Eberle , Daniel Stierli , Christian Pillonel , Hugo Ziegler
IPC分类号： C07D401/04 , A01N43/54 , C07D213/46
CPC分类号： C07D231/12 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/76 , A01N43/78 , A01N43/84 , A01N47/06 , A01N47/12 , A01N47/16 , A01N47/18 , A01N47/36 , A01N55/00 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to a method of protecting plants against attack or infestation by phytopathogenic organisms, such as nematodes or especially microorganisms, preferably fungi, bacteria and viruses, or combinations of two or more of these organisms, by applying at least one compound of the formula (I): wherein n is 0 or 1, R1 is halogen, alkoxy, haloalkyl, haloalkoxy or alkyl, R2 is hydrogen, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy, each of R3, R4 and R5 is, independently of the others, hydrogen, lower alkyl or halogen, and R6 is as defined in claim 1. The invention also relates to new compounds of formula (I), their preparation, use and compositions comprising said compound
摘要翻译：本发明涉及一种保护植物免受植物病原性生物如线虫或特别是微生物（优选真菌，细菌和病毒）或这些生物体中两种或更多种的组合的侵袭或侵袭的方法，其中通过施用至少一种化合物式（I）：其中n是0或1，R 1是卤素，烷氧基，卤代烷基，卤代烷氧基或烷基，R 2是氢，卤素，烷基，卤代烷基，烷氧基或卤代烷氧基，R 3，R 4和R 5各自独立地为氢，低级烷基或卤素，和 R 6如权利要求1所定义。本发明还涉及式（I）的新化合物，其制备，用途和组合物，其包含所述化合物

7. 发明授权

US07074787B2 Microbiocidal N-phenyl-N-[4-(4-pyridyl-2-pyrimidin-2-yl]-amine derivatives 失效
公开(公告)号：US07074787B2
公开(公告)日：2006-07-11
申请号：US10451930
申请日：2001-12-20
申请人： Martin Eberle , Hugo Ziegler , Fredrik Cederbaum , Peter Ackermann , Anita Schnyder
发明人： Martin Eberle , Hugo Ziegler , Fredrik Cederbaum , Peter Ackermann , Anita Schnyder
IPC分类号： C07D401/04 , C07D413/04 , A01N43/54
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D419/14
摘要： The invention relates to novel N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives of the general formula (I) wherein the sum of (m+p) together is 0, 1, 2 or 3; n and q are independently of each other 0 or 1, and the sum of (m+p+q) together is 1, 2, 3 or 4; R1 is hydrogen, halogen, alkoxy, haloalkyl, haloalkoxy or alkyl; R2 is hydrogen, C1–C6-alkyl, C1–C6-haloalkyl or C1–C6-alkoxy; R2A is hydrogen, C1–C6-alkyl, C3–C4-alkenyl or C3–C4-alkynyl; each of R3, R4, R5 and R6 is, independently of the others, hydrogen, C1–C6-alkyl, C1–C6-haloalkyl, hydroxy-C1–C6-alkyl or C1–C6-alkoxy-C1–C6-alkyl, or the ring members CR3R4 or CR5R6 or CR2R2A are independently of each other a carbonyl group (C═O) or a group C═S; X is C═O, C═S, S═O or O═S═O; Y is O, S, C═O, CH2, —N(R8)—, —O—N(R8)—, —N(R8)—O— or NH—; R7 is hydrogen, C1–C4-alkyl, C3–C4-alkenyl, C3–C4-alkynyl, —CH2OR8, CH2SR8, —C(O)R8, —C(O)OR8, SO2R8, SOR8 or SR8; and R8 is C1–C8-alkyl, C1–C8-alkoxyalkyl, C1–C8 haloalkyl or phenylC1–C2-alkyl wherein the phenyl may be substituted by up to three groups selected from halo or C1–C4-alkyl; or a salt thereof. The invention also relates to the preparation of the compounds and to agrochemical compositions comprising at least one of those compounds as active ingredient as well as the preparation of the said compositions and to the use of the compounds or of the compositions in controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

8. 发明授权

US06525092B1 Pesticidal bis-oxime compounds 失效
标题翻译：杀虫双肟化合物
公开(公告)号：US06525092B1
公开(公告)日：2003-02-25
申请号：US09787481
申请日：2001-04-27
申请人： Hugo Ziegler , Stephan Trah
发明人： Hugo Ziegler , Stephan Trah
IPC分类号： A01N3734
CPC分类号： C07C251/48 , A01N37/50 , C07C251/60 , C07C255/61
摘要： Bis-oxime compounds of the general formula (I) are provided wherein X, Y, R1, R2 R3 and n are as defined in the specification. The bis-oxime compounds possess pesticidal activity, which may provide plants with protection from phytopathogenic microorganisms.
摘要翻译：提供通式（I）的双肟化合物，其中X，Y，R 1，R 2，R 3和n如说明书中所定义。双肟化合物具有杀虫活性，可为植物提供植物病原微生物的保护。

9. 发明授权

US5726343A Process for the preparation of arylacetic ester derivatives via palladium-catalyzed cross coupling reaction 失效
标题翻译：通过钯催化的交叉偶联反应制备芳基乙酸酯衍生物的方法
公开(公告)号：US5726343A
公开(公告)日：1998-03-10
申请号：US676364
申请日：1996-07-22
申请人： Hugo Ziegler , Denis Neff , Wolfgang Stutz
发明人： Hugo Ziegler , Denis Neff , Wolfgang Stutz
IPC分类号： C07D317/46 , B01J23/44 , C07B61/00 , C07C249/12 , C07C251/38 , C07C251/48 , C07C251/60 , C07C253/30 , C07C255/62 , C07C255/64 , C07C323/46 , C07D213/53 , C07D213/55 , C07D307/52 , C07D307/81 , C07D311/58 , C07D311/74 , C07D317/56 , C07D317/58 , C07D319/18 , C07D319/20 , C07D333/22 , C07F5/02
CPC分类号： C07D213/53 , C07C249/12 , C07C251/38 , C07C251/48 , C07C251/60 , C07C255/64 , C07D307/52 , C07D307/81 , C07D317/58 , C07D319/18 , C07D319/20 , C07D333/22 , C07F5/025 , C07C2102/08 , C07C2102/10
摘要： Process for the preparation of 2-methoxyimino-2-arylacetic esters of formula (I) in which R is C.sub.1 -C.sub.12 alkyl, which comprises reacting an appropriately substituted boronic acid of general formula (II) or the trimeric form (lII) herein, which is in equilibrium with it, in the presence of a Pd catalyst, with a methoxyiminoacetic ester of formula (IV) in which R is C.sub.1 -C.sub.12 alkyl and X is a leaving group. According to a further process variant, in principle the groups which split off the two reactants may change places. The process can be applied not only to phenyl derivatives but also to larger ring systems (naphthyl, pyridyl, heterocycles).
摘要翻译： PCT No.PCT / EP95 / 00146 Sec。 371日期：1996年7月22日 102（e）日期1996年7月22日PCT提交1995年1月16日PCT公布。出版物WO95 / 20569 日期1995年8月3日制备式（I）的2-甲氧基亚氨基-2-芳基乙酸酯的方法，其中R是C 1 -C 12烷基，其包括使适当取代的通式（II）的硼酸或三聚体形式 IIII），其在Pd催化剂的存在下与其平衡，与式（IV）的甲氧基亚氨基乙酸酯反应，其中R是C 1 -C 12烷基，X是离去基团。根据进一步的方法变体，原则上分裂两种反应物的基团可以改变位置。该方法不仅可用于苯基衍生物，而且可用于较大的环系（萘基，吡啶基，杂环）。

10. 发明授权

US10094633B2 Silencer device 有权
公开(公告)号：US10094633B2
公开(公告)日：2018-10-09
申请号：US15040845
申请日：2016-02-10
申请人： Werner Bertschinger , Hugo Ziegler
发明人： Werner Bertschinger , Hugo Ziegler
IPC分类号： F41A21/30
摘要： A silencer device for a firearm has a center portion including at least two substantially semi-circular chamber partition wall elements being spaced from one another in the longitudinal direction of the center portion, a housing portion into which the center portion is introduced, wherein between the at least two substantially semi-circular chamber partition wall elements and the inner wall of the housing portion at least one chamber is formed; and a positioning portion being at least connectable to the housing portion. The at least two substantially semi-circular chamber partition wall elements respectively comprise on their outer sides at least one chamfer, which form a lateral passage for explosive gases with the inner wall of the housing portion.

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